JOURNAL OF HEALTHCARE AND LIFE-SCIENCE RESEARCH
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OG'IZ BO'ZIQ SHILLIQ QAVAT KASALLIKLARINING TARQALISH TENDENSIYASI, ULARNI TASHXISLASH, RAK VA RAK OLDI KASALLIKLARINI OLDINI OLISH
Get PDFUshbu tadqiqot zamonaviy stomatologiyaning dolzarb muammolari orasida og'iz bo'shlig'i shilliq qavati (OBSHQ) kasalliklarini tashxislash, davolash va oldini olish muhim o'rinlardan birini egallaydi. Og'iz bo'shlig'i shilliq qavati organizmning eng muhim tizimlaridan biri bo'lib, patogen biologik, fizik va kimyoviy omillar ta'siriga qarshi to'siq (baryer) vazifasini bajarad
ВНУТРИБОЛЬНИЧНЫЕ ИНФЕКЦИИ В СТОМАТОЛОГИЧЕСКИХ УЧРЕЖДЕНИЯХ ПРОБЛЕМЫ И ПУТИ ИХ РЕШЕНИЯ
Get PDFВнутрибольничная инфекция(ВБИ) – это любое инфекционное заболевание, которое поражает пациента после его поступления в больницу или обращения за медицинской помощью. Также это касается и сотрудников медучреждений.
Рассмотрены основные принципы, средства и меры профилактики возможного инфицирования пациента на стоматологическом прием
MODERN ASPECTS OF DIAGNOSTICS OF RHEUMATOID ARTHRITIS AT THE EARLY STAGES OF ITS FORMATION
Get PDFRheumatoid arthritis (RA) is a complex chronic disease that develops on the basis of immunological mechanisms. In the past, it was diagnosed only at clinical stages, but today, the possibilities for early diagnosis are significantly expanding. Early detection of RA at its initial, formative stage can greatly reduce the consequences of the disease. This article discusses the early immuno-biochemical changes occurring in the pathogenesis of RA, molecular markers, genetic factors, and the modern technologies used for their identification
COMPARATIVE AMONG THE EFFECTS OF THIAMINE, AN ERTUGLIFLOZIN, AND LIRAGLUTIDE ON PATHOLOGICAL AND BIOCHEMICAL MARKERS IN RATS WITH LIVER CIRRHOSIS AND SPLENOMEGALY
No full textThe purpose of this project was to study determining the efficacy of thiamine, ertugliflozin and liraglutide alone and in combination for treating the induced splenomegaly and liver cirrhosis. The first experiment was induction liver cirrhosis (122) total male rats and tanked was induction of (111) male rats with thioacetamide at a dose of (200) mg/kg IP for (2) months. After end the period of induction, the (10) rats were Scarified (5) positive control (5) negative control. The T1 (6) rats were a negative group. The T2 (6) rats were a positive group. The T3 group (6) were treated with thiamine of (2.797) mg/kg. The T4 (6) were treated with ertugliflozin of (1.395) mg/kg, the T5 (6) were treated with a liraglutide of (0.128) mg/kg, theT6 (6) were treated with a combination of thiamine, ertugliflozin and liraglutide of (1.385, 0.692 and 0.064) mg/kg respectively for each drug. The results showed in positive control group a significant decrease in, albumin concentration, catalase activity, red blood cells and haemoglobin, but a significant increase in Prothrombin time, copipten concentration and WBCs, comparison with all treated groups
К АНАЛИЗУ ИЗУЧЕНИЯ МИКРОБИОТОВ В АСПЕТЕ МИКРОБИОЛОГИИ
No full textВ статье представлен литературный анализ изучения микробиотов в аспекте микробиологии, который вызывают повышенныӗ интерес к нему многих специалистов
MULTIDISCIPLINARY APPROACHES IN THE MANAGEMENT OF CHRONIC RHINOSINUSITIS WITH NASAL POLYPS: CLINICAL OUTCOMES AND TREATMENT OPTIMIZATION
No full textChronic rhinosinusitis with nasal polyps (CRSwNP) is a complex, persistent inflammatory disorder of the sinonasal mucosa characterized by polyp formation, nasal obstruction, and impaired quality of life. Despite advances in medical and surgical therapies, the disease remains challenging due to its heterogeneous pathophysiology and high recurrence rates. This study aimed to analyze the clinical outcomes of a multidisciplinary treatment approach incorporating pharmacotherapy, endoscopic sinus surgery, and biologic agents in patients with CRSwNP. Using a prospective cohort design, 150 patients treated at the Department of Otorhinolaryngology No. 2, Samarkand State Medical University, were followed over 24 months. Outcome measures included symptom scores, endoscopic evaluation, imaging findings, and recurrence rates. The integrated treatment protocol significantly improved symptom control, reduced polyp size, and minimized the need for revision surgery. The findings underscore the importance of personalized, multidisciplinary strategies in optimizing care for CRSwNP patients and provide a foundation for future research on targeted therapies. The article addresses the pressing issue of chronic suppurative otitis media (CSOM), a common and challenging otolaryngological disorder characterized by persistent inflammation and discharge from the middle ear. Despite advances in medical and surgical treatments, CSOM remains a significant cause of hearing loss and morbidity worldwide, particularly in developing countries. This study aims to evaluate the clinical presentation, diagnostic approaches, and treatment outcomes of patients with CSOM managed at the Department of Otorhinolaryngology No. 2, Samarkand State Medical University. The research involves a comprehensive analysis of 150 patients diagnosed with CSOM, utilizing both conservative medical management and surgical interventions including tympanoplasty and mastoidectomy. The study employs a combination of audiometric testing, otoscopic examination, microbiological cultures, and imaging techniques to assess disease severity and guide treatment decisions. Results reveal that early diagnosis and tailored treatment strategies significantly improve hearing outcomes and reduce complications. The article further discusses the challenges faced in managing CSOM, including antibiotic resistance, recurrence, and patient compliance. Emphasis is placed on the importance of multidisciplinary approaches involving otolaryngologists, audiologists, and microbiologists. This work contributes valuable data to the understanding of CSOM in the Central Asian population and offers recommendations for optimizing therapeutic protocols to enhance patient quality of life and reduce the burden of this chronic disease
THE CLINICAL AND AUDIOLOGICAL EVALUATION OF PATIENTS WITH SEROUS OTITIS MEDIA: DIAGNOSTIC APPROACH AND TREATMENT OUTCOMES
Get PDFSerous otitis media (SOM), also known as otitis media with effusion, is a non-purulent inflammation of the middle ear characterized by the presence of fluid in the middle ear cavity without signs of acute infection. It is a frequent cause of hearing impairment in children but also affects adults.
