Journal for Research in Applied Sciences and Biotechnology
Not a member yet
709 research outputs found
Sort by
The Path of Divine Surrender: A Spiritual Analysis of Rabindranath Tagore\u27s "Ami Tomar Premer Hobo Sobar Kolonkho Bhagi": A Comprehensive Examination of Devotional Transcendence in Rabindra Sangeet and Hindu Spiritual Practice
Full text linkThis comprehensive study presents an in-depth analysis of Rabindranath Tagore\u27s profound devotional composition "Ami Tomar Premer Hobo Sobar Kolonkho Bhagi" ("I will bear everyone\u27s shame in your love"), exploring its multifaceted spiritual significance within the rich context of Hindu devotional traditions. Through detailed textual examination, musical analysis, and contextual interpretation, this research illuminates how the song articulates a fundamental aspect of authentic spiritual pursuit: the transformative willingness to transcend societal judgment and embrace divine love regardless of worldly consequences. The investigation establishes how the song\u27s central message harmonizes with core Hindu philosophical concepts, particularly those found in Bhakti traditions, Upanishadic thought, and Tantric practice, where the devotee\u27s surrender (sharanagati) necessarily involves moving beyond conventional social and religious boundaries. Drawing on comparative analysis with other devotional traditions and examining the song\u27s continued relevance in contemporary spiritual discourse, this study demonstrates how Tagore\u27s composition offers profound insight into the paradoxical journey of spiritual seekers who must often navigate societal disapproval to achieve authentic divine communion. The research further contextualizes the work within Tagore\u27s broader philosophical vision and personal spiritual journey, revealing how this composition represents a perfect synthesis of artistic expression and spiritual wisdom that continues to inspire seekers across cultural and religious boundaries
Pharmacological Modulation of the Nrf2–Keap1 Pathway in Diabetes: Mechanisms, Therapeutic Advances, and Future Directions
Full text linkDiabetes mellitus remains a major global challenge driven by oxidative stress, inflammation, and metabolic imbalance. The nuclear factor erythroid 2–related factor 2 (Nrf2)–Kelch-like ECH-associated protein 1 (Keap1) pathway acts as a pivotal intracellular Défense axis against redox and inflammatory insults. This review comprehensively explores the pharmacological modulation of the Nrf2–Keap1 system in diabetic complications, including nephropathy, retinopathy, neuropathy, and cardiomyopathy. Natural compounds such as sulforaphane, curcumin, and resveratrol, alongside synthetic activators like bardoxolone methyl and dimethyl fumarate, demonstrate multi-organ protection through the restoration of antioxidant, mitochondrial, and anti-fibrotic functions. However, translation to clinical success remains constrained by poor bioavailability, tissue-selectivity issues, and safety concerns. Advanced drug-delivery platforms, such as redox-responsive nanocarriers and prodrug formulations, offer promising precision in targeting oxidative microenvironments. Future therapeutic paradigms should integrate controlled Nrf2 activation with metabolic modulators, including SGLT2 inhibitors and GLP-1 receptor agonists, to achieve synergistic efficacy without exceeding toxicity thresholds. Ultimately, the convergence of pharmacogenomic profiling, biomarker discovery, and nanotechnological innovation is expected to transform Nrf2-based interventions from experimental insights into clinically viable therapies for diabetes management
Metal-Based Drugs: Mechanisms of Action and Anticancer Activity of Platinum and Ruthenium Complexes
Full text linkMetal-based drugs, particularly those involving platinum and ruthenium complexes, have gained significant attention as pivotal agents in cancer chemotherapy due to their distinctive chemical properties and therapeutic potential. Platinum-based drugs, such as cisplatin, carboplatin, and oxaliplatin, have long been established as cornerstone treatments for various malignancies, including testicular, ovarian, and lung cancers, by inducing apoptosis through DNA cross-linking and disruption of replication processes. However, issues like drug resistance, nephrotoxicity, and limited selectivity have motivated the exploration of alternative transition metal-based therapeutics. In this context, ruthenium complexes have emerged as promising next-generation candidates owing to their adjustable oxidation states, ligand exchange kinetics, and ability to target tumors selectively through transferrin-mediated uptake. These complexes not only demonstrate potent cytotoxic effects but also exhibit lower systemic toxicity and potential activity against cisplatin-resistant cancer cells. This paper comprehensively reviews the mechanisms of action, pharmacological profiles, structure–activity relationships, and biological interactions of both platinum and ruthenium complexes, emphasizing their synergistic roles, current clinical applications, and existing challenges in advancing metal-based cancer therapy
