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Evaluation of the oxytocin effect in a rat model with experimental periodontitis
No full textThe aim of the present study was to evaluate the inhibitory effects of oxytocin on the development of periodontitis based on its properties against bone loss and resorption. Thirty-two Wistar albino rats were divided into four equal groups: control, periodontitis + saline, periodontitis + 0.5 mg/kg/day oxytocin, and periodontitis + 1 mg/kg/day oxytocin. Periodontitis groups received 4.0 silk ligatures around their cervixes of the right and left mandibular incisors in an 8 shape, kept for 14 days. Animals in oxytocin groups were injected once every day during 14 days with oxytocin. The mandibles were fixed and scanned using microcomputed tomography to quantify bone resorption and volumetric measurements. Blood samples were collected to analyze the concentrations of macrophage colony-stimulating factor (M-CSF), receptor activator of nuclear factor-kappa Beta ligand (RANKL), osteoprotegerin (OPG), matrix metalloproteinase-8 (MMP-8), tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, glutathione peroxidase (GPx), superoxide dismutase (SOD), and malondialdehyde (MDA). Histopathological evaluations were conducted to examine the gingiva and alveolar bone. Oxytocin prevented the development of periodontitis by decreasing ligament deteriorations and leukocytes in the gingival connective tissue and promoting reintegration with the alveolar bone. Bone resorption in all regions was less in the periodontitis + 1 mg/kg/day oxytocin group than in the periodontitis + saline group. Although TNF-alpha, IL-6, and RANKL values were lower in the periodontitis + 1 mg/kg/day oxytocin group, OPG was higher than that in the periodontitis + saline group. M-CSF, MMP-8, and MDA were lower in the oxytocin groups than in the periodontitis + saline group. Oxytocin may be an effective agent for periodontal diseases because it decreased bone resorption, oxidative stress, and inflammation in an experimental periodontitis
Accuracy investigation of GNSS-reflectometry for sea level monitoring on Horseshoe Island, Antarctica: preliminary results of the Turkish permanent GNSS station (TUR1)
Get PDFAntarctica is called a natural laboratory and is highly important for investigating climate change and its evolution over time. Sustainability is a critical concern due to the challenges posed by glacier melting and rising sea levels due to global warming. According to the Intergovernmental Panel on Climate Change, since the industrial age, the global mean sea level has risen by about 20 cm as a result of the increase in the average world temperature by 1 degrees C. Therefore, long-term observations by satellite-based techniques in and around Antarctica are of great importance for monitoring the impacts of climate change. In the last two decades, the Earth has been monitored by satellite-based remote sensing systems with high temporal and spatial resolution. Nowadays, Global Navigation Satellite System (GNSS) signals are increasingly being used in climate change studies. In this context, Turkiye's first GNSS stations were successfully installed during the fourth Turkish Antarctic Expedition (TAE-IV) on Horseshoe Island, Antarctica, within the scope of a project by the Scientific and Technological Research Council of Turkey (TuBITAK) titled "Monitoring the troposphere and snow depth/thickness in the Antarctic region with GNSS meteorology and GNSS-reflectometer methods". These stations have been monitoring atmospheric water vapor and changes in snow/sea levels since February 24th, 2020. In this study, one of the permanent GNSS Station (TUR1) signals was analyzed using GNSS-reflectometry (GNSS-R) in order to monitor the sea level changes on Horseshoe Island. Sea level changes of around 1 m in this region, due to the tidal effect, were observed using GNSS-R and compared with ultrasonic distance measurement sensor results for validation. The first results for monitoring sea levels obtained from the TUR1 GNSS Station demonstrated that sea levels in the region can be monitored using GNSS-R with an accuracy of 3-4 cm and correlation of 0.91
