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مرور نظاممند نقش دین و سلامت معنوی در پیشگیری و مقابله با خودکشی در ایران
No full textخلفية البحث وأهدافه: يُعدّ الانتحار أحد أبرز القضايا المثيرة للقلق في مجال الصحة العامة في إيران، حيث تم الإبلاغ عن معدلات متزايدة بين مختلف الفئات السكانية. إن فهم العوامل التي تسهم في ضبط السلوكيات الانتحارية أمر بالغ الأهمية لتطوير استراتيجيات فعّالة للوقاية. من بين هذه العوامل، يُعَدُّ الدين والصحة الروحية من العوامل الوقائية التي قد تساهم في تقليل خطر الانتحار. تهدف هذه الدراسة إلى مراجعة دور الدين والصحة الروحية في الوقاية من الأفكار والسلوكيات الانتحارية ومواجهتها بين مختلف شرائح المجتمع الإيراني.
منهجية البحث: أُجريت هذه الدراسة المنهجية من خلال بحث شامل في قواعد البيانات المحلية والدولية، بما في ذلك ,Web of Science ,PubMed SID ,Magiranومحرك البحث العامGoogle scholar. تم تقييد استراتيجية البحث باستخدام اللغتين الفارسية والإنجليزية لتحديد الدراسات التي تناولت العلاقة بين المعتقدات الدينية، الصحة الروحية، والسلوكيات الانتحارية في المجتمع الإيراني. شملت معايير الإدراج الدراسات التجريبية المنشورة في المجلات المحكمة بين عامي 2014 و2024. تم استخراج البيانات وتحليلها لتحديد الموضوعات والنتائج الرئيسة المتعلقة بالتأثيرات الوقائية للدين والروحانية على السلوكيات الانتحارية. لم يذكر المؤلفون وجود أي تضارب في المصالح.
المعطیات: من بين 208 دراسة تمت مراجعتها، تم اختيار 10 دراسات استوفت معايير الإدراج. اشتملت هذه الدراسات على تصاميم بحثية متنوعة وناقشت الجوانب المتعلقة بتأثير الصحة الروحية على تقليل الأفكار الانتحارية. أظهرت الدراسة الحالية أنّ الأفراد ذوي المستويات الأعلى من الصحة الروحية والمشاركة الدينية الفعّالة كانوا أقل عرضة للأفكار والسلوكيات الانتحارية. كما بينت النتائج الرئيسة أنّ الأنشطة الروحية مثل الدعاء والمشاركة المجتمعية تساهم في تحسين التنظيم العاطفي وتقديم الدعم الاجتماعي، وهما عاملان حاسمان في تعزيز الصمود أمام الأفكار الانتحارية.
الاستنتاج: تؤكد هذه المراجعة المنهجية على أهمية مراعاة الدين والصحة الروحية في فهم ومنع السلوكيات الانتحارية في إيران. إنّ ادماج هذه العناصر في استراتيجيات الصحة النفسية يمكن أن يوفر رؤىً ودعمًا قيّمًا للأشخاص الذين يواجهون أفكارًا انتحاريةً، مما يساهم في نهاية المطاف في الوقاية من السلوك الانتحاري وتحسين نتائج الصحة النفسية في المجتمع الإيراني.Background and Objective: Suicide remains a significant public health concern in Iran, with increasing rates reported among various populations. Understanding the factors that contribute to suicidal behavior is crucial for developing effective prevention strategies. Among these factors, religion and spiritual health have emerged as potential protective elements that may reduce the risk of suicide. This systematic review aims to investigate the role of religion and spiritual health in preventing and addressing suicidal ideation and attempts among different populations in Iran.
Methods: A comprehensive search was conducted in the literature across several databases, including PubMed, Scopus, and Google Scholar, to identify studies that examined the relationship between religious beliefs, spiritual health, and suicidal behavior in Iranian populations. Inclusion criteria encompassed empirical studies published in peer-reviewed journals from 2010 to 2024. Data were extracted and analyzed to identify key themes and outcomes related to the protective effects of religion and spirituality on suicidal behavior. The authors reported no conflicts of interest in this study.
