JOURNAL OF HEALTHCARE AND LIFE-SCIENCE RESEARCH
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PREDICTIVE ANALYTICS FOR PATIENT RECRUITMENT
Get PDFPredictive analytics has emerged as a transformative tool in the realm of patient recruitment for clinical trials. This review article explores the significance of predictive analytics in addressing challenges associated with traditional recruitment methods. Delving into the role of machine learning algorithms, data sources, and the integration of electronic health records, it examines the advantages, regulatory considerations, and future directions of predictive analytics in patient recruitment. The article also discusses challenges, ethical considerations, and presents case studies showcasing successful implementations. As clinical trial design evolves, predictive analytics stands as a promising approach to enhance efficiency, reduce timelines, and improve overall trial outcomes
EARLY DIAGNOSIS OF TERMINAL RENAL FAILURE IN PATIENTS WITH DIABETES MELLITUS
No full textThe article examines these risk factors for end-stage renal failure in patients with diabetes mellitus.The aim of the study was early prediction of renal failure in patients with diabetes mellitus. Kidney function was assessed at the stage when it was not yet affected by the pathological process. The materials and methods of the study included 71 patients receiving hemodialysis with an approved main diagnosis of diabetes mellitus, the complications of which were end-stage renal failure
MODERN METHODS OF CHECKING THE CHARACTERISTICS OF ONCOVIRUSES
No full textPancreatic cancer ranks among the most common tumors in humans in the world. In this context, the search for cases of EBV-related pancreatic cancer, the determination of frequency among all tumors of this localization, as well as the role of the virus in etiotogenesis are among the most current scientific studies
As a Carrier Protein of a Medicinal Product the Main Properties of Р-Glycoprotein
Get PDFTo predict the pharmacokinetic interaction of drugs during absorption, distribution and excretion, it is also necessary to know the potential of substances to affect the body's transport systems, including glycoprotein-P (Pgp) and change its functional activity. This will eliminate the ineffectiveness of pharmacotherapy and undesirable reactions of drugs associated with changes in their concentration in blood plasma
The Effect of the Pesticide on Physical Development Young Rats
Get PDFThat prolonged intake of even small doses of pesticides into the body can cause negative shifts in the metabolic processes of the body. In this regard, the organochlorine pesticide widely used in agriculture – magnesium chlorate, in violation of environmental norms and rules of its use, entering the body and being a chemically active substance, causes a number of functional and morphological changes in various organs, in particular in the liver. The liver of a young, growing organism is especially sensitive to such toxic effects, since it is still functionally very labile and structurally underdeveloped
Diabetes
Get PDFThis article contains information about the causes of diabetes, its prevention, diagnosis, physiological, anatomical and morphological manifestation
INTRAUTERINE DEATH: PLACENTAL HISTOARCHITECTURAL FACTORS
Get PDFIntrauterine death (IUD) remains one of the most distressing outcomes in obstetrics, accounting for a significant proportion of perinatal mortality worldwide. Despite advancements in maternal–fetal medicine, a considerable number of IUD cases remain unexplained. The placenta, being the central organ of materno–fetal exchange, is often considered a mirror of the intrauterine environment. Histopathological examination of the placenta provides essential insights into the underlying etiological factors contributing to IUD, thereby guiding both clinical management and future preventive strategies.
Placental histoarchitecture in IUD cases commonly demonstrates a spectrum of pathological changes. Gross findings often reveal variations in weight and shape, areas of infarction, retroplacental clots, and abnormal cord insertion. Microscopic evaluation is more revealing, showing villous immaturity, increased syncytial knots, stromal fibrosis, and intervillous fibrin deposition. Fibrinoid necrosis and extensive calcification are frequently noted, suggesting chronic hypoxia. Vascular abnormalities such as thrombotic occlusion of fetal vessels, chorangiosis, and villous edema further compromise oxygen and nutrient exchange, leading to fetal demise. In some cases, infectious etiologies are implicated, as evidenced by chorioamnionitis, villitis, and intervillositis with inflammatory cell infiltration. These inflammatory lesions point towards ascending or hematogenous maternal infections, which remain important preventable causes of IUD.
Hypertensive disorders of pregnancy and maternal vascular malperfusion are strongly associated with placental infarction and villous maturation defects. Similarly, maternal diabetes, thrombophilia, and autoimmune conditions contribute to altered villous architecture. The recurring observation of syncytial knots and trophoblastic proliferation indicates compensatory changes in response to chronic hypoxic stress. Notably, placental pathology not only explains the cause of death in the present pregnancy but also helps in identifying women at risk of recurrence in subsequent gestations.
The histoarchitectural assessment of the placenta should be regarded as a routine part of IUD evaluation, particularly when clinical history and maternal investigations fail to identify a cause. By categorizing lesions into maternal vascular malperfusion, fetal vascular malperfusion, and inflammatory or infectious origins, pathologists can provide valuable input to clinicians. This approach aids in establishing a multidisciplinary strategy for preventing future pregnancy losses through targeted interventions, including better antenatal monitoring, infection control, and management of maternal comorbidities
Preventive Measures to Prevent Pollution of the Environment With Pesticides
Get PDFoai:ojs2.jhlsr.innovascience.uz:article/2Based on the conducted research, the safety of the use of the new insecticide Seller in agriculture was established. Scientifically substantiated the maximum permissible concentration of insecticide in atmospheric air, air of the working area, in the soil. Approximately permissible concentration of the drug in products of plant origin, in the water of water bodies has been developed
Development of Professional Thinking of Future Specialists in the Educational Process
Get PDFThe article is devoted to the development of professional and operational thinking of future specialists in the educational process, as well as the role of professional and operational thinking of students in the field of medical pedagogy for solving pedagogical and psychological problems