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Replication Data for: Acidic hydrothermal processing of wheat using citrate buffer largely enhances iron and zinc bioaccessibility and bioavailability to Caco-2 cells
No full textPhytate chelates iron (Fe) and zinc (Zn) in wheat. A multifactorial experiment showed that hydrothermal processing (45 – 60 °C, pH 4.0 – 6.0, 8 – 24 h) of wheat using acetate or lactate buffers reduced phytate contents by a factor 1.4 to 2.8 and increased bioaccessibility, determined with an in vitro digestion, maximally 1.9 (Fe) or 1.5 (Zn) times relative to unprocessed wheat. In contrast, hydrothermal processing using citrate buffer reduced phytate contents by a factor 1.3 to 2.0 and increased bioaccessibility values 9.8 (Fe) and 8.8 (Zn) times, due to formation of soluble chelates. The in vitro digests were supplied to Caco-2 cells, showing that mineral bioavailabilities in these processed wheat grains were 6-fold (Fe) and 12-fold (Zn) higher than in unprocessed wheat. Thus, hydrothermal processing of wheat using citrate buffer can be used for developing whole grain-based products with increased Fe and Zn bioavailability
Code for "Enhancing model identification with SINDy via nullcline reconstruction"
No full textArchived version of code used for the manuscript "Enhancing model identification with SINDy via nullcline reconstruction". The code has been developed around the PySINDy package (version 1.7) of SINDy for Python (version 3.8.12). Instructions on how to use the scripts can be found in the ReadMe file here and the Gitlab respository
General European Public Humour Database
No full textThis dataset is developed for a research project “Humour Scandals (Hu-Sca): A cross-national analysis of humour controversies in Europe”, funded by KU Leuven, Una Europa Research Acceleration Fund.
The data contains an overview of humor scandals i.e. public controversies originating from humor and dealing with the boundaries of transgressive humor in public debate and their reception in legacy media for eight European countries between 1990 and 2022.
The data contains quantatively coded descriptive markers of each humor scandal (e.g. nature of norm transgression, actors involved, duration, timespan) as well as qualitative analysis of the way that the humor scandal was either justified or condemned in national legacy media.
This data can be used for the analysis of the role of humor in socio-political conflict and the role of media in the creation and mediation of humor-related controversies
Replication Data for: Ice-nucleating particle concentration impacts cloud properties over Dronning Maud Land, East Antarctica, in COSMO-CLM²
No full textOutput of COSMO-CLM² required for reproduction of the figures found in "The impact of the concentration of ice-nucleating particles (INPs) on
clouds in Dronning Maud Land in a regional climate model". The dataset contains relevant atmospheric variables on a 400 by 400 grid over East Antarctica and the Southern Ocean, split between a summer (10 January 2012 to 19 February 2012) and a winter (20 July 2022 to 15 August 2022) period and between different runs forced with different concentrations of Ice Nucleating Particles
Replication Data for: Vatican II Vota from the Catholic Church in Africa
No full textThis collection offers an English translation of the responses sent to the Vatican by bishops and prelates of the Catholic Church in Africa, requested through a letter dated 18 June 1959 (and a reminder of 21 March 1960) to propose agenda items for the Second Vatican Council (1962-1965). Penned predominantly by expatriate missionaries in Latin, these responses were dispatched between 1959 and 1960. One finds in them, among other things, the manifold challenges that the Catholic African missions contended with, including the ones connected with the decolonial movements rife in the continent at the time, lack of personnel and funds, contentions with especially Islam and Protestant sects in the battle for souls, as well as the dread for communism and other isms (modernism, materialism, positivism, existentialism, etc.) that these Church leaders wanted the upcoming Council to condemn as modern errors. However, it was the desire for various liturgical reforms and adaptations, notably the permission to use the vernacular in the liturgy, that stood out the most. These responses are documented in the Acta et Documenta Concilio Oecumenico Vaticano II Apparando, Series I (Antepraeparatoria), Vol. II, Consilia et Vota Episcoporum ac Praelatorum, Pars V, Africa (Typis Polyglottis Vaticanis, 1960), hereafter referenced as ADA II/V
Bidirectional permeability of model medicines in an in vitro model based on primary culture of human (hMECs) or Göttingen minipig (mpMECs) mammary epithelial cells.