Results: In total, out of the 208 examined studies, 10 met the inclusion criteria and were selected for the review purpose. These studies encompassed various research designs and explored different aspects of the impact of spiritual health on reducing suicidal thoughts. The review identified several studies indicating that higher levels of spiritual well-being and active religious involvement correlate with a lower likelihood of suicidal thoughts and attempts. Key findings revealed that spiritual practices, such as prayer and community involvement, enhance emotional regulation and provide social support, which are critical factors in resilience against suicidal ideation.
Conclusion: This systematic review underscores the importance of considering religion and spiritual health in understanding and preventing suicidal behavior in Iran. Incorporating these elements into mental health strategies may provide valuable insights and support for individuals facing suicidal ideation, ultimately contributing to improved mental health outcomes in Iranian populations.سابقه و هدف: خودکشی یکی از نگرانیهای عمدۀ بهداشت عمومی در ایران است و نرخهای روبهرشدی در میان گروههای مختلف گزارش شده است. درک عواملی که به کنترل رفتارهای خودکشی کمک میکند برای توسعۀ راهبردهای پیشگیری مؤثر بسیار مهم است. از جملۀ این عوامل مذهب و سلامت معنوی بهعنوان عوامل محافظتکنندهای که ممکن است خطر خودکشی را کاهش دهند، شناخته شده است. پژوهش حاضر به بررسی نقش مذهب و سلامت معنوی در پیشگیری و مقابله با افکار و اقدام به خودکشی در جمعیتهای مختلف ایران پرداخته است.
روش کار: این مطالعۀ مروری از طریق جستوجوی جامع در پایگاههای اطلاعاتی داخلی و بینالمللی از جمله پابمد، وبآوساینس، مگیران و اسآیدی و موتور جستوجوی عمومی گوگل اسکولار انجام شد. راهبرد جستوجو با استفاده از دو زبان فارسی و انگلیسی محدود شد تا مطالعاتی که رابطۀ بین باورهای مذهبی، سلامت معنوی و رفتارهای خودکشی را در جمعیتهای ایرانی بررسی کردهاند، شناسایی شود. معیارهای ورود شامل مطالعات تجربی منتشرشده در نشریات داوریشده از سال ۲۰۱4 تا ۲۰۲۴ بود. دادهها استخراج و تحلیل شد تا موضوعات و نتایج کلیدی مربوط به تأثیرات محافظتی مذهب و معنویت بر رفتارهای خودکشی شناسایی شود. مؤلفان مقاله تضاد منافعی گزارش نکردهاند.
یافتهها: در مجموع، از بین 208 مطالعۀ بررسیشده، ۱۰ مطالعه مطابق با معیارهای ورود به پژوهش انتخاب شد. این مطالعات شامل طراحیهای مختلف پژوهشی بود و در آنها جنبههای مرتبط با تأثیر سلامت معنوی بر کاهش افکار خودکشی بررسی شده بود. مطالعۀ حاضر نشان داد افراد با سطوح بالاتر سلامت معنوی و مشارکت فعال مذهبی با احتمال کمتری دچار افکار و اقدام به خودکشی میشوند. نتایج کلیدی نشان داده است که فعالیتهای معنوی مانند دعا و مشارکت در جامعه به بهبود تنظیم هیجانی و ارائۀ حمایت اجتماعی کمک میکنند که از عوامل بحرانی در افزایش تابآوری در برابر افکار خودکشی هستند.
