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Pecoma of The Talus, a Rare Case and The Literature Review
Get PDFPerivasküler epiteloid hücreli neoplazmlar (PEComalar), perivasküler epiteloid hücrelerden (PEC’ler) gelişen mezenkimal tümörlerdir. Yumuşak doku, iç
organlar ve deri en çok karşılaşılan vücut bölgeleridir. Primer kemik PEComaları, özellikle talusun PEComaları oldukça nadirdir; Bilgimize göre 2002’den bu
yana yalnızca 16 primer kemik PEComa vakası rapor edilmiştir. Biz de, talusta PEComa ile başvuran 51 yaşında bir erkek hasta ve literatür derlemesini rapor
ediyoruz.Perivascular epithelioid cell neoplasms (PEComas) are mesenchymal tumors which evolve out of the perivascular epithelioid cells (PECs).Soft tissue,
visceral organs, and skin are the most encountered body regions. Primary bone PEComas,especially PEComas of talus, are remarkably rare; to the best of
our knowledge, only sixteen primary bone PEComa cases have been reported since 2002. We report a 51-year-old male presented with PEComa of the talus
and review the literature
Investigating the Efficacy of a Handheld Fan Intervention in Children With Dyspnea: A Randomized Controlled Study
No full textIntroduction: Dyspnea associated with acute respiratory tract infections is a common cause of emergency admissions and can be distressing for children. This study aimed to evaluate the impact of a handheld fan intervention on physiological parameters in pediatric patients with dyspnea. Methods: A total of 59 children aged 2 to 12 years presenting to an emergency department for upper respiratory tract infection between March 2022 and March 2023 were assigned to the experimental group (n = 32) or control group (n = 27) by urn randomization. Both groups received the hospital's standard care, including 3 doses of inhaled bronchodilator at 20-minute intervals. The fan intervention consisted of parents applying a handheld electric fan to the child's face at a distance of 15 cm for 5 minutes after each inhaler treatment. Oxygen saturation, heart rate, and respiratory rate were recorded before treatment and after the 3 inhaler treatments. Results: There were no statistical differences in descriptive characteristics between the experimental and control groups (P > .05). Oxygen saturation values were significantly higher in the control group before treatment but showed greater increases in the intervention group after treatment (P < .001). The intervention group also exhibited greater reductions than the control group in both heart rate and respiratory rate after the third treatment than pretreatment values (P < .05). Discussion: The handheld fan intervention effectively supports inhaler treatment for children with dyspnea. Further studies are recommended to assess its impact across different age groups and clinical conditions
Masking Ability of Monolithic CAD/CAM Laminate Veneers Over Different Resin Cement Shades and Substrate Colors
No full textPurpose: To compare the masking ability of monolithic CAD/CAM veneers placed over different resin cement shades and substrate colors. Materials and methods: Veneers were milled from four different monolithic CAD/CAM restorative materials: feldspathic ceramic (VMII), lithium disilicate ceramic (Emax CAD), zirconiareinforced lithium silicate ceramic (VS), and high-translucency zirconia ceramic (YZ-XT). Veneers were luted on natural tooth-colored (ND1) or discolored substrates (ND3 or ND5) using two different resin cement shades (opaque white or translucent). Each CAD/CAM material, resin cement shade, and substrate combination comprised 9 sample veneers (N = 216). Color parameters were obtained using a dental spectrophotometer before and after luting. Color differences (Delta E00) were calculated using CIEDE2000 formula and compared to perceptibility (P = .81 Delta E00 units) and acceptability (AT = 1.77 Delta E00 units) visual thresholds. Color variation data were statistically analyzed using Kruskal-Wallis and Mann-Whitney U tests with Bonferroni-Holm correction (alpha = .05). Results: The highest Delta E00 value was obtained in the VMII group placed over a discolored substrate, followed by the Emax CAD, YZ-XT, and VS groups. The effect of material types on Delta E00 values was significantly observed when the veneers were luted on discolored substrates using translucent resin cement (P < .05). Conclusions: Restorative material type, substrate color, and resin cement shade affect the masking ability of monolithic CAD/CAM laminate veneers
