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In vitro evaluation of the cytotoxic effects of alkasite restorative material on human dental pulp stem cells
Get PDFAim: The clinical suitability of restorative dental materials is determined by evaluating their biocompatibility, and physical and chemical properties. The present
study examined the cytotoxic effects of three different dental restorative materials on human dental pulp stem cells (DPSCs).
Material and Methods: In this study, composite, high-viscosity glass ionomer cement (HVGIC), and an alkasite were used. In total, 12 samples of each material
were prepared for cytotoxicity assays. Cytotoxic effects were determined by considering biomaterial releases. Cell viability and proliferation were observed and
analyzed at intervals of 24 and 72 hours using both the methyl-thiazole-diphenyl-tetrazolium (MTT) and xCELLigence cytotoxicity assays. Data were calculated
using the RTCA-DP integrated software of the xCELLigence system and the GraphPad Prism 9.1.1 program. Data from the proliferation experiments were
statistically evaluated using the Two-way ANOVA test.
Results: Alkasite exhibited the highest cytotoxicity, whereas HVGIC and composite did not exhibit any significant difference compared with the control. There
was no difference between the two time points in the cytotoxicity of composite and alkasite in the MTT assay. However, the cytotoxicity of HVGIC was higher
at 72-hours than at 24-hours. Similar results were obtained with both assays. Although alkasite exhibited higher cytotoxicity than composite and HVGIC, all
materials exerted slightly cytotoxic effects (60%–90% cell viability) on DPSCs.
Discussion: Considering its aesthetic, and mechanical properties, alkasite can be clinically preferred instead of other materials in cavities that are not close
to the dental pulp
Multi-Criteria Analysis of Capesize Bulk Carrier Design Optimization Model
Get PDFIn engineering problems, the concepts of design and optimization are two basic topics that are related to each other. The problem owner should prioritize the design or optimization on each other. In this regard, two different ways can be followed in engineering problems: firstly designing and then optimizing or using optimized parameters in the design process. In this study, the basic design parameters of a capesize bulk carrier for a specific purpose were created and exemplified on a model. The prototype development problem is handled as a multi-criteria optimization problem by creating appropriate and pareto optimal solutions. Parameter Space Investigation method was used to solve this optimization problem, and this method was applied in a program called Multi-criteria Optimization Vector Identification. As a result of the study, the design parameters of the capesize bulk carrier sample were created and the objective function criteria were obtained better than the prototype and the value in the literature
Özel öğrenme güçlüğü olan okul çağı çocuklarında fonolojik terapinin değerlendirilmesi/ In school - age wıth specıfıc learınıng dısabılıtıes evaluatıon therapy
No full textÖzel öğrenme güçlüğü tanısı olan çocuklarda fonolojik terapinin etkililiğini değerlendirmeyi amaçlayan bu çalışmaya yaşları 8 ile 14 arasında değişen 20 kız, 10 erkek olmak üzere toplam 30 katılımcı katılmıştır. Çalışmaya katılan bireylere okuma ve yazma becerilerini değerlendirmek amacıyla; Özgül Öğrenme Güçlüğü Bataryası, işitsel farkındalık becerilerini değerlendirmek amacıyla; İşitsel Ayırt Etme Testi ve anlamsız kelimeleri okuma testi uygulandı. Bu değerlendirmelerden sonra katılımcılara her biri 40 dakika süren 8 haftalık bir fonolojik terapi uygulandı. Fonolojik terapi tamamlandıktan sonra terapiden önceki ön test değerlendirmelerinin tümü tekrar terapi sonrasında da uygulandı. Değerlendirmeler sonucunda katılımcıların okuma, yazma, işitsel ayırt etme becerilerinde ve anlamsız kelimeleri okuyabilme becerilerinde istatistiksel olarak anlamlı farklılıklar gözlendi (p<0.05). Katılımcıların okuma hızları değerlendirildiğinde terapi öncesi ve sonrasında istatistiksel olarak anlamlı farklılık gözlenmedi. Sonuç olarak özel öğrenme güçlüğü olan çocuklarda fonolojik terapinin; okuma, yazma ve fonolojik becerilerin geliştirilmesinde etkili olabileceği düşünüldü.A total of 30 