JOURNAL OF HEALTHCARE AND LIFE-SCIENCE RESEARCH
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CARDIOVASCULAR INSUFFICIENCY ON THE BACKGROUND OF ISCHEMIC HEART DISEASE
Get PDFOne of the basic tenets of medicine is that optimal treatment of a disease is not possible without knowledge of its cause. However, this principle is difficult to apply when it comes to chronic heart failure (CHF). This is because, although the diseases that lead to the development of CHF are many and varied, the final outcome for all is the same: decompensation of cardiac function.
Heart failure (HF) on the background of coronary heart disease (CHD) is one of the main causes of disability and death among patients with cardiovascular diseases. It develops due to chronic oxygen deficiency in the myocardium, which leads to impairment of its function and structural changes. The main mechanisms of CH progression are myocardial ischemia, infarction, fibrosis, and activation of neurohumoral mechanisms such as sympathetic nervous system and renin-angiotensin-aldosterone system. This article discusses the pathogenesis of heart failure on the background of CHD, the main clinical manifestations, diagnostic methods and modern approaches to treatment. Special attention is paid to the importance of early diagnosis and complex approach to treatment, including drug therapy, surgical interventions and rehabilitation programs
IRSIY KASALLIKLAR KELIB CHIQISHIDA MODDALAR ALMASHUNIVINI AHAMIYATI
Get PDFIrsiy kasalliklar – genetik axborotning buzilishi natijasida kelib chiqadigan kasalliklar; asosan, xromosomalar yoki genlardagi mutatsiyalar tufayli paydo boʻlib, nasldan naslga oʻtadi. Mutatsiyalar tashqi muhit omillari (ionlashtiruvchi nurlar, ayrim biologik faol kimyoviy birikmalar) hamda organizm va hujayralardagi salbiy taʼsirlar oqibatida roʻy berishi mumkin
MANAGEMENT OF ANEMIA IN PATIENTS WITH CHRONIC GLOMERULONEPHRITIS
Get PDFChronic glomerulonephritis (CGN) is a significant cause of chronic kidney disease (CKD) and contributes to the development of anemia through various mechanisms, including decreased erythropoietin production and iron dysregulation. Anemia in CGN negatively impacts the quality of life and increases cardiovascular risks. [1]This review explores the etiology, pathogenesis, diagnostic approaches, and treatment options for anemia associated with CGN. The integration of erythropoiesis-stimulating agents (ESAs), iron supplementation, and novel therapies offers hope for improving outcomes in these patients. [2]
БОЛАЛАРДАГИ ДИҚҚАТ ТАНҚИСЛИГИ ВА ГИПЕРАКТИВЛИК СИНДРОМИ ПАТОФИЗИОЛОГИЯСИДА НЕЙРОКИМЁВИЙ (НЕЙРОТРАНСМИТТЕРЛАР) ВА НЕЙРОАНАТОМИК ЎЗГАРИШЛАР (АДАБИЁТЛАР ТАҲЛИЛИ)
Get PDFДиққат танқислиги ва гиперактивлик синдроми (ДТГС) болаларда энг кенг тарқалган неврологик ривожланиш бузилишларидан бири бўлиб, унинг патофизиологиясида мураккаб нейрокимёвий ва нейроанатомик ўзгаришлар муҳим аҳамият касб этади. Мазкур мақолада ДТГСнинг нейробиологик асослари, хусусан, дофамин ва норадреналин каби нейротрансмиттерлар фаолиятининг бузилиши ҳамда миянинг префронтал соха, базал ганглиялар ва мияча каби асосий тузилмалардаги анатомик ўзгаришлар таҳлил қилинган. Илмий адабиётлар асосида, дофаминергик ва норадренергик тизимларнинг дисфункцияси ДТГС симптомларининг пайдо бўлишида марказий ўрин тутиши кўрсатилган. Шунингдек, миянинг дорсолатерал префронтал сохасидаги гипоактивлик ва бошқа нейроанатомик алоқаларнинг бузилиши диққат, импульсларни назорат қилиш ва ҳаракатларни мувофиқлаштиришдаги муаммоларга олиб келиши таъкидланган. Мақола ДТГС патофизиологиясига оид янги тадқиқотларни таҳлил қилиш ва ушбу соҳадаги келгуси изланишлар учун йўналишларни белгилашга қаратилган
ПОКАЗАТЕЛЕЙ СВЕРТЫВАНИЯ КРОВИ ВО ВРЕМЯ БЕРЕМЕННОСТИ
Get PDFПо мере развития беременности происходят изменения в частях системы гемостаза, связанных с развитием плода. Активация системы гемостаза во время беременности создает фон для тромбогеморрагических осложнений. Интерпретация лабораторных показателей системы гемостаза у беременных с учетом анамнеза женщины и срока беременности является основой своевременной диагностики, адекватной лечебной тактики и эффективной профилактики осложнений беременности
THE ORIGIN AND PREVENTION OF NECROSIS IN THE CARDIOVASCULAR SYSTEM
Get PDFMyocarditis is inflammation of the myocardium with necrosis of cardiomyocytes. Myocarditis can be caused by a variety of factors (e.g., infectious diseases, cardiotoxins, drugs, systemic diseases such as sarcoidosis), but is most often idiopathic. Symptoms can be varied and include fatigue, shortness of breath, edema, tachycardia, and sudden death. Diagnosis is based on symptoms and clinical findings, including abnormal electrocardiogram, cardiac biomarkers, and cardiac imaging in the absence of cardiovascular risk factors. Endomyocardial biopsy confirms the clinical diagnosis of myocarditis. Treatment depends on the cause, but common measures include medications and devices to treat heart failure and arrhythmias, and rarely, surgery (e.g., intra-aortic balloon pump, left ventricular assist device, transplantation). Immunosuppression is used in some types of myocarditis (e.g., hypersensitivity myocarditis, giant cell myocarditis, and myocarditis caused by sarcoidosis)
