KU Leuven Research Data Repository
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Replication Data for: Lambrechts et al (2025) - Botulinum Neurotoxin A-Induced Muscle Morphology Changes in Children with Cerebral Palsy: A One-Year Follow-Up Study.
No full textThis is a longitudinal dataset consisting of macroscopic muscle (size) data from the medial gastrocnemius over a one-year period. The data is available for children with cerebral palsy (CP) who received botulinumtoxin (BoNT) treatment and children with CP in a control group. Cross-sectional data from children in a CP reference group is also included. Macroscopic muscle parameters were assessed through 3D freehand ultrasound and included muscle volume, anatomical cross-sectional area, muscle belly length and echo-intensity
Replication Data for: Simulation and Measurement Based Study of the Asymptotic Low-Frequency Electric and Magnetic Shielding Effectiveness for Board Level Applications
No full textThis dataset supports the evaluation of board-level shielding effectiveness against electric and magnetic field sources from 10 MHz to 10 GHz. It includes FDTD simulation and measurement data using the SAE ARP 6248 stripline method, adapted for on-board sources. The dataset captures shielding effectiveness in near-field conditions, total radiated power metric, and wave impedance characteristics to distinguish between electric and magnetic source behavior. Strong agreement is observed between simulated and measured results, offering a validated resource for EMI analysis and shield design
Food Literacy Tool for Personalized Food Literacy Guidance
No full textFood literacy refers to all practicalities associated with healthy eating. Current food literacy tools are limited in practical use in clinical practice. Therefore, an integrated food literacy tool (IFLT) to assess food literacy and to personalize food literacy guidance was developed and validated
Replication Data for: The effects of task-specific home-based touchscreen training in people with Parkinson’s disease: a pilot randomized controlled trial
No full textBackground: Manual dexterity deficits impair the ability to effectively use touchscreen devices in people with Parkinson’s disease (PD).
Objective: To examine the effects and feasibility of a home-based, unsupervised tablet-task training on task-specific performance in a randomized controlled trial and to determine which individuals are likely to benefit.
Methods: Thirty-four PD patients were randomized and included into an experimental training (EXP, N=16) and passive control group (CTL, N=18). The EXP practiced a Swipe-Slide Pattern (SSP) task on a tablet (5x/week for 2 weeks) as fast and accurately as possible in single and dual task conditions. Performance on the SSP and an untrained Mobile Phone Task (MPT) were tested before and after two weeks training and after four weeks follow-up. SSP-Time (primary outcome), SSP-Accuracy (% correct) and MPT-Time were recorded. Linear mixed models were used to assess training effects.
Results: The home-based task-specific training program significantly improved the SSP-Time immediately after training (p<0.001, d=0.917) and at follow-up (p=0.006, d=0.663), and showed excellent compliance rates (average 98%). No transfer occurred to the untrained MPT. Worse baseline SSP-performance and older age were significantly associated with short- and long-term gains (p<0.010).