نتیجهگیری: این مرور نظاممند بر اهمیت در نظر گرفتن مذهب و سلامت معنوی در درک و پیشگیری از رفتارهای خودکشی در ایران تأکید میکند. گنجاندن این عناصر در راهبردهای بهداشت روانی میتواند بینشها و حمایتهای ارزشمندی برای افرادی که با افکار خودکشی مواجه هستند، فراهم کند و درنهایت به پیشگیری از اقدام به خودکشی و بهبود نتایج سلامت روان در جمعیتهای ایرانی کمک کند
بررسی نقش تأمین نیازهای معنوی همسران در ارتقای کیفیت زندگی: رویکردی مبتنی بر سلامت معنوی قرآنبنیاد
No full textخلفية البحث وأهدافه: تمثل الصحة الروحية المستوحاة من القرآن اتجاهًا حدیثًا في دراسات الصحة الروحية، وهي تقوم على آيات القرآن الكريم، وتَتَجَلّى من خلال عدة مصادیق مثل التزكية، والحياة الطيبة، والتقوى، والسلام، وتتسع إلی عوالم الغيب والشهادة. الأسرة واحتياجات الزوجين الروحية إحدى المجالات التي تؤثّر فيها هذه المقاربة، حيث ينعكس ذلك إيجابياً على تعزيز جودة حياتهما. یهدف هذا البحث إلى دراسة دور تلبیة الاحتياجات الروحية لدى الزوجين لتحسین جودة حياتهما، وذلك من منظور هذا البحث.
منهجية البحث: تعتمد هذه الدراسة على منهجٍ يجمع بين الاتجاهین النظري والتحليلي، وقد تمّ جمع البيانات بأسلوب مكتبي من خلال التدوين اليدوي والإلكتروني. في البداية، تمّت مراجعة الدراسات السابقة المحلية في هذا المجال، حيث جرى استخراج العوامل المؤثّرة في تلبية الاحتياجات الروحية لدى الزوجين وتصنيفها. وفي المرحلة التالية، تمّ جمع وتحليل الشواهد والنماذج القرآنية المرتبطة بكلّ عامل، وذلك استناداً إلى منهج الصحة الروحية المستندة إلى القرآن الكريم. ولم یُذکر أي تعارض في المصالح من قبل مؤلفي المقالة.
المعطیات: أدّت نتائج البحث إلى التصنیف الثلاثي للعوامل الإعتقادية والأخلاقية والقیمیة والثقافیة و المناسبات الإجتماعية المؤثرة في تلبية الإحتياجات الروحية للزوجين. العوامل الإعتقادية تأثِّر على النظام الإدراكي للإنسان في أربع مجالاتها، الوجود "الكينونة"، نقطة البداية والغاية المفهومة، العوامل الأخلاقية و الدوافع القيمية مع التركيز على تقليل النواقص الأخلاقية، تعزيز الدعم الروحي بين الزوجين و تصحيح التصورات الجنسية و الدوافع الإجتماعية مع التركيز على التهذيب الروحي الواسع، تعزيز السمعة "المكانة" الإجتماعية، تنسيق المشاعر داخل الأسرة و تعزيز الإتصال الروحي المحوري في العبادة يؤدي دورًا إيجابيًا في تغطية الإحتياجات الروحية بين الزوجين.
الاستنتاج: تؤكد مُعطيات هذا البحث على أهمية الإهتمام بالإحتياجات الروحية للزوجين و دَوْره المؤثر في تحسين العلاقة بین أفراد الأسرة و تدلّ على أنّ الإهتمام بهذه الإحتياجات، بالإستعانة من توجيهات القرآن الكريم، تساهم في تحقيق حياة ذات معنى.Background and Objective: The Quran-based spiritual health is a new approach in the studies of spiritual health, which has been manifested in the form of Quranic concepts such as cultivation, good life, piety and peace, and its scope includes the worlds of the unseen and the intuitive as well. One of the areas affected by this approach is the family and spiritual needs of couples, which has a positive effect on improving their quality of life. The purpose of this research is to investigate the role of satisfying spiritual needs of spouses in improving their quality of life from the perspective of this approach.
Methods: The present research method is a combination of review and analytical research, the information of which was collected using library sources and through manual and electronic receipt taking. First, by reviewing domestic studies in this field, factors affecting the spiritual needs of spouses were extracted and categorized, and in the next step, Quranic evidence and indicators related to each of the factors were presented and analyzed based on the Quran-based spiritual health approach. The authors of the article reported no conflicts of interest.
