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An investigation of healthy aging among older adults in nursing homes: A cross-sectional study
No full textAim This cross-sectional study examined healthy ageing and associated factors among 249 older adults aged 65 years and above residing in nursing homes in Istanbul, T & uuml;rkiye. Methods Data were collected using the "Personal Information Form," "Standardized Mini-Mental State Examination," "Katz Daily Life Activity Index," "Mini Nutritional Assessment Short Form," "Satisfaction with Life Scale," and "Physical Activity Scale for the Elderly." Analyses included chi-square tests, independent t-tests, and logistic regression. Results Results showed a healthy ageing rate of 38.5 %. Significant predictors included cardiovascular diseases, fear of falling, number of medications, and life satisfaction. Cardiovascular diseases decreased healthy ageing odds by 3.015 times, while fear of falling reduced them by 0.516 times. Conversely, higher life satisfaction increased healthy ageing by 0.886 times. Conclusions.Only 4 out of 10 elderly met the criteria for healthy ageing. Interventions should focus on promoting physical activity, psychological and social support, chronic disease management, and personalized care to enhance healthy ageing among older adults in T & uuml;rkiye. (c) 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similartechnologi
The effect of head and neck basal cell carcinoma on body image, quality of life, and Skin Cancer Quality of Life Impact Tool - Experience of a tertiary dermatology clinic: A cross-sectional study
No full textThe aim of this study was to examine the impact of head and neck localized basal cell carcinoma (BCC) on body image, dermatological quality of life, and skin cancer-related quality of life. A total of 119 patients were enrolled. Patients diagnosed with BCC were asked to complete the Dermatology Life Quality Index (DLQI), Body Image Scale (BIS), and Skin Cancer Quality of Life Impact Tool (SCQOLIT). Additionally, demographic information, tumor type, localization, size, and duration of the tumors were recorded. Descriptive statistics, including mean, standard deviation, median, minimum, maximum, frequency, and ratio values, were calculated. Among the 119 patients, 45% were female, and 55% were male. SCQOLIT scores for BCC ranged from 0 to 11, with a mean score of 5.56 +/- 2.14. The BIS scores ranged from 1 to 7, with a mean score of 3.16 +/- 1.27. The DLQI scores ranged from 0 to 4, with a mean score of 1.74 +/- 1.01. The average score of the SCQOLIT was 5.56 +/- 2.14, indicating that the quality of life of BCC patients was moderately affected in the past week. The average BIS score was 3.16 +/- 1.27, suggesting that patients experienced a minimal impact on their body perception. The average DLQI score was 1.74 +/- 1.01, revealing that BCC had a minimal impact on patients' dermatological quality of life
Hypotrichosis and Juvenile Macular Dystrophy-First Homozygous Family Case from Turkiye
No full textHypotrichosis with juvenile macular dystrophy (HMJD) is a rare autosomal recessive disease that leads to blindness in the first thirty years of life. It is characterized by hypotrichosis and progressive macular degeneration. Approximately fifty cases of this very rare entity have been reported. HMJD is associated with mutations in the CDH3 gene. This article presents the case of a 4-year-old child who visited the dermatology clinic with hypotrichosis and underwent genetic screening due to clinical suspicion. His father, who was initially diagnosed with retinitis pigmentosa, was later identified as having HMJD. In both cases, the homozygous c.830del variant in the CDH3 gene was detected. Considering eye involvement, revealed bilateral pigmentary changes at the fovea and loss of the outer retinal layers. In the second case, marked pigmentary changes in the posterior pole bilateral photoreceptor layer irregularity and retinal pigment epithelium atrophy, and a full-thickness macular hole on the right eye and foveal atrophy on the left eye were found. This is the first report of homozygous Turkish father-daughter cases with HJMD. Our discoveries offer deeper insights into CDH3-associated HJMD, providing valuable knowledge that could enhance the expertise of both dermatologists and ophthalmologists