Finite Difference Method for Mechanical Adaptation of Arteries to Sustained Hypertension
Full text linkThe dynamics of arterial wall remodelling under hypertensive conditions is discussed here. Sustained hypertension was simulated by a step increase in blood pressure. The arterial wall was considered to be a thick walled tube made of non linear elastic incompressible material the driving stimuli for the geometric adaptation are the normalized deviations of wall stresses from their values under normotensive conditions. Meachanical adaption is driven by the difference between the area compliance under hypertensive and normotensive conditions. The predicted time course of the geometry and mechanical properties of arterial wall are in good qualititative agreement with published findings. Crank Nicolson finite difference scheme is used for computation purpose which is fast conversing in comparision to the method used by Rachev et al (1998)
Ethnopharmacological, Phytochemical and Pharmacological Uses of Genus Morchella: A Systematic Review
Full text linkMorel is an edible fungus belonging to the genus Morchella that is highly prized for value-added foods due to its unique flavor and planar nutrition profile. Aside from their culinary importance, morels have gained much attention in regard with their ethnopharmacological and pharmacological properties. Different species of this genus have been used in folk medicine in various cultures, mostly in Asia, Europe, and North America. Potential therapeutics from Morchella spp. over their broad spectrum of bioactive compounds, such as polysaccharides, sterols, fatty acids, alkaloids, and phenolic compounds. These constituents demonstrate a diverse spectrum of biological actions including antioxidant, anti-inflammatory, antimicrobial, immunomodulatory, and anticancer activities. There are ethnopharmacological studies showing that Morchella spp. shown to help with fatigue, respiratory problems, and gastrointestinal disorders. In traditional Chinese medicine, they are commonly used to boost health and immune health. Modern pharmacological research has confirmed some of these uses, as in vitro and in vivo studies have shown considerable health benefits. Morchella polysaccharides exhibit immunomodulatory activity and extracts exhibit antimicrobial activity against a variety of pathogenic organisms. Furthermore, Morchella-derived compounds showed potential anticancer effects via apoptosis and cell cycle arrest in cancer. Morchella spp have been shown through phytochemical analyses to contain are important sources of essential amino acids, vitamins, and minerals, which is why it has nutritional and medicinal values. Their antioxidative potential is also rooted in the unique profile of sterols and phenolic compounds. Over the past few years, researchers have isolated and characterized these bioactive molecules to identify their mechanisms of action and potential therapeutic applications. Although the medicinal properties of morels have been documented in the literature, further clinical studies are required to establish both their clinical efficacy and safety in human cohorts
Economic and Health Consequences of Unregulated Pharmaceutical Distribution in Assam: Examining Religious Patterns and the Path to Regulatory Reform
Full text linkBackground: Unregulated over-the-counter (OTC) medication sales, particularly antibiotics and non-steroidal anti-inflammatory drugs (NSAIDs), represent a significant public health challenge in Assam, India. This study examines the relationship between unregulated pharmaceutical distribution, development of chronic diseases, associated financial burdens, demographic patterns in distribution networks, and pathways to regulatory reform.
Methods: We employed a multi-phase mixed-methods approach across 7 districts in Assam (January 2023-March 2024). Our innovative methodology integrated market surveillance (n=94), pharmaceutical tracing investigations (n=127), healthcare provider surveys (n=312), patient interviews (n=543), and in-depth case studies of 18 distribution networks. We employed social network analysis to map distribution pathways and developed sophisticated economic models to estimate financial impacts at household, healthcare system, and macroeconomic levels. This novel integration of pharmaceutical tracing, patient outcomes, and religious demographic analysis provides unprecedented insights into the organized nature of unregulated distribution networks.
Results: Unregulated medication sales demonstrated significant correlation with chronic disease prevalence (r=0.74, p<0.001) and catastrophic health expenditure incidence (OR 3.8, 95% CI: 2.9-4.7). Laboratory analysis of unregulated pharmaceuticals revealed 41.7% failed quality standards, with significant variation across medication categories (antibiotics: 53.2%, NSAIDs: 39.4%, corticosteroids: 68.7%). Distribution network analysis identified organized supply chains with 72.3% linked to specific religious affiliations. These operations resulted in estimated annual healthcare system costs of ₹1,297 crores (US$171 million)—equivalent to 11.3% of Assam\u27s total health budget—and pushed 11.4% of affected households below the poverty line.
