Jurnal Farmasi Fakultas Kedokteran Universitas Mataram
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Perkembangan targeted therapy pada kanker payudara dengan pertimbangan luaran biaya dan kualitas hidup: narrative review
Full text linkBreast cancer is a malignant tumour that grows in the breast tissue and can spread to the lymph nodes and metastasize to other parts of the body. Targeted therapy is currently developed as a therapeutic management for breast cancer with hormone receptor positive/human epidermal growth factor receptor 2 negative (HR+/HER2-). This review aims to determine the effectiveness both in terms of clinical and cost on the use of single or combined targeted therapy when compared with conventional therapy, namely chemotherapy in breast cancer patients. The results show that the use of targeted therapy can provide greater health benefits in both single and combination use even though it can increase the cost of therapy
Influence of extraction method on total phenolic content and antioxidant activity of Sappan Wood (Caesalpinia sappan L.) extract
Full text linkSappan wood is a botanical species that contains a high concentration of phenolic compounds, which contribute to several pharmacological properties, including antidiabetic, antibacterial, antioxidant, and wound-healing activities. In order to achieve phenolic compounds of high quality and quantity, it is crucial to select an appropriate extraction procedure. Plant extraction is an important step for chemical isolation, chemical analysis, and evaluating the biological and pharmacological activities of plant compounds. Therefore, determining the most favorable extraction conditions is a critical undertaking in order to maximize both the quantity of active plant compounds and the extraction yield. This research aimed to compare extraction methods based on total phenolic content (TPC) and antioxidant activity (IC50). The extraction techniques employed include maceration, stirring-assisted extraction (SAE), ultrasound-assisted extraction (UAE), and microwave-assisted extraction (MAE). The results show TPC values for maceration, SAE, UAE, and MAE, which are 132.85±1.44, 150.99±1.69, 206.70±6.56, and 115.70±1.44 mg GAE/g DE, respectively. The DPPH antioxidant activity (IC50) values are 32.33±2.64, 25.01±0.34, 20.68±0.29, and 29.18±0.70 µg/mL, respectively. The research findings indicate that various extraction procedures can impact the extraction yield, total phenolic content (TPC), and antioxidant activity (IC50) of sappan wood, and UAE is the best extraction method
Pelatihan pembuatan minuman probiotik fermentasi dari limbah kulit nanas (Ananas comosus L.) di Desa Seruawan
Full text linkPineapple skin is an ingredient that can be processed into a probiotic drink. The biggest component of pineapple peel waste besides water is carbohydrates. Pineapple skin can be a good substrate as a source of microbial growth. Pineapple skin can reach 47% of the total fruit and has a chemical composition of 87.80% water, 8.60% sugar and 1.35% reducing sugar. The potential chemical content of pineapple skin has encouraged many researchers to create fermented prebiotic drink products. The ingredients used in making pineapple peel fermented probiotic drinks include: pineapple fruit, fermented yeast, water, palm sugar, cinnamon and granulated sugar. This community service activity was carried out with the aim of educating the public about how to make pineapple peel prebiotic drinks for household scale. There is a need for training in making fermented prebiotic drinks from pineapple peel in local communities. This training will be carried out for the community in Seruawan village, Seram Island, Maluku
Optimasi formula sampo ekstrak etanol daun delima (Punica granatum L.) dengan metode Simplex Lattice Design