Nasal profile changes after orthodontic tooth extraction in Class II, Division 1 malocclusion patients: A retrospective study
Get PDFIntroduction: This study aimed to investigate changes in the facial soft -tissue profile, especially the nose, following fixed orthodontic treatment, with or without tooth extraction, in individuals diagnosed with dental Class II malocclusion. Materials and methods: Cephalometric images of 81 individuals with dental Class II malocclusion who underwent fixed orthodontic treatment were assessed before and after treatment. The participants were categorized into three groups: non -extraction; upper first premolar extraction; and four first premolar extractions. The parameters measured were: upper lip height, upper lip to E -plane, lower lip to E -plane, lower lip height, nasolabial angle, nasomental angle, facial convexity, lower anterior face height, soft -tissue facial convexity, nasal tip angle, nasal bridge length, N0 -nasal bridge point, nasal bone length, nasal bone angle, nasal depth, columella convexity, and nose height. Results: Within the upper two extraction group, there were significant increases at the start and end periods in nasolabial angle (P = 0.023), nasal depth Pr to Ac (P = 0.027), and nasal depth Pr to N-Prn (P = 0.040); and decreases in columella convexity (P = 0.010), upper lip to E -plane (P = 0.009), and nasomental angle (P = 0.009). There were significant results in comparisons between measurements based on the extraction status in the mean nasolabial angle (P = 0.011), mean columella convexity (P = 0.028), and mean lower lip to E -plane (P = 0.045). Conclusion: Orthodontic treatment involving tooth extraction may potentially affect the nasolabial angle and nasal depth. During treatment planning, it is crucial to consider the potential changes that may occur to the nose and any alterations that may be needed to achieve the desired esthetic outcome. (c) 2023 The Author(s). Published by Elsevier Masson SAS. This is an open access article under the CC BY licens
Enhanced anticancer effect of newly synthesised albumin-bound Fe(III)-S-Methyl-thiosemicarbazones on breast cancer cells
Get PDFThiosemicarbazones and their analogues are of significant interest due to their antiviral, antibacterial and anticancer properties. Recent advancements in nanoparticle-based therapeutics have enabled targeted cancer cell treatment while minimizing harm to healthy cells. This study focused on encapsulating patented N(1)-R1-salicylidene-N(4)-R2-salicylidene-S-methylisothiosemicarbazone complexes into albumin nanocarriers, creating albumin-bound Fe(III)-S-methyl-thiosemicarbazone (ALB-FeTc) nanoparticles via a novel UV-C lamp-assisted method. The nanoparticles were characterized using FTIR, UV-Vis, DLS and EDX-SEM. Cytotoxicity was evaluated in MCF-7 breast cancer cells and HUVEC cells using an MTT assay. Fluorescence microscopy and flow cytometry were employed to investigate the mechanism of cell death. The study demonstrated strong cytotoxicity of FeTcs against cancer cells, with enhanced effects observed for ALB-FeTcs. The ALB-FeTcs induced apoptosis selectively in cancer cells while sparing normal cells. These results suggest that ALB-FeTcs are promising candidates for breast cancer treatment
Diyabetli yaşlılarda diyabetik ayak ülseri ve ilişkili faktörlerin kırılganlık üzerine etkisi
Get PDFBu tanımlayıcı araştırma, diyabetik ayak ülseri olan ve olmayan diyabetli yaşlı hastalarda kırılganlık düzeylerini incelemek ve kırılganlığı belirleyici faktörleri araştırmak amacıyla gerçekleştirilmiştir. Araştırma 65 yaş ve üzerinde, diyabetik ayak ülseri olan (n=80) ve olmayan (n=80), toplam 160 diyabetli hasta ile yapılmıştır. Araştırmada veri toplamak için literatür doğrultusunda hazırlanan ve sosyodemografik bilgiler, diyabet ve sağlık durumu ile ilişkili özellikler ve diyabetik ayak ile ilişkili özellikleri kapsayan Hasta Tanılama Formu, Tilburg Kırılganlık Ölçeği (TKÖ) ve Geriatrik Depresyon Ölçeği (GDS- 5) kullanılmıştır. Diyabetik ayak ülseri olmayan hastalarda kırılganlık oranı %66.2, diyabetik ayak ülseri olan hastalarda ise %85 olarak saptanmıştır (p<0.05). Diyabetik ayak ülseri olmayan hastalarda depresyon belirtilerinin görülme oranı %50 iken diyabetik ayak ülseri olan hastalarda bu oran %70 bulunmuştur (p<0.05). Lojistik regresyon analizi sonucuna göre, kırılganlığı, tüm katılımcılarda depresyon belirtileri varlığının 