Results: The findings resulted in a tripartite categorization of the factors influencing the fulfillment of spouses' spiritual needs: beliefs, ethics and values, and social culture and relations. Belief-related factors, by influencing the human cognitive system in four dimensions -self, existence, origin, and purpose- ethical and value-based factors, focusing on reducing moral deficiencies, strengthening spiritual support for spouses, and reforming gender-based concepts, and social factors, emphasizing comprehensive spiritual education, enhancing social status, regulating intra-family emotions, and strengthening prayer-centered spiritual connection, all play a positive role in meeting the spiritual needs of spouses.
Conclusion: The findings of the present study underscore the significance of addressing the spiritual needs of couples and its substantial impact on improving their quality of life. The study demonstrates that paying attention to these needs, guided by the teachings of the Quran, can contribute to the realization of a meaningful life.سابقه و هدف: سلامت معنوی قرآنبنیاد رویکردی نوین در مطالعات سلامت معنوی است که با ابتناء بر آیات قرآن کریم در قالب مصادیقی نظیر تزکیه، حیات طیّبه، تقوا و سلام تجلی یافته است و گستره آن تا عوالم غیب و شهود را نیز در بر میگیرد. یکی از عرصههای تأثیرگذاری این رویکرد فضای خانواده و نیازهای معنوی زوجین است که تأثیر مثبتی بر ارتقای کیفیت زندگی آنان دارد. هدف از پژوهش حاضر، بررسی نقش تأمین نیازهای معنوی همسران در ارتقای کیفیت زندگی آنان از منظر این رویکرد است.
روش کار: روش پژوهش حاضر ترکیبی از پژوهش مروری و تحلیلی است که اطلاعات آن بهشیوۀ کتابخانهای و از طریق فیشبرداری دستی و الکترونیکی گردآوری شده است. ابتدا با مرور پیشینۀ پژوهشهای داخلی صورتگرفته در این زمینه، عوامل مؤثر بر تأمین نیازهای معنوی همسران استخراج و دستهبندی شد و در مرحلۀ بعد، شواهد و مصادیق قرآنی مرتبط با هر یک از عوامل بر اساس رویکرد سلامت معنوی قرآنبنیاد ارائه و تحلیل شد. مؤلفان مقاله تضاد منافعی گزارش نکردهاند.
یافتهها: نتایج پژوهش منجر به دستهبندی سهگانۀ عوامل اعتقادی، اخلاق و ارزشها و فرهنگ و مناسبات اجتماعی مؤثر بر تأمین نیازهای معنوی همسران شد. عوامل اعتقادی با تأثیرگذاری بر نظام ادراکی انسان در چهار فضای خود، هستی، مبدأ و غایت ادراکشده، عوامل اخلاقی و ارزشی با تمرکز بر کاهش کاستیهای اخلاقی، تقویت یاریگری معنوی همسران و اصلاح پندارههای جنسیتی و عوامل اجتماعی با تمرکز بر تربیت معنوی فراگیر، تقویت حیثیت اجتماعی، تنظیم عواطف درون خانوادگی و تقویت ارتباط معنوی نیایشمحور نقشی مثبت در تأمین نیازهای معنوی همسران ایفا میکنند.
نتیجهگیری: یافتههای این پژوهش بر اهمیت توجه به نیازهای معنوی زوجین و نقش مؤثر آن در بهبود کیفیت زندگی آنان تأکید میکند و نشان میدهد که توجه به این نیازها با بهرهگیری از رهنمودهای قرآن کریم میتواند به تحقق زندگی معنادار کمک کند
Transdiagnostic Mechanisms in Autism Spectrum Disorder and Its Common Comorbidities: A review selected literature
No full textIntroduction:Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition marked by persistent social-communicative deficits and repetitive behaviors. Its wide clinical heterogeneity and frequent psychiatric comorbidities, such as anxiety, obsessive-compulsive disorder (OCD), and attention-deficit/hyperactivity disorder (ADHD), challenge traditional diagnostic models. Given these complexities, the transdiagnostic approach has gained attention for targeting shared psychological and neurobiological mechanisms that transcend categorical diagnoses. The main purpose of this study was to review and synthesize existing articles on transdiagnostic mechanisms relevant to ASD and its common comorbidities.