Full text linkAnti-dandruff shampoo on the market still uses zinc pyriton which has the side effect of causing hair loss. Pomegranate leaves have strong antifungal activity against dandruff-causing fungi. This research aims to determine the optimum formula and physical properties of pomegranate leaf shampoo preparations with variations of SLS and cocamide DEA. The ethanol extract of pomegranate leaves was extracted by soxhletation and carried out in a tube test. Eight shampoo formula designs were determined using the SLD method. The shampoo was tested for foam height, pH, and viscosity to obtain the optimum formula. The optimum shampoo preparation was tested for physical properties, including organoleptic tests, homogeneity, foam stability, foam height, pH, and viscosity. The results of the test for the physical properties of the optimum shampoo preparation were verified using the SPSS application with the one-sample t-test method. Pomegranate leaf ethanol extract positively contains alkaloids, flavonoids, tannins, and saponins. The optimization results obtained the optimum shampoo formula, namely a combination of SLS 5.5% and cocamide DEA 15.5%. Optimum formula shampoo has a black color, menthol odor, gel form, ingredients mixed homogeneously, foam stability 81.83%, foam height 9.30 ± 0.26 cm, pH 5.91 ± 0.45, and viscosity 1646.66 ± 220.23 cP
Edukasi pembuatan simplisia sebagai bahan baku obat herbal pada siswi MA Darunnajah Duman
Full text linkPlants can be used as medicine (herbs) and used directly or processed into simplisia. Knowledge about plants used as medicine and how to process them among students is still limited. The purpose of this activity is to provide education to students about making simplisia and its benefits in traditional medicine. This education can increase the knowledge and skills of female students in processing herbal plants. The method used was a combination of lectures, discussions, and practical demonstrations of the steps of making simplisia using plants in the MA Darunnajah school. The result of the activity can be seen through the students' improved understanding of herbal plants, from sampling to storing procedures. In conclusion, the student's knowledge about the efficacy of various plants in the school environment increased, and they had good skills in processing fresh plants into simplisia
Evaluasi penggunaan antibiotik pada neonatus di NICU rumah sakit umum milik pemerintah daerah Banyumas
Full text linkInfection is one of the leading causes of death in neonatal patients. One of the causes of these infectious diseases is bacteria, so antibiotics are the primary therapy in treating infections. The harmful effects of improper administration of antibiotics are pathogenic bacterial resistance, unwanted drug reactions, and inefficient treatment costs. The purpose of this study was to evaluate the quality of antibiotic use in neonatal patients treated in the Banyumas District Government Hospital NICU from December 2019 to March 2020 by using the Gyssens flow criteria and knowing the outcome of antibiotic use. This research is descriptive and observational. Data obtained from medical records and patient monitoring data with prospective data collection techniques. The inclusion criteria of this study were neonatal patients who were admitted to the NICU and received antibiotics for prophylactic and curative treatment. Total respondent for this study is 56 patients. The Gyssens flow criteria evaluation results were obtained from 53 medical records (94%)tegorized in category 0. There is one medical record each categorized in categories IV D (2%), IV B (2%), and III A (2%). Most of the use of antibiotics is rational. Antibiotics are not a determining factor for the outcome of patients with the same diagnosis and laboratory test results
Comparison of the total phenolic and flavonoid contents of Amomum compactum Sol. Ex Maton from districts Linggo Asri and Paninggaran, Pekalongan Regency
Full text linkCardamom (Amomum compactum Sol. Ex Maton) is one of the largest contribution in biopharmaceutical production plants in Indonesia that is equal to 12.22% and yield reaching 105.735 kg/year in Pekalongan Regency. The largest cardamom production in Pekalongan Regency is in 2 districts, namely Linggo Asri and Paninggaran. Cardamom is used in traditional medicines, because it has chemical compounds such as flavonoids and phenolics. The aim of this study was to compare total flavonoids and total phenolics content in Amomum compactum Sol. Ex Maton extract originates from Linggo Asri and Paninggaran district, Pekalongan Regency. The samples were extracted by water extraction, and then phytochemical contents were identified with HCl and FeCl3 reagent. The samples were calculated of total flavonoids and total phenolics content by spectrometric using aluminum chloride colorimetric assay and Folin–Ciocalteu method. The result showed a significant difference in the levels of total phenolic content between Amomum compactum Sol. Ex Maton extract origin from Linggo Asri district 41.43±0.54 µg/mg and Paninggaran district 120.55±1.89 µg/mg, but it was not found in total flavonoid content where from Linggo Asri district 289.06±4.1 µg/mg and Paninggaran district 303.81±0.5 µg/mg. The conclusion is Amomum compactum Sol. Ex Maton extract originates from Linggo Asri and Paninggaran district of Pekalongan city showed a significant difference in the levels of total phenolic content, but it was not found in total flavonoid content
