İstanbul Atlas University Institutional Repository
Not a member yet
783 research outputs found
Sort by
Exploring the phenomenon of social appearance anxiety in individuals suffering from seborrheic dermatitis: Comprehensive insights derived from a case-control study
Full text linkOBJECTIVE: The primary objective of our meticulously designed study is to thoroughly investigate and delineate the extent to which individuals afflicted with seborrheic dermatitis, particularly those exhibiting facial manifestations of this dermatological condition, experience significant psychological distress that may adversely impact their self-perception as measured by the Social Appearance Anxiety Scale (SAAS), while simultaneously comparing these findings against a group of healthy individuals serving as controls. METHODS: In the framework of our research, we meticulously recruited a sample comprising 120 individuals diagnosed with seborrheic dermatitis characterized by facial involvement, whose ages ranged from 18 to 65 years, alongside 118 healthy control participants who were strategically matched for key demographic variables, including age, gender, and educational attainment to ensure the integrity of our comparative analysis. Both the patient participants and the healthy controls underwent a systematic administration of a range of validated psychometric tools, particularly the SAAS and the Hospital Anxiety and Depression (HAD) scale. Further, the Dermatology Life Quality Index (DLQI) and Visual Analog Scales (VAS) were exclusively utilized for the subset of individuals within the patient population. RESULTS: Through comprehensive statistical analysis, the mean scores acquired from the Social Appearance Anxiety Scale (SAAS) for the patient and control groups were 52.10 and 21.35 points, respectively. Accordingly, it was concluded that the average SAAS score observed in the patient group was substantially higher than that recorded in the control group, with a p-value of less than 0.01 reflecting a statistically significant observation. CONCLUSION: The presence of seborrheic dermatitis lesions located on visible areas of the skin engenders a notable degree of anxiety among affected individuals, primarily stemming from concerns regarding their physical appearance. This investigation underscores the critical need for individuals experiencing such dermatological manifestations to receive holistic treatment that addresses their psychiatric and dermatological needs
Evaluation of sociodemographic and nutrition-related factors for type 2 diabetes risk: a sample from Turkiye
Full text linkBackground Considering the increasing prevalence of diabetes, we aimed to evaluate the risk of diabetes in our sample and its relationship with sociodemographic and nutrition-related factors. Methods We conducted the study in Afyonkarahisar province of Turkiye with participants aged 18-65 years. In this face-to-face study, we used a questionnaire on sociodemographic information and general dietary habits and the FINDRISC screening tool. We also recorded participants' 24-hour food recall and assessed anthropometric measurements. We analyzed epidemiological data using binary logistic regression models to assess possible risk factors associated with the presence of diabetes risk. Results Overall, this study included 3,990 participants, 50.03% (n = 1996) and 49.97% (n = 1994) of whom were males and females, respectively. The FINDRISC score was higher in females (p = 0.001), married individuals (p 30 kg/m(2 )increased the risk by 7.33 folds compared with having a BMI of < 25 kg/m(2). Significant but very low correlation coefficients were found between main meal consumption, energy, lipid and iron intake and diabetes risk (p < 0.001). Conclusions Our findings suggest that increasing age, increasing BMI, lower education level, and having a disease diagnosis can be significant risk factors for diabetes. However, more studies are needed to clarify risk factors, especially those related to nutrition
Compositional Analysis and Systemic Considerations of Fluoridated Toothpastes for Children Available in Ankara, Türkiye
No full textPurpose: This study aimed to analyze the composition, fluoride content, and potential health risks of fluoride-containing children's toothpaste available in Turkey. Given the rising concerns over fluoride toxicity and market trends favoring fluoride-free products, the study also evaluated the presence of potentially harmful excipients and assessed their compliance with international pediatric dental guidelines. Methods: A total of 92 children's toothpaste products were identified through Turkey-based online marketplaces, of which 18 (19.56%) contained fluoride. Fluoride concentrations were classified into 500-990 ppm (9.78%) and 1000 ppm (9.78%), the latter aligning with European Academy of Paediatric Dentistry (EAPD) recommendations. A comprehensive ingredient analysis was performed, categorizing compounds based on their function, prevalence, and toxicity risk. The safety of these ingredients was further assessed using PubMed, ScienceDirect, and Google Scholar