participants, 20 female and 10 male, aged between 8 and 14, participated in this study, which aims to evaluate the effectiveness of phonological therapy in children diagnosed with specific learning disabilities. The Spesific Learning Disability Battery was administered to the individuals participating in the study to evaluate their reading and writing skills, and the Auditory Discrimination Test and the Nonsense Word Reading Test were administered to evaluate auditory awareness skills. After these evaluations, the participants underwent an 8-week phonological therapy, each lasting 40 minutes. After phonological therapy was completed, all pre-test assessments before therapy were administered again after therapy. As a result of the evaluations, statistically significant differences were observed in the participants reading, writing, auditory discrimination skills and ability to read nonsense words (p<0.05). When the participants reading speeds were evaluated, no statistically significant difference was found before and after therapy. As a result, phonological therapy in children with specific learning disabilities; It was thought that it could be effective in developing reading, writing and phonological skills
The Effect of Virus-Specific Vaccination on Laboratory Infection Markers of Children with Acute Rotavirus-Associated Acute Gastroenteritis
Get PDFObjective: Rotavirus (RV) is one of the most common and important causes of acute gastroenteritis (AGE) in newborns and children worldwide. The aim of this study was to evaluate the effect of the RV vaccine on the natural history of RV infections using the neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and systemic immune inflammatory index (SII) as hematological indexes, clinical findings, and hospitalization. Method: Children aged 1 month to 5 years who were diagnosed with RV AGE between January 2015 and January 2022 were screened, and 630 patients were included in the study. The SII was calculated by the following formula: neutrophil x platelet/lymphocyte. Results: Fever and hospitalization were significantly higher and breastfeeding was significantly lower in the RV-unvaccinated group than in the RV-vaccinated group. The NLR, PLR, SII, and CRP were significantly higher in the RV-unvaccinated group (p 0.05). SII and PLR were significantly lower in the RV-vaccinated group than in the RV-unvaccinated group in both the breastfed and non-breastfed subgroups. For NLR and CRP, while there was no significant difference according to RV vaccination status in the breastfed group, there was a significant difference in the non-breastfed group (p value: <0.001; <0.001). Conclusions: Despite the low level of vaccine coverage, the introduction of RV vaccination had a positive impact on the incidence of RV-positive AGE and related hospitalizations in children. These results showed that breastfed and vaccinated children were less prone to inflammation because their NLR, PLR, and SII ratios were lower. The vaccine does not prevent the disease 100%. However, it can prevent severe disease with exsiccation or death
Presence of Portomesenteric Venous Gas and Pneumatosis Intestinalis in Nonocclusive Mesenteric Ischemia as a Complication of Transrectal Ultrasound-Guided Prostate Biopsy
Get PDFA 58-year-old man with a history of mechanical aortic valve replacement, on anticoagulation with warfarin, presented to the
emergency department with hematochezia 1 day after undergoing transrectal ultrasound-guided prostate biopsy. On presentation,
he was found to have hemorrhagic shock. Fluid resuscitation, packed red blood cell transfusion, and empiric antibiotic therapy were
initiated, and the patient was admitted to an intensive care unit. Abdominal-pelvic computed tomography demonstrated portomesenteric venous gas and pneumatosis intestinalis. Colonoscopy showed ischemic ulcers at the ascending colon and stigmata of
recent bleeding at the site of biopsy in the rectum, which was treated endoscopically. The patient was discharged after continued
improvement during hospitalization. On follow-up, the patient continued to be symptom-free, and a repeat colonoscopy demonstrated healing colonic ulcers
Effect of Cold Therapy on Managing Postoperative Pain Following Breast Conserving Surgery