Üniversite öğrencilerinin probiyotikler ve probiyotiktakviyeleri hakkında bilgi tutum ve davranışlarının değerlendirilmesi = Correlation of information attitudes and behaviors of universitystudents about probiotics and probiotic supplements
No full textİnsan vücudunun daha iyi anlaşılmasıyla vücuttaki mikroorganizmaların farklı işlevleri olduğu görülmüştür. Yapılan çalışmalar probiyotiklerin birçok hastalık üzerindeki olumlu etkisini kanıtlamıştır. Probiyotik ve prebiyotiklerin sağlık faydaları ile birlikte takviye ürün pazarında hem dünyada hem ülkemizde büyük bir genişleme meydana gelmiştir. Bu çalışma geleceğin sağlık profesyonelleri olacak olan Sağlık Bilimleri Fakültesi öğrencilerinin probiyotik takviyesi kullanımının yaygınlığını saptamayı, probiyotikler ile ilgili doğru bilinen yanlışları tespit etmeyi ve bu popülasyonun bilgi düzeyini ölçmek amaçlamıştır. Çalışmaya İstanbul Atlas Üniversitesi Sağlık Bilimleri Fakültesi'nde okuyan 166 öğrenci dahil edilmiştir. Katılımcılara gönüllülük esasına dayalı olarak anket uygulanmıştır. Anketlerde katılımcıların sosyodemografik özellikleri, probiyotik bilgi, tutum, davranışları ve besin tüketim özelliklerini sorgulanmıştır. Katılımcıların %91.6'sı kadın %8.4 erkek olup öğrencilerin yaş ortalaması 20.291.49'dur. Katılımcıların %16'sı Beslenme ve Diyetetik, %17'si Dil Konuşma Terapisi, %19'u Ebelik, %10'u Ergoterapi, %5'i Fizyoterapi ve Rehabilitasyon ve %33'ü Hemşirelik bölümü öğrencisidir. Katılımcıların %29'u daha önce probiyotik takviyesi kullanmış iken %71'i daha önce probiyotik takviyesi kullanmamıştır. Daha önce probiyotik takviyesi kullanan katılımcıların %58.3'ü probiyotikleri "sindirim sistemi sorunları" için kullandığını belirtirken %39.6'sı "bağışıklık sistemi sorunları" için %2.1'i ise "dolaşım sistemi sorunları" için kullandığını belirtmiştir. Daha önce probiyotik takviyesi kullanmayan katılımcıların %49.2'si probiyotik takviye kullanmama sebebinin "ihtiyaç duymamak" olduğunu belirtmiştir. Katılımcıların %97'si "yoğurt, kefir gibi fermente süt ürünlerinin probiyotik kaynakları" olduğunu düşünürken katılımcıların %77.1'i "yoğurt, kefir gibi fermente süt ürünlerini probiyotik kaynaklar olduğu için tükettiğini" belirtmiştir. Katılımcıların %53'ü günde en az bir kere bir porsiyon yoğurt tüketirken %1'i yoğurt tüketmediğini bildirmiştir. Katılımcıların %3'ü günde en az bir kere bir porsiyon kefir tükettiğini belirtirken %61'i kefir tüketmediğini bildirmiştir. Katılımcıların çoğu probiyotiklerin sağlığa faydalı olduğunu düşünmektedir ancak probiyotiklerin sağladığı faydalar konusunda bilgi eksikliği mevcuttur. Probiyotikler ile ilgili çeşitli çalışmalardan elde edilen bilimsel kanıtların sağlık bilimleri fakültelerinin eğitim müfredatlarına dahil edilmesi probiyotiklerin daha iyi anlaşılmasına, gelecekteki tedavi protokollerinden daha fazla kullanılmasına yardımcı olabilir.With a better understanding of the human body, it has emerged that microorganisms in the body have different functions. Studies have proven the positive effect of probiotics on diseases such as gastrointestinal diseases, allergic diseases, obesity, insulin resistance. Along with the health benefits of probiotics and prebiotics, there has been a great expansion in the supplement product market both in the world and in our country. This study aims to determine the prevalence of probiotic supplement use among students studying at the Faculty of Health Sciences, who will be the health professionals of the future, to identify the misconceptions about probiotics and to measure the knowledge level of the population. 166 students studying at Istanbul Atlas University Faculty of Health Sciences were included in the study. A questionnaire was applied to the participants on a voluntary basis. In the first part of the questionnaire, there are questions to determine the sociodemographic characteristics of the participants, in the second part of the probiotic knowledge, attitudes and behaviors, and in the third part of the food consumption characteristics. 