databases to determine their documented health effects. Results: The majority (80.44%) of children's toothpaste products were fluoride-free, raising concerns regarding effective caries prevention. Additionally, fluoridated products contained potentially harmful preservatives (Sodium Benzoate-44.44%), surfactants (Sodium Lauryl Sulfate-5.55%), and whitening agents (Titanium Dioxide-27.77%), all of which have been linked to cytotoxic, irritative, or systemic toxic effects. Conclusions: These findings highlight a disparity between fluoride availability and professional recommendations, emphasizing the need for improved regulatory oversight, consumer education, and safer pediatric oral care formulations. Given growing concerns about fluoride toxicity, future research should explore fluoride-free remineralization alternatives such as hydroxyapatite and calcium phosphate-based compounds
A nano-scale design of Vedic multiplier for electrocardiogram signal processing based on a quantum technology
Full text linkAn electrocardiogram (ECG) measures the electric signals from the heartbeat to diagnose various heart issues; nevertheless, it is susceptible to noise. ECG signal noise must be removed because it significantly affects ECG signal characteristics. In addition, speed and occupied area play a fundamental role in ECG structures. The Vedic multiplier is an essential part of signal processing and is necessary for various applications, such as ECG, clusters, and finite impulse response filter architectures. All ECGs have a Vedic multiplier circuit unit that is necessary for signal processing. The Vedic multiplier circuit always performs multiplication and accumulation steps to execute continuous and complex operations in signal processing programs. Conversely, in the Vedic multiplier framework, the circuit speed and occupied area are the main limitations. Fixing these significant defects can drastically improve the performance of this crucial circuit. The use of quantum technologies is one of the most popular solutions to overcome all previous shortcomings, such as the high occupied area and speed. In other words, a unique quantum technology like quantum dot cellular automata (QCA) can easily overcome all previous shortcomings. Thus, based on quantum technology, this paper proposes a multiplier for ECG using carry skip adder, half-adder, and XOR circuits. All suggested frameworks utilized a single-layer design without rotated cells to increase their operability in complex architectures. All designs have been proposed with a coplanar configuration in view, having an impact on the circuits' durability and stability. All proposed architectures have been designed and validated with the tool QCADesigner 2.0.3. All designed circuits showed a simple structure with minimum quantum cells, minimum area, and minimum delay with respect to state-of-the-art structures
A candidate paradigm changing method for dissolution of coronary atherosclerotic plaques
No full textA CANDIDATE PARADIGM CHANGING METHOD FOR DISSOLUTION OF CORONARY ATHEROSCLEROTIC PLAQUES Biol. Onur Yolay1, Assoc. Prof. Emine Esra Kasapbasi2, Dr. Vedat Ozturk3, Dr. Erdem Tezcan4, Dr. Hasan Karaoglu5, Dr. Ceyhun Küçük5, Dr. Ceyhun Haziroglu6, Prof. Serdar Baki Albayrak7 , Prof. Ayhan Olcay7 1Technology Transfer Office, Bezmialem Vakif University, 2Department of Molecular Biology and Genetics, Halic University, 3Department of Mechanical Engineering, Istanbul Aydin University, 4Department of Nutrition and Dietetics, Istanbul Gedik University, 5The Council of Forensic Medicine, Ministry of Justice, 6Department of Internal Medicine, Marmara University, 7Department of R&D, Innoway R&D Kft Background and Aims Postmortem studies showed that atherosclerotic plaques which are associated with coronary thrombosis, sudden death, and plaque rupture contain less fibrous tissue, thinner fibrous cap, and a larger necrotic core than stable plaques. Atherosclerotic plaque which is most frequently associated with rupture is the thin-cap fibroatheroma, where a cap of <65 μm separates a relative large necrotic core from the lumen. We experimented with different pharmaceutical solution combinations one of which was Phosphatidylcholine (PC) and sodium deoxycholate (DC) compound for dissolution and reduction of necrotic core of atherosclerotic plaque in autopsy coronary specimens. Methods PC and DC compound is used for the purpose of partial lipolysis and is valued for its efficacy and lower invasiveness compared to liposuction and dermolipectomy in cosmetic applications. We obtained 10 atherosclerotic coronary artery autopsy samples for phosphatidylcholine/deoxycholate treatment. Coronary artery segments were equally divided into 2 pieces by longitudinal incision to see effect of treatment modality on same patient sample. The phosphatidylcholine/deoxycholate mixture solution was applied to treatment arm of 10 autopsy specimens while control arm was treated in a liquid of 0.9% benzyl alcohol only. Treatment and control tissue pieces were kept in solutions for 10 minutes, then washed with distilled water and cleaned. Results We