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Atrazine derangement of GLUT-4 and Insulin metabolism and the ameliorative effect of Virgin coconut oil in male wistar rats
No full textWe assessed the ameliorative effect of Virgin Coconut Oil following atrazine-induced metabolic derangement in rats. Adult male wistar rats weighing 180-200g were used; randomly separated into two major groups. Thirty-five rats in the test group were randomly divided into five sub-groups of 7 rats per sub-group and treated thus: Sub-group (SG) 1, 2 and 3 received 10ml/kg of distilled water, 10ml/kg VCO, 123mg/kg of Atrazine respectively, SG4 was diabetic control; SG 5 was the diabetic group treated with 10ml/kg of VCO for 2 weeks, after which the animals were sacrificed and blood collected for analysis. 35 rats for the recovery group were also divided into 5 sub-groups of 7 rats per sub-group and were treated; SG 1, 2, 3, 4 and 5 received 10ml/kg distilled water, 10ml/kg VCO, 123mg/kg of ATZ respectively. After 2 weeks, the animals were re-treated thus: SG 1,2,3,4 and 5 received 10ml/kg of distilled water, 10ml/kg of VCO, 123mg/kg of ATZ, 10ml/kg VCO and 10ml/kg distilled water respectively. After 2 weeks, the animals were also sacrificed and blood collected for analysis. ATZ reduced serum insulin and a reduced expression of GLUT4. VCO restored GLUT4 levels but did not significantly restore the insulin to the normal level
Body composition in coronary artery disease in KONKAN region of India-Is non- obesity an indicator of Coronary Artery Disease?
No full text Background
India is witnessing a rising prevalence of non communicable diseases like diabetes, hypertension, coronary artery disease. This is attributed to rapid nutrition and lifestyle transition taking place since last 2 decades. Obesity is a well known independent risk factor but very little information is available about role of leanness (low BMI). We investigated whether non-obesity could be an independent risk factor for Coronary artery disease in a rural clinic in KONKAN.
Methods
In a cross sectional study we studied body composition of 300 patients (207 men) who underwent Coronary angiography in a rural hospital in KONKAN region. History of diabetes, hypertension and history smoking, tobacco chewing was recorded. Body composition was estimated using bio-impedance analyser. Based on results of coronary angiography, we generated a SYNTAX score derived by number of vessels involved and classified them into groups of severity of coronary artery disease (CAD).
Results
There were 95 (31 %) diabetes and 189 (63%) hypertensive patients in the sample and 60% of them smoked or chewed tobacco. There were 43 (28 males) patients with SYNTAX score of zero. Among those with coronary artery disease (n=257) increasing severity of CAD was associated with lower body weight, BMI, body fat percentage, and body fat mass and ejection fraction as against positive trend for lean mass and visceral fat.
Conclusion
BMI, fat mass decreased with severity of CAD while lean mass and visceral fat increased. We observed high proportion of CAD in underweight and lean KONKAN adults. These findings need further investigations
RELATIONSHIP OF PELVIC ALIGNMENT WITH BALANCE AND GAIT IN PATIENTS WITH STROKE: A SYSTEMATIC REVIEW: Pelvic alignment and balance
No full textBackground- Pelvis is the key structure that connects the spine and the lower limbs. Altered Pelvic Alignment and asymmetrical weight bearing on affected lower limbs is a common problem leading to pelvic instability which may have an effect on balance and gait in patients with stroke. Hence, it was aimed to investigate the interdependence of these three components in patients with stroke. Methods- Four databases (PubMed, Google Scholar, Cochrane, Science Direct) were searched to identify eligible studies using the keywords Pelvic Alignment, Gait, Balance, Stroke. Only observational studies published in last 10 years (2010-2020) were included in this review. Results- Thirteen studies were included in the review conducted on sub-acute and chronic stage. All studies investigated the affection of pelvic mal-alignment, balance and gait in combination of two variables except 3 studies which investigated the combined effect of pelvic inclination on both balance and gait. The abnormal pelvic tilt results in lateral displacement of the pelvis on affected side, altered Base of Support, reduced balance control, asymmetry in weight bearing leading to altered gait. Conclusion- Pelvic tilt, anterior and lateral has a significant impact on static balance, gait variables, weight bearing symmetry
Comparison of electromyographic activity of quadriceps muscle in persons with unilateral traumatic transtibial amputation using patellar tendon bearing supracondylar endoskeletal prosthesis with the unaffected limb in weight bearing positions.
No full textAbstract
Purpose: comparison of electromyographic activity of quadriceps muscle in persons with unilateral traumatic transtibial amputation using patellar tendon bearing supracondylar endoskeletal prosthesis with the unaffected limb in weight bearing positions.
Method: 30 individuals aged 18-60 years were assessed using surface electromyography with functional level K3 according to K-level functional assessment scale to compare the activity of quadriceps of affected side using patellar tendon bearing supracondylar endoskeletal prosthesis with the unaffected side. The data was analysed using paired t-test.
Result: There was a significant difference in the activity of VMO and VLO muscles of the quadriceps in high sitting positions. There was also a significant difference in the activity of VMO muscle in single limb stance and bipedal stance. However, there was no significant difference between the activity of VLO muscle in bipedal stance but there was reduced activity of VLO muscle in the prosthetic limb in single limb stance.
Conclusion: The quadriceps activity was reduced in the affected limb in high sitting position, single limb stance and bipedal stance. However, no difference in the muscle activity was noted in VLO muscle in bipedal stance.
Keywords: trans tibial amputation, patellar tendon bearing supracondylar prosthetis, surface electromyography. 