91.6% of the participants are female and 8.4% are male, and the average age of the students is 20.291.49. 16% of the participants are Nutrition and Dietetics, 17% Language and Speech Therapy, 19% Midwifery, 10% Occupational Therapy, 5% Physiotherapy and Rehabilitation, and 33% Nursing. While 29% of the participants had used a probiotic supplement before, 71% had not used a probiotic supplement before. While 58.3% of the participants who used probiotic supplements before stated that they used probiotics for "digestive system problems", 39.6% stated that they used them for "immune system 20 problems" and 2.1% for "circulatory system problems". While 49.2% of the participants who did not use probiotic supplements before stated that the reason for not using probiotic supplements was "not needing". While 97% of the participants thought that "fermented milk products such as yoghurt and kefir are probiotic sources", 77.1% of the participants stated that they "consume fermented milk products such as yoghurt and kefir because they are probiotic sources". While 53% of the participants consumed a portion of yogurt at least once a day, 1% reported that they did not consume yogurt. While 3% of the participants stated that they consumed a portion of kefir at least once a day, 61% reported that they did not consume kefir. Most participants agree that probiotics provide health benefits, but they lack knowledge about the benefits of probiotics. The inclusion of scientific evidence from various studies on probiotics in the education curricula of health science faculties may help to better understand probiotics and use them more in future treatment protocols
Atorvastatin Improves the Propionic Acid- Induced Autism in Rats: The Roles of Sphingosine-1-Phosphate and Anti-inflammatory Action
Get PDFoai:acikerisim.atlas.edu.tr:20.500.12900/187Amaç Bu çalışmanın amacı, atorvastatinin propiyonik asit kaynaklı otizm modelinde sfingozin-1-fosfat ve antiinflamatuar etkilerini artırarak görüntüleme ve beyin dokusu incelemeleri ile faydalarını araştırmaktır. Malzemeler ve yöntemler Yirmi beş mg/kg/gün/sıçan propiyonik asit (PPA), 20 erkek Wistar sıçanına intraperitoneal olarak uygulandı ve 10 erkek Wistar sıçanı ağızdan beslendi. Çalışma grupları şu şekilde tasarlandı: Grup 1: Kontrol Grubu (ağızdan beslenen kontrol, n=10); Grup 2 (PPA+salin, n=10); Grup 3 (PPA+Atorvastatin, n=10). Grupları karşılaştırmak amacıyla beyin biyokimyasal ve histopatoloji değerlendirmeleri ve manyetik rezonans (MR) görüntüleme yapıldı. Sonuçlar PPA+Atorvastatin grubunun, PPA+salin grubuna kıyasla önemli ölçüde daha düşük beyin malondialdehit, IL-2 düzeyi, IL-17, tümör nekroz faktörü-alfa (TNF-??) ve laktat düzeylerine sahip olduğu bulundu. PPA+Atorvastatin grubunda daha yüksek seviyelerde sinir büyüme faktörü ve nükleer faktör eritroid 2 ile ilişkili faktör 2 (NRF-2) ve sfingozin-1-fosfat vardı. Histopatoloji değerlendirmelerinde, PPA+Atorvastatin grubunun hipokampusta CA1 ve CA2 nöron sayılarının ve beyincikte Purkinje hücrelerinin anlamlı derecede yüksek olduğu bulundu. Sonuçlar Mevcut bulgular, atorvastatinin sfingozin-1-fosfat düzeylerini arttırdığını ve bu çalışmada uygulanan otizmli kemirgen modelini karakterize eden inflamatuar eylemleri azalttığını göstermektedir. Bu ön sonuçların daha ileri deneysel ve klinik çalışmalarla doğrulanması gerekmektedir.Purpose The aim of this study is to investigate the benefits of atorvastatin on the propionic acid-induced autism model via increasing sphingosine-1-phosphate and anti-inflammatory actions with imaging and brain tissue investigations. Materials and methods Twenty-five mg/kg/day/rat of propionic acid (PPA) was administered intraperitoneally to 20 male Wistar rats, and 10 male Wistar rats were fed orally. Study groups were designed as follows: Group 1: Control Group (orally fed control, n=10); Group 2 (PPA+saline, n=10); Group 3 (PPA+Atorvastatin, n=10). The brain biochemical and histopathology assessments and magnetic resonance (MR) imaging were conducted across groups in order to compare them. Results The PPA+Atorvastatin group was found to have significantly lower levels of brain malondialdehyde, IL -2 level, IL-17, tumor necrosis factor-alpha (TNF-??), and lactate compared to the PPA+saline group. The PPA+Atorvastatin group had higher levels of nerve growth factor and nuclear factor erythroid 2-related factor 2 (NRF-2) and sphingosine-1-phosphate. In histopathology assessments, the PPA+Atorvastatin group was found to have significantly higher neuronal counts of CA1 and CA2 in the hippocampus, and Purkinje cells in the cerebellum. Conclusions Current findings suggest that atorvastatin increases sphingosine-1-phosphate levels and decreases inflammatory actions which characterize the autism rodent model implemented in this study. These preliminary results have to be confirmed by further experimental and clinical studies
Effects of Cornus mas L. on anthropometric and biochemical parameters among metabolic associated fatty liver disease patients: Randomized clinical trial
Get PDFEthnopharmacological relevance: Cornus mas L. (Cornelian cherry, CM) fruits have been utilized for decades in numerous European and Asian countries as traditional cuisine and folk medicine. CM has antioxidant, anti-diabetic, anti-inflammatory, anti-obesity, and hypolipidemic activities due to its rich bioactive compounds, and CM fruits and other parts have been used for the prevention and treatment of a diverse variety of diseases in folk medicine. Obesity, insulin resistance, and inflammation are strongly associated with metabolic-associated fatty liver disease (MAFLD), therefore, CM may be hope for MAFLD patients.Aim of the study: The study aimed to evaluate the effect of lyophilized CM fruit powder with/without diet therapy on biochemical parameters and anthropometric measurements in patients with MAFLD.Materials and methods: This randomized clinical trial was conducted on 87 patients with MAFLD and 21 healthy individuals. Patients were randomly assigned into 4 groups: group-1 receiving 30 g/d lyophilized CM fruit powder plus diet therapy, group-2 receiving only diet therapy, group-3 receiving only 30 g/d lyophilized CM fruit powder, and group-4 had not undertaken any pharmacological treatment and diet therapy or lyophilized CM fruit powder for 8 weeks. Biochemical parameters, and anthropometric measurements at baseline and after the intervention were taken.Results: After 8 weeks of intervention, a significant decrease in body weight, body mass index, body fat mass, waist and hip circumferences, fasting blood glucose, insulin, hbA1c, liver enzymes, total triglycerides, low-density lipoprotein, total cholesterol were found in group-1, 2 and 3.Conclusion: Lyophilized CM fruit powder in addition to diet therapy and only diet therapy had a positive and similar effect on anthropometric measurements and biochemical parameters in MAFLD patients. Furthermore, only lyophilized CM fruit powder improved glycemic parameters. Therefore, lyophilized CM fruit powder may be beneficial for adult patients with MAFLD
Effects of creative dance on functional capacity, pulmonary function, balance, and cognition in COPD patients: A randomized controlled trial
Get PDFAbstract Background: Exercise training is key to the comprehensive management of patients with chronic obstructive pulmonary disease (COPD). Creative dance can be an innovative approach as effective as traditional exercise training. Objectives: This study aimed to investigate effect of creative dance-based exercise (CDE) training on functional capacity, postural stability and balance, pulmonary and cognitive functions, respiratory and peripheral muscle strength in COPD patients. Methods: Twenty-four patients with COPD were randomly allocated to either “chest physiotherapy and home-based walking program” (PT) or “CDE alongside home-based chest physiotherapy