Open Library Archives of Kagawa University (OLIVE)
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Taiwan-Japan Comparison of ‘Play’ as a Quality Indicator in Early Childhood Education and Care
No full textThis project aims to explore the common issues of quality indicators in Early Childhood Education and Care （ECEC） across the differences in social and cultural beliefs, values, and traditions between Taiwan and Japan. One question worthy of ongoing research is what issues regarding play are recognised through ECEC practices in both countries. This study attempted to clarify this issue through the literature review. It would expand our understanding of improving the quality of ECEC practices and contribute to a debate about the best ways to support young children’s personal, social, and emotional development. The quality of ECEC affects children’s
development of non-cognitive skills. Therefore, exploring the way to assess process quality in ECEC can enhance the SDG’s action in Goal 4; to ensure inclusive and equitable quality education and promote lifelong learning opportunities for all.departmental bulletin pape
Higher Indocyanine Green Retention Is Associated with Improved Prognosis in Patients with Hepatocellular Carcinoma Treated with Transcatheter Arterial Chemoembolization
No full textPurpose
To test indocyanine green retention rate at 15 minutes (ICG-R15) as a prognostic biomarker in patients with hepatocellular carcinoma (HCC) treated with transcatheter arterial chemoembolization (TACE) therapy.Materials and Methods
This retrospective cohort study was performed on the data of 278 consecutive patients with HCC treated with TACE after ICG-R15 testing at a single university hospital. Cox proportional hazard model analysis was performed to identify independent prognostic factors. After adjusting for age, sex, stage of HCC, albumin–bilirubin score, etiologies, and baseline year by propensity score matching, the prognostic impact of higher ICG-R15 was evaluated using the Kaplan–Meier curve.Results
Univariate and multivariate analyses identified higher ICG-R15 as a positive prognostic factor for overall survival. Propensity score matching generated two 77-patient cohorts: ICG-R15 20% group. The overall survival of the ICG-R15 >20% group was significantly better than that of the ICG-R15 <20% group.Conclusions
Higher ICG-R15 acted as a positive long-term prognostic factor in patients with HCC treated with TACE.journal articl
Relationship between multi-pool model-based chemical exchange saturation transfer imaging, intravoxel incoherent motion MRI, and 11C-methionine uptake on PET/CT in patients with gliomas
No full textPurpose
Magnetization transfer ratio asymmetry (MTRasym) analysis is used for chemical exchange saturation transfer (CEST) in patients with gliomas; however, this approach has limitations. CEST imaging using a multi-pool model (MPM) may allow a more detailed assessment of gliomas; however, its mechanism remains unknown. This study aimed to assess the relationship between CEST imaging by MPM, intravoxel incoherent motion (IVIM), and 11C-methionine (11C-MET) uptake on positron emission tomography/computed tomography (PET/CT) to clarify the clinical significance of CEST imaging using MPM in gliomas.Methods
