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PSYCHOLOGICAL COMPARISON OF ADULTS WITH DIZZINESS: DEPRESSION, ANXIETY, AND SOMATIZATION IN TYPICAL vs. ABNORMAL VESTIBULAR TEST RESULTS
Full text linkObjective: This study aimed to investigate the relationship between vestibular test results and levels of depression, anxiety, and somatization in patients with dizziness. It also examined the correlation between vestibulo-ocular reflex (VOR) findings and subjective assessment scales. Materials and Methods: Sixty patients with complaints of dizziness were divided into two groups: Group I (n=30, abnormal vestibular test findings) and Group II (n=30, normal vestibular test results). All participants underwent audiological and vestibular evaluations [videonystagmography (VNG), video head impulse test (vHIT)] as well as psychological assessments using the Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), and the Somatization subscale of the Symptom Checklist-90 (SCL-90). Data were analyzed using SPSS version 22.0, with statistical significance set at p0.05). However, Group I had significantly higher total and emotional subscale scores on the Dizziness Handicap Inventory (DHI) (p<0.05). In this group, DHI scores showed a positive correlation with both BDI and BAI scores (p<0.05). No significant correlation was observed between vHIT results and psychological measures in either group. Conclusion: Vestibular test results do not appear to significantly influence levels of depression, anxiety, or somatization. However, subjective tools such as the DHI may reflect the psychological impact of dizziness and can be useful in guiding appropriate clinical management
Validation of the Turkish Version of the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (Quip-Rs)
Full text linkBackground: Impulse control disorders and related behaviors (ICDs-RBs) significantly affect the quality of life of Parkinson's disease (PD) patients. The Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS) was developed to identify and monitor these behaviors. This study aimed to translate and validate the Turkish version of QUIP-RS. Methods: The translation process involved back-translation and expert review. Ninety-three patients with PD completed the Turkish QUIP-RS, Movement Disorder Society-Unified PD Rating Scale part III, Hoehn-Yahr stage, Standardized Mini-Mental State Examination, Frontal Assessment Battery, and self-report tools for depression, anxiety, and impulsivity. Internal consistency, factor analysis, convergent and divergent validity were assessed, along with relationships between QUIP-RS domains, clinical features, and dopaminergic medication. Results: Eighty-seven patients were included in this analysis. The QUIP-RS's total Cronbach's alpha value was 0.925, demonstrating good reliability. Factor analysis showed a good model fit, reflecting different ICDs-RBs domains. Thirty-nine percent of the patients were screened with at least 1 ICDs-RB, 17.2% of participants had single ICDs-RBs, and 21.8% had multiple ICDs-RBs. The most prevalent ICDs-RBs were punding, compulsive eating, and dopamine dysregulation syndrome (DDS). Total levodopa equivalent daily dose (LEDD) was related to only ICD-related behaviors (hobbyism, punding, DDS). In contrast, the dopamine agonist LEDD was significantly correlated with all ICDs-RBs except pathological gambling. Conclusion: ICD-RBs are common in the sample recruited fromT & uuml;rkiye, and the Turkish version of the QUIP-RS is a valid and reliable tool for assessing ICD-RBs in Turkish-speaking groups
Kronik ayak bileği instabilitesi olan yetişkinlerde dengeyi etkileyen faktörlerin belirlenmesi
Full text linkKronik Ayak Bileği İnstabilitesi (KABİ), tekrarlayan burkulmalar, ağrı, denge kaybı ve güvensizlik hissi ile karakterize, sensorimotor sistemdeki bozulmalara bağlı gelişen bir klinik tablodur. Bu durumun yalnızca periferik yapıları değil, aynı zamanda merkezi sinir sistemi adaptasyonlarını da etkileyerek postural kontrol bozukluklarına yol açabileceği bildirilmektedir. Bu çalışma, KABİ tanısı almış bireylerde statik ve dinamik denge ile ayak bileği kas kuvveti (dorsifleksiyon ve plantar fleksiyon), ağrı düzeyi, kinezyofobi, fiziksel aktivite seviyesi ve yaşam kalitesi arasındaki ilişkileri incelemek; bu bireylerin ilgili parametreler açısından sağlıklı bireylerle karşılaştırmalı olarak değerlendirilmesini sağlamak ve dengeyi etkileyen klinik belirleyici faktörleri saptamak