ERKAKLARDA BEPUSHTLIK KASALLIGI KELIB CHIQISHIDA PROSTATA BEZINING FUNKSIYASINI BUZILISHINING O`RNI
Get PDFHozirgi rivojlangan zamonaviy dunyoda o`smirlar balog`atga yetishining tezlashuvi sodir bo`lmoqda. Bu o`z navbatida har xil internet tarmog`idagi kinolar va ijtimoiy roliklar sababli jinsiy aloqaga qiziqish erta uyg`onmoqda. Natijada erta va tartibsiz jinsiy aloqaning bo`lishi, turli xil jinsiy yo`l bilan yuqadigan kasalliklarni yuqtirib olishlar sonini ortishiga olib kelmoqda. Yana bir asosiy sabablardan biri shuki, doimiy ish bilan shug`ullanish va streslarning ko`pligi, jinsiy aloqani kamashishi va sustlashuviga olib kelmoqda. Bularning barchasi prostatit kasalligini kelib chiqishi va Prostatani bez faoliyatini buzilishiga olib keladi
РОЛЬ И ОЦЕНКА ЭФФЕКТИВНОСТИ ЛИВОМЕДА ПРИ КОРРЕКЦИИ ПРОЦЕССА ПЕЧЕНОЧНОГО ФИБРОЗА РАЗЛИЧНОГО ГЕНЕЗА
Get PDFВ данной статье рассматривается значение препарата Ливомед как эффективного средства, оказывающего положительное влияние на обменные и структурные процессы в печени. Особое внимание уделено его способности повышать активность коллагеназ – ферментов, ответственных за разрушение избыточных коллагеновых волокон, что играет ключевую роль в замедлении прогрессирования фиброзных изменений. Полученные данные подчёркивают важность дальнейших клинических исследований для более детального изучения его механизмов действия и подтверждения высокой терапевтической ценности препарата
ЭФФЕКТИВНОСТЬ TAVAMED В КОМПЛЕКСНОМ ЛЕЧЕНИИ ЛЕКАРСТВЕННО-УСТОЙЧИВЫХ ФОРМ ТУБЕРКУЛЁЗА ЛЕГКИХ
Get PDFРезультаты предварительных клинических и экспериментальных исследований подтверждают, что включение TAVAMED в стандартные схемы терапии способствует более быстрому снижению бактериальной нагрузки, уменьшению числа осложнений, повышению вероятности достижения стойкой микробиологической ремиссии, а также снижению риска рецидивов заболевания. Дополнительным преимуществом является возможность его применения в рамках индивидуализированных схем, учитывающих уровень резистентности возбудителя и состояние пациента. Таким образом, использование TAVAMED в терапии туберкулёза с множественной лекарственной устойчивостью открывает новые перспективы для клинической практики, позволяя существенно повысить эффективность лечения, сократить длительность терапии и улучшить прогноз для пациентов. Актуальность применения данного препарата определяется как клиническими потребностями, так и глобальными задачами Всемирной организации здравоохранения (ВОЗ) по борьбе с лекарственно-устойчивыми формами туберкулёза
OUTCOMES OF ARTHROSCOPIC PARTIAL MENISCECTOMY IN WORK-RELATED AND NON–NON-WORK-RELATED PATIENT COHORTS: A RETROSPECTIVE STUDY
Get PDFBackground/Aim. To retrospectively evaluate and compare the outcomes of arthroscopic partial meniscectomy among patients who sustained meniscal injuries of work-related and non–work-related origin.
Materials and Methods
This study included 60 patients treated at the Traumatología de Comahue Center between January 2025 and September 2025. All patients had acute meniscal injuries that failed to respond to conservative management. Preoperative magnetic resonance imaging (MRI) was performed in all cases.
Patients were divided into two cohorts: 30 with work-related injuries and 30 with non–work-related injuries. The sample comprised 45 men and 15 women aged 18 to 45 years. In total, 49 medial and 11 lateral meniscal tears were recorded. The mean follow-up duration was 18 months. Clinical outcomes were assessed using the Lysholm Knee Scoring Scale and the visual analog scale (VAS) for pain.
Results
In the group of patients with non–work-related injuries (n = 30), 28 individuals (93%) demonstrated favorable outcomes, with the mean Lysholm score increasing from 53 to 93 points and pain intensity on the visual analog scale (VAS) decreasing from 7 to 1 point. Most patients returned to their preinjury level of physical activity. Two patients reported minor residual symptoms that did not interfere with daily activities.
In the work-related injury group (n = 30), 14 patients (47%) achieved favorable outcomes: the mean Lysholm score improved from 48 to 74 points, and the VAS score decreased from 7 to 2 points. These patients fully resumed their previous occupational activities. Sixteen patients continued to experience moderate pain, allowing only partial return to work or requiring modification of their physical workload.
Conclusion
In patients with non–work-related injuries, the outcomes of arthroscopic partial meniscectomy were rated as good to excellent: 96% returned to their usual daily activities. In contrast, the work-related cohort demonstrated less favorable results—only 53% were able to resume their prior professional duties.These between-group differences underscore the impact of occupational demands and the intensity of physical workload on functional outcomes after meniscectom