Open Library Archives of Kagawa University (OLIVE)
Not a member yet
10866 research outputs found
Sort by
Necessary and sufficient factors of keratinocytes in psoriatic dermatitis
No full text乾癬の抗体医薬は効果が高い一方、高額である。筆者らはこれまでに乾癬型皮膚炎の必要条件と十分条件を見出した。この成果を網羅的に解析し、表皮が必要十分条件で産生する因子を2つに絞った。新たな創薬が期待できる。journal articl
Aggressive prostate cancer in patients treated with active surveillance
No full text早期前立腺癌に対する監視療法は診断後に即時の治療介入を行わず厳格なプロトコールで病状を監視し、病状の悪化が確認された場合に治療介入を行う治療戦略である。香川大学泌尿器科はわが国の監視療法の中心的な役割を担っており、監視療法の多機関共同研究の事務局や前立腺癌診療ガイドラインに携わってきた。この総説では、監視療法中の病状増悪のリスク因子について先行研究を調査しまとめた。Active surveillance has emerged as a promising approach for managing low-risk and favorable intermediate-risk prostate cancer (PC), with the aim of minimizing overtreatment and maintaining the quality of life. However, concerns remain about identifying “aggressive prostate cancer” within the active surveillance cohort, which refers to cancers with a higher potential for progression. Previous studies are predictors of aggressive PC during active surveillance. To address this, a personalized risk-based follow-up approach that integrates clinical data, biomarkers, and genetic factors using risk calculators was proposed. This approach enables an efficient risk assessment and the early detection of disease progression, minimizes unnecessary interventions, and improves patient management and outcomes. As active surveillance indications expand, the importance of identifying aggressive PC through a personalized risk-based follow-up is expected to increase.journal articl
エピガロカテキンガレートは高脂肪食とエタノール摂取によるラットの肝障害を悪化させる
Get PDFHeavy drinking and obesity, which often coexist, have been shown to promote liver injury, steatohepatitis, and fibrosis developments. The recent increase in the incidence of metabolic syndrome highlights the potential of heavy drinking and obesity to cause liver damage and consequent inflammation synergistically. Tea is consumed worldwide. Catechin, a bitter tea component, is a polyphenol. Catechins have many physiological effects, including antioxidant, bactericidal, anticancer, hypotensive, cholesterol‐lowering, and blood sugar‐suppressing effects. Recently, it has been suggested that they exert anti‐obesity effects. This study investigated the effects of epicatechin gallate combined with a high‐fat diet and chronic alcohol consumption on liver damage in rats. Twenty male Wistar rats were randomized into four groups of five: control, high‐fat diet, high‐fat‐ethanol diet, and high‐fat‐ethanol‐epicatechin gallate diet groups. The rats in each group were fed the experimental diets ad libitum for eight weeks. High‐fat diet and ethanol consumption induced fatty liver in rats. Additionally, epicatechin gallate exacerbated liver injury. However, epicatechin gallate content in normal green tea intake is considered safe, and caution should be exercised when consuming concentrated supplements.多量飲酒と高脂肪食誘発性肥満は、肝損傷、脂肪肝および肝線維症の発症を促進することが明らかにされている。近年、メタボリックシンドロームの発生率の増加は、多量飲酒と肥満が相乗的に肝臓損傷とそれに伴う炎症を引き起している可能性がある。一方、茶は世界中で広く普及している飲料である。茶の苦味成分であるカテキンは、ポリフェノールの一種であり、これまでに抗酸化作用、殺菌作用、抗がん作用、血圧降下作用、コレステロール低下作用、血糖抑制作用および抗肥満作用など、多くの生理学的作用が報告されている。本研究では、長期の高脂肪食およびエタノール摂取によるラットの肝損傷に対するエピカテキンガレートの影響について検討した。20匹のWistar系雄ラットを5匹ずつ4群に分け、それぞれ対照群、高脂肪食群、高脂肪・エタノール食群、および高脂肪・エタノール・エピカテキンガレート食群とした。各グループのラットには実験食を8週間自由に与えた。その結果、高脂肪食とエタノール摂取は、ラットの脂肪肝を誘発し、エピカテキンガレートは肝障害を悪化させた。通常摂取レベルでの緑茶に含まれるエピカテキンガレートは安全であると考えられているが、濃縮サプリメントを摂取する場合には注意が必要かも知れない。departmental bulletin pape
Comparison of impressions of COVID-19 vaccination and influenza vaccination in Japan by analyzing social media using text mining