Alt ekstremite amputelerinde ikili göreve ait akut etkilerin incelenmesi
Full text linkBu çalışma, alt ekstremite amputelerinde ikili göreve ait akut etkileri incelemeyi ve sağlıklı kontroller ile kıyaslamayı amaçlamaktadır. Çalışmaya, alt ekstremite amputasyonuna sahip 16 katılımcı ile benzer demografik özelliklerde seçilen 16 sağlıklı katılımcı olmak üzere toplam 32 gönüllü katıldı. Fonksiyonel değerlendirme; 2 Dakika Yürüme Testi (2DYT), Zamanlı Kalk Yürü Testi (ZKYT) ve Fonksiyonel Uzanma Testi (FUT) ile; bilişsel değerlendirme ise Stroop Testi TBAG Formu (ST), İz Sürme Testi (İST) ve Nelson El Reaksiyon Testi ile yapıldı. Otonom sinir sistemi ölçümleri POLAR H10 cihazı kullanılarak gerçekleştirildi. Katılımcılar, birinci görev olarak 2DYT'ni, ikinci görev olarak ise eş zamanlı bilişsel ve motor görevleri yerine getirdi; tüm değerlendirmeler ikili görev öncesinde ve sonrasında uygulanarak elde edilen sonuçlar karşılaştırıldı. Tüm verilerin analizinde SPSS v.26 (SPSS Inc., ABD) yazılımı kullanıldı. Kategorik veriler χ² testi ile değerlendirildi. Normal dağılım göstermeyen veya sıralı verilerin analizinde, grup içi karşılaştırmalar için Wilcoxon testi, gruplar arası karşılaştırmalar için Mann-Whitney U testi kullanıldı. Normal dağılım gösteren sayısal verilerin analizinde, grup içi karşılaştırmalarda eşleştirilmiş örneklem t-testi, gruplar arası karşılaştırmalarda ise bağımsız örneklem t-testi uygulandı. Tüm analizlerde anlamlılık düzeyi p<0,05 olarak kabul edildi. Ampute grubunda, ikili görev sonrası fiziksel performans testlerinden ZKYT süresinde istatistiksel olarak anlamlı bir düşüş, FUT mesafesinde ise istatistiksel olarak anlamlı bir artış gözlendi. Bilişsel değerlendirmelerde ST 1 süresi, ST 3 ve İST A1 süresi anlamlı düzeyde düştü ancak ST 3 düzeltme sayısında anlamlı bir artış kaydedildi. Otonom sinir sistemi yanıtlarından kalp hızı ve sempatik sistem aktivitesini yansıtan SNS İndeks anlamlı artış gösterirken parasempatik sistem aktivitesini yansıtan PNS İndekste ise anlamlı azalma kaydedildi. Kontrol grubunda ise ikili görev sonrası fiziksel performans testlerinden ZKYT süresi istatistiksel olarak anlamlı şekilde azalırken, FUT mesafesi arttı. Bilişsel performans değerlendirmelerinde, ST'nin 1., 3., 4. ve 5. bölüm süreleri ile İz Sürme Testi A1, A2, B1 ve B2 sürelerinde istatistiksel olarak anlamlı düşüş gözlendi; ayrıca B Formu - A Formu süre farkında da anlamlı azalma kaydedildi. Ancak, otonom sinir sistemi değerlendirmelerinde ikili görev öncesi ve sonrası arasında istatistiksel olarak anlamlı bir fark saptanmadı. Her iki grupta da denge parametrelerinde istatistiksel olarak anlamlı fark gözlenirken, gruplar arası karşılaştırmada yalnızca ZKYT süresinde ampute grup lehine anlamlı fark saptandı. Bu bulgu, ikili görev uygulamasının dinamik denge üzerinde daha belirgin bir etki yarattığını düşündürmektedir. Sonuçlar, ikili görev uygulamasının her iki grupta da özellikle dikkat ve yürütücü işlevleri akut olarak artırdığını gösterdi. Ancak ampute bireylerde ST'de inhibisyon yükü arttıkça hata yapma eğilimi yükseldi ve bilişsel kazanımlar daha sınırlı kaldı. İki grup arasında yalnızca bilişsel değerlendirmelerden İST A1 süresinde ampute grup lehine ve otonom sinir sistemi değerlendirmelerinden PNS indeksinde ise kontrol grubunun lehine anlamlı fark saptandı. Bu bulgular, ikili görev uygulamasının temel düzeyde bilişsel hız ve görsel-motor işleme becerileri üzerinde etkili olabileceğini ancak ampute bireylerin kısa süreli stres karşısında parasempatik dengeyi sürdürmekte güçlük yaşayabileceğini düşündürmektedir. Alt ekstremite amputelerinde motor becerilere ek olarak bilişsel işlevleri destekleyen ve otonom sinir sistemi regülasyonunu hedefleyen bütüncül yaklaşımların gerekliliğine işaret etmektedir.This study aimed to examine the acute effects of dual-task in individuals with lower limb amputation and to compare the outcomes with healthy controls. A total of 32 volunteers participated in the study, including 16 individuals with lower limb amputation and 16 healthy participants selected with similar demographic characteristics. Functional assessment was conducted using the 2-Minute Walk Test (2MWT), Timed Up and Go Test (TUG), and Functional Reach Test (FRT), while cognitive