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The importance of serum apelin-13, apelin receptor, nitric oxide and nitric oxide synthase levels in the differentiation of patients with ST elevation and non-ST elevation myocardial infarction
No full textMeeting Abstract P-41-07
Easy and Rapid Methods for Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells and Human Umbilical Wharton's Jelly-Derived Mesenchymal Stem Cells
No full textThese protocols describe modified methods that use Ficoll-Paque density gradient for umbilical cord blood-derived mesenchymal stem cells and explant method for Wharton's jelly-derived mesenchymal stem cells. The Ficoll-Paque density gradient method allows to obtain mesenchymal stem cells while eliminating monocytic cells. In this method, precoating the cell culture flasks with fetal bovine serum helps remove the monocytic cells and instruct more pure mesenchymal stem cells. On the other hand, the explant method for Wharton's jelly-derived mesenchymal stem cell is user-friendly and cost-effective than enzymatic methods. In this chapter, we provide a collection of protocols to obtain mesenchymal stem cells from human umbilical cord blood and Wharton's jelly
Enhancing Solar Convection Analysis With Multi-Core Processors and GPUs
Get PDFIn the realm of astrophysical numerical calculations, the demand for enhanced computing power is imperative. The time-consuming nature of calculations, particularly in the domain of solar convection, poses a significant challenge for Astrophysicists seeking to analyze new data efficiently. Because they let different kinds of data be worked on separately, parallel algorithms are a good way to speed up this kind of work. A lot of this study is about how to use both multi-core computers and GPUs to do math work about solar energy at the same time. Cutting down on the time it takes to work with data is the main goal. This way, new data can be looked at more quickly and without having to practice for a long time. It works well when you do things in parallel, especially when you use GPUs for 3D tasks, which speeds up the work a lot. This is proof of how important it is to adjust the parallelization methods based on the size of the numbers. But for 2D math, computers with more than one core work better. The results not only fix bugs in models of solar convection, but they also show that speed changes a little based on the gear and how it is processed
Ultrasound-Guided PRP and SVF Therapy Shows Sustained Improvement in Severe Knee Osteoarthritis: A 12-Month Retrospective Study
Get PDFBackground: Knee osteoarthritis (OA) is a chronic disease caused by cartilage degeneration in the joint accompanied by joint deformities, pain, and stiffness. This study assessed the changes over time in the Western Ontario and McMasters Universities Osteoarthritis Index (WOMAC) and Visual Analog Scale (VAS) values of patients after the combined application of stromal vascular fraction (SVF) and platelet-rich plasma (PRP). Material/Methods: A retrospective clinical study was designed. Thirty-four patients (8 males, 26 females, mean age 65.21 +/- 10.71, range 30-83 years) with pain due to knee osteoarthritis received SVF and PRP between 2019 and 2020. During and after the procedure, ultrasound-guided intra-articular spread was checked. Results: PRP+SVF injection provided significant improvement in the clinical symptoms of the patients measured according to their VAS and WOMAC scores, and this improvement continued until the twelfth month. The change in VAS scores of the patients was 1.76 +/- 1.18 (P=0.000) P =0.000) in the first month, 1.50 +/- 1.46 (P=0.000) P =0.000) in the sixth month, and 1.53 +/- 1.41 (P=0.000) P =0.000) in the twelfth month. VAS scores decreased 6.6 to 1.6 point at the end of the twelfth month. The WOMAC scores of the patients were 23.20 +/- 12.12 (P=0.000) P =0.000) in the first month, 19.48 +/- 12.0 (P=0.000) P =0.000) in the sixth month, and 20.01 +/- 10.48 (P=0.000) P =0.000) in the twelfth month. WOMAC scores decreased 51.99 to 20.48 point at the end of the twelfth month. Conclusions: Applying ultrasound-guided PRP+SVF injection into the knee joint once in OA patients improved VAS and WOMAC scores
Hemşirelerin Sağlık Hizmetlerinde İş Sağlığı ve Güvenliği Konusunda Rol ve Sorumlulukları
Get PDFDünya Sağlık Örgütü tarafından yalnızca hastalık veya sakatlığın olmayışı değil, fiziksel, ruhsal ve sosyal yönden tam bir iyilik hâli olarak tanımlanan sağlıklı
olma durumu, sağlık alanında görev yapan her mesleğin amacıdır. Bu meslek gruplarının arasında yer alan hemşireler ise yönetsel, iletişimsel ve eğitimsel
müdahaleler aracılığıyla insan ve toplum sağlığını yükseltmek amacıyla girişimlerde bulunmaktadır. Günümüzde hızla gelişen küreselleşme hareketleri,
sanayi, teknoloji, yeni hastalıklar ve ekonomik süreçler, beraberinde güvenlik yönetimi anlayışının da değişimine sebep olmuştur. Dünyada her yıl iş kazaları
sonucunda ölümler, iş göremezlikler meydana gelmektedir. Bunların sonucunda insan kaybı ve artan maliyetler ortaya çıkmaktadır. Bu kayıpların azalması,
güvenlik yönetimi kültürünün yaygınlaşmasında en etkili politika olan iş sağlığı ve güvenliği eğitimi vermek ile gerçekleşebilir. Eğitim, güvenlik bilincini ve
önleme kültürünü geliştirerek sağlıklı çalışma ortamı anlayışının oluşturulmasına katkı sağlayacaktır. İş yerinde sağlıkla ilgili olarak hemşireler, girişimlerini
yalnızca çalışma ortamına değil, aynı zamanda spesifik çalışma faaliyetinin sürdürüldüğü sağlık hizmeti özelliklerine de uyarlayabilirler. Bu bağlamda
Dünya Sağlık Örgütü, iş sağlığı hemşiresi profili için bir belge yayımlamıştır. Bu belgeye göre iş sağlığı hemşiresi, nüfusun sağlığının korunmasında ve
