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Detection of Candida albicans in the screening of cervical cancer in rural population of Lucknow: Detection of Candida albicans in the screening of cervical cancer
No full textBackground
Study of Candidal infection is very essential in rural women who being illiterate and financially weak are not aware of personal genital hygiene and thus harbour persistent vaginal infections due to poor availability of medical amenities.
Method
Rural cervical cancer screening is in progress in the western region of Lucknow, India since May 2013 through camp approach and till date, a total of 2949 women have been cytologically examined. Candidal infection has been observed in the 143 cervical smears of women and findings have been analyzed in relation to the different predisposing factor of cervical carcinogenesis.
Result
The incidence of Candida albicans seen in cervical smears of the total 2949 women examined was found to be 4.8% which is much higher than in their urban counterparts (1.2%). The Candida was seen more in the inflammatory smears (9.4%) and those showing squamous intraepithelial lesions of cervix (SIL). – (8.2%). The fungus was found more prevalent in the reproductive age group and women complaining of vaginal discharge and was result of persistent vaginal infections in the rural women which should be treated. The Candida was commonly seen in erosion cervix cases but its incidence was high in women with cervicitis and cervix bleeds on touch.
Conclusions
This persistent vaginal infections were seen in the illiterate and poor rural women who are not aware of personal genital hygiene. There is a need to create awareness for personal genital hygiene through health workers for making any cancer screening program meaningful and successful
HYPOMAGNESAEMIA AND HYPOCALCAEMIA THE MAJOR MISSED OUT CLINICAL CONDITION IN THE MANAGEMENT OF DIABETES
No full textMagnesium (Mg) and Calcium (Ca) is one of the essential factors for the insulin to get released from the pancreatic cell. To evaluate the relation of hypomagnesemia and hypocalcaemia in the glycaemic control and to analyse the importance of both Mg and Ca in the insulin secretion mechanism. The study was conducted in the laboratory department, Billroth hospitals. A total of 239 individuals were selected for this study, HbA1c level, serum magnesium and calcium were assessed for all the individuals and in addition to this serum electrolytes were also checked. Out of 239 individuals, 79 were found out as uncontrolled diabetic by calculating HbA1c as a gold standard, males are higher in ratio compared to female. By studying serum magnesium and calcium level, hypocalcaemia is present in more individuals and females (31%) are much prone to both than males (20%). The different correlation was also analysed for hypomagnesemia and hypocalcaemia. The electrolytes like sodium (Na) and potassium (K) was analysed, females are highly affected by electrolyte imbalance but in hypomagnesemia diabetic individuals the males are high in electrolyte imbalance. Since Mg and Ca plays a vital role in insulin synthesis, secretion, repair, and the alteration, along with the hypoglycaemic agents the supplementation of magnesium or calcium could be suggested via, dietary or drug supplements. In addition to this, regular monitoring of electrolytes is essential to maintain fluid balance
Pattern of Acute Organophosphorus Poisoning at a Tertiary Care Hospital of Western Maharashtra
No full textBackground: Every year, 3 million cases of pesticide, mainly O.P. poisoning, occurs all over the world. Therefore, statistics regarding O.P. poisoning in a specific region will aid in the early diagnosis and treatment of cases. The main objective of this research project is to find out the pattern of O.P. poisoning cases at the tertiary care center. Methods: We conducted a retrospective cross-sectional study, in which we analyzed data from 40 cases of O.P. poisoning, including patient information regarding gender, age, time of ingestion, type of poison, mode of poisoning, any first aid received, treatment given, duration of hospital stay and outcome of the treatment. Results: There were 16 females (40%) and 24 males (60%). The most common age group was 21 to 40 years, with 19 participants (47.50%). The majority of the participants were from the rural area, 38 cases (95%), while in 36 cases, the poisoning was suicidal (90%). 28 participants (70%) received some form of first aid. In addition, 21 of the participants received Atropine (52.50%), 13 received only gastric lavage (32.50%), 5 received both Atropine and Pralidoxime (12.50%), while one patient only received Pralidoxime (2.5%) as treatment. I.C.U. admission was required in 39 participants (97.50%), and ventilatory support was required in 2 participants (5%). Our study observed 4 deaths (10%) amongst our participants. The multivariate analysis of deaths in our study showed that specifically not receiving any first aid (p = 0.039) and requirement of the ventilator (p<0.001) were seen to have a significant association with deaths in our study. Conclusion: O.P. poisoning is the commonest cause of suicidal deaths in developing countries. Creating awareness regarding O.P. poisoning and legislative action on using hazardous poisons will help reduce the deaths
