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Effect of hyperglycemia on serum uric acid levels - A real world comparative study
No full textObjective: - To determine the relationship between hyperglycaemia and uric acid levels.
Material and methods:- Patients, with known diabetes or impaired glucose tolerance/newly detected patients of diabetes treated on OPD basis or in patients admitted in B.T.G.H over a period of 1yr from April 2017 to March 2018.Study design: - randomized, comparative, cross-sectional.
Result: - 19 cases of type 2 DM had hypouricemia while 6 in controls .7 cases of IGT had hyperuricemia, 6 controls had hyperuricemia and none in patients with type 2 DM.Conclusion:- Serum uric acid concentration is slightly reduced in patients with type 2 DM. Serum uric acid concentration is increased in patients with IG
Sleep disorders, Diagnosis, treatment and A Dentist’s role in early diagnosis and treatment of sleep disorders: A Review: sleep disorders and Dentists role
No full textObjective/Background: Sleep disorders are interdisciplinary and involve a number of specialties such as respiratory medicine, neurology, psychiatry, otolaryngology, and Dentistry. 87.5% of the patients with loud snoring suffer from sleep-disordered breathing, of which 72% complain of excessive daytime sleepiness. Controversial evidence exists on the association of sleep disorders as a primary or secondary risk factor for many common systemic conditions. Yet, sleep medicine is not given emphasis in medical school education. In addition, dentists now participate in the recognition and treatment of sleep disorders, Dentist’s role and involvement in the treatment and management of a sleep-disordered patient may be indirect or direct. Hence, this review explains sleep disorders, diagnosis and treatment, and the role of dentists in early diagnosis and treatment.
Specificity and Personalized medicine: a novel approach to Cancer management
No full textWith the advent of precision and personalized medicine (PPM), medical care may now be adapted to each patient's unique needs. Among the top causes of death in India is cancer. Maximum chemotherapeutic treatments are utilized for cancer patients, despite the lack of long-term effectiveness and significant side effects from these agents. To improve therapeutic success, a new tool called PPM was developed. Insights into pharmacogenomics have aided in the development of and the possibility for individualized cancer treatment. In modern PPM, genetic or other information on a particular patient is used systematically to select or optimize preventative and therapeutic therapy for that patient. Knowledge of a patient's protein, genetic, and metabolic profile can help doctors give them the best possible care. The development of companion diagnostics, in which molecular assays measuring levels of proteins, genes, or specific mutations are used to stratify disease status, pick the appropriate drug, and tune dosages there, is a central feature of this medical strategy. As a result, recent breakthroughs in oncology have piqued interest in the field as a whole, prompting calls for greater emphasis on the role of the oncology department or health care system in the quest for greater accuracy and individualization. In this article, we will examine the state of the art and discuss potential future developments that could help expedite the creation of PPM medicines for the treatment of cancer that has become resistant to standard therapies in individual patients. The focus will be on the phenotypic (activity-based) rather than the genotypic (mechanism-based) approach to PPM development, and how it can benefit cancer patients. The path to precise and individualized treatment has been opened by the article's perspective, in which focus is placed on the specific modifications of the tumor
Alteration of Coagulation Profiles in Hypothyroid Patients
No full textBackground:
Hypothyroidism is an underactive thyroid gland that results in too little thyroid hormones in circulation causing a slowdown in metabolism, therefor hypothyroid modifies physiological process of primary and secondary hemostasis and may lead to a higher bleeding risk.
Objectives: The aim of this study is to assess the coagulation profiles [Prothrombin Time (PT), International Normalize Ratio (INR), Activated Partial Thromboplastin Time (PTT)] in patients with hypothyroidism.