Conclusions: Our findings document systematic circumvention of pharmaceutical regulations with specific religious demographic patterns, resulting in significant public health and economic consequences. We propose a three-phase implementation strategy beginning with a 6-month stakeholder engagement process, followed by 12-month regulatory infrastructure development, and culminating in coordinated cross-sector enforcement with technology-enabled monitoring. Urgent comprehensive regulatory reform focusing on pharmacovigilance, cross-sector enforcement, and accountability mechanisms is essential to address this "pharmacy terrorism" and protect public health
Sindoor Loss in Terrorism: The Pallathadka-Roy Identity Reconstitution Theory and Sacred Resilience Framework
Full text linkThis groundbreaking paper introduces the Pallathadka-Roy Identity Reconstitution Theory for understanding trauma and divine resilience in Hindu women whose sindoor was forcibly removed during terrorist attacks that killed their husbands. Initially validated with 37 road accident widows and subsequently with 26 terrorism victims, our research reveals how attacks on sacred cultural symbols create unique trauma patterns while simultaneously awakening Bhārat\u27s timeless resilience mechanisms. We identify three phases—symbolic rupture, identity liminality, and reconstitutive integration—that illuminate how attacks on sindoor represent assaults on the sacred bond connecting Hindu wives to divine protection, marital status, and Sanātana Dharma itself. Our culturally-grounded interventions demonstrate the profound power of Hindu spiritual wisdom in healing, community strengthening, and transformative growth. This research honors India\u27s unparalleled contribution to trauma studies by centering indigenous healing practices and recognizing the profound sanctity of cultural symbols beyond physical manifestation. The findings showcase how Bhārat\u27s spiritual traditions offer the world\u27s most sophisticated frameworks for addressing complex trauma, positioning Indian psychological approaches at the vanguard of cultural trauma studies globally
The Impact of Uranium on Reproductive Health: A Study on Fertility Outcomes
Full text linkEffects of uranium on fertility as a component of reproductive health is the subject of research in this paper. Uranium is a chemically toxic and radioactive metal found in the environment and which becomes a health danger when it enters the body through the environment or occupation. Despite appreciable information on nephrotoxicity in uranium, there is limited data on its impact on human reproductive physiology. In this study, a cohort survey is conducted with a sample population to measure the extent of uranium exposure and relates to fertility factors of sperm concentrations, ovulation, and gestational outcomes.
The information was obtained from the participants who had different levels of occupational uranium exposure, and marker of exposure was estimated by urine and blood analysis. Difference in the fertility outcomes was elicited by comparing the different exposure categories while adjusting for possible cofactors including age and life style practices. To the best of our knowledge, our study is the first to report on dose-relationship between uranium and adverse impacts in male and female fertility biomarkers.
The research helps to develop knowledge about the ability of uranium to impact reproductive system and demonstrate concern of the populations concerning legislation on exposure to it. The conclusions presented in the paper have theoretical and applied implications for occupational health policies and environmental surveillance; they indicate the necessity for additional studies concerning the relationships between uranium and human fertility
Altitudinal Variation of Avian Fauna from Kalimpong Town to Nokdara of West Bengal, India
Full text linkThe spatial distribution of bird species across altitudinal gradients is governed by a complex interplay of ecological and biogeographic factors, making this relationship a central focus in avian research. The Kalimpong Town – Nokdara stretch study region examines important study sites within the 80 Km range. It was subdivided into three zones with altitudinal ranges: which are, Pudung Khasmal, Relli, and the lower part of Lolay (less than 1000 m asl); upper Lolay to Budhabare (1000 -1500 m asl); Gitdabling, Nokdara, and Lava (greater than 1500 m asl). This preliminary study documented 48 avian species representing 25 distinct families within the study area. Avian species composition varied significantly across elevational gradients, with the highest species diversity and richness observed in low-elevation zones (<1000 m asl). This pattern may be attributed to greater vegetation diversity at lower elevations, which provides enhanced shelter and more abundant food resources, supporting a wider array of bird species. Concerns regarding ecological imbalances and possible long-term behavioural changes are raised, for example, by the concentration of species near waste disposal sites
Theorizing Symbolic Reconstitution: A New Framework for Cultural Trauma
Full text linkThis paper introduces a theoretical framework for understanding cultural trauma through the lens of symbolic reconstitution. Drawing on empirical studies across diverse cultural contexts and integrating perspectives from cultural psychology, anthropology, and trauma studies, we conceptualize symbolic reconstitution as the process through which communities recover from trauma directed at their cultural symbols. We propose a three-phase model; symbolic rupture, liminal reconfiguration, and integrative reconstitution; to map the trajectory of recovery when cultural symbols are targeted in violence. This framework addresses significant gaps in existing trauma theories that often neglect the role of cultural symbols as repositories of collective identity and meaning. Through analysis of multiple case studies spanning diverse cultural contexts, we demonstrate how attacks on cultural symbols create unique trauma signatures that require culturally-specific interventions. This theoretical framework contributes to decolonizing trauma studies by centering indigenous epistemologies and recognizing cultural symbols not merely as static markers but as dynamic resources for resilience and recovery. Implications for culturally-responsive trauma intervention, community resilience enhancement, and post-trauma identity reconstruction are discussed