Jurnal Farmasi Fakultas Kedokteran Universitas Mataram
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Warna-warni berbahaya: edukasi bahaya pewarna kimia pada jajanan anak sekolah di desa Karang Bunga
Full text linkChildren are highly exposed to various snacks sold freely around schools, many of which may contain hazardous synthetic food dyes. These dyes can pose health risks, especially when consumed continuously without supervision. This community service aimed to increase students' awareness at SDN Karang Bunga about the dangers of synthetic food coloring in school snacks. The activity was conducted through counseling and education sessions on June 27, 2024. Methods included presentations, discussions, games, pretests and posttests, and questionnaire-based evaluations. The results showed increased knowledge based on the pretest and posttest scores and high satisfaction from teachers and students. This program is expected to build critical awareness among school-aged children in choosing safe food
Physical characterization of paracetamol granule preparation using goroho banana starch as binder and disintegrant
Full text linkThe research aims to formulate Goroho banana starch (GBS) as a binding and disintegrating agent in paracetamol (PCT) granule preparations. PCT granules were made using GBS as a binding agent in 3 concentrations of 6, 8, and 10%, respectively. PCT granules using GBS as a disintegrating agent were made with three concentrations of 10, 15, and 20%, respectively. Paracetamol granules are made using the wet granulation method. Granules were evaluated using six parameters: flow rate, angle of repose, water content, bulk density, tapped density, and compressibility index. GBS as a binder showed good physical properties. F1 (6% GBS) showed a flow rate of 8.1 g/sec, an angle of repose of 22.9 degrees, a water content of 1.2%, and a compressibility index of 19.3%. F2 (8% GBS) shows a flow rate of 8.5 g/sec, an angle of repose of 18.5 degrees, a water content of 1.3%, and a compressibility index of 17.6%. F3 (10% GBS) shows a flow rate of 9.0 g/sec, an angle of repose of 21.5 degrees, a water content of 1.4%, and a compressibility index of 19.3%. 8% GBS showed the best physical properties as a binding agent for PCT granules. GBS as a disintegrating agent, shows excellent physical properties. F4 (10% GBS) shows a flow rate of 12.9 g/sec, an angle of repose of 17.0 degrees, a water content of 4.3%, and a compressibility index of 13.3%. F5 (15% GBS) shows a flow rate of 11.4 g/sec, an angle of repose of 18.0 degrees, a water content of 1.4%, and a compressibility index of 14.5%. F6 (20% GBS) shows a flow rate of 10.7 g/sec, an angle of repose of 23.0 degrees, a water content of 3.5%, and a compressibility index of 14.6%. 10% GBS showed the best physical properties as a disintegrants agent for PCT granules
Kajian aktivitas antioksidan dan sitotoksik ekstrak etil asetat daun jarak pagar (Jatropha curcas)
Full text linkAntioxidants are chemical substances that have the ability to protect body cells from damage caused by excessive oxidation reactions. One of the uses of antioxidants from natural materials is jarak pagar leaves (J. curcas). This study aims to determine the antioxidant and cytotoxic activity against shrimp larvae from ethyl acetate extract of J. curcas leaves. Ethyl acetate extract from J. curcas leaves was extracted using the soxhletation method. Phytochemical testing was carried out using the tube method, antioxidant testing using the DPPH method and cytotoxic using the BSLT method. The results of the research showed that J. curcas contained secondary metabolite compounds in the form of flavonoids and polyphenols, the antioxidant activity test of Ethyl acetate extract from J. curcas leaves and the comparison control (vitamin C) produced an IC50 of 71,79±0.35 ppm and 8.78±0.21 ppm, respectively. The cytotoxic test of the ethyl acetate extract of J. curcas leaves contains active compounds that are toxic to the shrimp larvae with an LC50 of 72.13 ppm (LC50≤1000 ppm). The most effective concentration in free radicals scavenging is 160 ppm. Based on the results obtained, the ethyl acetate extract of J. curcas showed strong antioxidant activity and potential as an anticancer agent
Solusi sehat di lahan sempit: edukasi penanaman TOGA mandiri di perkotaan