No full textBackground: Cold therapy is an important non-pharmacologic method used for pain relief.Aim: In the present study, we aimed to evaluate the therapeutic effect of cold therapy on managing postoperative pain following breast-conserving surgery (BCS) and assess its effect on recovering quality.Method: The study was planned and implemented as a randomized controlled clinical study. Sixty pa-tients with breast cancer were included in this study. All patients underwent BCS at Istanbul Faculty of Medicine. There were 30 patients in both the cold therapy and control groups. In the cold therapy group, a cold pack was placed around the incision line for 15 minutes every hour from the first hour after the operation until the 24th hour. To all the patients in both groups, pain levels were measured by visual analog scale (VAS) at the postoperative 1st, 6th, 12th, and 24th hours, respectively, and the quality of recovery was evaluated by a Quality of Recovery-40 questionnaire at the postoperative 24th hour.Results: The patients' median age was 53 (range: 24-71). All patients were T1-2 clinically and had no lymph node metastasis. Interestingly, the mean of pain level in the cold therapy group was statisti-cally significantly lower in the first 24 hours (1st, 6th, 12th, and 24th hours) of the postoperative period ( p = .001). Notably, the cold therapy group had higher recovering quality than the control group. In the first 24 hours, only 4 (12.5%) patients in the cold therapy group received additional analgesics, whereas all patients (100%) in the control group received additional analgesics ( p = .001).Conclusions: Cold therapy is an easy and effective non-pharmacologic method for pain relief after BCS in patients with breast cancer. Cold therapy reduces the acute pain of the breast and contributes to the quality of recovery of those patients.& COPY; 2023 American Society for Pain Management Nursing. Published by Elsevier Inc. All rights reserved
Peritoneal Tuberculosis
No full textPeritoneal tuberculosis (PT) is the most common form of abdominal tuberculosis. Diagnosis of PT can be difficult because of vague clinical symptoms, insidious onset, limitations of available diagnostic tests, and variable imaging findings. Early and timely diagnosis and treatment are important in preventing morbidity and mortality in PT. In this review, we summarize the current literature on presentation, diagnosis, and management of PT
Kronik pelvik ağrılı kadın hastalarda transvers friksiyon masajı ile thiele masajının etkinliğinin karşılaştırılması = Comparison of the effectiveness of transverse friction massage and thiele massage in female patients with chronic pelvic pain
No full textKronik pelvik ağrı (KPA), pelvik bölgede altı aydan fazla süren; hamilelik, menstrüal siklus, lokal travma veya pelvik cerrahilere bağlı olmayan ağrı olarak tanımlanır. Prevalansı yadsınamayacak şekilde yüksek olan KPA genellikle muskuloskeletal sorunlardan kaynaklanır. Tedavide fizyoterapi girişimleri son derece önemlidir. Bu çalışmanın amacı, KPA'lı kadın hastalarda pelvik taban kaslarına uygulanan transvers friksiyon masajı (TFM) ile Thiele masajının (TM) etkinliğin karşılaştırılmasıdır. 20 hasta TFM grubu ve TM grubu olmak üzere 10'ar kişilik iki gruba ayrılmıştır. TFM grubuna 4 hafta boyunca haftada 2 gün TFM, TM grubuna ise aynı süre ve sıklıkla TM uygulanmıştır. Pelvik taban kaslarında hassasiyet, skar doku, tetik nokta ve spazm varlığı fizyoterapist tarafından dijital palpasyon ile, ağrı Vizüel Analog Skala ve McGill Melzack Ağrı Anketi ile, yaşam kalitesi Nottingham Sağlık Profili ile, cinsel fonksiyonlar Kadın Cinsel İşlev Ölçeği ile, alt üriner sistem semptomları ise Bristol Kadın Alt Üriner Sistem Semptomları İndeksi ile değerlendirilmiştir. Değerlendirmeler tedaviden önce ve sonra olmak üzere 2 kez uygulanmıştır. Çalışmanın sonunda tedavi öncesine göre TFM grubunda ağrı, yaşam kalitesi, cinsel fonksiyonlar ve alt üriner sistem semptomları skorlarında istatistiksel olarak anlamlı iyileşmeler görülmüştür (p0,05). İki grubun birbiriyle karşılaştırılmasında ise gruplar hiçbir parametrede istatistiksel olarak anlamlı bir fark bulunamamıştır (p>0,05). Sonuç olarak KPA hastalarında pelvik taban kaslarına uygulanan TFM ve TM, hastalığın semptomlarını azaltabilecek ve hastaların yaşam kalitesini artırabilecek kolay uygulanabilir noninvaziv