Conclusion: Home-based, unsupervised touchscreen training is feasible and effective to improve movement time of the trained task, albeit without transfer to an untrained task. The heterogeneity and variability of the effects underscore the importance of personalizing rehabilitation programs in PD, according to baseline performance. Future studies should investigate a wider range of transfer tasks and clinical determinants that could impact the training response
Replication Data for: Alterations in the lipid profile of critically ill children in relation to outcome. Lauren De Bruyn et al. Crit Care 2025. doi.org/10.1186/s13054-025-05327-5
No full textBackground: Critically ill adults typically develop hypocholesterolemia, associated with poor outcome. Whether similar alterations occur in critically ill children is less clear. Methods: In secondary analyses of the PEPaNIC RCT (n = 1440), we first documented the time course of plasma cholesterol and triglyceride concentrations, and the effect of randomization to early-parenteral-nutrition (early-PN) or late-PN hereon, for 96 matched critically ill children staying ≥ 5 days in PICU. Second, for 1165 children with available admission plasma samples, lipid profiles were determined and their independent associations with outcome (time to live PICU discharge, new infection and 90-day mortality) were assessed with Multivariable Cox proportional hazard and logistic regression, adjusting for baseline risk factors. Results: Plasma HDL-cholesterol, LDL-cholesterol, total-cholesterol and triglycerides were low throughout the 5 PICU days, with only HDL-cholesterol further decreasing over time (P < 0.0001) and without effect of randomization to early-PN or late-PN, and with admission values lower in infants than older children and in patients with infection (P < 0.05). Lower admission HDL- and total-cholesterol concentrations were independently associated with a lower likelihood of an earlier live PICU discharge (P < 0.001) and with a higher risk of 90-day mortality (P ≤ 0.01), whereas higher plasma triglycerides were independently associated with higher risk of 90-day mortality (P = 0.004). Low admission plasma HDL-cholesterol was independently associated with a higher risk of acquiring a new infection (P = 0.05). Conclusion: Critically ill children presented with low circulating levels of lipids. Low plasma cholesterol concentrations were associated with poor outcomes, most robustly for HDL-cholesterol. Whether these associations are causal or casual requires further investigation
EXIMIOUS questionnaire for participants
No full textThis research data entails a questionnaire for the collection of exposome information in the different EXIMIOUS cohorts. It interrogates basic demographic and anthropometric information, education, habits regarding smoking, diet, alcohol, and exercise, hobbies and activities, household product use, pets, metal implants, tattoos, sleeping difficulties, and post-COVID hygiene. The questionnaire is in English but is also available in other languages (Dutch, Danish, Spanish, and Romanian) upon request
Replication Data for: CovFUZZ: Coverage-based fuzzer for 4G&5G protocols
No full textThis repository provides the implementation (source code) of CovFuzz fuzzing framework and experimental results associated with the paper "CovFuzz: Coverage-based fuzzer for 4G&5G protocols", presented at EuroS&P 2025.
It provides everything needed to reproduce the results from the paper and to run fuzzing campaigns against both simulation-based and real (physical) 4G and 5G targets
Replication Data for: A pilot study on midazolam sedation for murine echocardiography: A potential alternative to isoflurane anesthesia and awake imaging
No full textData described in the manuscript - Isoflurane anesthesia is often used to facilitate murine echocardiography, butcan suppress cardiac function. Awake imaging avoids pharmacological inter-ference, but can induce sympathetic activation. In this Midazolam sedation.Parameters were compared using repeated-measures ANOVA. Midazolam ena-bled imaging without overt stress behavior. Compared to midazolam, heart ratewas similar under isoflurane and higher while awake (p ≤ 0.01). End-systolicvolume was larger under isoflurane and smaller while awake; stroke volumesremained similar across conditions. Global longitudinal and circumferentialstrain were less negative under isoflurane (p = 0.03) but similar during awakeimaging, while radial strain was higher during awake imaging. Peak longitudi-nal strain rate was less negative under isoflurane (p ≤ 0.01) and more negativewhile awake (p = 0.05). Early diastolic strain rate was similar under isofluraneand lower while awake (p = 0.02). In conclusion, cardiac function was mostdepressed under isoflurane and most enhanced during awake imaging, likelystress-driven. Murine echocardiography under midazolam sedation was feasi-ble, yielding better function than isoflurane anesthesia, closer to awake imag-ing but without overt handling stress. These findings require further validationacross disease models, sexes, and strains
Service lives of building elements in the European Union
No full textThe dataset was developed to support the "Analysis of Life-cycle Greenhouse Gas Emissions and Removals of EU Buildings and Construction" project, the aim of which is to assess the current and future environmental impacts of the European building sector through the development of a building stock model, using a life cycle assessment (LCA) approach.
The dataset contains information on the estimated service lives of common building elements and components in each EU Member State.
The data were collected to be used as background information for the aforementioned LCA, and specifically with the goal of identifying the replacement interval of each building element within the building stock model
Dataset explorative study S60516_S64871
No full textAim for which the data were collected: To compare esophageal pressure swings and airway pressure swings and their relationship with the activation of extradiaphragmatic inspiratory muscles in patients with weaning difficulties across different loaded and unloaded breathing conditions