This retrospective study included 17 patients with gliomas who underwent 11C-MET PET/CT at our institution between January 2020 and January 2022. Two-dimensional axial CEST imaging was conducted using single-shot fast-spin echo acquisition at 3 T. The apparent diffusion coefficient (ADC), true diffusion coefficient (D), pseudo-diffusion coefficient (D*), f, MTRasym (3.5 ppm), parameters of MPM-based CEST imaging, and tumor-to-contralateral normal brain tissue (T/N) ratio were calculated using a region-of-interest analysis. Shapiro–Wilk test, weighted kappa coefficient, and Spearman's rank correlation coefficients were used for statistical analysis.Results
Significant correlations were found between APT_T1 and T/N ratio (ρ = 0.87, p < 0.001), APT_T2 and T/N ratio (ρ = 0.47, p < 0.05), MTRasym and T/N ratio (ρ = 0.55, p < 0.01), and T2/T1 and T/N ratio (ρ = −0.36, p < 0.05). Furthermore, significant correlations were observed between APT_T1 and ADC (ρ = −0.67, p < 0.001), APT_T1 and D (ρ = −0.70, p < 0.001), APT_T2 and D* (ρ = −0.45, p < 0.05), and T2/T1 and D (ρ = 0.39, p < 0.05).Conclusion
These preliminary findings indicate that MPM-based CEST imaging parameters correlate with IVIM and 11C-MET uptake on PET/CT in patients with gliomas. In particular, the new parameter APT_T1 correlated more strongly with 11C-MET uptake compared to the traditional CEST parameter MTRasym.journal articl
Cabozantinib inhibits the growth of lenvatinib-resistant hepatoma cells restoring FTCD expression
No full textCabozantinib is a newly developed tyrosine kinase inhibitor, which is applied on patients with hepatocellular carcinoma (HCC) unresponsive to conventional tyrosine kinase inhibitors, including lenvatinib. However, the mechanism of cabozantinib efficacy for lenvatinib-resistant tumor cells has not been well established in basic studies. The purpose of this study is to elucidate the mechanisms by which cabozantinib inhibits tumor growth of lenvatinib-resistant hepatocellular carcinoma cell lines in vitro and in vivo. We established a lenvatinib-resistant Hep3B cell line (Hep3B-LR) and evaluated the inhibitory effect of cabozantinib on the growth of Hep3B-LR cells. Hep3B-LR exhibited approximately 20 times greater IC50 for lenvatinib than the wild type. Compared with wild-type Hep3B, Hep3B-LR was characterized by enhanced expression of EGFR, MET and ErbB2. Cabozantinib suppressed tumor growth of Hep3B-LR in vitro and in vivo. Microarray analysis and real-time qPCR using the xenografts revealed cabozantinib downregulated miR-126-3p, a tumor suppressor miRNA, suggesting that miR-126-3p did not contribute to tumor inhibitory effect of cabozantinib. Proteome analysis using xenograft tissues demonstrated an upregulation of FTCD, a tumor suppressor gene, by cabozantinib administration. The enhanced expression of FTCD by cabozantinib was confirmed by western blot and immunohistochemistry analysis. Furthermore, FTCD expression in Hep3B-LR before cabozantinib administration was weaker than that in wild-type Hep3B. FTCD expression was weakened along with acquisition of lenvatinib-resistance, and was restored by cabozantinib administration. FTCD may be a novel therapeutic target of cabozantinib in case of lenvatinib treatment failure.journal articl
History of the international exchange program with Chiang Mai University: achievements and prospects