Pembuatan sabun mandi padat susu kambing dengan ekstrak eceng gondok (Eichhornia crassipes)
Full text linkKeberadaan eceng gondok di perairan membuat cahaya matahari sulit menembus perairan dan mengurangi kandungan oksigen di dalam perairan. Dengan populasi yang melimpah dan pengendalian yang kurang optimal, eceng gondok digunakan sebagai bahan tambahan dalam pembuatan sabun. Metode yang digunakan dalam pembuatan ekstrak eceng gondok adalah maserasi dengan perendaman selama 1x24 jam. Produk yang dihasilkan adalah sabun susu kambing dengan penambahan ekstrak eceng gondok. Oleh karena itu untuk mengurangi limbah tanaman eceng gondok maka perlu dilakukan pengolahan tanaman eceng gondok menjadi sabun batang organik dengan penambahan susu kambing, sehingga limbah dari tanaman eceng gondok memiliki nilai ekonomi bagi masyarakat, tidak hanya mencemari perairan
Aflatoksin: Aspek kesehatan, metode reduksi dan deteksinya
Full text linkFood contaminant aflatoxin is a mycotoxin produced by Aspergillus flavus and A. parasiticus. This article aims to discover the pathophysiological, immunological, pharmacological, toxicity, and reduction and detection methods of aflatoxin. Kinds of literature were obtained from Research Gate, Pubmed, and Science Direct with the primary keyword “aflatoxinâ€. Pathophysiologically, aflatoxin-contaminated food has been proven to cause necrosis in liver cells, developing into liver cancer. Immunologically, aflatoxin decreases monocyte and dendritic cell phagocytosis, neutrophil cell ATP production, and pro-inflammatory cytokine synthesis. Aflatoxin toxicity is at the LD50 of 12-16 mg/kg b.w, causing death. Pharmacologically, 120-201 µg/kg b.w causes aflatoxicosis, in vivo studies indicated that NovaSil, Sulfarophan, and Monanthotaxis caffra leaf extract may reduce its toxicity. Aflatoxins are highly thermostable; hence, once food has been contaminated, they cannot be destroyed by normal cooking process. The control and reduction should be conducted in post-harvest handling, common physical means practiced are heating, drying, and smoking. Chemically using ozone, 0.5 sodium bisulfate, 1% sodium hydroxide, 5% acetic acid, and prochloraz. Biologically using Flavobacterium aurantiacum B-184, Bacillus velezensis DY3108, and, a consortium of Geobacillus and Tepidimicrobium bacteria. Aflatoxin can be detected using TLC, HPLC, MS, ELISA, and UHPLC-ESI MS/MS. The prevention of aflatoxin occurrence is done through good post-harvest handling, good manufacturing practices, and applying regulations accordingly to ensure food products and feed are at acceptable levels of aflatoxin
Pelatihan pendampingan orang tua dalam edukasi gizi dan makanan sehat anak usia dini
Full text linkOne of the key factors that affects a child's development is their level of  health and nutrition. Health and nutrition are very important because it can support optimal growth and development. Children need balanced nutrition to stay healthy and have optimal development. The intention of this activity is to educate the public and conduct workshops on the advantages of a healthy diet for kids' growth and development.  The target of this training is mothers who have early childhood (0-8 years) who are in Way Hui Village. Three steps are taken to resolve a problem, these are; 1) Stage of initial; 2) Stage of implementation; and 3) the last stage. The evaluation activity is carried out for every stage by collecting and concluding data. The results of the correlation test showed that there were differences in skill abilities before and after the training given to parents. This is evidenced by the difference in the average  pretest score of 48.33 and the average  posttest of 80.33. By increasing the value of the posttest, It showed that a person's abilities and skills can be developed through existing knowledge and followed up with training that supports improving the expected skills