Get PDF香川大学Kagawa University博士（医学）The aim of this study was to compare impressions of COVID-19 vaccination and influenza vaccination in Japan by analyzing social media (Twitter®) using a text-mining method. We obtained 10,000 tweets using the keywords “corona vaccine” and “influenza vaccine” on 15 December 2022 and 19 February 2023. We then counted the number of times the words were used and listed frequency of these words by a text-mining method called KH Coder. We also investigated concepts in the data using groups of words that often appeared together or groups of documents that contained the same words using multi-dimensional scaling (MDS). “Death” in relation to corona vaccine and “severe disease” for influenza vaccine were frequently used on 15 December 2022. The number of times the word “death” was used decreased, “after effect” was newly recognized for corona vaccine, and “severe disease” was not used in relation to influenza vaccine. Through this comprehensive analysis of social media data, we observed distinct variations in public perceptions of corona vaccination and influenza vaccination in Japan. These findings provide valuable insights for public health authorities and policymakers to better understand public sentiment and tailor their communication strategies accordingly.doctoral thesi
Predictive value of local control by 4’-[methyl-11C]-thiotymidine PET volume parameters in p16-negative oropharyngeal, hypopharyngeal, and supraglottic squamous cell carcinoma
Get PDF香川大学Kagawa University博士（医学）Purpose: We investigated the potential of baseline 4'-[methyl- 11 C]-thiothymidine ([ 11 C]4DST) PET for predicting loco-regional control of head and neck squamous cell carcinoma (HNSCC).Methods: A retrospective analysis was performed using volumetric parameters, such as SUVmax, proliferative tumor volume (PTV), and total lesion proliferation (TLP), of pretreatment [ 11 C]4DST PET for 91 patients with HNSCC with primary lesions in the oral cavity, hypopharynx, supraglottis, and oropharynx, which included p16-negative patients. PTV and TLP were calculated for primary lesions and metastatic lymph nodes combined. We examined the association among the parameters and relapse-free survival and whether case selection focused on biological characteristics improved the accuracy of prognosis prediction.Results: The area under the curves (AUCs) using PTV and TLP were high for the oropharyngeal/hypopharyngeal/supraglottis groups (0.91 and 0.87, respectively), whereas that of SUVmax was 0.66 ( P < 0.01). On the other hand, the oral group had lower AUCs for PTV and TLP (0.72 and 0.77, respectively). When all cases were examined, the AUCs using PTV and TLP were 0.84 and 0.83, respectively.Conclusion: Baseline [ 11 C]4DST PET/CT volume-based parameters can provide important prognostic information with p16-negative oropharyngeal, hypopharyngeal, and supraglottic cancer patients.doctoral thesi
Developing user interfaces to support people with disabilities through natural language processing
Get PDF重度重複障害を持った人は、発話、表情や身振り等の対人関係のコミュニケーションが困難な場合が多く、自分の意見を伝える事が困難なため、小さい時から周囲の意見に同調させられる事が多かった。このため、多くの人は自分の持つコミュニケーションの可能性を諦めてしまい、成人になっても受動的態度となる事が多かった。しかし、何らかの方法で「自分の意思を他人に伝えられる=コミュニケーション」が取れる事に気づけば、自分が本来持っている自発的意思（能動的態度）に気づく可能性がある。本研究では、機械学習を用いた音声認識を用いて家電製品の操作をコントロールする、重度重複障害を持った人のコミュニケーション支援用スマートホームモデルの試作を行った。本研究では、この支援システムを通じて、重度重複障害を持った人が自分自身のもつ能動的な力に気づいてもらえるシステムを目指す。departmental bulletin pape
Examining language activities that lead to learning outcomes in physical education classes using goal-based games : Through analysis of physical education classes using cest-ball teaching materials
Get PDF本研究では、セストボールを教材化した学習プログラムを作成し、子どもの話し合活動と学習成果との関係を明らかにしようとした。その結果、クラス全体のゲームパフォーマンスは単元を通して高い適切率を示したことから学習プログラムが有効であり、ゲームデータやプレー集を基にした話し合い活動の結果、自チームの課題と課題解決の方法が明確化され、実際のゲーム場面でその課題を解決することができた。departmental bulletin pape