JOURNAL OF HEALTHCARE AND LIFE-SCIENCE RESEARCH
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ОПРЕДЕЛЕНИЕ КЛИНИКО-ЭПИДЕМИОЛОГИЧЕСКОЙ ХАРАКТЕРИСТИКИ ЭНДЕМИЧЕСКОГО ЗОБА И АУТОИММУННОГО ТИРЕОИДИТА У ВОЕННОСЛУЖАЩИХ
Get PDFАутоиммунный тиреоидит прогрессирует медленно. Может пройти несколько месяцев или лет прежде, чем диагностируют это состояние. Симптомы обусловлены гипотиреозом. На начальной стадии гипотиреоз сопровождается малозаметными признаками, которые могут развиться до ярких клиническим проявлений
THE IMPACT OF BROCCOLI ON CANCER PREVENTION
Get PDFThis article explores the health benefits of broccoli (Brassica oleracea var. italica), focusing on its bioactive compounds and their potential effects in cancer prevention. The mechanisms by which broccoli protects cells, its anti-inflammatory properties, and its role in reducing cancer risk are discussed based on recent scientific studies
Dental Examinations of Odontogenic Inflammatory Diseases in Children Who do Not Have a Premorbid Background
Get PDFThe results of numerous epidemiological studies show that an average of 3-5 acute respiratory viral infections (O'RVI) have been found in each child per year. The prevalence of O'RVIE has been observed in preschool children and primary school children. Children in the first 3 years of life are infected with infectious diseases 10 times faster than children aged 4-4.5 years and older in one year. Severe respiratory infections have led to a violation of the functional state of the body, there is a violation of adaptation and the development of chronic pathology. Asoral infections in children are often caused by viruses, Chlamydia spp and Mycoplasma spp, Haemophilus influenzae, Streptococcus pneumoniae, Streptococcus pyogenes, Staphylococcus aureus, Moraxella spp. Low immune system activity, metabolic disorders, decreased pain sensitivity alter the course of the clinical picture and many surgical diseases, which can lead to serious diagnostic errors and negatively affect the results of surgical pathology
СОВЕРШЕНСТВОВАНИЕ МЕТОДОВ НЕМЕДИКАМЕНТОЗНОЙ ПРОФИЛАКТИКИ ГИПЕРГЛИКЕМИИ ПРИ МЕТАБОЛИЧЕСКОМ СИНДРОМЕ
Get PDFНарушенная толерантность к глюкозе (НТГ) и нарушенная гликемия (НГН) натощак представляют собой ранние нарушения углеводного обмена, распространенность которых в Узбекистане и во всем мире ежегодно растет. Данные состояния в последующем влекут развитие сахарного диабета 2 типа (СД2). Понимание критериев диагностики предиабета, механизмов его развития, выявление групп риска, знание о возможной патогенетической терапии позволят своевременно выявлять, применять на практике рекомендации по изменению образа жизни (немедикаментозную), медикаментозную терапию, предупреждать или же отодвигать дебют СД2 и сердечно-сосудистые заболевания.
Предиабет сегодня представляет особый интерес в отношении диагностики и механизмов формирования. Часто в основе развития ранних нарушений углеводного обмена лежат избыточная масса тела и ожирение. Следствием предиабета являются ранние сердечно-сосудистые осложнения, атеросклеротическое поражение сосудистого русла и такие тяжелые осложнения, как острая коронарная патология, сердечная недостаточность. Необходимо обращать внимание не только на показатели гликемического контроля в качестве скрининга предиабета, но и на индекс массы тела (ИМТ), особую актуальность приобретают значения окружности талии (ОТ), окружности бедер (ОБ) и их соотношение
РОЛЬ СОСУДИСТОЙ ФЕНОТИПИЗАЦИИ СЛИЗИСТОЙ ОБОЛОЧКИ НОСА (СИНУСОИДАЛЬНЫЕ ИЗМЕНЕНИЯ СОСУДА) В ПАТОГЕНЕЗЕ ХРОНИЧЕСКОГО РИНОСИНУСИТА
Get PDFЦель:
Оценить роль сосудистой фенотипизации слизистой оболочки носа, особенно синусоидальных изменений сосудов, в патогенезе хронического риносинусита (ХРС).