iyileştirilmesinde önemli bir rol oynayabilir, işletmelerde ve topluluklarda sürdürülebilir kalkınmaya, gelişmiş rekabet gücüne, iş güvenliğine ve artan kârlılığa
önemli bir katkı sağlayabilir. Bu derleme hemşirelerin sağlık hizmetlerinde iş sağlığı ve güvenliği konusunda rol ve sorumluluklarını incelemektedir.The state of being healthy defined by the World Health Organization (WHO) as not just the absence of disease or disability, but as a complete state of wellness in physical, mental, and social terms is the aim of all professions active in the field of health. Nurses among such professional groups take initiatives
to increase human and social health through managerial, communicative, and educational interventions. The globalization activities that develop fast in
our day caused change in industry, technology, new diseases, and economic processes together with safety management understanding. Every year deaths
and disabilities take place as a result of occupational accidents in the world. Loss of humans and increased costs come up as a result. Decreasing these
losses can be achieved by giving occupational health and safety training that is the most effective policy in ensuring safety management culture becomes
widespread. Education would raise awareness on safety and the culture of prevention, contributing to creation of “healthy workplace environment understanding”. Regarding occupational health, nurses can apply their initiatives not just on workplace environment, but also on health service properties where
specific work activities are carried out. In this context, the World Health Organization issued a document reflecting the profile of occupational health nurse.
According to this document, occupational health nurse may play a significant role in protecting and improving the population’s health, make a significant
contribution to sustainable development, improved competitive power, occupational safety and increased profitability at businesses and communities. This
review examines the roles and responsibilities of occupational health and safety in official health services
Silver Nanowire-Coated Porous Alginate Films for Wound Dressing Applications: Antibacterial Activity, Cell Proliferation, and Physical Characterization
No full textIn the present study, porous calcium alginate films have been developed by the addition of 0.02, 0.1, and 0.5% (w/v) PVA to sodium alginate film solutionss. Poly(vinyl) alcohol played the role of a pore-forming agent for calcium alginate films, and the controlled pore sizes of the films were investigated by scanning electron microscopy and Fourier transform infrared spectroscopy analyses. Human fibroblast cell attachment was performed on the porous calcium alginate films (0.5-Ca-Alg), and then the film was coated with 1 and 3 wt % silver nanowires. Cell proliferation was enhanced on films after the coating of the silver nanowires. The MTT assay was performed on the calcium alginate films and silver nanowire-coated films, and the films were found to be nontoxic to human foreskin fibroblast cells at the end of 72 h of exposure. The existence of silver nanowires on the porous calcium alginate film endowed the material with good antibacterial activity. The swelling ability of the porous and silver nanowire-coated film (0.5-Ca-Alg-1/AgNW) increased by similar to 64% in simulated body fluid (pH = 7.4) and distilled water compared to a nonporous film (Ca-Alg). The water vapor transmission rate of Ca-Alg was similar to 45% enhanced thanks to the porosity of films and the existence of AgNW. Hereby, it is demonstrated that the novel silver nanowire-doped porous alginate materials would be potential wound dressing agents with desired physical properties, antibacterial activity, and availability to cell proliferation
The effect of single-task versus dual-task assessment on muscle strength and performance in individuals with knee osteoarthritis
Get PDFBackground Dual-task activities, which involve performing two separate tasks simultaneously, often result in reduced motor function and daily activity performance among individuals with knee osteoarthritis (OA). Objective This study aimed to investigate the impact of single- and dual-task conditions on muscle strength and performance in individuals with knee OA and examine how cognitive load influences physical task performance in this population. MethodsSixty patients with knee OA were included. Baseline data included demographic characteristics, pain (Visual Analog Scale), and physical function (Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)). Muscle strength and performance were assessed using isokinetic and sit-to-stand tests, initially under single-task conditions, and then under dual-task conditions three days later. Dual-tasking involved physical tasks with varying cognitive exercises (changed between sessions) and familiarization sessions to minimize learning effects. Results The investigation revealed that individuals with knee OA showed reduced muscle strength and impaired sit-to-stand performance during dual-task activities, with lower peak torque (p = .0025), total work (p = .026), and longer time to peak torque (p = .011). Decreased muscle performance correlated with worse WOMAC scores (p <= .01, r = -0.506), particularly in dual-task conditions. Regression analysis identified extension total work and the sit-to-stand test as key predictors of dual-task performance, explaining 32.2% of the variance. Conclusion Dual-task performance impairs muscle strength and physical function in individuals with knee OA, demonstrated by reduced peak torque, total work, and sit-to-stand performance. Extension total work and sit-to-stand test emerged as key predictors of dual-task performance, emphasizing the need to address cognitive load in rehabilitation strategies
