Open Library Archives of Kagawa University (OLIVE)
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Antiproliferative effects of D-allose associated with reduced cell division frequency in glioblastoma
Get PDF香川大学Kagawa University博士（医学）Recent studies have shown that D-allose, a rare sugar, elicits antitumor effects on different types of solid cancers, such as hepatocellular carcinoma, non-small-cell lung cancer, and squamous cell carcinoma of the head and neck. In this study, we examined the effects of D-allose on the proliferation of human glioblastoma (GBM) cell lines (i.e., U251MG and U87MG) in vitro and in vivo and the underlying mechanisms. D-allose treatment inhibited the proliferation of U251MG and U87MG cells in a dose-dependent manner (3–50 mM). However, D-allose treatment did not affect cell cycles or apoptosis in these cells but significantly decreased the cell division frequency in both GBM cell lines. In a subcutaneous U87MG cell xenograft model, intraperitoneal injection of D-allose (100 mg/kg/day) significantly reduced the tumor volume in 28 days. These data indicate that D-allose-induced reduction in cell proliferation is associated with a subsequent decrease in the number of cell divisions, independent of cell-cycle arrest and apoptosis. Thus, D-allose could be an attractive additive to therapeutic strategies for GBM.doctoral thesi
Improvement of Balance and Coordination through Instruction of Pitching Motion Based on Sensory Function Analysis: Collaboration between Occupational Therapists and Teachers at the Lower-secondary Department of Special Needs School
Get PDF知的障害特別支援学校中学部では，新体力テストの結果から「タイミングの良さ」や「力強さ」の項目が特に低いことが明らかになった。これらを改善するため，タイミングやバランス，力強さが重要な要素となっている投球動作に着目した。作業療法士と教師とで協働し，個々の生徒の投球動作の動画分析を行い，感覚機能に基づいた運動指導を実施した。結果協調運動や握力，投球動作の質的な向上がみられた。departmental bulletin pape
Development of a Platform for Online Lesson Study in Undergraduate Classes
Get PDF本研究は，オンライン授業研究プログラムを構築し，それを教育学部の授業で実施し，受講者の省察レポートを分析することでプログラムの成果と課題を検討した。学部の授業「教育の方法と技術」で本プログラムを実行し，107名の受講生が参加した。Darling-Hammond（1997，2006）から導出した教師に必要な省察の5観点を基にした分析の結果，本プログラムの具体的な成果と課題が明らかとなった。departmental bulletin pape
Sustainability & Technology Session
No full textWe had the sustainability & technology sessions at Hayashi-cho Campus, and visited two companies located in Takamatsu City. The participants from the three universities engaged in lively discussions and we believe it was a very successful event.departmental bulletin pape
Ⅰ．インターナショナルオフィス全体に関わる報告
No full text１．インターナショナルオフィス概要２．香川大学の国際化の基本方針と重点戦略課題３．2023年度インターナショナルオフィス年間行事（2023年４月～2024年３月）４．Trilateral Symposium on SDGs 2023
- 2023年度香川大学・チェンマイ大学・国立嘉義大学合同シンポジウム開催報告５．学長・インターナショナルオフィス長表敬訪問６．International Month７．留学生のつどい８．グローバル・インスピレーション・イニシアティブ開催９．独立行政法人国際協力機構（JICA）との連携10．留学生宿舎departmental bulletin pape
Upgraded architecture of TWDM-PON with type B protection for capacity and budget improvement
No full textThe next-generation mobile fronthaul system based on technologies beyond 5G requires optical access networks with excellent disaster resistance. For passive optical networks (PONs), also known as economical optical access networks, the Type B protection method that considers disaster resistance is a practical conventional approach to address transceiver and link failure. However, the transmission capacity upgrade and effective utilization of optical power of time wavelength division multiplexing (TWDM)-based-PON with Type B protection have not been extensively studied. In this study, we intend to upgrade the architecture by applying Type B protection to a 40 Gbit/s-class TWDM-PON that uses the uplink C band/downlink L band specified by NG-PON2. To improve the downlink capacity, we have considered a bidirectional asymmetric modulation transmission system to introduce a dual-polarization quadrature phase-shift keying system for the downlink C band. The downlink coherent signal is transmitted by selecting either the primary or secondary link using the optical switch. There are no major drawbacks with either the primary or secondary link. Moreover, we have numerically and experimentally clarified the impact of improving the reception power by receiving a burst single-input multi-output in the uplink under the condition of no link failure. Additionally, we describe the bidirectional transmission feasibility of C-band asymmetric modulation under link failure and reflection. We have found that bidirectional transmission at the same wavelength is possible by allowing a specific penalty even for asymmetric symbol rate/polarization/modulation formats. A principle verification experiment revealed that SIMO reception could be improved by a 1.5 dB budget on the uplink. The method of upgrading the TWDM-PON system can be changed while effectively using NG-PON2 technology until the future coherent PON method is completely introduced.departmental bulletin pape
