European Journal of Medical and Health Research
Not a member yet
578 research outputs found
Sort by
Quercetin: Exploring Its Unique Flavonol Properties, Bioavailability, Safety Profile, and Therapeutic Potential in High-Impact Medical Conditions
Get PDFQuercetin, an abundant flavonoid in various foods and plants, exhibits diverse therapeutic potential due to its antioxidant, anti-inflammatory, and anticancer properties. This review explores its biological and pharmacological activities, mechanisms of action, formulations, absorption, bioavailability, adverse effects, and potential therapeutic applications.Initially isolated in the 1800s as a dye and in 1936 as a polyphenol, quercetin has garnered attention for its antioxidant capabilities, particularly in preventing oxidative damage from low-density lipoprotein (LDL) cholesterol, reducing the risk of cardiovascular disease (CVD). Studies also suggest its efficacy in lowering blood glucose levels, improving insulin sensitivity, and inhibiting viral infections, including COVID-19.Despite its promising benefits, quercetin’s bioavailability is limited by factors such as poor water solubility and rapid metabolism. Researchers have explored various formulations and delivery systems, including quercetin glycosides, nano-formulations, and phytosomes, to enhance quercetin’s absorption and effectiveness.While generally considered safe, high doses of quercetin supplements may lead to gastrointestinal disturbances, headache, and tingling sensation. Furthermore, its interaction with other medications warrants further investigation.Quercetin has therapeutic advantages in CVDs, metabolic syndrome, neurodegenerative disorders, respiratory conditions, skeletal conditions, bacterial and fungal infections, cancer, diabetes, iron-induced toxicity, oxidative stress, and viral infections. However, research in humans is limited, and optimal dosage and formulations remain to be established.Quercetin’s diverse pharmacological activities make it a promising therapeutic agent for various conditions, disorders, and diseases. Future research should focus on standardizing formulations, investigating long-term safety, elucidating mechanisms of action, and clarifying interactions with other medications to optimize quercetin’s therapeutic use
Covid-19 Outcome Prediction Model by Using Radio-Diagnostic Methods
Get PDFResearch goal: The goal of this research is to create a prediction model for a possible outcome (death or survival) of COVID-19, which model incorporates the easily available radio diagnostic methods such as classical radiology and the disease scoring system. Part of the goal of this study is to define the chances and probabilities of occurrence of death as a result of the primary disease and to identify the risk factors that have the highest influence on the final outcome of COVID-19. Methodology: The methodological approach used in this study is the binary logistic regression which is part of the group of generalized linear statistical methods. Results: Results show that patients with complications and comorbidities have the highest chances of death from COVID-19 (OR 16,53 with CI 8,21 - 33,25 and 4,08 with CI 1,34 - 12,38). Men are also exposed to higher but insignificant mortality risk with OR 1,55 with CI 0,86 - 2,80. Every additional year of age increases the mortality risks by 1,06 times (CI 1,03 - 1,09), while every additional score of the primary disease leads to increased chances of unwanted outcome by 1,24 (CI 1,04 - 1,47). Conclusion: The mortality outcome of COVID-19 is not an exclusive consequence of the primary disease but it is usually determined in correlation with different comorbidities and existing complications as well as other standard influencing factors such as age and gender. Contribution and significance of the research: The primary importance of this research is the fact that it allows for an improved precision and upgrade to the basic model of standard factors by using new predictors, specifically secondary complications from the radio-graphic picture and scoring of the primary disease, which leads to higher utilization of cheap and easily available radio-diagnostic methods
Efficacy of Using Alpha-Lipoic Acid Supplement in Patients with Diabetic Neuropathy: A Meta-Analysis and Systematic Review
Get PDFBackground: In the 21st century, diabetes mellitus and its complications have become the most common health-care problem. The most common complication is diabetic neuropathy. Many drugs were tried to alleviate the neurological symptoms, whereas Alpha-lipoic acid has proven its effectiveness.Aim: we aim in our study to assess the efficacy of Alpha-lipoic acid versus other lines in diabetic patients complicated with neuropathy.Methods: We searched online databases such as (PubMed, Scopus, WOS, and Cochrane Library) for related randomized clinical trials (RCTs). Retrieved articles were screened, and relevant studies were included in a meta-analysis. Continuous data were pooled as mean difference (MD) with 95% confidence interval (CI), and dichotomous data were pooled as relative risk (RR) and 95% CI. Analysis was conducted using RevMan software (Version 5.4). Our primary outcome was the alleviation of neurological symptoms, while the 2ry outcome was the occurrence of adverse events.Results: four RCTs (358 cases) were included. ALA treatment produced favorable results for TSS (a dose-related trend was observed), NDS. ALA treatment resulted in a dose-dependent response relative to the placebo for TSS and the global satisfaction score. The use of ALA to prevent neurological symptoms should be further researched.Conclusion: Alpha-lipoic acid has a satisfactory effect on neurological symptoms, there was a marked decrease in sensory symptoms