Research on Mount Wilson Magnetic Classification Based on Deep Learning
No full textThe Mount Wilson magnetic classification of sunspot groups is thought to be meaningful to forecast flares’ eruptions. In this paper, we adopt a deep learning method, CornerNet-Saccade, to perform the Mount Wilson magnetic classification of sunspot groups. It includes three stages, generating object locations, detecting objects, and merging detections. The key technologies consist of the backbone as Hourglass-54, the attention mechanism, and the key points’ mechanism including the top-left corners and the bottom-right corners of the object by corner pooling layers. These technologies improve the efficiency of detecting the objects without sacrificing accuracy. A dataset is built by a total of 2486 composited images which are composited with the continuum images and the corresponding magnetograms from HMI and MDI. After training the network, the sunspot groups in a composited solar full image are detected and classified in 3 seconds on average. The test results show that this method has a good performance, with the accuracy, precision, recall, and mAP as 0.94, 0.93, 0.94, and 0.90, respectively. Moreover, the flare productivities of different types of sunspot groups from 2011 to 2020 are calculated. As Itot ≥ 1, the flare productivities of α,β,βγ,βδ, and βγδ sunspot groups are 0.14, 0.28, 0.61, 0.71, and 0.87, respectively. As Itot ≥ 10, the flare productivities are 0.02, 0.07, 0.27, 0.45, and 0.65, respectively. It means that the βγ,βδ, and βγδ types are indeed very closely related to the eruption of solar flares, especially the βγδ type. Based on the reliability of this method, the sunspot groups of the HMI solar full images from 2011 to 2020 are detected and classified, and the detailed data are shared on the website (https://61.166.157.71/MWMCSG.html)
Small Mars Mission Architecture Study
No full textWhile the vast majority of ESA’s funding for Mars exploration in the 2020s is planned to be invested in ExoMars and Mars Sample Return, there is an interest to assess the possibility of implementing a small mission to Mars in parallel with, or soon after, the completion of the MSR programme. A study was undertaken in the Concurrent Design Facility at ESA ESTEC to assess low-cost mission architectures for small satellite missions to Mars. Given strict programmatic constraints, the focus of the study was on a low-cost (<250MEuro Cost at Completion), short mission development schedule with a cost-driven spacecraft design and mission architecture. The study concluded that small, low-cost Mars missions are technically feasible for launch within the decade
Evaluation of Phenotypic Variations in the Antibiotics Sensitivity of Escherichia Coli by Repeated Exposure
No full textEnterobacteriaceae, in particular Escherichia coli, are habitual residents of the gastrointestinal tract, capable of causing a large number of infections. The MIC varies according to the bacterial strains and the antibiotics used, hence the need to carry out antibiotic sensitivity tests. The objective of this study is to evaluate the behavior of Escherichia coli after repeated exposure to the same antibiotic to demonstrate a possible correlation between excessive intake of antibiotics and bacterial resistance.
A prospective and descriptive study was carried out in the Laboratory of Microbiology of Fundamental and Applied Biochemistry (Faculty of Sciences Antananarivo) during the month of November 2019. The strains studied were the reference strain Escherichia coli ATCC 25922 provided by the Laboratory and two clinical strains from the Microbiology Laboratory of the Joseph Ravoahangy Andrianavalona University Hospital Center (CHU JRA) Antananarivo. Repeated exposure to Tobramycin and Ofloxacin of these strains were performed.
The results of our study showed that most E. coli is exposed to the antibiotic, the more it develops resistance. The evolution of E. coli's sensitivity is different in the presence of Tobramycin with MICs up to 4 times the starting value while in the presence of Ofloxacin, the MIC increases to 125 times the initial value. This difference may be due to the different target of the antibiotic which causes the bacteria to develop variable mechanisms to escape it.
Key words: E. coli - MIC - antibiotics - repeated exposur
Magnetohydrodynamic Fluid Flow due to an Unsteady Stretching Sheet with Thermal Radiation, Porous Medium, and Variable Heat Flux
No full textA shooting method has been introduced for determining the numerical solution of the ordinary differential equations which describe the Newtonian magnetohydrodynamic laminar fluid flow due to an unsteady stretching sheet together with the presence of thermal radiation and variable heat flux. The variable viscosity and variable conductivity are taken into consideration. Absence of magnetic field in some studies restricts the development of the energy-efficient heat transfer mechanism as is desired in numerous applications. The present study encompasses parameters such as unsteadiness parameter, porous parameter, viscosity parameter, magnetic number, radiation parameter, and conductivity parameter. It has been consummated that the proposed model is superior to other existing models for the industrial fluid
Modification of Gravitational Field Equation due to Invariance of Light Speed and New System of Universe Evolution
No full textWe make a systematic examination of the basic theory of general relativity and reemphasize the meaning of coordinates. Firstly, we prove that Einsteinʼs gravitational field equation has the light speed invariant solution and black holes are not an inevitable prediction of general relativity. Second, we show that the coupling coefficient of the gravitational field equation is not unique and can be modified as 4πG to replace the previous −8πG, distinguish gravitational mass from the inertial mass, and prove that dark matter and dark energy are not certain existence and the expansion and contraction of the universe are proven cyclic, and a new distance-redshift relation which is more practical is derived. After that, we show that galaxies and celestial bodies are formed by gradual growth rather than by the accumulation of existing matter and prove that new matter is generating gradually in the interior of celestial bodies. For example, the radius of the Earth increases by 0.5 mm every year, and its mass increases by 1.2 trillion tons. A more reasonable derivation of the precession of planetary orbits is given, and the evolution equation of planetary orbits in the expanding space-time is also given. In a word, an alive universe unfolds in front of readers and the current cosmological difficulties are given new interpretations