4.08 kat, diyabet tanı süresinin 1.16 kat ve diyabetik ayak dışında kronik komplikasyon varlığının 8.58 kat; diyabetik ayak ülseri olan grupta depresyon belirtileri varlığının 10.89 kat ve diyabetik ayak dışında kronik komplikasyon varlığının 29.54 kat; diyabetik ayak ülseri olmayan grupta depresyon belirtileri varlığının 3.02 kat arttırdığı belirlenmiştir. Diyabetik ayak ülseri olan hastalarda kırılganlık artmaktadır. Depresyon her iki hasta grubunda ve tüm grupta kırılganlığın ilk belirleyicisi olarak öne çıkan faktördür.This descriptive study was conducted to examine frailty levels in elderly patients with and without diabetic foot ulcers and to investigate the factors determining frailty. The study was conducted with a total of 160 patients aged 65 and over, with (n=80) and without (n=80) diabetic foot ulcers. In the study, a Patient Identification Form, which includes sociodemographic information, characteristics related to diabetes and health status, and features related to diabetic foot, prepared in line with the literature, Tilburg Frailty Indicator (TFI) and Geriatric Depression Scale (GDS-5) was used for data collection. The frailty rate was found to be 66.2% in patients without diabetic foot ulcers and 85% in patients with diabetic foot ulcers (p<0.05). While the rate of depression symptoms was 50% in patients without diabetic foot ulcers, this rate was found to be 70% in patients with diabetic foot ulcers (p<0.05). When the determinants of frailty were examined with logistic regression analysis, these factors were determined as the presence of symptoms of depression, duration of diabetes diagnosis and presence of chronic complications other than diabetic foot in all participants. When the two groups were examined separately, these factors were found to be the presence of symptoms of depression and the presence of chronic complications other than diabetic foot in the group with diabetic foot ulcer, while in the group without diabetic foot ulcer, these factors were found to be the presence of symptoms of depression. Frailty increases in patients with diabetic foot ulcer. Depression is the first determinant of frailty in both patient groups and in the entire group
Sağlık Çalışanlarında Teknostres ile Mesleki Motivasyon, Algılanan İş Yükü ve Yaşam Kalitesi Arasındaki İlişkinin İncelenmesi / Investıgatıon of the Relatıonshıp Between Technostress and Professıonal Motıvatıon, Perceıved Workload and Qualıty of Lıfe in Healthcare Workers
No full textBu araştırma, sağlık çalışanlarının teknostres düzeyleri ile mesleki motivasyon, algılanan iş yükü ve yaşam kalitesi arasındaki ilişkiyi incelemek amacıyla gerçekleştirilmiştir. Araştırma kapsamında, 23-47 yaş aralığında çeşitli meslek gruplarından (ergoterapist, fizyoterapist, hemşire, diğer) 300 sağlık çalışanından anket yoluyla veri toplanmıştır. Teknostres ölçeğinin alt boyutları olan tekno-aşırı yüklenme, tekno-istila, tekno-karmaşa, tekno-güvensizlik ve tekno-belirsizlik ile mesleki motivasyon, iş yükü ve yaşam kalitesi boyutları arasındaki ilişkiler analiz edilmiştir. Elde edilen bulgular, sağlık çalışanlarının bilgi ve iletişim teknolojilerini kullanımlarının aşırı yüklenme, verimlilik kaybı ve belirsizlik gibi stres faktörleri ile ilişkili olduğunu göstermiştir.This study was conducted to examine the relationship between healthcare workers' technostress levels and professional motivation, perceived workload, and quality of life. Data were collected via a survey from 300 healthcare workers aged between 23 and 47 from various professional groups (occupational therapists, physiotherapists, nurses, and others). The relationships between the sub-dimensions of the technostress scale—techno-overload, techno-invasion, techno-complexity, techno-insecurity, and techno-uncertainty—and the dimensions of professional motivation, workload, and quality of life were analyzed. The findings showed that healthcare workers' use of information and communication technologies is associated with stress factors such as overload, loss of productivity, and uncertainty
Deep study on autonomous learning techniques for complex pattern recognition in interconnected information systems