Objective: To evaluate the clinical presentation, audiological findings, and effectiveness of various treatment approaches in patients diagnosed with SOM.
Methods: A prospective observational study of 47 patients (aged 3–45 years) diagnosed with SOM at the ENT department of Samarkand State Medical University over a 6-month period. Diagnostic tools included otoscopy, tympanometry, and pure-tone audiometry. Treatment included medical therapy and, when necessary, surgical intervention (myringotomy with or without grommet insertion).
Results: Tympanometry proved critical for diagnosis. Medical management was effective in 68% of cases, while 32% required surgical intervention. All patients reported hearing improvement post-treatment.
Conclusion: SOM is effectively diagnosed through audiological tests and otoscopy. Early identification and appropriate management significantly improve hearing outcomes and prevent complications such as speech delays and chronic middle ear disease
ЭНЗИМОТЕРАПИЯ ДЛЯ ПРОФИЛАКТИКИ ОСЛОЖНЕНИЙ ДЕСТРУКТИВНОГО АППЕНДИЦИТА
No full textDestruktiv appendifit — bu appendifitning o‘rta shakli bo‘lib, peritonit va septikgi kabi jiddiy qiyinchiliklarga olib kelishi mumkin. Standart davolanish appendifektomiya va antibiotiklar bilan amalga oshiriladi, ammo operatsiyadan keyin yuzaga keluvchi qiyinchiliklarni oldini olish uchun, ayniqsa adgezionlarni oldini olish uchun, enzimoterapiya kabi qo‘shimcha davolanishlarga qiziqish bor. Adabiyot ko‘rinishida appendifit davolanishida enzimoterapiya qo‘llanishi bo‘yicha cheklangan to‘g‘ridan-to‘g‘ri dalillar topildi, ammo hayvonlarda amalga oshirilgan tadqiqotlar uni adgezionlarni kamaytirishini ko‘rsatadi. Insonlarda destruktiv appendifitda uni qo‘llanishi bo‘yicha maxsus tadqiqotlar mavjud emas. Shuning uchun, hozirgi vaqtda enzimoterapiya standart davolanish sifatida tavsiya etilmaydi, lekin unda yanada tadqiqotlar amalga oshirilishi mumkin
КОЛОРЕКТАЛЬНЫЙ РАК И ЕГО МЕХАНИЗМЫ РАЗВИТИЯ
No full textВ нашей работе отражены механизмы развития колоректального рака на основе литературных данных
ASSESSMENT OF COGNITIVE IMPAIRMENT IN PATIENTS WITH CHRONIC CEREBROVASCULAR DISEASE: CLINICAL AND NEUROPSYCHOLOGICAL EVALUATION
Get PDFChronic cerebrovascular disease (CVD) often leads to progressive cognitive impairment affecting memory, attention, executive functions, and daily living activities. Chronic cerebrovascular disease (CVD) represents a significant public health challenge worldwide, often leading to progressive and debilitating cognitive impairment. This impairment manifests primarily in executive functions, memory, attention, and information processing speed, severely affecting patients’ independence and quality of life. Despite its prevalence, cognitive dysfunction in chronic CVD patients is frequently underrecognized and undertreated in clinical settings. This study undertook a comprehensive clinical and neuropsychological evaluation of 75 patients diagnosed with chronic cerebrovascular disease to characterize the patterns and severity of cognitive impairment. Utilizing standardized tools such as the Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Trail Making Test, Stroop Test, and Wechsler Memory Scale, the research aimed to detect subtle and overt cognitive deficits and correlate these findings with clinical variables including disease duration, vascular risk factors, and neuroimaging data. The results indicated a high incidence of mild to moderate cognitive impairment, with executive dysfunction and memory deficits being the most prominent features. These findings highlight the critical need for incorporating routine cognitive screening into the management of chronic CVD patients to enable early detection and timely intervention. The study advocates for multidisciplinary treatment approaches including cognitive rehabilitation, vascular risk factor control, and patient education to improve cognitive outcomes and enhance the overall quality of life for affected individuals.
This study aims to evaluate the cognitive profile of patients with chronic CVD using clinical and neuropsychological methods. Early detection of cognitive deficits is critical for timely intervention and improving patient quality of life. The study involved 75 patients diagnosed with chronic CVD and employed comprehensive neuropsychological testing alongside clinical assessments. Results indicated a high prevalence of mild to moderate cognitive impairment, predominantly in executive functioning and memory domains. Findings underscore the need for routine cognitive screening in chronic CVD management and development of tailored rehabilitation programs