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Comparative study of Negative Pressure Wound therapy Vs. Local antibiotic cream dressings in acute hand burns second-degree superficial to deep
No full textBackground: The hand is one of the most common parts of the body involved in burns, i.e., 80%. Even minor burns in the hand may result in severe limitations of function. Early initiation of physiotherapy, topical antibiotic cream treatment, collagen application, splintage, passive exercise for second-degree superficial burns. Materials and methods: A prospective comparative study was conducted in 10 patients with acute hand burns due to thermal burns (scald, flame). All patients with second-degree superficial to intermediate thickness burns were given Negative pressure wound therapy (indigenous NPWT Kit) to one hand and local antibiotic cream to the other hand or other parts of the body to study clinical profile and outcome. Results: A total of 10 patients were studied. The majority of patients were in 19 to 30 years of age group 6 patients (60%), five females, and one male. Pediatric patients account for 4 patients (40%), two female and two male children. Incidence of burns in females 70% and males’ group 30%. Significant reduction in postburn edema in NPWT hand compared to topical antibiotic cream dressing. Healing is fast in NPWT applied hand/part. Conclusion: Negative Pressure Wound Therapy for Acute second-degree superficial burns showed promising results in wound healing and reduced post-burn edema burn in hand in our study
Differential diagnosis of benign ovarian cysts using tumor markers in serum and cyst fluid
No full textA cross-sectional study about socio-demographic factors and clinical characteristics of male patients with alcohol dependence syndrome
No full textBackground: Alcohol abuse is one of the major causes of death and disability globally; and a key risk factor for health, social, and economic problems in the communities. Consumption of alcohol by Indians has increased drastically due to various factors and in an unrestricted manner; and the age of initiation of drinking is progressively coming down. Objective: To determine the socio-demographic and clinical profile of the patients coming for treatment of alcohol dependence syndrome in the psychiatry department. Methods: A cross-sectional study was conducted on 50 male outpatients of alcohol dependence syndrome attending the department of psychiatry at a tertiary care hospital. Sociodemographic data and clinical details were recorded with the help of a pre-designed questionnaire. Results: Nuclear family, family history of alcoholism, unmarried status, higher educational level, unemployment, and peer pressure are the factors significantly associated with early age at first drink and age of dependence on alcohol (p < 0.05). Conclusion: Adolescents having a family history of alcoholism are a high-risk group for developing alcohol dependence and should be targeted for intervention strategies. Community based-longitudinal studies are needed to understand multiple factors influencing alcohol use and recommend targeted preventive measures.
Keywords: Alcohol, Alcohol dependence syndrome, Peer pressure, Intoxication, Socio-demographic factor
Chaotic Oscillation of Satellite due to Aerodynamic Torque
No full textThis study presents the chaotic oscillation of the satellite around the Earth due to aerodynamic torque. The orbital plane of the satellite concurs is same as the tropical plane of Earth. The half-width of riotous separatrix is assessed utilizing Chirikov’s measure. Variety of boundary techniques shows that streamlined force boundary (ɛ), unpredictability of circle (e), and mass-proportion (ω0) convert normal wavering to the disorganized one. We studied the behavior of trajectories due to change in parameters with Lyapunov exponents and time series plots. The theory is applied to Resourcesat-1, an artificial satellite of the Earth
Myoinositol with Metformin and Myoinositol alone in infertile PCOS women undergoing ovulation induction cycles: A comparative study
No full textBackground: This was a prospective observational study conducted over a twelve-month duration in our institute to compare the combined effect of metformin and myoinositol with metformin alone. Method: A total of sixty patients were included in the study, and they were divided into two groups depending on whether they were given the combination or the single drug. Group A (n=30) was given Myoinositol 600 mg+Metformin 500 mg thrice a day, and Group B ( n=30) was given only Myoinositol 600 mg thrice a day. The outcome measure was clinical pregnancy rate and improvement in clinical and hormonal parameters after drug therapy. Results: BMI (p<0.01), modified Ferriman Gallaway score (p>0.05), and the was a significant improvement in the hormonal parameters (LH,FSH) in both the groups and the levels were found to be comparable after a period of 6 months. The clinical pregnancy rate after six cycles of ovulation was significantly higher in Group A as compared to Group B. In Group A, the total clinical pregnancy rate was 43.33%, and in Group B, it was 26.67%, respectively, and the end of 6 months and the difference was statistically significant (p = <0.01) Conclusion: Equal response in reduction of hormonal levels and clinical and laboratory parameters were seen in both groups, while better results in terms of clinical fertility rates were observed in the group that was given a combination of myoinositol with metformin
Artificial Intelligence in Pharma