Serum Afamin in Prediabetic Individuals in Association with Insulin Resistance and Glycemic Indices: A Case-Control Study
Get PDFBackground: Prediabetes is a metabolic disorder characterized by higher serum glucose levels than normal and below the diagnostic threshold for diabetes mellitus. Afamin is a glycoprotein mainly excreted from the liver and facilitates vitamin E transport. Afamin is one of the albumin gene family that includes albumin, α-Fetoprotein, and vitamin D-binding protein. Aim: This study aimed to evaluate serum afamin levels in prediabetic individuals and ascertain the association of serum afamin with insulin resistance and glycemic indices. Material and Methods: A case-control study was performed at Azadi Teaching Hospital, Kurdistan Region, Iraq, consisted of 88 participants, 44 prediabetic individuals and 44 apparently healthy individuals as a control group. Prediabetic individuals were obtained from relatives of patients with diabetes mellitus visiting Azadi Teaching Hospital, whereas, healthy individuals were chosen from the medical staff and college employees. The diagnosis of prediabetes was made according to the American Diabetes Association criteria. Serum afamin were assessed by Enzyme-Linked Immunosorbent Assay, while other biochemical parameters such as HbA1c, glucose and insulin were analyzed by Cobas 6000 (Roche, Hitachi/ Germany). Results: Mean level of serum afamin was higher in prediabetic individuals (115.31±62.74) compared to their level in the control group (91.57±43.46), with a statistically significant difference (p = 0.042). The mean age of prediabetics was (44.05±10.56) with males predominant (63.6%) and 70.5% of them were more than 40 years and 88.6% were obese. Conclusion: The study concluded the presence of higher mean serum afamin levels among prediabetic individuals compared to the healthy control
The Multisystem Impact of Pseudoxanthoma Elasticum (PXE): Systemic Manifestations, Multidisciplinary Management, and Diagnostic and Therapeutic Advances
Get PDFThe review discusses pseudoxanthoma elasticum (PXE) as a multisystem disorder with diverse manifestations across dermatological, ophthalmological, and cardiovascular systems. It covers the primary dermatological signs, such as yellowish papular lesions and altered skin texture, typically in flexural areas. The review also addresses ophthalmological issues, like angioid streaks and progressive vision loss, and cardiovascular effects, including arterial calcification, hypertension, increased risk of aneurysms, and peripheral arterial disease. Also, the review mentions less common symptoms involving the gastrointestinal, pulmonary, and urological systems. It examines how systemic calcification leads to gastrointestinal problems, impacts lung function, and potentially affects the urinary tract. The diagnostic approach is outlined, encompassing patient history, imaging, blood tests, genetic analysis, and skin biopsies, with supplementary diagnostic tools for gastrointestinal, pulmonary, and urological assessments. The review emphasizes the benefits of a multidisciplinary management strategy, noting how various specialties address skin, eye, cardiovascular issues, and other specific complications. It presents emerging technologies like artificial intelligence (AI) and health informatics for improved diagnosis and personalized treatment. The review also covers advances in toxicology, environmental medicine, and gene therapy, focusing on how these fields contribute to targeted and individualized treatment strategy development
Social Causes of Abortion in Tanzania
Get PDFThe article "Social Causes of Abortion in Tanzania" explores the multifaceted social factors contributing to abortion rates in the country. It highlights the interplay of cultural, educational, and systemic challenges that influence the decision to terminate a pregnancy. Juvenile delinquency and truancy, compounded by a lack of comprehensive sex education, create an environment where adolescents are ill-prepared to navigate sexual health. The pressures of academic achievement further complicate this landscape, as many young people feel compelled to prioritize schooling over parenting. Limited access to reproductive health services exacerbates the issue, with many women unable to obtain necessary information or support.Fear of stigma and discrimination plays a crucial role, as societal attitudes towards single motherhood and abortion lead to social exclusion and negative stereotypes, increasing the burdens felt by women. Additionally, peer pressure, along with familial and relationship dynamics, such as pressure from boyfriends or physicians, further complicates personal decision-making. The article also discusses the implications of timing and the physician's role in oversimplifying abortion procedures, contributing to the dilemma faced by women. By examining these intertwined social causes, the article aims to shed light on the broader societal context influencing abortion in Tanzania, ultimately calling for more inclusive policies and support systems that address these pressing issues. Through a deeper understanding of these factors, stakeholders can better advocate for reproductive and comprehensive health education, fostering a more supportive environment for the lives of women and youth
Understanding Polycystic Ovary Syndrome (PCOS) and Mental Health Disparities in Bangladeshi Women: A Mixed Method Approach