Method:This systematic review was conducted in accordance with PRISMA guidelines. A comprehensive literature search was performed in PubMed, Scopus, and PsycINFO for studies published from 2010 to 2024. Eligible studies examined emotion regulation, cognitive flexibility, or neural connectivity in individuals with ASD.
Result:Seventeen studies met inclusion criteria. Emotion regulation deficits, cognitive inflexibility, and atypical neural connectivity emerged as prominent transdiagnostic factors. These processes were consistently linked to broader symptom profiles and psychiatric comorbidities.Conclusion:Identifying and addressing these shared mechanisms may improve intervention outcomes across diagnostic categories and support more personalized care in ASD. Integrating transdiagnostic insights into clinical practice could enhance functional outcomes and quality of life for individuals with ASD
Profile of Myopic Patients with Convergence Insufficiency at an Eye Care Center in Northern India
Full text linkPurpose: This study aimed to evaluate the profile of myopic patients suffering from convergence insufficiency (CI) at an eye care center in northern India.Patients and Methods: A total of 172 myopic patients aged 5 to 39 years who attended Tamojyoti Netralaya eye clinic, Gurugram, India, from December 2023 to December 2024 were included. All patients underwent comprehensive ophthalmic evaluations, including visual acuity, subjective refraction, and assessments of near point of convergence (NPC), accommodative functions, positive fusional vergence (PFV) and negative fusional vergence (NFV).Results: CI was prevalent among myopic patients, and patients with compound myopic astigmatism showed a higher rate of CI. The degree of CI increased with age and the severity of myopia. Notably, even low degrees of myopia (0.5 D and above) were associated with CI.Conclusion: Our study results indicate that CI is commonly associated with myopia. CI was more prevalent in patients with compound myopic astigmatism, especially among adults aged 20–24 years. Therefore, regular eye examinations are essential to reduce asthenopic symptoms in these patients
Bilateral Horizontal Vogt’s Striae: A Case Report
Full text linkCase Report: A 30-year-old male presented with progressive blurred vision and a suspected family history of KCN. Clinical examination revealed high astigmatism, a scissor reflex on retinoscopy, and fine horizontal striae in the posterior stroma and Descemet’s membrane of both corneas, resembling Vogt’s striae. Pentacam imaging confirmed the diagnosis of KCN, demonstrating central corneal thinning, elevated front and back elevation maps, and high dioptric power points in the curvature map of both eyes. Due to intolerance to rigid gas permeable (RGP) lenses, deep anterior lamellar keratoplasty (DALK) was performed as the definitive treatment.Conclusion: This case highlights a rare bilateral presentation of horizontal Vogt’s striae in KCN, an uncommon slit-lamp finding. The presence of these atypical stress lines may be attributed to mechanical stretching or corneal distortion induced by the cone. Recognizing such rare variations can enhance the understanding of KCN pathophysiology and aid in its clinical diagnosis and management
A Comparative Study on the Efficacy of Lignocaine with Adrenaline and Ropivacaine for Post Tonsillectomy Pain Relief
Full text linkBackground: Post-operative pharyngeal pain is one of the major problems with tonsillectomy. Thus, Adequate analgesia is crucial in the immediate post-operative period, which enables the patients to speak and swallow normally. Though there are various routes to administer the anesthetic agents, intraoperative peritonsillar injection of local anesthetics is one of the preferred technique.
Aim: The present study was done to find out the effectiveness of lignocaine with adrenaline versus ropivacaine in controlling post-operative pain and intra operative blood loss.
