JOURNAL OF HEALTHCARE AND LIFE-SCIENCE RESEARCH
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ADVANCES IN THE DIAGNOSIS AND MANAGEMENT OF ENDOMETRIOSIS
Get PDFEndometriosis is a chronic gynecological disorder characterized by the presence of endometrial-like tissue outside the uterine cavity, leading to pain, infertility, and reduced quality of life. In recent years, significant advancements have been made in diagnostic strategies—including imaging modalities, biomarkers, and artificial intelligence–based tools—as well as in medical and surgical management. This article provides an updated overview of current progress in the diagnosis and treatment of endometriosis, emphasizing evidence-based approaches that improve early detection and therapeutic outcomes. Endometriosis is a chronic estrogen-dependent inflammatory disorder in which endometrial-like tissue grows outside the uterus and causes pain, subfertility, and progressive structural damage. The global burden of the disease has encouraged scientists to develop earlier, more accurate diagnostic tools and safer, individualized therapeutic strategies. Recent studies highlight the role of advanced imaging technologies, molecular signatures, and digital-health–based assessment systems that improve recognition of subtle lesions and guide tailored interventions. Likewise, novel medical regimens and refined surgical options have broadened the therapeutic landscape for different patient profiles. This article provides an expanded and updated scientific overview of these developments, focusing on diagnostic innovation, multimodal treatment pathways, and strategies that support long-term symptom relief and reproductive function
YURAK KASALLIKLAR
Get PDFYurak kasalliklari dunyo bo‘ylab eng ko‘p uchraydigan surunkali kasalliklar qatoriga kiradi va inson salomatligiga jiddiy tahdid soladi. Ushbu maqolada yurak kasalliklarining asosiy turlari, ularning sabab va xavf omillari, shuningdek kasalliklarni oldini olish va davolash usullari batafsil tahlil qilinadi. Kasalliklar ichida ishemik kasallik, yurak yetishmovchiligi, aritmiyalar va gipertenziya eng ko‘p uchraydiganlari sifatida ko‘rib chiqiladi. Shu bilan birga, sog‘lom turmush tarzini shakllantirish, to‘g‘ri ovqatlanish, jismoniy faollik, stressni kamaytirish va zamonaviy tibbiy yondashuvlar yurak kasalliklarini kamaytirishdagi samarali usullar sifatida taqdim etiladi. Maqola yurak salomatligini saqlash va yurak kasalliklariga qarshi kurashishning amaliy tavsiyalarini bir joyda jamlash orqali mutaxassislar va keng o‘quvchi auditoriyasi uchun foydali manba bo‘lib xizmat qiladi
СУРУНКАЛИ ЮРАК ЕТИШМОВЧИЛИГИДА ЭНДОТЕЛИАЛ ГЛИКОКАЛИКС ДИСФУНКЦИЯСИНИ ТАШХИСЛАШДА АЛЬФА-ЎСМА НЕКРОЗ ОМИЛИ, СИНДЕКАН-1 ВА ГЕПАРАН СУЛЬФАТЛАРНИНГ АҲАМИЯТИ
Get PDFСурункали юрак етишмовчилиги (СЮЕ) – юқори ногиронлик ҳамда ўлим даражасига эга мураккаб клиник синдром ҳисобланади. Сўнги йилларда олиб борилган илмий изланишлар натижасида ушбу касаллик асосида эндотелиал гликокаликс (ЭГ) дисфункцияси муҳим ахамиятга эга эканлиги асосланган. Синдекан-1, гепаран сульфат ва гиалуронан кислотаси каби ЭГ маркёрларининг қон зардобида юқори даражада бўлиши СЮЕ билан оғриган беморларда ҳаёт сифати кўрсатгичлари йомонлашуви билан узвий боғлиқлиги аниқланган
EFFECTS OF CALCIUM AND VITAMIN D SUPPLEMENTATION ON BONE MORPHOLOGY AFTER OVARIECTOMY
Get PDFOvariectomy-induced estrogen deficiency leads to accelerated bone turnover, reduced bone mineral density, and significant microstructural deterioration characteristic of postmenopausal osteoporosis. This article examines the protective effects of calcium and vitamin D supplementation on bone morphology following ovariectomy, emphasizing their roles in calcium homeostasis, bone remodeling, and mineralization. The findings demonstrate that adequate supplementation improves bone mineral density, strengthens trabecular architecture, and reduces bone resorption by enhancing calcium absorption and supporting osteoblast function. Vitamin D additionally regulates gene expression, immune pathways, and osteocalcin synthesis, contributing to improved bone quality and mechanical resistance. Combined nutrient supplementation shows a synergistic effect, supporting both structural and functional restoration of bone in estrogen-deficient states. These results highlight the importance of a combined nutritional, hormonal, and lifestyle-based strategy to mitigate bone loss and reduce osteoporosis risk in postmenopausal conditions
БОЛАЛАРДА ОШҚОЗОН-ИЧАК ТРАКТИНИ ФУНКЦИОНАЛ БУЗИЛИШИ, ТАШҲИСИ ВА ДАВОСИ