Methodology: This is a case-control hospital-based study carried out at the National Cancer Institute – University of Gezira (NCI-UG), Wad Medani, Sudan from January to October 2020. A total of 100 (50 patients with hypothyroidism as cases (38.50 ± 10.46 years) matched with 50 normal healthy individuals as controls (35.52 ± 11.64 years) participated in this study. Two ml of venous blood sample was collected in a trisodium citrate container. Coagulation profiles (PT, INR, and PTT) were measured using a Coatron M4 coagulometer. SPSS computer program (v 21.0) was used for data analysis.
Results: The prolonged PTT account for 74%. The average PTT of cases (42.29 ± 7.22 sec) was higher than controls (32.67 ± 5.90 sec) giving highly statistically significant differences (P value = 0.000) between them. There were significant differences in PTT between mild and severe hypothyroidism (P value = 0.0470). PTT had significant positive correlation within TSH (P value = 0.048; r = 0.070) and significant negative correlation within T3 (P value = 0.000; r = - 0.490) and T4 (P value = 0.020; r = - 520; P value = 000).
Conclusion: The study concluded that PTT was significantly higher in a patient with hypothyroidism when compared to the control. PTT results showed there was a significant negative correlation between T3 and T4 levels and a significant positive correlation with TSH levels. So, PTT should be included as a follow-up routine test for patients with hypothyroidism.
Keywords: Prothrombin time, International Normalized Ratio, Partial Thromboplastin Time, Hypothyroidism, Sudan
Immunogenicity of a single dose mRNA vaccine in SARS-CoV-2 exposed subjects: A systematic review
No full textBackground: The novel coronavirus is quickly spreading and mutating, putting the public health and lifestyle in shambles. The development and approval of mRNA vaccines came up as a breakthrough. The breadth of immune response after a single-dose vaccination in the already infected population is discovered for understanding the hybrid immunity and side effects associated with second dose. Administering a single-dose vaccine to the seropositive population can spare the doses for the population at higher risk.
Methods: PubMed, Web of Science, Google scholar, medRxiv and Cochrane library were explored to extract the original data on the efficacy of single-dose mRNA vaccines in seropositive subjects. The Cochrane risk of bias tool was used to assess the risk of bias in the studies.
Results: 6 studies evaluating the immunogenicity of single-dose mRNA vaccine were incorporated along with some observational studies and literature. These studies present promising evidence for administering only single-dose mRNA vaccine in seropositive subjects, providing biphasic immune response of higher breadth and duration.
Limitations: Most studies had a small sample size, did not correlate the results with higher age groups, with potential risk factors and the percentage of individuals who contracted breakthrough infections.
Conclusions: Single-dose mRNA vaccine can be immunogenic and protective enough for already seropositive population by increasing the number of Spike protein-specific memory B-cells. Vaccination schedules based on existing anti-body titers in such individuals can spare doses for vulnerable groups, especially when there is limited production and supply of vaccines worldwide
Reproductive Health of Women: Implications and attributes
No full textComplete access to sexual and reproductive health is a fundamental human right. Women and girls all across the world, particularly those living in poverty, have little or no access to reproductive health and rights information and services. Discrimination, shame, restrictive laws and regulations, and long-held traditions are just a few of the barriers to sexual and reproductive health that exist. Despite evidence that these rights may affect not only individual women but also families, communities, and national economies, progress has been slow. Women's lifestyles have evolved throughout history. In the past, most women's lives were challenging. Many ladies were having unintended pregnancies. Childbirth used to be dangerous, and it often resulted in the mother's death. Because they didn't live long enough, most women didn't have to deal with menopause or old age in the past. Reproductive health is an important aspect of a person's entire development and well-being. It could be the result of a positive upbringing, which is critical during adolescence and sets the tone for excellent health throughout adulthood and beyond reproductive years for both men and women. A woman's reproductive life span does not begin at puberty and end at menopause, and a man's reproductive life span does not stop when he is no longer likely to bear children. It is present and vital at all stages of a person's development and maturation. Reproductive health needs may vary depending on one's age and stage of life. However, there is a long term effect over the course of one's life, and each stage has significant ramifications for one's future well-being