performance was evaluated using the Stroop Test TBAG Form (ST), Trail Making Test (TMT), and Nelson Hand Reaction Test. Autonomic nervous system measurements were obtained using the POLAR H10 device. Participants performed the 2MWT as the primary task and executed simultaneous cognitive and motor tasks as the secondary task. All assessments were administered both before and after the dual-task intervention, and the results were compared. Statistical analyses were conducted using SPSS v.26 (SPSS Inc., USA). Categorical variables were analyzed using the χ² test. For non-normally distributed or ordinal data, the Wilcoxon test was used for within-group comparisons and the Mann–Whitney U test for between-group comparisons. For normally distributed numerical variables, paired samples t-test was used for within-group comparisons, and independent samples t-test was applied for between-group comparisons. Statistical significance was set at p<0.05. In the amputee group, a statistically significant decrease in TUG duration and a significant increase in FRT distance were observed following the dual-task intervention. In cognitive assessments, significant reductions were found in ST-1, ST-3, and TMT A1 durations, whereas a significant increase was noted in ST-3 correction counts. Regarding autonomic responses, the SNS index reflecting sympathetic activity showed a significant increase, while the PNS index indicating parasympathetic activity decreased significantly. In the control group, post-intervention analysis revealed a statistically significant reduction in TUG duration and an increase in FRT distance. Significant decreases were observed in ST sections 1, 3, 4, and 5, as well as in TMT A1, A2, B1, and B2 durations; additionally, a significant reduction was found in the B Form – A Form time difference. However, no statistically significant differences were detected in autonomic nervous system parameters between pre- and post-task measurements. Although both groups showed statistically significant improvements in balance parameters, between-group comparisons revealed a significant difference only in TUG duration in favor of the amputee group. This suggests that the dual-task intervention had a more pronounced effect on dynamic balance. The findings indicated that dual-task practice acutely enhanced attention and executive functions in both groups. However, as inhibition demands increased in the Stroop Test, the tendency to make errors rose among amputee participants, and cognitive gains remained limited. Between-group comparisons revealed a significant difference only in the TMT A1 duration in favor of the amputee group and in the PNS index in favor of the control group. These findings suggest that dual-task interventions may improve basic-level cognitive speed and visuomotor processing skills, but individuals with amputation may have difficulty maintaining parasympathetic balance in response to short-term stress. Overall, the results highlight the necessity of integrative rehabilitation approaches in lower limb amputees that not only target motor skills but also support cognitive functions and autonomic nervous system regulation
The Quality of Life Levels of Turkish-speaking Individuals With Total Laryngectomy
Full text linkTotal laryngectomy (TL) is defined as a life-altering operation involving surgical removal of laryngeal structures. Quality of life levels of individuals with TL might be severely affected, therefore current study sought to examine these levels using validated tools in Turkish. The study design was comperative, correlational, and descriptive. Turkish versions of Self-Evaluation of Communication Experiences after Laryngectomy (TR-SECEL) and University of Washington Quality of Life Questionnaire (TR-UW-QOL) were administered online to 39 participants with TL (Meanage = 62.10, SD = 9.81). Participants were stratified into two or three groups according to age, education, alaryngeal communication method (ACM), and time after TL as scores of these groups were compared accordingly. Correlation between a number of variables and scores was examined. Regarding TR-SECEL, General domain scores were significantly higher in individuals with TL using tracheoesophageal speech (TES) compared to esophageal speech (ES), there was a