The Stability of Certain Motion of a Charged Gyrostat in Newtonian Force Field
No full textThis work aims to study the stability of certain motions of a rigid body rotating about its fixed point and carrying a rotor that rotates with constant angular velocity about an axis parallel to one of the principal axes. This motion is presumed to take place due to the combined influence of the magnetic field and the Newtonian force field. The equations of motion are deduced, and moreover, they are expressed as a Lie–Poisson Hamilton system. The permanent rotations are calculated and interpreted mechanically. The sufficient conditions for instability are presented employing the linear approximation method. The energy-Casimir method is applied to gain sufficient conditions for stability. The regions of linear stability and Lyapunov stability are illustrated graphically for certain values of the parameters
Ocimum Species: Ethnomedicinal Uses, Phytochemistry and Pharmacological Importance
No full textPlant species belonging to the Ocimum genus are among the most popular medicinal plants and are being used for several purposes in ethnomedicine. Ocimum is universally cultivated however; the geographical distribution highlights three major centers of Ocimum diversity, these are: the tropical areas of America, the tropical region of Asia and the tropical and subtropical regions of Africa. Ocimum species have been employed traditionally for several medicinal purposes including antioxidant, antibacterial, hypoglycaemic, hepatoprotective, antiviral and other medicinal purposes. Though scientists have carried-out studies and chronicled the pharmacological potentials of Ocimum species, documents containing these data seem to be disassembled, making it difficult to really distinguish the pharmacologically useful species from those that are not and also to get comprehensive information about the medicinal species in this genus. Hence, the aim of this review is to outline classified information on the ethnopharmacology, phytochemistry and pharmacological importance of some Ocimum species that have been reported by different researchers. In carrying-out this review, the search for literature was done via relevant databases including PubMed, Springer, Web of Science, Science Direct, Embase, SciFinder, Google Scholar and Scopus. The species reviewed are the most widely used from the Ocimum genus in traditional medicine and they are also the most researched for intended use in conventional therapeutic practice. Literature reveals that these species contain several compounds which are responsible for the numerous pharmacological activities elicited by them including antimalarial, anticancer, antidiabetic, antiinflammatory and antioxidant effects
Fault Tolerance for Active Surface System with Actuator Faults
No full textThe QiTai Radio Telescope (QTT) will be equipped with the active surface adjustment system (ASAS) to correct the main reflector deformation caused by environmental loading. In order to guarantee the stability and performance of the active surface system under fault conditions, it is necessary to adopt the fault-tolerant method when actuator faults have occurred. In this paper, a fault control method based on actuator faults weighting is proposed to solve the active surface fault control problem. According to the coordinates of the adjustable points of the panels corresponding to the faulty actuators, a new paraboloid is fitted by a weighted health matrix, and the fitting surface is taken as the target to adjust the surface shape
Bouncing Cosmology in fG,T Gravity with Logarithmic Trace Term
No full textThis study is devoted to explore bouncing cosmology in the context of fG,T theory of gravity. For this purpose, a Gauss–Bonnet cosmological model with logarithmic trace term is considered. In particular, the possibility of obtaining bouncing solutions by considering two equations of state parameters is investigated. A graphical analysis is provided for analyzing the obtained bouncing solutions. The energy conditions are discussed in detail. It is interesting to notice that null and strong energy conditions are violated near the neighborhood of bouncing points justifying the accelerating universe in the light of the recent observational data. The behavior of the scale factor, red shift function, deceleration parameter, and Hubble parameter is also debated. An important feature of the current study is the discussion of conservation equation in fG,T gravity. The possibility of some suitable constraint equations which recover the standard conservation equation is discussed, and all the free parameters are assumed accordingly. All the results in this study suggest that the proposed fG,T gravity model provides good bouncing solutions with the chosen EoS parameters