group” (PT+CDE). Both groups performed chest PT program twice a day for 5 days per week for 8 weeks. PT+CDE group received CDE training 2 days a week for 8 weeks. Primary outcome was six minute walk test (6MWT). Secondary outcomes were postural stability and balance, pulmonary function, maximum inspiratory (MIP) and expiratory (MEP) pressure, peripheral muscle strength, Montreal Cognitive Assessment (MoCA), COPD Assessment Test (CAT), and BODE index. Outcome measures were assessed at baseline and after 8 weeks of training. Results: Both groups showed statistically significant improvements in 6MWT distance, MIP, MEP, MoCA score, CAT, and BODE index (p < 0.05). Only with CDE training was achieved improvements in postural stability and balance scores, pulmonary function, and peripheral muscle strength (p < 0.05). The improvements in 6 MWT distance, MEP, MoCA score, and CAT were greater in PT+CDE group (p < 0.05). Conclusion: Use of creative dance training in addition to home-based chest PT program was more effective than chest PT program regarding primary and secondary outcomes in COPD patients
Significance of Plasma Irisin, Adiponectin, and Retinol Binding Protein-4 Levels as Biomarkers for Obstructive Sleep Apnea Syndrome Severity
Get PDFObjective: Obstructive sleep apnea syndrome (OSAS) is a common sleep disorder that is caused by the reduction or cessation of airflow in the upper airway. Irisin, retinol-binding protein-4 (RBP-4), and adiponectin are the three significant factors in the metabolic process of the human body. The objective of this study was to investigate whether plasma irisin, RBP-4, and adiponectin levels are associated with the severity of OSAS. Methods: According to inclusion and exclusion criteria, 125 patients with OSAS and 46 healthy, gender-matched controls were included in this study. The patients were classified according to the apnea hypopnea index (AHI) as 14 mild cases (5 30). The plasma irisin, RBP-4, and adiponectin levels were measured and compared between groups. Results: RBP-4 levels were higher in severe OSAS compared to other groups, and irisin levels were significantly lower in severe OSAS compared to other groups. There was a negative correlation between irisin and RBP-4 (r = -0.421; p < 0.001), and irisin and AHI (r = -0.834; p < 0.001), and a positive correlation between irisin and adiponectin (r = 0.240; p = 0.002). There was a negative correlation between RBP-4 and adiponectin (r = -0.507; p < 0.001) and a positive correlation between RBP-4 and AHI (r = 0.473; p < 0.001). As a predictor of OSAS, adiponectin showed the highest specificity (84.8%) and RBP-4 the highest sensitivity (92.0%). Conclusion: Circulating adiponectin, irisin, and RBP-4 may be new biomarkers in OSAS patients in addition to risk factors such as diabetes, obesity, and hypertension. When polysomnography is not available, these parameters and clinical data can be used to diagnose the disease. As a result, patients with an AHI score greater than thirty should be closely monitored for metabolic abnormalities
Düşme nedeni ile kalça kırığı ameliyatı geçiren yaşlı yetişkin bireylerin duyusal işlemleme ve potansiyel etki faktörleri arasındaki ilişkinin incelenmesi = Investigation of the relationship between sensory processing and potential ımpact factors in elderly adults receiving hip fracture surgery for falling
No full textDüşme Nedeni ile Kalça Kırığı Ameliyatı Geçiren Yaşlı Yetişkin Bireylerin Duyusal İşlemleme ve Potansiyel Etki Faktörleri Arasındaki İlişkinin İncelenmesi. Yüksek Lisans Tezi, İstanbul Atlas Üniversitesi Lisansüstü Eğitim Enstitüsü, Ergoterapi Anabilim Dalı, İstanbul. Bu çalışma, son 6 ay içinde düşmeye bağlı kalça kırığı ameliyatı geçiren yaşlı yetişkin bireylerin farklı paternlere göre duyusal işlemleme süreçlerini değerlendirmeyi ve duyusal işlemleme ile ilişkili olabilecek fiziksel performans, düşme riski, düşme korkusu ve depresyon parametreleri arasındaki ilişkiyi incelemeyi amaçlamaktadır. Çalışmaya 65 yaş ve üzerinde, düşmeye bağlı