RocScholar (Rochester Regional Health)
Not a member yet
3788 research outputs found
Sort by
Trends in sepsis-related mortality among patients with Acute Myeloid Leukemia: A 24-year nationwide analysis
No full textTrends in chronic lymphocytic leukemia mortality among older adults with renal failure in the United States: A 25-year retrospective study
No full textEfficacy and safety of brentuximab vedotin versus standard therapy for cutaneous T-cell lymphoma: A systematic review and meta-analysis
No full textS3764 Colo-Cutaneous Fistula Formation Secondary to Infected Mesh Leading to Recurrent Abscess Formation Successfully Treated With an Over the Scope Clip (OTSC)
No full textCharacterization and risk factors of anticoagulation-related bleeding in patients with thrombotic antiphospholipid syndrome: An analysis using a synthetic real-world data platform
No full textExternal validation of TTP-14: A novel machine learning model that improves rapid diagnosis of immune TTP
No full textThrombotic Microangiopathies
No full textThrombotic Microangiopathies. Dr. Ahmed Salman, Hematology/Oncology, Rochester General Hospital
Objectives: To be able to recognize different TMAs and learn treatment modalitie
Non-bacterial thrombotic endocarditis: a clinical and pathophysiological reappraisal
No full textNon-bacterial thrombotic endocarditis (NBTE), formerly recognized as marantic endocarditis, represents a rare cardiovascular pathology intricately linked with hypercoagulable states, notably malignancy and autoimmune disorders. Characterized by the development of sterile vegetations comprised of fibrin and platelets on cardiac valves, NBTE poses a diagnostic challenge due to its resemblance to infective endocarditis. Therapeutic endeavours primarily revolve around addressing the underlying aetiology and instituting anticoagulant regimens to forestall embolic events, with surgical intervention seldom warranted. Non-bacterial thrombotic endocarditis frequently coexists with malignancies and autoimmune conditions, such as lupus and antiphospholipid antibody syndrome, and, more recently, has been associated with COVID-19. Its pathogenesis is underpinned by a complex interplay of endothelial dysfunction, hypercoagulability, hypoxia, and immune complex deposition. Clinical manifestations typically manifest as embolic phenomena, particularly cerebrovascular accidents, bearing substantial mortality rates. Diagnosis necessitates a high index of suspicion and meticulous exclusion of infective endocarditis, often facilitated by advanced cardiac imaging modalities. Anticoagulation, typically employing low molecular weight heparin or warfarin, constitutes the cornerstone of pharmacological intervention. Surgical recourse may be warranted in instances of refractory heart failure or recurrent embolic events. Given its multifaceted nature, the management of NBTE mandates a multidisciplinary approach, with prognosis contingent upon individual clinical intricacies. Future endeavours should prioritize further research to refine therapeutic strategies and enhance patient outcomes
Unique Case of Acute Pancreatitis Linked to L-Arginine Supplement Use In A Bodybuilder
Full text linkThe two most common etiologies of acute pancreatitis are alcohol abuse and gallstones which comprise greater than 80% of all cases. There are many other possible etiologies, including hypertriglyceridemia, trauma, ischemia, autoimmune, drugs such as anabolic steroids and toxins such as scorpion venom. We report a unique case of acute pancreatitis in a 34-year-old body-builder related to use of the L-arginine protein product. The patient denied any alcohol use or any use of anabolic steroids for bodybuilding. He had a past medical history of bipolar disorder treated with valproic acid but had no longer been taking this medication for the past 8 months and had never complained of epigastric pain like this in the past. With the most common etiologies of his presentation being ruled out, it was discovered that he had been taking the L-arginine protein product which has been shown in multiple mouse studies to lead to development of acute pancreatitis.
Although the mechanism of L-arginine pancreatitis is not clear, awareness should be raised with the increase of the consumption of supplements among young adults