No full textThis paper aims to provide a better understanding of the possible applications of Artificial Intelligence (AI) in the field of Pharmacy. Artificial intelligence basically involves complex information processing. It enables machines to carry out certain functions which were originally done by human and which required human intellect. Over the past few years, the use of artificial intelligence in the pharma has grown unimaginably and is now able to revolutionize the way drugs are discovered and handled. AI is capable of impacting the field of pharmacy at multiple levels. Pharmacy and medical education, drug development, personalization of drug therapy, drug safety, rational drug use, manufacture and formulation of dosage forms are areas of impact by AI. The fact that AI can displace humans at their own tasks is a matter of concern. Although there are ethical concerns regarding the implementation of AI in healthcare, it can be assured that no machine or system can replace many of the humanitarian duties
Ocimum Species: Ethnomedicinal Uses, Phytochemistry and Pharmacological Importance
No full textPlant species belonging to the Ocimum genus are among the most popular medicinal plants and are being used for several purposes in ethnomedicine. Ocimum is universally cultivated however; the geographical distribution highlights three major centers of Ocimum diversity, these are: the tropical areas of America, the tropical region of Asia and the tropical and subtropical regions of Africa. Ocimum species have been employed traditionally for several medicinal purposes including antioxidant, antibacterial, hypoglycaemic, hepatoprotective, antiviral and other medicinal purposes. Though scientists have carried-out studies and chronicled the pharmacological potentials of Ocimum species, documents containing these data seem to be disassembled, making it difficult to really distinguish the pharmacologically useful species from those that are not and also to get comprehensive information about the medicinal species in this genus. Hence, the aim of this review is to outline classified information on the ethnopharmacology, phytochemistry and pharmacological importance of some Ocimum species that have been reported by different researchers. In carrying-out this review, the search for literature was done via relevant databases including PubMed, Springer, Web of Science, Science Direct, Embase, SciFinder, Google Scholar and Scopus. The species reviewed are the most widely used from the Ocimum genus in traditional medicine and they are also the most researched for intended use in conventional therapeutic practice. Literature reveals that these species contain several compounds which are responsible for the numerous pharmacological activities elicited by them including antimalarial, anticancer, antidiabetic, antiinflammatory and antioxidant effects
Body composition in coronary artery disease in KONKAN region of India-Is non- obesity an indicator of Coronary Artery Disease?
No full text Background
India is witnessing a rising prevalence of non communicable diseases like diabetes, hypertension, coronary artery disease. This is attributed to rapid nutrition and lifestyle transition taking place since last 2 decades. Obesity is a well known independent risk factor but very little information is available about role of leanness (low BMI). We investigated whether non-obesity could be an independent risk factor for Coronary artery disease in a rural clinic in KONKAN.
Methods
In a cross sectional study we studied body composition of 300 patients (207 men) who underwent Coronary angiography in a rural hospital in KONKAN region. History of diabetes, hypertension and history smoking, tobacco chewing was recorded. Body composition was estimated using bio-impedance analyser. Based on results of coronary angiography, we generated a SYNTAX score derived by number of vessels involved and classified them into groups of severity of coronary artery disease (CAD).
Results
There were 95 (31 %) diabetes and 189 (63%) hypertensive patients in the sample and 60% of them smoked or chewed tobacco. There were 43 (28 males) patients with SYNTAX score of zero. Among those with coronary artery disease (n=257) increasing severity of CAD was associated with lower body weight, BMI, body fat percentage, and body fat mass and ejection fraction as against positive trend for lean mass and visceral fat.
Conclusion
BMI, fat mass decreased with severity of CAD while lean mass and visceral fat increased. We observed high proportion of CAD in underweight and lean KONKAN adults. These findings need further investigations
Ovarian cysts trends at tertiary care hospital of Western Maharashtra: Retrospective analysis
No full textBackground: Ovary is an essential organ of the female body concerned with the production of progeny. If a neoplastic change occurs in the ovaries, then a variety of tumors can develop. An ovarian cyst is a common gynecological problem. The main complications which can arise include torsion, infarction, rupture, and hemorrhage. Methodology: This was a retrospective and prospective study of 108 cases of ovarian pathology encountered over the period of 18 months. All the specimens sent for the histology, multiple sections were taken from each case, and routine Hematoxylin and Eosin staining was done. The diagnosis was based on the WHO classification, and results were tabulated. Results: Out of total ovarian lesions, nonneoplastic lesions were 73(60.33%), and neoplastic lesions were 48(39.66%). The most common nonneoplastic histopathological lesion seen was a follicular cyst (57.53%), and surface epithelial tumors (83.33%) were the most common neoplastic lesion noted in the present study. The mucinous cystadenoma was the largest tumor encountered. The common chief complaint was abdominal pain (41.49%), followed by incidental findings (20.40%). Conclusion: The goal of histopathological diagnosis is to identify the type of the ovarian lesion, the risk of malignancy and assessment of timing and necessity of further interventions like chemotherapy and radiotherapy