kalça kırığı ameliyatı geçiren ve Mini Mental Durum Test sonucu ≥ 24 olan 137 yaşlı yetişkin birey (92 kadın, 45 erkek) dahil edildi. Yaşlı yetişkin bireylerin demografik bilgilerini değerlendirmek için çalışma için özel olarak hazırlanan demografik bilgi formu, duyusal işlemleme süreçlerinin değerlendirilmesi için Yetişkin Duyusal İşlemleme Ölçeği (YDİÖ), Fiziksel ve fonksiyonel performansı değerlendirmek amacıyla Kısa Fiziksel Performans Bataryası (KFPB), düşme riskinin değerlendirilmesi için Zamanlı Kalk ve Yürü Testi (ZKYT), düşme korkusunun değerlendirilmesi için Düşme Etkinlik Ölçeği (DEÖ), depresyonun değerlendirilmesi için Geriatrik Depresyon Ölçeği (GDÖ) kullanıldı. Elde edilen bulgulara göre düşmeye bağlı kalça kırığı nedeni ile ameliyat olan yaşlı yetişkin bireylerin duyusal işlemleme süreçlerinde zorluklar yaşadıkları faktörler olduğu ve fiziksel performans (yürüme, sandalyeden kalkma, denge), düşme riski, mobilite, düşme korkusu ve depresyonun duyusal işlemleme becerileri arasında anlamlı ilişki olduğu tespit edilmiştir(p<0,05). Çalışmanın sonucunda; vestibüler girdiye aşırı tepki veren, genel yetersiz tepki veren ve postural-motor yetenekleri etkileyen propriyoseptif vestibüler girdiye yetersiz tepki veren yaşlı yetikinlerin fiziksel performansının daha kötü olduğu, genel yetersiz tepki veren, postural-motor yetenekleri etkileyen propriyoseptif vestibüler girdiye yetersiz tepki veren,vestibüler girdiye aşırı tepki veren yaşlı yetişkinlerin düşme riskinin ve düşme korkusunun arttığı görülürken proprioseptif arayışı olan yaşlı yetikinlerin düşme riskinin,düşme korkusunun ve depresyonun azaldığı görülmüştürInvestigation of the Relationship Between Sensory Processing and Potential Impact Factors in Elderly Adults Receiving Hip Fracture Surgery for Falling. Master Thesis, Istanbul Atlas University Graduate Education Institute, Department of Occupational Therapy, Istanbul. This study aims to evaluate the sensory processing processes of elderly adults who have undergone fall-related hip fracture surgery in the last 6 months, according to different patterns, and to examine the relationship between physical performance, fall risk, fear of falling, and depression parameters that may be related to sensory processing. 137 elderly adults (92 females, 45 males) aged 65 years and older, who had undergone fall-related hip fracture surgery and had a Mini Mental State Test result ≥ 24, were included in the study. Demographic information form specially prepared for the study to evaluate the demographic information of older adults, Adult Sensory Processing Scale (ASPS) to evaluate sensory processing processes, Short Physical Performance Battery (FPB) to evaluate physical and functional performance, Timed Get Up and Down to assess fall risk. The Walk Test (TUG), the Fall Efficiency Scale (FES) were used to evaluate the fear of falling, and the Geriatric Depression Scale (GDS) was used to evaluate the depression. According to the findings, it was found that elderly adult individuals who underwent surgery for hip fracture due to fall had difficulties in sensory processing processes, and there was a significant relationship between physical performance (walking, getting up from a chair, balance), risk of falling, mobility, fear of falling, and sensory processing skills of depression determined (p<0.05). As a result of the study; Older adults who overreact to vestibular input, have a general underreaction to proprioceptive vestibular input that affects postural-motor abilities, have poorer physical performance, have a poor general response, underreact to proprioceptive vestibular input that affects postural-motor abilities, overreact to vestibular input It was observed that the risk of falling and fear of falling increased in older adults who reacted to it, while the risk of falling, fear of falling and depression in elderly adults who were seeking proprioceptive were decreased (p<0.05
Can Acellular Dermal Matrix and Kombucha Cellulose Membrane Be Used in Calvarial Reconstruction?