Get PDFБолаларда ошқозон-рчак трактининг функционал бузилиши кенг тарқалган муоммолардан бири ҳисобланади. Олимларнинг фикрича ошқозон-ичак трактининг функционал бузилиши (ФБ) болалар ҳаётининг биринчи ойларида 50--70% учрайди. Бола улғайган сари фунционал бузилишлар, уларни турлари кўп учрайди.Бир ёшгача бўлган болаларда қайд қилиш кузатилади, 3- 8 яшар болаларда циклик қксиш, 8 ёшдан катта болаларда абдоминал оғриқ ва диспепсия кузатилади.Бу ҳолатга олиб келишини сабаби болалар ошқозон-ичак трактини анатомо-физиологик хусусиятлари , кичик болаларда овқатлантириш режимини ва техникасини бузилиши ва катта ёшдаги болаларда бола ейдиган овқат характерини ўзгариши, жисмоний ва психоэмоционал зўриқишларни кучайиши таъсир қилади ва марказий нерв тизими патологияси билан бирга келишини аҳамияти катта. Кичик ёшдаги болаларни хусусиятларидан бири оғриқни жойлашган жойини аниқ кўрсата билмаслик, шикоятларини носпецификлигиди
HAZM TIZIMIDA SUYUQLIKLAR HARAKATINING FIZIK QONUNIYATLARI
Get PDFUshbu maqolada hazm tizimida suyuqliklar harakatining fiziologik va fizik asoslari tahlil qilinadi. Me’da shirasi, o‘t va ichak fermentlarining oqimi laminar, turbulent va yarim turbulent oqimlar orqali nazorat qilinadi. Suyuqliklarning viskozligi, bosim farqi va peristaltik to‘lqinlar hazm jarayonining samarali kechishini ta’minlaydi. Shu bilan birga, oqim buzilishi turli patologiyalarga olib kelishi mumkin
STUDY OF SPATIAL MEMORY IN RATS AFTER EXPERIMENTAL TRAUMATIC BRAIN INJURY
Get PDFThe article describes the role of the hippocampus in spatial orientation, data fixation, and the memorization of specific spatial locations. It outlines the significance, purpose, and conditions of the behavioral training test “Morris Water Maze” (MWM), used to assess spatial memory in rats after experimentally induced traumatic brain injury. The parameters for evaluating the Morris Water Maze test are presented
TIZIMLI SKLEROZNING PATOGENEZIDA VASKULOPATIYA VA AUTOIMMUNITETNING AHAMIYATI
Get PDFTizimli skleroz (TSSc) - bemorlarning hayot sifatini pasaytiradigan autoimmun kasallik. TSSc vaskulopatiya, yallig'lanish va fibroz orqali bir nechta organlarga ta'sir qilishini bilsakda, uning aniq patofiziologiyasi noma'lumligicha qolmoqda. Mikrovaskulyar shikastlanish va vaskulopatiya kasallikning dastlabki patologik xususiyatlari hisoblanadi. Klinik jihatdan, TSScdagi vaskulopatiya Reyno fenomeni (sovuq yoki hissiy stressga reaksiyada qaytariladigan vazospazm) va ishemik shikastlanish tufayli barmoq yaralari sifatida namoyon bo'ladi. Bosentan va eruvchan guanilat siklaza (sGC) modulyatorlari kabi vaskulopatiya uchun dorilar nafaqat vaskulopatiyani, balki dermal fibrozni ham yaxshilaydi, bu esa vaskulopatiya TSScda muhim ahamiyatga ega ekanligini ko'rsatadi. Vaskulopatiya TSSc patogenezining muhim dastlabki bosqichi bo'lsa-da, vaskulopatiyaning yallig'lanish va fibroz bilan qanday bog'liqligi hali ham noma'lum. Ushbu maqolada biz peritsitlarni o'z ichiga olgan patogenezning asosiy hujayrali o'yinchilari bo'lgan vaskulopatiyaning klinik dalillariga e'tibor qaratdik
КЛИНИЧЕСКО-МИКРОБИОЛОГИЧЕСКАЯ ХАРАКТЕРИСТИКА, ОСЛОЖНЕНИЕ И ЛЕЧЕНИЕ ХРОНИЧЕСКОГО ГНОЙНОГО СРЕДНЕГО ОТИТА У ЧАСТО БОЛЕЮЩИХ ДЕТЕЙ
Get PDFХронический гнойный средний отит (ХГСО) у часто болеющих детей представляет собой одно из наиболее распространенных заболеваний у детей, сопровождающееся длительным воспалением среднего уха и гнойными выделениями. Это заболевание может привести к серьезным осложнениям, включая потерю слуха, мастоидит и внутричерепные инфекции. В статье рассматриваются микробиологические аспекты заболевания, включая выявление основных патогенов, таких как Streptococcus pneumoniae, Haemophilus influenzae и Moraxella catarrhalis, с акцентом на проблему антибиотикорезистентности. Подробно анализируются клинические проявления заболевания, такие как нарушение слуха, а также влияние аллергических заболеваний и респираторных инфекций на его развитие. Особое внимание уделяется необходимости комплексного подхода к лечению, включая как медикаментозное, так и психологическое вмешательство. Исследование подчеркивает важность ранней диагностики, сезонных профилактических мероприятий и улучшения условий жизни детей для предотвращения рецидивов заболевания
INFLUENCE OF ENVIRONMENTAL CHARACTERISTICS ON THE DISTRIBUTION OF CILIATES FROM SELECTED AREA OF KALAR KAHAR LAKE, PUNJAB, PAKISTAN
Get PDFCiliates are very important organisms in aquatic ecosystems. They produce a link between organisms of lower taxa and higher taxa. Growth of ciliates depends upon temperature and pH of aquatic body. Maintenance of natural environmental conditions is very important to grow ciliates in lab. Natural conditions were checked using water samples collected from Rivers Jhelum. The results pointed out the suitable natural conditions for the survival of ciliates. For identification of optimum temperature and pH, this study used three culture media including hay infusion, alfalfa and Gamborg B5 medium. Identification of Paramecium species was done by using morphology based microscopy and staining. Three temperature ranges 10-20℃, 20-30℃ and 30-40℃ were studied with three pH conditions (acidic, neutral, basic). Results for growth in hay infusion and Gamborg medium was positive. Temperature range of 10-20℃ with neutral pH showed maximum growth