positive and moderate relationship between age and General domain scores. Regarding TR-UW-QOL, Mood domain scores of individuals aged 60+ were significantly higher while Anxiety domain scores of individuals with nine or more years of education were significantly higher than the other groups. Appearance domain scores were higher in favor of individuals using TES as well as with a duration of 121 months and above following TL, while Shoulder domain scores were in favor of those with ES. As reported in previous studies, it does not seem plausible to state one specific ACM has priority over the other or it fulfills voice restoration in the long term without any complications
Evaluation of prognostic nutritional index (PNI) and hemoglobin-albumin-lymphocyteplatelet (HALP) index in breast cancer
No full textMeeting Abstract P-30-09
Sağlıklı yetişkinlerin anlatı örneklerinde doğal akıcısızlıkların dilbilimsel ve söylem düzeyinde incelenmesi
Full text linkSözcük bulma güçlüğü, Alzheimer hastalığı ve primer progresif afazi gibi demans türlerinin en erken klinik belirtilerinden biri olarak kabul edilmekte ve sağlıklı bireylerdeki doğal akıcısızlıklarla benzer bir klinik görünüme sahip olmaktadır. Bu nedenle, doğal akıcısızlıklardaki yaşa bağlı değişimlerin incelenmesi, sağlıklı yaşlanma ile nörodejenerasyonu ayırt edebilmek açısından büyük önem taşımaktadır. Bu çalışma, 20-25 yaş aralığındaki 30 sağlıklı bireyin anlatı örneklerinde sıkça karşılaşılan doğal akıcısızlıkların hangi bağlamlarda ortaya çıktığı analiz edilmiştir. Katılımcıların bilişsel olarak sağlıklı bireyler olduklarını göstermek için MoCA-TR uygulanmıştır. Anlatı örnekleri, "Kurbağa Neredesin?" hikayesi kullanılarak toplanmış ve SALT-TR programı ile suprasegmental parametreler ve mikroyapısal özellikler analiz edilmiştir. Araştırmada mikro yapısal özellik olarak '-(y)I','-(y)A','-DA','-DAn' durum ekleri ve eylemsi kullanımı; suprasegmental parametrelerden zenginleştirme, tonlama, konuşturma, ünlem kullanım sıklığı incelenmiştir. Çalışmada incelenen tüm mikroyapısal ve suprasegmental elementlerin varlığında, ortaya çıkan doğal akıcısızlık sayılarının istatistiksel olarak birbirlerinden farklı olduğu (p < .001) görülmüştür. Bulgularda, '-(y)A' eki en yüksek doğal akıcısızlık gereksinimine sahipken (Sıra Ortalama = 7.22), ünlem ve konuşturma bağlamları en düşük doğal akıcısızlık davranışlarının ortaya çıktığı durumlar olarak (Sıra Ortalama = 3.33) dikkat çekmektedir. Türkçe'de durum ekleri konum ve yön bildirdiği için bilişsel yükü arttırarak doğal akıcısızlığın ortaya çıkışını arttırır. Suprasegmental unsurların, doğal akıcısızlık davranışlarını azaltıcı bir etkisi olduğu sonucuna ulaşılmıştır.Word-finding difficulties are considered to be one of the earliest clinical manifestations of dementias such as Alzheimer's disease and primary progressive aphasia and have a similar clinical appearance to natural disfluencies in healthy individuals. Therefore, the study of agerelated changes in natural disfluencies is of great importance to distinguish healthy aging from neurodegeneration. This study analyzed the contexts in which natural disfluencies frequently occur in the narrative samples of 30 healthy individuals between the ages of 20-25. MoCATR was applied to show that the participants were cognitively healthy individuals. Narrative samples were collected using the story "Frog, Where are you?" and analyzed for suprasegmental parameters and microstructural features using SALT-TR software. In the study, the use of '-(y)I','-(y)A','-DA','-DAn' case suffixes and the use of verbs as microstructural features; and the frequency of enrichment, intonation, speech, and interjections as suprasegmental parameters were examined. In the presence of all microstructural and suprasegmental elements analyzed in the study, the number of natural disfluencies was statistically different (p < .001). In the findings, the suffix '-(y)A' has the highest natural disfluency requirement (Rank Mean = 7.22), whereas exclamation and speech contexts have the lowest natural disfluency behaviors (Rank Mean = 3.33). In Turkish, case suffixes increase the cognitive load and increase the occurrence of natural disfluency behaviors because they indicate position and direction. It was concluded that suprasegmental elements have a reducing effect on natural disfluency behaviors