tedavi yöntemleridir.Chronic pelvic pain (CPP) is defined as pain lasting more than six months in the pelvic region which is not related to pregnancy, menstrual cycle, local trauma or pelvic surgery. CPP, whose prevalence is undeniably high, is usually caused by musculoskeletal problems. Physiotherapy interventions are extremely important in treatment. This study conducted to investigate to compare the effects of transverse friction massage (TFM) and thiele massage (TM) in female patients with CPP. Study planned as a pilot study and 20 patients participated. Patients divided into two groups as TFM group and TM group (nTFM=10 ; nTM=10). TFM was applied to the TFM group 2 days a week for 4 weeks, and TM was applied to the TM group for the same duration and frequency. Presence of tenderness, scar tissue, trigger points and spasm in the pelvic floor muscles evaluated by digital palpation, pain levels evaluated by Visual Analog Scale and McGill Melzack Pain Questionnaire, quality of life evaluated by Notthingam Health Profile Questionnaire, sexual functions evaluated by Female Sexual Function Index and lower urinary tract symptoms evaluated with the Bristol Female Lower Urinary System Symptom Index. Evaluations were applied before and after the treatment. At the end of the study, statistically significant improvements were observed in pain, quality of life, sexual functions and lower urinary system symptoms scores in the TFM group compared to pre-treatment (p0.05). When the two groups were compared with each other, no statistically significant difference was found in any of the parameters between the groups (p>0.05). As a result, TFM and TM applied to the pelvic floor muscles in CPP patients are easily applicable noninvasive treatment methods that can reduce the symptoms of the disease and increase the quality of life of the patients
Picnic, Accident or Cookies? A Systematic Approach to Guide the Selection of the Picture Definition Tasks in Linguistic Assessment
No full textObjective Picture description tasks are used to elicit language samples in individuals with aphasia and other cognitive disorders. However, task selection may affect the type of language variables elicited. In this study, our goal is to compare the strengths and the weaknesses of the two internationally used picture description tasks with a novel picture description task developed specifically for Turkish-speaking individuals. Materials and methods In sum, 20 cognitively healthy individuals with a mean age of 52 +/- 14/3 were included. Three different picture description tasks composed of single pictures were used: The Picnic Scene from the Western Aphasia Battery-Revised, the Cookie Theft picture from the Boston Diagnostic Aphasia Examination and the Accident Scene from the Turkish Language Assessment Test for Aphasia. All language samples were recorded using a digital voice recorder. Automated and semi-automated approaches were used for the systematic analysis of the language features that were classified into four levels: general language measures, the morphosyntactic level, the lexicosemantic level and the sentence level. Results Participants showed greater efficiency and produced the greatest number of subordinate clauses, derivational suffixes, passive voice suffixes and relative past tense construction during the Accident Scene description. On the lexicosemantic level, the Picnic Scene was particularly superior to the Cookie Theft Picture in eliciting nouns. Imperfective aspect use was less frequent in the Accident Scene description. Conclusion All three tasks had limitations and advantages compared with each other. We recommend the development of novel picture description tasks that would be more effective in eliciting specific language features in Turkish-speaking individuals
Evaluation of the relationship between monocyte to high-density lipoprotein cholesterol ratio and thrombus burden in patients with deep vein thrombosis
No full textBu çalışmanın amacı, derin ven trombozlu hastalarda monosit sayısı ve yüksek yoğunluklu lipoprotein kolesterol düzeylerini ve oranlarını (monosit/yüksek yoğunluklu lipoprotein oranı) değerlendirmek ve tanı anında bu oranın uygulanıp uygulanamayacağını belirlemektir. derin ven trombozunda trombüs yerleşimi açısından trombüs yükünün bir göstergesidir.