microscopically observed that plaque cores in atherosclerotic plaques were completely dissolved without damaging surrounding cells or tissue structure in all 10 samples (Figure 1,2). When the microscopic examination of the samples with and without phosphatidylcholine/deoxycholate application was compared, it was observed that the lipid containing atherosclerotic plaque core part was fragmented. Microscopic images showed that application of phosphatidylcholine/deoxycholate, which dissolves the unwanted subintimal lipid accumulation, did not damage the tissue structure. Conclusions: Microscopic atherosclerotic plaque staining allowed observation of the structural features of the tissues with and without phosphatidylcholine/deoxycholate application. Subintimal fat accumulation was dissolved in treatment arm. Microscopic images have also shown that phosphatidylcholine/deoxycholate application does not disrupt the structure of the tissues while dissolving the fat deposit
Prevalence and associated factors of pathologic root resorption in primary molars and canines: a retrospective cross-sectional study
No full textObjectives: Pathologic root resorption in primary teeth affects dental health and future orthodontic needs. This study aimed to evaluate the prevalence and associated factors of pathologic root resorption in a pediatric population. Method and materials: A retrospective cross-sectional analysis was performed using panoramic radiographs from 691 pediatric patients aged 4 to 11 years at a university hospital in Turkiye. Teeth were evaluated for internal (IRR) and external pathologic root resorption (ERR) by two calibrated observers, adhering to the 2023 European Society of Endodontics Position Statement. Tooth status was categorized as healthy, carious (with or without pulp involvement), filled, or endodontically treated, and dental crowding was also recorded. Statistical analyses included chi-square tests, multiple logistic regression, and post-hoc analyses, with significance set at P < .05. Results: A total of 7,729 primary teeth (5,075 molars and 2,654 canines) were evaluated, with interobserver reliability of 82% and intraobserver reliability of 98.8%. The study cohort included 691 children (mean age 7.05 +/- 1.45 years; 49.8% boys, 50.2% girls). Pathologic root resorption was observed in 21.2% of cases (n = 1,638), with ERR accounting for 81% and IRR for 19%. Among 2,654 healthy teeth, 3.76% exhibited pathologic resorption, with no significant association with dental crowding. Significant relationships were identified between pathologic root resorption and age (P= .000), tooth status (P= .049), and sex (P= .042). Conclusion: Reducing high caries levels in Turkiye is critical to lowering pathologic root resorption and associated complications. Further studies should explore dental crowding and pathologic root resorption relationships in larger samples
The Effect of Pet Ownership on Quality of Life and Traits in Individuals
No full textBackground The management of chronic diseases is important in managing global health and reducing mortality. The management of chronic diseases is an important factor affecting the quality of life. The perception of chronic diseases reveals the management of the disease process, reactions the individual reveals, and the differences in coping styles. Different approaches to events arise from different personality traits. In addition to medical treatment, psychosocial treatments/interventions are recommended in compliance with chronic diseases that reduce the quality of life and the management of symptoms. One of these intervention methods is animal-supported interventions based on human-animal interaction. Aim This study aimed to examine the effect of pet ownership on quality of life and personality traits in individuals with chronic diseases. Methods Data were collected in face-to-face interviews in a private hospital in & Idot;stanbul, Turkiye between October 2021 and 2022. A descriptive characteristics information form, the Eysenck Personality Questionnaire Revised-Abbreviated (EPQR-A, and the Quality-of-Life Scale Short Form (SF-12) were used for data collection. Results In the study, there was a significance between the SF12-Mental composite score of individuals with chronic diseases who were not with their pets and stated that they had difficulty in pet care. There was also a significance between those who stated that they had difficulty in pet care and SF12-Physical composite score, extraversion, and lie subscales. There was a significance between SF12-Mental composite score and those who had a dog, cat, hamster, or rabbit and between SF12-Physical composite score and those who had a dog, cat, or hamster. Conclusions The status of being with their pets, having difficulty in their care, and thinking that pets limited their lives affect the quality of life of people with chronic diseases. In addition, the personality traits of these patients change according to the pets they have and their quality of life is affected
Breath of relief: Transforming pediatric asthma care with telemedicine-guided exercises