No full text香川大学が1990年にチェンマイ大学との学術交流協定を締結して33年になる。初期の交流は、農学部を中心とした技術協力プロジェクトなどが中心であった。2007年にチェンマイ大学を海外教育研究交流拠点校と位置付けてから、全部局の交流へと進展した。その際には香川大学チェンマイ大学合同シンポジウムの開催が大きな役割を果たした。国際交流の活性化のための組織体制整備として、2003年に留学生センターが設置され、さらに2009年にインターナショナルオフィスへと発展・拡充し、全部局との連携体制が確立した。また、交流資金確保のため、香川大学国際交流基金（現グローバル人材育成特定基金）事業を展開した。チェンマイ大学との交流は、本学の国際交流活動の大きな柱として発展し、他の協定校との活動のモデルにもなった。本学が2013年に制定した国際戦略「４＆１プラン」は、10年間で受入留学生を年間400人に、派遣日本人学生を100人（３カ月以上）にする計画であるが、このプラン策定にも大きな影響を与えた。33年の交流の中で非常に多くの人材交流がなされた。特に学生の交流プログラムの教育的効果は大きかった。交流拡大の潮流はさらに広がっており、教育、研究、地域貢献で様々な共同プロジェクトが行われている。departmental bulletin pape
Conflict opinions on the knowing the Japanese vernacular names of species, etc. between two Japanese zoologists of Naohide Yatsu and Tamiji Kawamura around 1920’s and 1930’s
Get PDF大正から昭和初期にかけて日本の動物学を支えた東京帝国大学教授谷津直秀と京都帝国大学教授川村多實二の初等教育における生物名に対する考え方を整理・比較検討した。両者は自然から学ぶという点では一致していたが，生物名を知ることについては見解を異にした。谷津は「名を知るは物を知る一つの手段であって，しかも必要なる手段でもない」とし，種の同定が難しいので一般市民がその同定を専門家に依頼する必要性を指摘した。川村は「一体物の名前を覚えるということは，知識の最後ではなくして最初である。（中略）ごく手近にある物の名前を覚えるということは，そんなに没趣味のことではない」と述べ，生物名を通じて身近な生き物に興味を持ち慣れ親しむことが生き物に対する理解の深まりへの端緒と考えていた。情報交流の場合には何が（what）を明確にする必要があり，それは物の名前であり，それには学名や慣習的に使われる生物名が必要となる。谷津の述べるようにすると一般市民は生物名を使った会話や会話による情報交流や誤りの発見も不可能となり，身近な生物への興味を失うであろう。上記の初等教育段階での教授方法についての両者の対立した見解は科学に対する両者の見方の相違によって生じたと推測された。In 1920, and 1932a,b, respectively,Professors Naohide Yatsu, Tokyo Imperial University,and Tamiji Kawamura, Kyoto Imperial University,discussed on whether or not knowing of the Japanese vernacular names of biological species, etc. is necessary in the early elementary education. Prof.Yatsu insisted on that knowing the name of plants or animals is not absolutely need for biological studies but it is no more than one method. Furthermore, he emphasized that beginners who want to know the name should ask professional researchers about it to get exact identification, because the identification is very difficult for them. On the contrary, opposing Yatsu’s opinion, Prof. Kawamura asserted that knowing the names is the first step to access friendly to these plants and animals living around our daily life, so that beginners would come to have an interest in plants and animals. If beginners ask these names for researchers every time according to Yatsu’s opinion, I suppose that beginners would feel troublesome and would give up to know these names after this. These conflict opinions would be brought about the difference of how to think of science between Yatsu and Kawamura.journal articl
Record of Postodius sanguineus Ariyama (Crustacea: Amphipoda: Odiidae) from Kagawa Prefecture, Japan
Get PDF2022 年1 月8 日,瀬戸内海東部に位置する香川県高松市亀水町の海岸においてチゴケスベヨコエビ Postodius sanguineus Ariyama を1個体採集した。本種の採集記録としては2 例目となる。その後の同海岸での調査により,大量の本種が生息し,海岸線にそって約1.5 kmにわたって生息していることが明らかとなった。大潮の干潮時に陸上に露出した拳大から長径30 cm 程の石の下面のコケムシの1 種の群体上か周辺部に静止した状態で観察された。観察された1 個の石あたりの最大個体数は長径約30 cm の石から34 個体であった。香川県下各地の海岸での調査結果で高松市亀水町の海岸と隣接した神在川窪町神在鼻および高松市屋島西町長崎の鼻における生息が確認された。journal articl
A new labdane-type diterpenoid from leaves of Vitex rotundifolia
No full textVitex rotundifolia is a folk medicinal plant that has been used to treat various diseases. We have previously found that the extract of its leaves shows cytotoxic and epithelial mesenchymal transition inhibitory effect in HHUA endometrial cells. In this study, a new labdane-type diterpenoid 1 was isolated and its structure was elucidated by NMR and CD spectroscopic analysis followed by density functional theory calculations. Compound 1 showed cytotoxicity toward HHUA cells with an IC50 value of 6.4 μM, but did not inhibit phorbol ester-induced epithelial mesenchymal transition nor lipopolysaccharide-stimulated nitric oxide production.journal articl