amacıyla yapıldı. Çalışmaya 24 KABİ tanılı birey ve demografik olarak benzer özelliklere sahip 24 sağlıklı gönüllü dahil edildi. Katılımcıların statik dengesi Tek Ayak Üzerinde Durma Testi, dinamik dengesi ise ALFA stabilometrik platform kullanılarak Stabilite Limitleri Testi ile değerlendirildi. Ayak bileği kas kuvveti izokinetik dinamometre ile, ağrı düzeyi Vizüel Analog Skala ile (VAS), kinezyofobi Tampa Kinezyofobi Ölçeği ile, fiziksel aktivite düzeyi Uluslararası Fiziksel Aktivite Anketi (IPAQ) kısa formu ile ve yaşam kalitesi SF-36 anketi ile ölçüldü. Verilerin analizinde SPSS v26.0 istatistik programı kullanıldı. Sürekli değişkenler ortalama±standart sapma, ordinal ve nominal veriler ise sayı ve yüzde olarak verildi. Verilerin normal dağılım özellikleri belirlendi. Normal dağılıma uygun veriler için Independent Samples T-testi, normal dağılıma uymayan veriler için Mann Whitney U testi, ilişkiler için Pearson veya Spearman korelasyon analizleri, yordayıcı etkileri değerlendirmek için çoklu doğrusal regresyon analizi uygulandı. Anlamlılık düzeyi p<0.05 olarak kabul edildi. Çalışma sonucunda, KABİ grubunda statik denge skorları (p<0.001) ve dinamik denge skorları (p=0.024) anlamlı şekilde daha düşük; ayak bileği dorsifleksiyon (p=0.039 ve p=0.045) ve plantar fleksiyon (p=0.040 ve p=0.036) kas kuvvetleri daha zayıf; ağrı düzeyi (p<0.001) ve kinezyofobi (p=0.027) anlamlı düzeyde daha yüksek; fiziksel aktivite düzeyi (p=0.031) ve yaşam kalitesi alt bileşenlerinden fiziksel fonksiyon (p<0.001), fiziksel rol kısıtlılığı (p=0.003), ağrı (p=0.001), enerji (p=0.005), sosyal fonksiyon (p=0.006), emosyonel rol kısıtlılığı (p=0.038), fiziksel bileşen özet skoru (p<0.001) ve mental bileşen özet skoru (p=0.004) anlamlı düzeyde daha düşük bulundu. Statik denge süresi ile dorsifleksiyon kas kuvveti (r=0.550; p=0.007) ve plantar fleksiyon kas kuvveti (r=0.477; p=0.018) arasında pozitif; ağrı düzeyi (r=-0.424; p=0.039) ile negatif yönde anlamlı korelasyon saptandı. Dinamik denge ise dorsifleksiyon kas kuvveti (r=0.374; p=0.039) ve fiziksel rol kısıtlılığı (r=0.354; p=0.040) ile pozitif ilişkili bulundu. Regresyon analizleri sonucunda, statik dengeyi anlamlı yordayan değişkenler arasında dorsifleksiyon (p=0.001) ve plantar fleksiyon (p=0.002) kas kuvveti ile ağrı düzeyi (p=0.006); dinamik dengeyi yordayan değişkenler arasında ise dorsifleksiyon kas kuvveti (p=0.003) ve fiziksel rol kısıtlılığı (p=0.009) yer aldı. KABİ'li bireylerde statik ve dinamik denge performansı, kas kuvveti düşüklüğü, artmış ağrı, düşük fiziksel aktivite ve yaşam kalitesi ile anlamlı şekilde ilişkili bulundu. Bu bulgular, dengeyi etkileyen çoklu fiziksel ve psikolojik belirleyicilere yönelik bütüncül rehabilitasyon yaklaşımlarının önemini ortaya koymaktadır.Chronic Ankle Instability (CAI) is a clinical condition characterized by recurrent sprains, pain, balance loss, and a sense of instability, resulting from disruptions in the sensorimotor system. This condition may affect not only peripheral structures but also central nervous system adaptations, leading to postural control impairments. This study aimed to examine the relationship between static and dynamic balance and ankle muscle strength (dorsiflexion and plantar flexion), pain level, kinesiophobia, physical activity level, and quality of life in individuals diagnosed with CAI; to compare these parameters with healthy individuals; and to identify clinical determinants affecting balance. The study included 24 individuals with CAI and 24 healthy volunteers matched demographically. Static balance was assessed using the Single Leg Stance Test, and dynamic balance was evaluated with the Stability Limits Test using the ALFA stabilometric platform. Ankle muscle strength was evaluated using an isokinetic dynamometer, pain level was assessed with the Visual Analog Scale (VAS), kinesiophobia was measured with the Tampa Scale for Kinesiophobia, physical activity level was determined with the short form of the International Physical Activity Questionnaire (IPAQ), and quality of life was evaluated with the SF-36 survey. Statistical analyses were conducted using SPSS v26.0. Continuous variables were reported as mean ± standard deviation, and categorical variables as numbers and percentages. Normality of data distribution was assessed. Independent Samples T-test or Mann-Whitney U test was used for group comparisons, Pearson or Spearman correlation for relationships, and multiple linear regression