Get PDFArtificial Intelligence (AI) and Machine Learning (ML) are being used more and more to handle complex tasks in many different areas. As a result, interconnected information systems are growing, which means that autonomous systems are needed to help them adapt, find complex patterns, and make better decisions in areas like cybersecurity, finance, healthcare, authentication, marketing, and supply chain optimization. Even though there have been improvements in self-learning methods for complex pattern recognition in linked information systems, these studies still do not have a complete taxonomy that sorts these methods by how they can be used in different areas. It is hard to fully understand important factors and do the comparisons that are needed to drive the growth and use of autonomous learning in linked systems because of this gap. Because these methods are becoming more important, new study is looking into how they can be used in different areas. Still, recent study shows that we do not fully understand the environment of other uses for independent learning methods, which encourages us to keep looking into it. We come up with a new classification system that puts applications into six groups: finding cybersecurity threats, finding fraud in finance, diagnosing and monitoring healthcare, biometric authentication, personalized marketing, and optimizing the supply chain in systems that are all connected. The latest developments in this area can be seen by carefully looking at basic factors like pros and cons, modeling setting, and datasets. In particular, the data show that Elsevier and Springer both put out a lot of important papers (26.5 % and 11.8 %, respectively). With rates of 12.9 %, 11 %, and 8 %, respectively, the study shows that accuracy, mobility, and privacy are the most important factors. Tools like Python and MATLAB are now the most popular ways to test possible answers in this growing field
Oxidative Stress and Asprosin Levels in Type 2 Diabetic Patients with Good and Poor Glycemic Control
Get PDFObjectives: HbA1c is the most widely used test as an indicator of glucoregulation in patients with type 2 diabetes mellitus (T2DM). Asprosin and oxidative stress levels can be reduced with good glycemic control (GC) and thus prevented or delayed micro/macro complications in patients with T2DM. The relationship between asprosin, which is thought to affect GC, and oxidative stress parameters such as lipid hydroperoxides (LOOHs), glutathione (GSH), malondialdehyde (MDA), superoxide dismutase (Cu,Zn-SOD), and total antioxidant capacity (TAC) was evaluated in T2DM patients. Materials and Methods: The study was conducted prospectively in 75 healthy people admitted to the hospital for a general health check-up and 150 T2DM patients treated in the diabetes outpatient clinic. The patient's glycemic status measurements were categorized as good glycemic control group (GGC) is defined as HbA1c = 7. Results: The study found a consistent increase in LOOH and MDA levels across the control, GGC, and PGC groups, while GSH, Cu/Zn-SOD, and TAC levels decreased in these respective groups. Additionally, asprosin levels showed a gradual rise in all groups. Positive correlations were observed between asprosin levels and various metabolic and oxidative stress markers, including BMI, WC, FBG, insulin, homeostasis model assessment for insulin resistance (HOMA-IR), DM duration, LOOH, and MDA, while negative correlations were noted with GSH, Cu/Zn-SOD, and TAC specifically in the PGC group. Furthermore, multivariate regression analysis identified HOMA-IR as the primary influencing factor on asprosin levels in PGC patients. Conclusions: Current glycemic dysregulation may lead to increased circulating asprosin and oxidative stress, which cause complications. Since asprosin levels may be an important hormonal factor in determining GC in T2DM, the use of this hormone may be recommended in the future to accelerate therapeutic approaches in T2DM. Early diagnosis and appropriate treatment may delay the development and progression of diabetic complications
Parametrized Half-Hyperbolic Tangent Function-Activated Complex-Valued Neural Network Approximation
Get PDFIn this paper, we create a family of neural network (NN) operators employing a parametrized and deformed half-hyperbolic tangent function as an activation function and a density function produced by the same activation function. Moreover, we consider the univariate quantitative approximations by complex-valued neural network (NN) operators of complex-valued functions on a compact domain. Pointwise and uniform convergence results on Banach spaces are acquired through trigonometric, hyperbolic, and hybrid-type hyperbolic-trigonometric approaches