Full text linkBackground: Alternative non-pharmacological strategies such as breathing exercises can be used in combination with pharmacological treatments. Objective: The aim of this randomized, controlled, single-blind study was to investigate the effectiveness of breathing exercises in asthma patients on respiratory function, symptom control and quality of life. Methods: We enrolled pediatric asthma patients who were eligible and motivated for the study and randomly assigned them to either the exercise group (EG) or the control group (CG). The CG received a postural exercise program, while the EG received a breathing exercise program. At baseline and after 12 weeks, respiratory function (FEV1-FVC-FEV1/FVC-PEF), symptom control (using asthma control test, asthma control questionnaire, global initiative for asthma symptom control assessment), quality of life (using pediatric asthma quality of life questionnaire), breath-holding test (BHT) and sit-to-stand test (30sSTS) were assessed and compared. Results: One hundred twelve patients were randomized, and 99 (n = 51 EG, n = 48 CG) completed the 12-week study. Baseline data were also similar in both groups. After 12 weeks, FEV1, Peak expiratory flow (by spirometry and peak flow meter) and BHT were significantly better in EG than in CG (p = 0.01 and p = 0.007 and p = 0.005, respectively). Asthma Control Test and GINA symptom control tool values were also significantly better in both groups. Discussion:Our participants were children with mild to moderate asthma. We conclude that our results show that breathing exercises can be an effective intervention for children with partially controlled asthma with FEV1,PEF, and BHTs
Factors determining the number of sessions in successful extracorporeal shock wave lithotripsy patients
Full text linkBackground and aim - The aim of this study is to investigate whether certain clinical nomograms influencing the success of extracorporeal shock wave lithotripsy (ESWL) also play a role in determining the number of treatment sessions required in patients who achieved stone-free status following ESWL. Methods - The data of 354 patients with successful ESWL outcomes were analyzed. Patients were evaluated 4-6 weeks post-ESWL using X-ray, ultrasound, or computed tomography. The presence of residual stones larger than 4 mm was considered a treatment failure. Data recorded included age, gender, laterality of stone localization (right/left), stone location (renal pelvis, mid calyx, upper calyx, proximal ureter, mid ureter, distal ureter), stone size (maximum longitudinal dimension), body mass index (BMI), and stone Hounsfield unit (HU) values. Patients were categorized into two groups: single-session and multiple-session treatment. Results - In the univariate model, factors such as age, BMI, distal ureter, renal pelvis, mid-calyx stone localization, stone size, and stone HU value showed a significant (p < 0.05) effect in distinguishing between single-session and multiple-session groups. Stone size and HU values were significantly higher (p < 0.05) in the multiple-session group compared to the single-session group. In the multivariate model, age, stone size, and HU value emerged as significant independent factors (p < 0.05) in differentiating between single-session and multiple-session treatments. Conclusion - Several factors influencing the success of ESWL also affect the number of sessions required. BMI, age, stone size, stone HU value, and certain stone locations are key determinants of the number of ESWL sessions
Determinants of Exercise Capacity in Children and Adolescents with Asthma: A Comparative Case-Control Study
Full text linkBackground:Asthma is a chronic disease that may affect exercise capacity. Despite the variety of existing tools for assessing exercise capacity, whether patients with asthma have lower exercise capacity than healthy controls and its potential determinants are still poorly understood. Aim:The primary aim of this study was to identify potential determinants of exercise capacity. The secondary aim was to compare exercise capacity, pulmonary function, and muscle strength of children and adolescents with asthma with healthy controls. Methods:Volunteers aged 7-17 participated in the study and were divided into two groups: the asthma (n = 60) and the healthy control (n = 40). Asthma control questionnaire, six-minute walk test, pulmonary function test, maximum inspiratory (MIP) and expiratory (MEP) pressure measurements, and 30-second sit-to-stand test (30-STST) were performed. Results:The study showed that exercise capacity and respiratory and peripheral muscle strength were significantly lower compared to controls (P < 0.001, P = 0.031, P = 0.001, P = 0.025, respectively). Another critical finding was MIP, 30-STST, and MEP were the determinants of exercise capacity in children with asthma (R2 = 0.403, P < 0.001). Conclusion:Clinicians should not ignore that exercise capacity may be reduced in children and adolescents with asthma and add assessment and training of respiratory and peripheral muscle strength in pulmonary rehabilitation programs