No full textThis data set contains results related to the application of an appropriate in vitro model for the human blood milk barrier. The aim of the present study was to to evaluate the utility of human mammary epithelial cells (hMECs), weighted to Göttingen Minipig mammary epithelial cells (mpMECs) and Caco-2 in vitro models, by conducting bidirectional permeability assays across a permeable membrane for physiochemically diverse medicines. hMECs and mpMECs were previously characterized as in vitro models for the human blood milk barrier. In the present study, bidirectional permeability assay was performed in hMECs and mpMECs. The selected medicines were amoxicillin, caffeine, cetirizine, levetiracetam, metformin, nevirapine, sertraline, tacrolimus, tenofovir, valproic acid, venlafaxine, and zidovudine. This dataset contains the permeability of the model medicines in three independent experiments for hMECs (Permeability_hMECs_L015.ods, Permeability_hMECs_L020.ods & Permeability_hMECs_L021.ods) and mpMECs (Permeability_mpMECs_L022.ods, Permeability_mpMECs_L023.ods & Permeability_mpMECs_L024.ods). Furthermore, this dataset contains the permeabilitiy of probe substrates for membrane transporters in mpMECs (Permeability_mpMECs_L025.ods & Permeability_mpMECs_L026.ods). The integrity of the monolayer was confirmed after the expeirments by measurement of the transepithelial electrical resistance and sodium fluorescien leakage (Permeability_Monolayer_integrity.ods). The permeabiility coefficients in hMECs are predictive for the in vivo M/P ratio. Linear regression showed a correlation between the in vitro data generated in hMECs and mpMECs after logarithmic transformation.
ConcePTION (Building an ecosystem for better monitoring and communicating safety of medicines use in pregnancy and breastfeeding: validated and regulatory endorsed workflows for fast, optimised evidence generation), funded by European Union, Horizon 2020 Programme (call H2020-JTI-IMI2-2017-13-two-stage). Grant Agreement num. 821520; https://www.imi-conception.eu/. Nina Nauwelaerts received a PhD scholarship by Research-Foundation-Flanders (1S50721N)
Replication Data for: "Wave-driven phase wave patterns in a ring of FitzHugh-Nagumo oscillators"
No full textThese Python scripts contain all the necessary functions to reproduce the results presented in the paper. The ".npy" and ".txt" files contain data, which can be replicated with the code, but are still required to run certain sections of the code. The scripts are further subdivided in cells that are thought to be run independently. Additional information on each data file and each cell of the script is given in the README.md file
Replication Data for: Glucocorticoid treatment increases cholesterol availability during critical illness: effect on adrenal and muscle function. Lauren De Bruyn et al. Crit Care 2024.
No full textData integrated in the manuscript “Glucocorticoid treatment increases cholesterol availability during critical illness: effect on adrenal and muscle function”.
Hypocholesterolemia hallmarks critical illness though the underlying pathophysiology is incompletely understood. As low circulating cholesterol levels could partly be due to an increased conversion to cortisol/corticosterone, we hypothesized that glucocorticoid treatment, via reduced de novo adrenal cortisol/corticosterone synthesis, might improve cholesterol availability and as such affect adrenal gland and skeletal muscle function. In a matched set of prolonged critically ill patients (n = 324) included in the EPaNIC RCT, a secondary analysis was performed to assess the association between glucocorticoid treatment and plasma cholesterol from ICU admission to day five. Next, in a mouse model of cecal ligation and puncture-induced sepsis, septic mice were randomized to receive either hydrocortisone (1.2 mg/day) (n = 17) or placebo (n = 15) for 5 days, as compared with healthy mice (n = 18). Plasma corticosterone, cholesterol, and adrenocortical and myofiber cholesterol were quantified. Adrenal structure and steroidogenic capacity were evaluated. Muscle force and markers of atrophy, fibrosis and regeneration were quantified. In a consecutive mouse study with identical design (n = 24), whole body composition was assessed by EchoMRI to investigate impact on lean mass, fat mass, total and free water. Methodology of data collection and processing is described in the method section of the manuscript DOI:10.1186/s13054-024-05079-
Replication Data for: Deciphering the Factors Influencing Electric Field Mediated Polymerization and Depolymerization at the Solution-Solid Interface
No full textStrong and oriented electric fields are known to influence structure as well as reactivity. The strong electric field (EF) between the tip of a scanning tunneling microscope (STM) and graphite has been used to modulate two-dimensional (2D) polymerization of aryl boronic acids where switching the polarity of the substrate bias enabled reversible transition between self-assembled molecular networks of monomers and crystalline 2D polymer (2DP) domains. Here, we untangle the different factors influencing the EF-mediated (de)polymerization of a boroxine-based 2D polymer on graphite. The influence of the solvent was systematically studied by varying the nature from polar protic to polar aprotic to non-polar. The effect of monomer concentration was also investigated in detail with a special focus on the time-dependence of the transition. Our experimental observations indicate that while the nucleation of 2DP domains is not initiated by the applied electric field, the depolymerization and subsequent desorption, is a consequence of the change in the polarity of the substrate bias within the area scanned by the STM tip. We conclude that the reversible transition is intimately linked to the bias-induced adsorption and desorption of the monomers, which, in turn, could drive changes in the local concentration of the monomers
Resuspended freeze-dried Nannochloropsis as a model laboratory system for concentrated fresh Nannochloropsis in ultrasound cell disruption experiments
No full textThis dataset contains the raw data supporting the article: "Resuspended freeze-dried Nannochloropsis as a model laboratory system for concentrated fresh Nannochloropsis in ultrasound cell disruption experiments". Raw data includes lipid masses after total- and HI-extractable lipid content determination, dry weight and ash determination and LC-MS FFA data.
Filenames refer to the experiment to which they belong, as described in the article.
Experiment 1: resuspension
Experiment 2: UA