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Elevated concentrations of soluble TCTA protein-derived products including an inhibitor of human osteoclastogenesis in peripheral blood of untreated patients with early-onset rheumatoid arthritis
Get PDFT-cell leukemia translocation-associated gene (TCTA) protein is expressed ubiquitously in normal human tissues, but its function is not completely understood. We have demonstrated that TCTA protein is essential for human osteoclastogenesis induced by NF-kB ligand (RANKL), inhibits the proliferation of both small-cell lung carcinoma and fibroblast-like synoviocytes in rheumatoid arthritis (RA), and may act as a coupling factor in bone metabolism. In the current study, we constructed a high sensitivity sandwich ELISA system and measured the concentration of soluble TCTA protein-derived products (sTDP), which include an inhibitor of human osteoclastogenesis, in the peripheral blood from two groups of untreated patients with early-onset RA and normal volunteers (NV). In the first group, the concentration of sTDP was significantly higher in the 4 RA patients than in the 3 NV (p=0.0339). The level of C-reactive protein(CRP) in serum was not correlated with the concentrations of sTDP in the RA patients. We confirmed these results by analyzing the second group, which was comprised of 22 untreated patients with early-onset RA and 5 NV. In conclusion, sTDP levels were elevated in untreated patients with early-onset RA independent of inflammation. These findings suggest that sTDP play an important role in the pathogenesis of RA by inhibiting both osteoclastogenesis and the proliferation of fibroblast-like synoviocytes.departmental bulletin pape
Association between hyperlipidemia and chronic kidney disease in a Japanese population; a cross-sectional study
Get PDFBackground: Strategies to prevent the development and progression of chronic kidney disease (CKD) are important in clinical practice as life expectancy increases. The present study investigated the prevalence of CKD as well as lipid profiles affecting CKD, especially triglyceride (TG) levels.
Methods: In total, 5,169 subjects were eligible for a cross-sectional analysis of baseline data from the Jichi Medical School Cohort Study. We examined CKD subjects with an estimated glomerular filtration rate (eGFR) of less than 60 mL/ min/1.73m2 and independent factors associated with reductions in eGFR.
Results: The prevalence of CKD was 17.7%. Age, systolic blood pressure, and hyperlipidemia were defined as related CKD factors. The lowest, second, third, and highest quartile ranges of total cholesterol (TC) were ≤166, 167-188, 189-212, and ≥213 mg/dL, respectively; the quartile ranges of TG were ≤71, 72-100, 101-148, and ≥149 mg/dL, respectively. The odds ratio (OR) of Q2 to Q4 of TC relative to that of Q1 for CKD increased linearly (OR [95%CI]: Q2, 1.3 [1.0-1.7]; Q3, 1.38 [1.1-1.8]; Q4, 1.5 [1.4-2.4]). The ORs of Q2 and Q3 of TG for CKD did not increase, whereas that of Q4 did (OR [95% CI]: Q2, 0.95 [0.7-1.2]; Q3, 0.98 [0.8-1.2]; Q4, 1.21 [1.0-1.5]).
Conclusion: Increases in TC and TG levels were both independently associated with CKD. The relationship with CKD became stronger as TC increased, and the TG had threshold was 149 mg/dL.departmental bulletin pape
音響放射力インパルス（Acoustic Radiation Force Impulse : ARFI)を伴う超音波が心臓に及ぼす生体作用、ならびに急性膵炎診断への臨床応用に関する系統的レビュー
No full text自治医科大学博士（医学）令和5年度doctoral thesi
Outcome of upfront docetaxel chemotherapy and combined androgen blockade therapy for metastatic hormone-sensitive prostate cancer
Get PDF転移性ホルモン感受性前立腺癌に対する，upfront docetaxel化学療法の全生存期間（overall survival ：OS）延長が過去の報告で示されている。当院におけるupfront docetaxel化学療法とcombined androgen blockade（CAB）療法の，OS，無増悪生存期間（progression free survival：PFS1）および，２次と３次後療法を含めたPFS2，PFS3と有害事象に関して検討した。OSとPFS1に有意差は認めず（p=0.28，p=0.068），PFS2とPFS3はいずれも化学療法群で有意に延長した（p=0.0062，p=0.012）。化学療法群においてGrade 3以上の好中球減少症を62%認めるも，発熱性好中球減少症の発症はなく，比較的安全に71%の患者で化学療法を６コース完遂できた。departmental bulletin pape