A novel guide device for pedicle screw insertion using three-dimensional preoperative planning in open lumbar spinal surgery: a comparative retrospective study
No full textObjectivePedicle screw stabilization (PSS) surgeries for spinal instability are still the most effective treatment approach. The use of preoperative planning can minimize the complications related to transpedicular screw (TPS) misplacement. The study aimed to evaluate the surgical outcomes of a guide device developed to improve the accuracy of the free-hand technique using three-dimensional planning in PSS. Patients and methodsPatients with degenerative spinal diseases who underwent open PSS between 2019 and 2022 were evaluated retrospectively. FG group included patients who were operated on using the fluoroscopy alone with preoperative two-dimensional planning. AFG group included patients who were operated on using a guide advice-assisted technique with preoperative 3DP. Between-group comparisons were performed. ResultsA total of 143 patients with a mean age of 59.6 years were included in the study. 71 patients were assessed in the FG group and 72 patients in the AFG group. Between-group comparisons regarding demographics, etiologies, radiation exposure, and functional improvements showed no significant differences (p > 0.05). Although the accuracy of TPSs positioning was 94.2% and 96.5% in the 2DG and 3DG, the difference between the groups was not statistically significant. The statistically significant differences regarding the upper-level facet joint violation and pedicle breach rates were lower in the AFG group (p < 0.0001; X2 = 19.57) and (p < 0.0001; X2 = 25.3), respectively. ConclusionUsing a guide device associated with preoperative 3PD reduced the upper-level facet joint violation and pedicle breach rates in open PSS surgeries performed by free-hand technique for degenerative spinal diseases
Assessment of sexual dysfunction, the quality of life and difficulties in broaching sexual issues in patients with chronic low back pain by using cluster analysis
Get PDFThe aim of this study is to investigate the physical and psychosocial problems and the clinical and sociodemographic factors affecting sexual life in patients with nonspecific chronic low back pain (CLBP), thus drawing attention to sexual disability and patients' concerns in the conservative management of the disease. A total of 140 patients were included in the study. The assessment of disease characteristics, information about sexual life and related factors were evaluated by a self-constructed questionnaire. Physical Activity Questionnaire (IPAQ), Tampa Scale of Kinesiophobia (TSK) and Beck Depression Inventory (BDI) were used to assess functional disability, pain-related anxiety, physical activity level, fear of movement and depression severity, respectively. Hierarchical cluster analysis was used to discover relationships among variables. Based on the dendrogram, the intensity of CLBP, the impact of CLBP on sexual life, decrease in libido, sexual satisfaction, frequency of intercourse, painful sexual behavior and questionnaire results (BDI, TSK, ODI, PCS) were in the same cluster. Consistent with this, positive correlations were found between BDI and PCS (p < 0.001, r = 0.481), BDI and TSK (p < 0.001, r = 0.319), and BDI and ODI (p < 0.001, r = 0.408). The other main clusters included demographic and clinical characteristics, ODI and IPAQ scores. The sexual lives of patients with CLBP are affected physically and psychosocially. In clinical practice, it is important to counsel sexual disability patients because of their concerns and hesitations
The Effect of Otitis Media with Effusion on Language and Cognitive Skills in School Age Children
Get PDFObjective: Otitis media with effusion (OME) is a common condition in childhood and can interfere with cognitive development. The fact that it can be easily overlooked causes it to become chronic and has negative consequences in the long term (1). The negative consequences of OME in terms of speech and language disorders include speech sound disorders and developmental language disorders. For this purpose, cases admitted to the speech and language therapy clinic were screened for OME consecutively, and its relationship with language disorders was analyzed. Materials and Methods: 50 children aged 8 to 10 years without mental retardation and hearing impairment were evaluated with audiology, language, repetition (non-word and sentence), and visual perceptual tests. In addition to standard language assessment, narrative samples were obtained and analyzed which is considered a descriptive approach. Results: 26 children were positive for OME. Children with OME scored lower on language and repetition tests. There was no significant difference between the groups with and without OME in terms of syntactic complexity, narrative skills and visual perceptual performance. The Mann-Whitney U test was used for the comparison of parameters between groups (p<0.05). Conclusion: The presence of OME negatively affected language development. However, the structural complexity dimension of storytelling, complex sentence production performance, and visual perceptual skills were not affected negatively by OME. Although OME positivity is not accompanied by mental retardation and developmental delay, language development and verbal working memory may be negatively affected. OME should be routinely screened in childhood and should be addressed more closely in children with speech and language disorders