analysis for predictive modeling. Statistical significance was set at p<0.05. The results showed that the CAI group had significantly lower static (p<0.001) and dynamic balance scores (p=0.024), reduced dorsiflexion (p=0.039 and p=0.045) and plantar flexion (p=0.040 and p=0.036) muscle strength, higher pain levels (p<0.001) and kinesiophobia (p=0.027), and lower physical activity levels (p=0.031). Quality of life scores were significantly lower in the CAI group for physical function (p<0.001), role-physical (p=0.003), pain (p=0.001), vitality (p=0.005), social functioning (p=0.006), emotional role (p=0.038), physical component summary (p<0.001), and mental component summary (p=0.004). Static balance was positively correlated with dorsiflexion strength (r=0.550; p=0.007) and plantar flexion strength (r=0.477; p=0.018), and negatively with pain level (r=-0.424; p=0.039). Dynamic balance was positively correlated with dorsiflexion strength (r=0.374; p=0.039) and role-physical score (r=0.354; p=0.040). Regression analyses revealed that dorsiflexion (p=0.001), plantar flexion (p=0.002) strength, and pain level (p=0.006) were significant predictors of static balance, while dorsiflexion strength (p=0.003) and role-physical score (p=0.009) predicted dynamic balance. In individuals with CAI, impaired static and dynamic balance was significantly associated with reduced muscle strength, increased pain, lower physical activity, and diminished quality of life. These findings highlight the importance of holistic rehabilitation approaches targeting multiple physical and psychological determinants of balance
Diagnostic value of hematological parameters in the early diagnosis of acute cholecystitis
Full text linkObjectives Accurate diagnosis of acute cholecystitis (AC) is critical because early laparoscopic cholecystectomy significantly reduces complications and mortality. This study evaluates the predictive value of inflammatory indices and hematological markers in diagnosing AC. Methods A retrospective review was performed on early laparoscopic cholecystectomy cases at the Gaziosmanpa & scedil;a Training and Research Hospital in Istanbul between August 2013 and August 2023. Patient demographics, preoperative laboratory values, inflammatory indices - including neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and aggregate index of systemic inflammation (AISI) - were evaluated, along with hospital length of stay and histopathological outcomes. Results Among 249 patients, 34 (13.6%) were diagnosed with AC, comprising 76 males (30.5%) and 173 females (69.5%), with a mean age of 48.9 +/- 14.6 years. The median hospital length of stay was 3 days (range: 1-21). Significant elevations in both the SIRI and neutrophil count were observed in AC cases compared to controls (P < 0.001). ROC (receiver operating characteristic) curve analysis demonstrated comparable diagnostic performance for the SIRI (AUC = 0.746; 95% CI: 0.658-0.835; optimal cutoff: 1.98) and neutrophil count (AUC = 0.746; 95% CI: 0.658-0.835; optimal cutoff: 7.1 x 103/mu L) in predicting AC. Conclusions The SIRI and neutrophil count are reliable markers that can improve the diagnostic accuracy and guide early management of AC
Impact of NAD(P)H: Quinone Oxidoreductase 1 (NQO1) C609T Polymorphism on Lung Cancer Risk
Full text linkBackground and Objectives: Many studies have demonstrated a relationship between cancer and the NAD(P)H quinone oxidoreductase 1 (NQO1) polymorphism. Lung cancer (LC) is one of the most common malignant diseases and is an expanding global health problem. This study aimed to evaluate the association between the NQO1 C609T polymorphism and LC risk, including its distribution across histopathological subtypes, and to assess its potential as a genetic susceptibility marker. Materials and Methods: A prospective study was conducted on 75 LC patients and 65 healthy controls. In this study, the C > T polymorphism occurring at position 609 in the NQO1 gene was examined in Turkish patients with LC. Demographic data and laboratory findings were collected from the patients and the hospital laboratory system. Results: The genotype frequencies (CC, CT, and TT) in LC patients were 66.7%, 32.0%, and 1.3%, respectively, compared with 60.0%, 35.4%, and 4.6% in the control group. Chi-square analysis revealed no significant association between the NQO1 C609T polymorphism and LC risk (p = 0.433). No correlation was observed between genotype distribution and histopathological subtypes. All patients had a long history of smoking (mean: 38.45 +/- 12.14 years and 1.63 +/- 0.64 packs/day). Conclusions: This is the first study conducted in Turkish people to determine the relationship between the C > T polymorphism occurring at position 609 in the NQO1 gene and the risk of LC. The patients with LC, regardless of their histopathological type, showed no relationship with the polymorphism in the NQO1 gene. Further high-quality investigations with more detailed environmental exposure information and larger sample sizes are warranted to confirm our findings.p
