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ミトコンドリア局在プロテアーゼCLPP による病原性ミトコンドリアtRNA 2-チオウリジン修飾酵素MTU1の分解促進とミトコンドリア病発症機序に関する研究
Get PDF熊本大学博士（医学）thesi
Super-resolution deep learning reconstruction approach for enhanced visualization in lumbar spine MR bone imaging
No full texthttps://www.sciencedirect.com/science/article/am/pii/S0720048X24003036journal articl
Relationship between the root processing method and quality of herbal medicine of Rauvolfia serpentina cultivated in Japan
Get PDFRauvolfia serpentina roots are used as herbal medicine for snake and insect bites, fever, malaria, abdominal pain, hypertension, and dysentery in Southeast Asian countries. This study evaluates the content of reserpine, ajmaline, and ajmalicine in R. serpentina roots obtained with an efficient root processing method. The plants were cultivated in Tanegashima Island in southern part of Japan, where NIBIOHN's experimental farm station is located. We examined both the type of cork layer removal method (manual work, drum mixer washing, and high-pressure washing) and dried roots. We found that the resulting active ingredient contents were not significantly different between manual work and 30 min of drum mixer washing, and high-pressure washing. The washing in a drum mixer for 30 min could be an efficient root processing method. The amount of each active ingredient was compared in each root part (large-, middle-, and small-diameter roots), and there were no significant difference in their contents. In conclusion, R. serpentina roots having a diameter ≥ 0.5 cm contain a similar amount of active ingredients, suggesting that the quality of the crude drug does not vary in the root part. Thus, our study provides significant insights into the use of R. serpentina roots for herbal medicine applications as well as constituents of active ingredients.journal articl