Get PDFBackground: PCOS is a common hormonal disorder that affects women's well-being. It is a chronic ailment without a cure, and poses a significant threat to women's health, with many going women untreated.Aims: Many women in Bangladesh lack knowledge about PCOS, leading to delays in diagnosis and treatment. This gap hinders the understanding of coping strategies, treatment options, and lifestyle improvements related to this condition.Methods: In total, 426 participants were included in this mixed methods study, and data were collected via a mixed-methods approach. A standard approach was used for the assessment of among Bangladeshi people’s knowledge about PCOS signs, and symptoms, causes, diagnosis, and treatment options, and impacts on health. The prevalence of diagnostic tests among people and the extent to which women are underdiagnosed were also determined.Results: A positive PCOS status had a significantly negative impact on mental health conditions. The knowledge levels about PCOS among participants were low (63.7%), moderate (21.6%), or high (14.7%). We found significant associations between knowledge level and age, education, occupation, place of residence, screening practices, and PCOS status (p-value <0.05). Notably, 63.4% of women in Bangladesh remain undiagnosed and have a symptomatic appearance.Conclusion: A significant number of women have limited knowledge about PCOS. Moreover, these studies failed to assess PCOS status, even though the prevalence of PCOS is more than thirty percent. Hence, it is important to arrange a health education initiative aimed at educating and encouraging women to actively engage in the diagnostic process to prevent PCOS complications
An Assessment of the Regulatory Framework for African Traditional Medicinal Practice in Nigeria
Get PDFTraditional medicine (TM) by World Health Organization (WHO) is the totality of knowledge, skills, and practices based on theories, beliefs, and experiences indigenous to different cultures, whether explicable or not, used in the maintenance and preservation of health, whether physical or mental. African traditional medicine is the holistic healthcare system specializing on divination, spiritualism, and herbalism. In Nigeria, most indigenes rely on TM to meet their primary healthcare needs. WHO’s strategy for TM is to promote TM integration and complementary and alternative medicine (CAM) into the healthcare systems of countries. Therefore, the aim of this study was to critically assess the regulatory framework for traditional medicinal practice in Nigeria. The research methodology was doctrinal approach, using expository and analytical research design. The main sources of data collection were literatures from physical library and e-library. This research found, among others, that there is need to have a working national framework for the safe practice of TM in Nigeria. Thus, this research recommended, among others, a distinct national framework for the practice of TM in Nigeria which will also establish a functioning regulatory institution in various states, thereby ensuring proper regulation and enlightenment in this milieu
Improving Nursing Leadership and Management Skills in PHC, Riyadh
Get PDFLeadership and management are necessary for all potential registered nurse (RN) leaders. Every nurse has some degree of management and leadership responsibility. The healthcare workforce, effective leadership, and decision-making are priority topics. Other topics include achieving clinical and operational excellence, which includes, but is not limited to, innovation, patient advocacy, quality, diversity, equity, and adapting to changes in hospital and interdepartmental policies and procedures. This is a pre- and post-study for leadership training aiming to equip all potential RN leaders with confidence and knowledge in leading the center for achieving sustainable success of the organization. Through interactive lectures and workshops, the objective of the study is to enhance knowledge regarding staff plan management, to develop administrative and management skills, to enhance knowledge regarding supply management and storage standards, to ensure compliance with infection control protocols, JCI and CBAHI standards, and to improve knowledge on preceptorship & training programs. From the pre-exam of the seven staff who participated in the nursing leadership and management program, the percentage ranges from 34% as the lowest score to 86% as the highest score. An increase in percentage that ranges from 91% to 98%, which is a significant improvement after conducting the team leadership and management skills lecture. Leadership training positively impacts all parameter scores of leadership and management skills related to nursing administration, supply and storage, infection control and safety, training and preceptorship, and National and International standards of JCI and CBAHI
Evaluating Patient Satisfaction with Services at the Pharmacy of the National Hospital of Obstetrics and Gynecology in 2024
Get PDFThe study aims to evaluate and identify factors associated with patient satisfaction with the pharmacy services at the National Hospital of Obstetrics and Gynecology in 2024. A total of 425 interview responses were collected using a questionnaire. Patients reported a high level of satisfaction, with an average satisfaction score of 9.13 (SD = 0.81). Notably, 98.8% of patients rated their satisfaction at 8 or higher. The highest proportion of patients, 39.1%, gave a rating of 9/10. Exploratory factor analysis revealed three extracted factor groups. Multivariate linear regression analysis identified two statistically significant factors influencing satisfaction: the outcomes of services provided at the pharmacy (p = 0.002) and accessibility and transparency of administrative procedures (p < 0.001). These two factors accounted for 25.9% of the variation in satisfaction levels. Patients expressed high satisfaction with the pharmacy services at the National Hospital of Obstetrics and Gynecology. The identified factors influencing satisfaction include the outcomes of services provided at the pharmacy and the accessibility and transparency of administrative procedures