Материалы и методы:
Обследованы 48 пациентов с ХРС и 15 здоровых добровольцев. Использованы видеомикроскопия и КТ-ангиография для изучения сосудистых параметров слизистой оболочки носа.
Результаты:
У больных ХРС выявлены выраженные сосудистые изменения: повышенная плотность, извилистость капилляров и формирование синусоидальных сосудов. У пациентов с полипозной формой изменения были более выражены.
Заключение:
Сосудистая фенотипизация слизистой оболочки, включая синусоидальные трансформации, является важным патогенетическим звеном ХРС. Инструментальная визуализация сосудов может использоваться для диагностики и оценки тяжести заболевания
EVALUATE THE ROLE OF INCREASING THE GENE EXPRESSION OF THE EPHA1 GENE IN PATIENTS WITH OSTEOPOROSIS AS A RISK FACTOR FOR INFECTION WITH TOXOPLASMA GONDII
Get PDFThis study aims to analyze the gene expression of EphA1 receptor in postmenopausal women with osteoporosis and Toxoplasma gondii parasite, in which the patients were divided into 4 groups: Osteoporosis 44 samples, Toxoplasma gondii 11 samples, Osteoporosis and Toxoplasma gondii 17 samples, and the fourth group was the control group 18 samples. A significant increase was observed in women with osteoporosis and women with osteoporosis and Toxoplasma gondii parasite with no significant difference in women with Toxoplasma gondii parasite only at the 0.05 probability level
HISTOPATHOLOGICAL CORRELATION OF RENAL MASSES WITH MULTI-PARAMETRIC MAGNETIC RESONANCE IMAGING (MPMRI)
Get PDFBackground: Renal cell carcinomas can be histologically classified into clear cell, papillary, chromophobe, collecting duct carcinoma, medullary carcinoma, and unclassified. The mpMRI based on numerous anatomic and functional factors plays a significant role in the identification and characterization of renal masses and provides diagnostic value.
Purpose: the aim of this study was to histopathological correlation of different mass lesions of kidney with multi-parametric magnetic resonance imaging (mpMRI).
Patients and Methods: Total of 41 patients had previously identified with renal masses, MR imaging was performed using a 1.5T MR system (ACHIEVA, Philips medical system/ Netherland) using phased array body coil. The patient was examined in supine position and the total examination time about 10-12 min. Patients undergo operation, Histopathological result was used to make the final diagnosis. For each patient, the findings obtained using mpMRI, were correlated with the outcomes of histological findings and follow-up results.
Results: The highest proportion of solid renal masses was clear cell RCC which represent (58.5%), followed by papillary type renal cell carcinoma represent (12%), followed by chromophobe type renal cell carcinoma represent (7.3%), the most common type of benign pathology was Angiomyolipoma (AML) which represent (17%), followed by oncocytoma represent (4.8%). Sensitivity= 90%, specificity= 96% and accuracy of mpMRI was 97% respectively. the enhancement pattern for solid renal masses in which clear cell RCC (n=24), 23 (95.9%) shows washout type dynamic curve and only one (4.1%) shows plateau type dynamic curve, papillary RCC (n=5) all of them (100%) shows progressive type dynamic curve, chromophobe RCC(n=3), two (66.6%) shows plateau type dynamic curve.
Conclusion: the sensitivity, specificity, and accuracy of mpMRI play vital role in differentiation between benign and malignant renal masses, in which malignant solid renal masses show diffusion restriction in histopathological sections, while benign masses show no restriction, DCE MRI play no significant role in differentiation between solid renal masses
KNOWLEDGE, ATTITUDES, AND PRACTICES ON ITN USE AMONG PREGNANT WOMEN IN IBADAN NORTH-EAST LOCAL GOVERNMENT AREA, OYO STATE, NIGERIA
Get PDFIntroduction: Malaria in pregnancy remains a major public health challenge in sub-Saharan Africa, contributing significantly to maternal and neonatal morbidity and mortality. Insecticide-Treated Nets (ITNs) are a cost-effective and widely promoted preventive measure, yet their optimal use is often limited by poor knowledge, negative attitudes, and inconsistent practices among pregnant women.