Supratentorial Intracranial Anomalies in Myelomeningocele Patients
No full textAIM: To assess associated cerebral supratentorial anomalies in patients who underwent myelomeningocele repair in hopes of developing a better morphological apprehension of the forebrain's anomalies in this category of patients. MATERIAL and METHODS: This retrospective observational study assessed 426 pediatric patients who underwent myelomeningocele repair between January 2013 and December 2020. Cranial MRIs with T1- and T2-weighted sequences were obtained as part of the postoperative assessment to determine the presence of associated supratentorial anomalies in pediatric patients following myelomeningocele repair. RESULTS: The most common supratentorial anomalies identified in patients who underwent myelomeningocele repair are associated with the configuration of the corpus callosum (CC). Moreover, the complete agenesis of the CC was noticed in 9 (2.1%) subjects, whereas partial agenesis was identified in 148 (34.7%) subjects. Hypoplasia of the CC was observed in three (0.7%) patients. Gray matter heterotopia were the second most commonly observed supratentorial anomalies in 110 (25.8%) patients. Furthermore, the absence of the septum pellucidum was observed in two (0.47%) of the total patients. The widening of the interhemispheric fissure and abnormal maturation of the white matter were observed in 10 (2.34%) patients and 11 (2.58%) patients, respectively. Polymicrogyria, a consequence of abnormal cortical organization, was identified in 22.53% of the patients (96 patients) included in our series. CONCLUSION: This study confirms that, except for hydrocephalus and Chiari malformation, other associated cerebral supratentorial anomalies may be observed in patients with myelomeningocele. However, only limited research has confirmed the interconnection between the cerebral supratentorial anomalies and cognitive function. Therefore, this study emphasizes the necessity for further supplementary studies, in conjunction with accurate postnatal followups, in order to assess the real significance and repercussions of these anomalies on neurological development and also to establish how these structural changes in brain anatomy translate clinically
Complex-Valued Multivariate Neural Network (MNN) Approximation by Parameterized Half-Hyperbolic Tangent Function
Full text linkThis paper deals with a family of normalized multivariate neural network (MNN) operators of complex-valued continuous functions for a multivariate context on a box of RN, Nis an element of N. Moreover, we consider the case of approximation employing iterated MNN operators. In addition, pointwise and uniform convergence results are obtained in Banach spaces thanks to the multivariate versions of trigonometric and hyperbolic-type Taylor formulae on the corresponding feed-forward neural networks (FNNs) based on one or more hidden layers
Görme Gereci Kullanıcıların Göz Sağlığı Okuryazarlığı Düzeylerinin Belirlenmesi
No full textAmaç: Bu araştırmanın amacı görme gereci kullanıcılarının göz sağlığı okuryazarlığı düzeylerinin belirlenmesidir.
Gereç ve Yöntem: Araştırma tanımlayıcı tasarımda gerçekleştirilmiştir. Çalışmaya optik gözlük ve kontakt lens kullanan gönüllü bireyler dahil edilmiş,
sağlık çalışanı ve/veya sağlık bölümü öğrencileri çalışma dışı bırakılmıştır. Veriler, Mayıs-Ekim 2023 tarihleri arasında Google Forms aracılığıyla 406 kişiden
toplanmıştır. Veri toplama aracının; birinci kısmında katılımcıların kişisel özellikleri ve göz sağlığı hakkında sorular yer alırken, ikinci kısmında “Göz Sağlığı
Okuryazarlığı Ölçeği” kullanılmıştır. Verilerin analizinde iki bağımsız grupta t testi, ikiden fazla bağımsız grup karşılaştırılmasında ise tek yönlü varyans analizi
(ANOVA) uygulanmıştır. Fark yaratan grubu bulmak için Bonferroni testi kullanılmıştır.