Methods: The study was conducted at Karuna Medical College, Kerala India, in which patients undergoing tonsillectomy for standard indications were included in the study. The patients were randomly divided into two groups- Group L and group R. The anesthetic agent was then injected into the peritonsillar region. Group L received lignocaine and group R received Ropivacaine. Intraoperative blood loss and pain during swallowing, speech, and at rest were assessed using visual analogue scale at 4, 8, 12 and 24-hours post-surgery.
Results: Lignocaine group showed slightly higher pain levels during swallowing, speaking, and at rest compared to ropivacaine at various intervals. Mean pain scores were significantly lower in Group R, at 4, 8, 12, and 24-hours post-surgery, with p-values <0.05. Additionally, ropivacaine demonstrated superior pain control, particularly during speech and swallowing. No significant correlations were observed between age, gender, or indications and pain levels.
Conclusion: Both ropivacaine and lignocaine with adrenaline can be used as effective local anesthetics in achieving post-operative pain control after tonsillectomy. Ropivacaine provides significantly better postoperative pain control compared to lignocaine with adrenaline in patients undergoing tonsillectomy
Synthesis, Characterization, and Investigation of Performance of Fe-MOF and Fe-MOF/Fe3O4 in Adsorption and Release of Naproxen as a Non-steroid Anti-inflammatory Drug (NSAID): Synthesis, Characterization, and Investigation of Performance of Fe-MOF
No full textDeveloping materials with a high capacity for drug adsorption and slow-releasing properties is promising in drug delivery. Metal-organic frameworks (MOFs) are materials with high adsorption and desorption capacities. Therefore, they can be very effective in targeted drug therapy. In this study, two Fe-MIL101 samples with different synthesis times (24 and 48 hours) were synthesized by solvothermal method and used as a naproxen carrier for the first time. The samples were analyzed using BET, FT-IR, XRD, and FESEM structural analyses at the nanoscale. The pHpzc of the Fe-MIL101 (48h) and Fe-MIL101/Fe3O4 was determined to be 3.3 and 3.5, respectively. The adsorption of the Naproxen on Fe-MIL-101/Fe3O4 followed the Freundlich adsorption isotherm (R²=0.996), indicating the multilayer adsorption of Naproxen molecules on the carriers. The release of naproxen from carriers was investigated at a phosphate-buffered saline (PBS( with a pH of 7.4 (the pH of human blood). The variables of release time, carrier synthesis time, and pH of the environment were considered in this study. The most effective release was with Fe-MIL-101/Fe3O4 synthesized over 48 hours. This method followed the kinetic model of Korsmeyer-Peppas (R²= 0.9843) with a release exponent (n) of 0.63, meaning that the naproxen release from MOFs follows the non-Fickian mechanism. To develop a magnetic and slow-releasing carrier, Fe-MIL-101/Fe3O4 was synthesized. The studies showed that naproxen release from Fe-MIL-101/Fe3O4 is slow and takes a long time. The n in Korsmeyer-Peppas mole for naproxen release from Fe-MIL-101/Fe3O4 was 0.886, indicating a case II transport mechanism for naproxen release with a constant release rate. The findings highlight the significant potential of Fe-MIL-101/Fe3O4 for enhancing targeted drug delivery, underscoring its importance in improving therapeutic outcomes
Evaluation of Anthelmintic Properties of Kalanchoe petitiana Essential Oil and Extracts on Caenorhabditis elegans
Full text linkThis study explores the chemical composition and anthelmintic activity of essential oils and extracts derived from the roots of Kalanchoe petitiana (Crassulaceae), a plant traditionally used in Ethiopian and Eritrean medicine. Essential oils were extracted through hydrodistillation and analyzed using gas chromatography-mass spectrometry (GC-MS), revealing 30 volatile compounds, with trans-myrtanol (43.23%), 1-octen-3-ol (5.43%), and bisabolene (6.02%) as the major components. The anthelmintic efficacy of the extracts and essential oil was evaluated in vitro against Caenorhabditis elegans nematodes. The methanol root extract exhibited significant nematocidal