Objective: This study assessed the knowledge, attitude, practice, and factors influencing the utilization of ITNs among pregnant women attending selected Primary Health Care centers in Ibadan North-East Local Government Area, Oyo State, Nigeria.
Method of Analysis: A descriptive cross-sectional survey was conducted among 200 pregnant women selected through a multistage sampling technique. Data were collected using a structured interviewer-administered questionnaire and analyzed using descriptive statistics such as mean, standard deviation, frequency, and percentage. Results were presented in tables, and respondents’ knowledge, attitude, and practice levels were categorized into good/poor and positive/negative.
Results: The mean age of respondents was 27.8 ± 5.6 years, with most being married (88%), Christians (65%), and traders (40%). Overall, 74% demonstrated good knowledge of ITNs, while 26% had poor knowledge. Regarding attitude, 62% exhibited positive attitudes toward ITN use, whereas 38% held negative perceptions such as inconvenience and fear of side effects. In terms of practice, only 55% reported consistent use of ITNs, and 48% had re-treated their nets appropriately. Major factors influencing ITN use included awareness from health campaigns (64%) and family influence (59%), while barriers included discomfort (sweating, heat) and misconceptions about safety.
Conclusion: Although knowledge and attitudes toward ITNs among pregnant women in the study area were relatively high, gaps remain in consistent utilization and adherence to proper practices. Strengthening health education, dispelling misconceptions, and improving accessibility and comfort of ITNs could enhance uptake and ultimately reduce malaria burden in pregnancy
CLIMATE-SMART AGRICULTURE IN CENTRAL ASIA: ECONOMIC AND ENVIRONMENTAL DIMENSIONS
Get PDFCentral Asia, characterized by its arid climate and fragile ecosystems, faces increasing agricultural vulnerability due to climate change. As the region’s economies depend heavily on farming and natural resources, the transition toward climate-smart agriculture (CSA) has become essential. This article explores the key principles, progress, and challenges of CSA in Central Asia, emphasizing the economic and environmental dimensions of sustainable farming. Drawing upon regional studies from Uzbekistan, Kazakhstan, Tajikistan, and Kyrgyzstan, it examines how adaptation, mitigation, and productivity can be jointly achieved through innovative practices, policy reforms, and investment mechanisms. Findings suggest that integrating technology, financial incentives, and knowledge-sharing systems can significantly enhance productivity, reduce greenhouse gas emissions, and promote long-term food security across the region
STOMATOLOGIK KASALLIKLAR VA OG‘IZ BO‘SHLIG‘I YALLIG‘LANISH HOLATLARIDA “STOMA-DENTA” ERITMASINING O‘RNI
Get PDFMaqolada og‘iz bo‘shlig‘i yallig‘lanish kasalliklarini davolashda tabiiy komponentlardan tashkil topgan “Stoma-Denta” antiseptik eritmasining farmakologik xususiyatlari, biologik faolligi va stomatologik amaliyotdagi o‘rni tahlil qilingan. Preparat tarkibidagi alunit, romashka (Matricaria chamomilla), shalfey (Salvia officinalis) ekstraktlari va oblepixa (Hippophae rhamnoides) moyi o‘zaro sinergik ta’sir ko‘rsatib, mikroorganizmlarga qarshi, yallig‘lanishga qarshi, antioksidant va regeneratsiyani tezlashtiruvchi samaraga ega.
Tadqiqot natijalari va adabiyot manbalari tahlili shuni ko‘rsatadiki, preparatning har bir komponenti og‘iz bo‘shlig‘i shilliq qavatining fiziologik tiklanishini qo‘llab-quvvatlaydi, parodont to‘qimalarining metabolik faolligini oshiradi hamda antiseptik himoyani kuchaytiradi. Shu jihatdan “Stoma-Denta” stomatit, gingivit, parodontit, travmatik shikastlanishlar va operatsiyadan keyingi og‘iz gigienasini ta’minlashda kompleks qo‘llanish uchun mosdir