Bulgular: Katılımcıların ölçekten aldıkları kontrol alt boyutu ortalaması 11,46±5,03, önleyici alt boyutu ortalaması 13,13±7,73, komplikasyon alt boyutu
ortalaması 16,83±10,74 olarak bulundu. Katılımcıların cinsiyet, yaş, eğitim, meslek, gelir düzeyi, göz muayenesi yaptırma sıklığı, kullandığı görme gereci türü
ve göz sağlığı hakkında bilgi edinme kaynağı ile göz sağlığı okuryazarlık düzeyleri arasında anlamlı fark bulundu (p<0,05).
Sonuç: Göz sağlığı okuryazarlığını farklı demografik değişkenler etkilemektedir. Katılımcıların göz sağlığını korumaya yönelik okuryazarlıkları ortanın üzerinde, göz hastalıklarının oluşumunu önleme ve komplikasyonlarına ilişkin okuryazarlıkları ise orta düzeydedir.Aim: The aim of this study is to examine the eye health literacy levels of vision aid users.
Materials and Methods: The study was carried out descriptively. Voluntary individuals using optical glasses and contact lenses were included in the
study. Health workers and/or students of health departments were excluded from the study. Data were collected from 406 participants between May and
October 2023 through Google Forms. The first part of the data collection tool includes questions about the personal characteristics of the participants and
eye health. In the second part, ‘Eye Health Literacy Scale’ was used. In the analysis of the data, t-test was applied in two independent groups and one-way
analysis of variance (ANOVA) was applied in the comparison of more than two independent groups. Bonferroni test was used to find the group that made a
difference.
Results: The mean of the control sub-dimension, the mean of the preventive sub-dimension, the mean of the preventive sub-dimension and the mean
of the complication sub-dimension were found to be 11.46±5.03, 13.13±7.73 and 16.83±10.74, respectively. A significant difference was found between the
participants’ gender, age, education, occupation, income level, frequency of eye examinations, type of visual aids used and source of information about eye
health and eye health literacy levels (p<0.05).
Conclusion: Different demographic variables affect eye health literacy. Participants’ literacy in protecting eye health is above average, while their literacy
in preventing the occurrence and complications of eye diseases is at an average level
Food Intolerance and Allergy: Do They Have an Etiological Role in Idiopathic Granulomatous Mastitis?
Full text linkBackground/Objectives: Despite its long-standing recognition, the etiopathogenesis of idiopathic granulomatous mastitis (IGM) remains poorly understood. This study aims to investigate the relationship between IGM and food intolerance, allergies, and immunological factors to shed light on its etiology. Materials and Methods: This case-control study included 32 patients with IGM and 32 healthy women. In order to examine their potential relevance to allergy and immunology, serum interleukin (IL)-4, IL-4 receptor, histamine, and histamine-releasing factor (HRF) were measured by ELISA. Furthermore, serum IgG antibodies against specific food allergens were measured to evaluate food intolerance. Results: The patient group exhibited significantly higher intolerance values for lentils and curry compared to the control group (p = 0.023 and p = 0.012, respectively). Histamine (p 0.05). Conclusions: Elevated histamine and IL-4 levels may suggest the involvement of allergy and immunological factors in IGM's etiopathogenesis. The integration of anti-histamine medications for IGM patients with elevated histamine levels could provide an alternative therapeutic strategy
The effect of tactile stimulation on spatial memory and hippocampal neuronal density in male rats with sensory deprivation during a critical period
No full textIt is well known that sensory information driven from whiskers serves as an example of tactile perception in rodents, and plays an important role in social behavior, environmental exploration, and decision-making processes, the influence of manipulations performed during the development of whiskers, on learning has been received little attention in the literature. This study aimed to evaluate the effect of tactile stimulation (TS) on spatial memory performance and neuronal density in the hippocampus during adulthood in early sensory-deprived rats. Wistar albino male rats were divided into four groups: control (CTL), bilateral whisker trimming (BWT), tactile stimulation (TS), and bilateral whisker trimming+tactile stimulation (BWT + TS). All whiskers were trimmed between P0-10, a critical period for whisker development. TS was applied from P3 to P21 using a soft brush. In this study, the 8-arm radial maze test was conducted from postnatal days 77 to 81 to assess spatial memory Animals sacrificed by intracardial perfusion and neuronal density in CA1, CA3, vDG, and dDG regions of the hippocampus were evaluated by Nissl staining. TS exposure negatively affected spatial memory performance and hippocampal neuronal density compared to BWT. We conclude that TS in healthy offspring can cause stress by interrupting maternal care, given the vulnerability of early development. On the contrary, the sensory deprivation protocol in this study was terminated at a time of high homeostatic plasticity and did not produce complete whisker deprivation, have triggered learning by inducing moderate stress early in development