Management of Recurrent Ventriculoperitoneal Shunt Infections in Adult Patients
No full textObjective: The objective of this study was to evaluate the demographic, clinical, laboratory, and microbiological features of ventriculoperitoneal shunt (VPS) infections through a 13-year retrospective study. VPS bacterial agents and their antibiotic susceptibility were also investigated through the occurrence of single VPS (SVPS) and recurrent VPS (RVPS) infections. Methods: This study included 110 patients with SVPS infections and 55 patients with RVPS infections. Results: In patients who developed multiple infections, Gram-negative organisms were found to be the most predominant (60%, 54/90). The resistance rates were 85.2% for third-generation cephalosporins (3GCs), 83.3% for piperacillin-tazobactam, and 10.4% for carbapenem. Of the patients in the SVPS infection group, 49% were treated with combinations with carbapenem; of the patients in the RVPS infection group, 84.4% were treated in the same way. Central nervous system (CNS) tuberculosis as the etiology of hydrocephalus; short duration of antibiotics used for treatment; high cerebrospinal fluid (CSF) protein and blood C-reactive protein (CRP) levels; and prolonged use of prophylactic antibiotics were found to be related to an increased rate of recurrent infection occurrence. A two-stage shunt change approach decreased the risk of recurrent infections. Conclusions: Based on the findings of our study, it is essential to closely monitor patients with independent risk factors for RVPS infection development, due to the high rates of resistant Gram-negative bacterial growth and the initiation of empirical antimicrobial treatment with glycopeptide plus carbapenem. Certain treatment options, such as 3GCs plus glycopeptide, should be revised based on clinical progress and microbiological culture results
Some mathematical properties of flexible hyperbolic tangent activation function with application to deep neural networks
Full text linkThis study rigorously delves into some analytic properties of an improved activation function
(referred as flx tanh). The determined results appear as a generalization of some results known
in the literature. The flx tanh is created by taking into account symmetry property, parameterizability, and deformability of the classical tanh function. Under the regime of certain
parameters, we examine the behaviours of flx tanh. Moreover, these dynamic properties of the
function flx tanh yields promising results as an activation function in deep neural networks.
We utilize the PyTorch library running on Python 3.9 to evaluate the performance of our
activation function. Additionally, we aim to encourage the readers to improve their computer
programming language skills by making the Python 3.9 codes available on GitHub
An inquiry into the application of biophilic design principles in contemporary university designs
Full text linkEnvironment can have a positive or negative effect on human beings. This effect has been a topic of interest for environmental psychologists, who have strived over the years to understand the environmental attributes, which would be favourable to people in physical, mental, and psychological terms. The present study focusses on biophilic design, one of the popular theories in the architectural literature aimed to create high quality and liveable environments. The positive effects of biophilic design have been investigated from different perspectives and thus it has become a well-accepted approach in the relevant architectural literature. Accordingly, the present study aims to investigate to what extent biophilic design principles were put into practice. In the context thereof, contemporary university structures were analysed within the framework of biophilic design principles. The results suggest that although biophilic elements were present in the design of these structures, they were not specifically intended as biophilic design strategies. Nevertheless, these designs reflected an approach that emphasized human-nature interaction. In that regard, the principles of biophilic design are aligned with key parameters of good design, and architects have regarded nature as a significant design element