KU Leuven Research Data Repository
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Code for: "Natiolectal variation in Dutch grammar: A data-driven approach"
No full textThis repository contains the code used for generating and/or analysing the data in De Troij, Robbert. 2022. Natiolectal variation in Dutch grammar: A data-driven approach. PhD dissertation, KU Leuven & Radboud University Nijmegen. Each of the four main research chapters (Ch. 3-6) has its own zip folder comprising the associated file(s). Files of the remaining chapters will be added to the repository after corresponding journal articles have been published
Replication Data for: Molecular Evolution of Aryl Hydrocarbon Receptor Signaling Pathway Genes
No full textThe Aryl hydrocarbon receptor is an ancient transcriptional factor originally discovered as a sensor of dioxin. In addition to its function as receptor of environmental toxicants, it plays an important role in development. Although a significant amount of research has been carried out to understand AHR signal transduction pathway and its involvement in species susceptibility to environmental toxicants, none of them to date has comprehensively studied its evolutionary origins. Studying evolutionary origins of molecules can inform ancestral relationships of genes. Vertebrate genome has been shaped by two rounds of whole-genome duplications (WGD) at the base of vertebrate evolution approximately 600 million years ago (Mya), followed by lineage specific gene losses, which often complicate assignment of functional homology. It is crucial to understand evolutionary origins of this transcription factor and its partners, in order to distinguish orthologs from ancient non-orthologous homologs. In this study, we have investigated evolutionary origins of proteins involved in the AHR pathway. Our results provide evidence of gene loss and duplications, crucial for understanding functional connectivity of human and model species. Multiple studies have shown that 2R-ohnologs (genes and proteins that have survived from the 2R-WGD) are enriched in signaling components relevant to developmental disorders and cancer. Our findings provide a link between AHR pathway’s evolutionary trajectory and its possible mechanistic involvement in pathogenesis