2018 ve 2022 yılları arasında ayakta tedavi gören hastalar için bir veri tabanı sorgusu kullanarak, hastanın venöz Doppler ultrason ile doğrulanan derin ven trombozu tanısını retrospektif olarak analiz ettik. Dahil edilen 378 hastadan 356'sının tanı anında kan sayımı sonuçları mevcuttu. ve kontrol grubu olarak, poliklinik veri tabanı sorgulanarak, kan sayımı uygun olan, derin ven trombozu tanısı olmayan cinsiyet uyumlu hastalar alındı. Monosit/yüksek yoğunluklu lipoprotein oranı, monosit sayısının yüksek yoğunluklu lipoprotein-C'ye oranından hesaplanmıştır. Hastalar, Doppler ultrason bulguları ile kanıtlandığı gibi, trombüs düzeyine ve tutulan damar segmentlerinin sayısına göre kategorize edildi.
Serum monosit/yüksek dansiteli lipoprotein oranı hasta grubunda kontrol grubuna göre anlamlı olarak yüksekti (p<0.01). Proksimal derin ven trombozu olan hastalarda ortalama monosit/yüksek yoğunluklu lipoprotein oranı (19.6±5.1'e karşı 17.1±5.5; p<0.01), distal derin ven trombozu olan hastalardan daha yüksekti. Monosit/yüksek yoğunluklu lipoprotein oranı tutulan damar segmenti sayısı ile arttı (p<0.01).
Monosit/yüksek dansiteli lipoprotein oranı derin ven trombozlu hastalarda kontrol grubu ile karşılaştırıldığında anlamlı olarak yüksektir. Monosit/yüksek yoğunluklu lipoprotein oranı seviyeleri, trombüsün konumu ve derin venöz tromboz hastalarında yer alan ven segmentlerinin sayısı tarafından yansıtılan hastalık yükü ile korele idi.The aim of this study is to evaluate the monocyte count and high-density lipoprotein cholesterol levels and ratios (monocyte/high-density lipoprotein ratio) in patients with deep vein thrombosis and to determine whether this ratio can be applied at the time of diagnosis. In deep vein thrombosis, it is an indicator of thrombus load in terms of thrombus location.
Using a database query for outpatients between 2018 and 2022, we retrospectively analyzed the patient's diagnosis of deep vein thrombosis, which was confirmed by venous Doppler ultrasound. Of the 378 patients included, 356 had blood count results at the time of diagnosis. and as the control group, gender-matched patients without deep vein thrombosis diagnosis and with appropriate blood count were included by querying the outpatient clinic database. The monocyte/high-density lipoprotein ratio was calculated from the ratio of monocyte count to high-density lipoprotein-C. Patients were categorized according to the level of thrombus and the number of involved vessel segments, as evidenced by Doppler ultrasound findings.
Serum monocytes/high-density lipoprotein ratio was significantly higher in the patient group than in the control group (p<0.01). The mean monocyte/high-density lipoprotein ratio (19.6±5.1 vs. 17.1±5.5; p<0.01) was higher in patients with proximal deep vein thrombosis than in patients with distal deep vein thrombosis. Monocyte/high-density lipoprotein ratio increased with the number of involved vessel segments (p<0.01).
Monocyte/high-density lipoprotein ratio was significantly higher in patients with deep vein thrombosis compared to the control group. Monocyte/high-density lipoprotein ratio levels were correlated with disease burden as reflected by the location of the thrombus and the number of vein segments involved in deep venous thrombosis patients