Get PDFAmaç: Amacımız aselüler dermal matriks (ADM) ve Kombucha membranının (KM) kalvarial dura onarımında uygulanabilirliğini araştırmaktı.
malzeme kusurları.
Yöntemler: Wistar sıçanları üzerinde yapılan bir çalışmada altı grup oluşturuldu. Tüm sıçanlarda dorsal kalvarial subperiosteal cep oluşturuldu. İki grup
bir ADM ve iki gruba da KM implante edildi. Diğer iki grup ise kontrol grubu olarak belirlendi. Altı grubun yarısı
30. günde sakrifiye edildi, diğer yarısı ise 60. günde sakrifiye edildi. Doku greftleri subperiosteal cepten çıkarıldı ve
histolojik analiz. Hematoksilen-eozin ve periyodik asit içeren örnekler hazırlanarak neovaskülarizasyon ve kalsifikasyon yoğunluğu incelendi.
Schiff lekeleri ve bunları ışık mikroskobu altında gözlemlemek.
Bulgular: Kontrol grubunda yoğun kalsifikasyon gözlendi ancak neovaskülarizasyon gözlenmedi. KM grubunda yoğun kalsifikasyon
hem 30 günlük hem de 60 günlük numunelerde hemen hemen tüm hayvanlarda gözlendi ve 30 günlük hayvanlarda neovaskülarizasyon mevcut olmasa da,
60 günlük hayvanların yarısında neovaskülarizasyon mevcuttu. ADM grubunda 30 günlük takipte neovaskülarizasyon bulgusuna rastlanmazken
ve 60 günlük dokularda, 30 günlük hayvanların yarısından fazlasında kalsifikasyon görüldü ve 60 günlük hayvanlarda ortadan kayboldu.
Sonuç: Bu çalışma KM'nin kalvarial rekonstrüksiyonda potansiyel kullanımını göstermektedir.Objective: Our objective was to study the applicability of acellular dermal matrix (ADM) and Kombucha membrane (KM) in repairing calvarial dura mater defects. Methods: In a study conducted on Wistar rats, six groups were formed. A dorsal calvarial subperiosteal pocket was created in all rats. Two groups were implanted with an ADM and two groups with a KM. The other two groups were designated as control groups. Half of the six groups were sacrificed on day 30, while the other half were sacrificed on day 60. Tissue grafts were removed from the subperiosteal pocket and subjected to histological analysis. Neovascularization and calcification intensity were examined by preparing samples with hematoxylin-eosin and periodic acid Schiff stains and observing them under a light microscope. Results: In the control group, intense calcification was observed, but neovascularization was not observed. In the KM group, intense calcification was observed in almost all animals in both the 30-day and 60-day samples, and while neovascularization was absent in the 30-day animals, signs of neovascularization were present in half of the 60-day animals. In the ADM group, while no signs of neovascularization were observed in the 30-day and 60-day tissues, calcification was seen in more than half of the 30-day animals and disappeared in the 60-day animals. Conclusion: This study demonstrates the potential use of KM in calvarial reconstruction
Determination of individual innovation characteristics of operating room nurses
Get PDFObjective: This study was conducted to determine the individual innovativeness of the operating room nurses and the individual factors affecting them. Operating room nurses, who work in operating rooms where many biomedical devices and sensitive instruments are used and are constantly changing with the developments in technology, need to lead in terms of individual innovative features and adapt quickly to change. Methods: A descriptive and cross-sectional study was conducted between 15 November and 31 December 2021 with the participation of 153 operating room nurses in the province of Istanbul. “Individual Innovation scale (IIS)” and “Descriptive Information Form” were used as data collection tools. Data analysis was done with the SPSS 25.0 program. Results: The operating room nurses’ total IIS score was 68.7±7.7, while their opinion leadership, resistance to change, and risk-taking subscale scores were 28.4±3.4, 23.2±5.5, 17.1±1.8 respectively. It was determined that gender, marital status, education level, years of experience in the operating room, surgical department, and institution characteristics affected individual innovativeness characteristics (p<0.05; p<0.01). Conclusion: It was determined that the innovative behavior characteristics of the operating room nurses are mostly interrogators and the need to support and develop their innovativeness characteristics