activity, achieving 91.5% mortality at a concentration of 10 mg/mL, while the chloroform root fraction demonstrated 61.7% efficacy at 2 mg/mL. The essential oil showed a potent effect with a 92.4% nematocidal rate at 60 μg/mL, closely comparable to the reference drug ivermectin (97.6% at 10 μg/mL). These results suggest that K. petitiana possesses substantial anthelmintic potential, likely due to its rich terpene content, particularly trans-myrtanol. This study provides the first report of trans-myrtanol identification from Kalanchoe species and supports using K. petitiana as a natural alternative for managing helminthic infections. Further research is recommended to isolate and characterize the active compounds and evaluate their vivo efficacy and safety
Comparison the Efficacy of Tetracycline and Triamcinolone Mucoadhesive Gels in Recurrent Aphthous Stomatitis: A preliminary Comparative Study
No full textRecurrent Aphthous Stomatitis (RAS) is a widespread oral condition characterized by painful lesions on the oral mucosa, affecting about 20-25% of the population, with a higher occurrence in females. The etiology remains unclear, but factors such as infections, nutritional deficiencies, and stress have been implicated. Current treatments often focus on symptom relief, and while topical formulations are common, their efficacy is limited by poor retention at the site of action. This study aims to develop a mucoadhesive gel containing Tetracycline (TC) and evaluate its effectiveness compared to a Triamcinolone (Tri) gel in treating RAS.
60 participants aged between 20-50 with RAS were recruited for a randomized double-blind clinical evaluation. Two groups of patients were formed, one of which received TC-gel and the other Tri-gel. Gel formulations were prepared using carboxymethyl cellulose (CMC) and Carbopol, with pH, in vitro drug release, mucoadhesive strength, and residence time assessed. Clinical evaluations included measuring ulcer diameter, pain intensity via the Visual Analogue Scale (VAS), and patient satisfaction over a 10-day treatment period.
The TC-gel demonstrated a mean pH of 6.63 and released 95.74% of TC after 240 minutes. The mucoadhesive strength was 1.59 N, with a residence time of 78 minutes. Both gels significantly reduced ulcer diameter and pain levels by day 10, with no significant differences between groups. Patient satisfaction was high, with 73% reporting excellent or good outcomes for both gels.
The TC-gel is an effective treatment for RAS, comparable to Tri-gel, with promising mucoadhesive properties and patient satisfaction. These findings support the potential of TC-gel as a viable therapeutic option for managing RAS symptom
In silico Approaches to Identify Phthalic Acid Derivatives as Inhibitors Tyrosinase, α-Glucosidase, and Dipeptidyl peptidase-4: In silico Approaches to Identify Phthalic Acid Derivatives
No full textIntegrating scientific and technological development in medicinal chemistry implies a great leap forward and speeds up the low-cost drug discovery process from natural resources. Therefore, in silico approaches were performed through molecular docking involving receptors crucial in metabolic processes, aiming to gain insights into how free radicals bind and how blood sugar levels can be lowered. The research aims to study the inhibitory mechanisms of phthalic acid derivatives such as tyrosine enzymes, alpha-glucosidase, and dipeptidyl peptidase-4 with in silico predictions. The in silico prediction instrument is in the form of computing software. Additional ligand sources were gained from a database of tyrosinase enzyme receptor (6JU9), alpha-glucosidase receptor (2JKE), and dipeptidyl peptidase-4 (1N1M). The active ingredients of Kenikir and Yacon leaves are used as test compounds with comparison drugs such as acarbose. The Diisooctyl Phthalate compound has an antioxidant potential through the 6JU9 target protein, with the most stable docking score of -81, 07. The target proteins for reducing blood sugar levels each have a value of -61.606 (2JKE ligand) and -86.945 (1N1M ligand). It is concluded that natural resources (Cosmos caudatus and Smallanthus sonchifolius) showed potential as natural drugs with an in silico approach study