Spectral Feature Extraction Using Partial and General Method
No full textWith the rapid growth in astronomical spectra produced by large sky survey telescopes, traditional manual classification processes can no longer fulfill the requirements of precision and efficiency of spectral classification. There is an urgent need to employ machine learning approaches to conduct automated spectral classification tasks. Feature extraction is a critical step which has a great impact on any classification result. In this paper, a novel gradient-based method together with principal component analysis is proposed for the extraction of partial features of stellar spectra, that is, a feature vector indicating obvious local changes in data, which corresponds to the element line positions in the spectra. Furthermore, a general feature vector is utilized as an additional characteristic centering on the overall tendency of spectra, which can indicate stellar effective temperature. The two feature vectors and raw data are input into three neural networks, respectively, for training and each network votes for a predicted category of spectra. By selecting the class having the maximum votes, different types of spectra can be classified with high accuracy. The experimental results prove that a better performance can be achieved using the partial and general methods in this paper. The method could also be applied to other similar one-dimensional spectra, and the concepts proposed could ultimately expand the scope of machine learning application in astronomical spectral processing
Evidence supporting the use of Combretum nigricans as an antimalarial agent in ethnomedicine
No full textBackground: Combretum nigricans (Combretaceae) is a small, smooth bark tree used in traditional medicine for the treatment of prurigo, dysentery, fever and other symptoms of acute malaria in North-Central Nigeria. Materials and Methods: The antimalarial activity of C nigricans hydro-methanol crude leaf extract was evaluated against Plasmodium berghei in mice. The Peters’ 4-day suppressive test against early malaria infection and Rane’s curative test against established malaria were employed in assessing the antimalarial activity of the crude extract. In each test model, five groups containing five mice each were used. Group 1 mice were administered with 10 ml distilled water/kg b.w. p.o., groups 2 - 4 were administered with 200, 400, and 800 mg extract/kg b.w. p.o. respectively, while group 5 mice were administered with artesunate 10 mg/kg b.w. p.o. Result: All doses of C. nigricans extract employed for the study (200 – 800 mg/kg b.w. p.o.) gave significant (P<0.05) chemosuppressive effect against P. berghei, this effect was observed to be dose-related; while the 400 mg/kg extract dose gave the highest curative effect. Compared to control, the extract also prolonged the mean survival time at all doses, and as well prevented the characteristic decrease in body temperature elicited by P. berghei in mice. The LD50 of the extract was >5000 mg/kg b.w. p.o. in mice. Conclusion: The result from the study indicates that C. nigicans crude leaf extract is safe orally and possesses significant antimalarial activity
HYPOMAGNESAEMIA AND HYPOCALCAEMIA THE MAJOR MISSED OUT CLINICAL CONDITION IN THE MANAGEMENT OF DIABETES
No full textMagnesium (Mg) and Calcium (Ca) is one of the essential factors for the insulin to get released from the pancreatic cell. To evaluate the relation of hypomagnesemia and hypocalcaemia in the glycaemic control and to analyse the importance of both Mg and Ca in the insulin secretion mechanism. The study was conducted in the laboratory department, Billroth hospitals. A total of 239 individuals were selected for this study, HbA1c level, serum magnesium and calcium were assessed for all the individuals and in addition to this serum electrolytes were also checked. Out of 239 individuals, 79 were found out as uncontrolled diabetic by calculating HbA1c as a gold standard, males are higher in ratio compared to female. By studying serum magnesium and calcium level, hypocalcaemia is present in more individuals and females (31%) are much prone to both than males (20%). The different correlation was also analysed for hypomagnesemia and hypocalcaemia. The electrolytes like sodium (Na) and potassium (K) was analysed, females are highly affected by electrolyte imbalance but in hypomagnesemia diabetic individuals the males are high in electrolyte imbalance. Since Mg and Ca plays a vital role in insulin synthesis, secretion, repair, and the alteration, along with the hypoglycaemic agents the supplementation of magnesium or calcium could be suggested via, dietary or drug supplements. In addition to this, regular monitoring of electrolytes is essential to maintain fluid balance