Full text linkTanaman Obat Keluarga (TOGA) are a valuable local resource that can be cultivated as an alternative approach to maintaining family health independently. However, public knowledge and practical skills related to the types of TOGA and proper cultivation techniques remain limited. This community service program aimed to improve community awareness and skills in cultivating TOGA within household environments. The program was implemented through socialization activities using educational pamphlets, instructional videos, and interactive door-to-door discussions across three target areas: urban settlements, rural villages, and residential complexes. The results demonstrated a significant improvement in participants' knowledge of TOGA varieties. Before the program, only about 40% of participants were familiar with more than five types of TOGA, which increased to 85% after the socialization activities. Furthermore, over 75% of participants could correctly describe the basic steps of TOGA cultivation, and approximately 60% of households had already begun planting TOGA in their yards or using simple containers such as pots and polybags. Evaluation also revealed strong enthusiasm and active involvement, as evidenced by participants' engagement in discussions and their initiative to form small groups for continuous TOGA development. In conclusion, this community service activity successfully enhanced participants' knowledge, skills, and motivation to cultivate TOGA. The program is expected to contribute to long-term community self-reliance in herbal-based health maintenance and foster the establishment of sustainable TOGA communities within local neighborhoods
Edukasi gema cermat penggunaan antibiotik dengan metode CBIA menggunakan Booklet di Desa Petaling Kabupaten Bangka
Full text linkBased on BPS (2022) data, healthcare facilities in Mendo Barat District are very limited. There is only 1 polyclinic, 2 public health centers, and 2 pharmacies, making it difficult for some residents in remote areas to access available healthcare services. This situation encourages the community to engage in self-medication by purchasing antibiotics from general stores rather than seeking treatment at healthcare facilities. In Petaling Village, many people still use antibiotics freely and store them at home because they stop taking antibiotics when they feel better, which can increase cases of resistance. According to research by Sari & Purba (2024) on antibiotic usage knowledge using leaflet media, the difference between pretest and posttest scores in Petaling Village was not very significant, increasing from 54% to 66%. The partners for this activity are Petaling Village, Mendo Barat District, Bangka Regency. The activity was carried out on June 6th, 2024. The method used was a community empowerment education model to improve skills in selecting medications, known as the Active Learning Method (CBIA), utilizing booklets. The study results showed a significant difference in knowledge before and after providing antibiotic education using booklets, with a p-value of 0.001 > 0.05
Pengendalian nyamuk Aedes aegypti dengan spray serai alami di Desa Gemawang
Full text linkDengue Hemorrhagic Fever (DHF) remains a major public health issue in Indonesia, particularly in areas like Gemawang Village, Temanggung Regency. Chemical insecticides commonly used for mosquito control pose health and environmental risks, necessitating safer alternatives. This study aimed to empower the local community with knowledge and skills to produce a natural mosquito repellent spray using lemongrass (Cymbopogon citratus), which contains citronella and geraniol known for their mosquito-repelling properties. Through a three-month community engagement program, residents participated in educational sessions, practical demonstrations, and were provided with materials to create the spray using lemongrass and 70% ethanol. A total of 100 participants showed a 30% increase in knowledge based on pre-test and post-test results. Additionally, 80% of participants reported regular use of the spray, and 70% observed a decrease in mosquito presence. While participants found the method practical and materials accessible, some noted reduced spray effectiveness over time, indicating a need for improved formulation. This community-based approach not only promoted an eco-friendly alternative to chemical insecticides but also enhanced local capacity for disease prevention. The findings suggest that such participatory programs can contribute significantly to sustainable dengue vector control in endemic areas
The effect of sodium metabisulfite concentration on the physicochemical stability of an L-Ascorbic Acid face mist formulation
Full text linkFace mist is a cosmetic that is included in skin fresheners, is more practical to use, and has the potential to add antioxidants. Vitamin C is one source of antioxidants. Although water-soluble, vitamin C is an antioxidant that oxidizes readily. Sodium metabisulfite must be added to prevent oxidized vitamin C from becoming unstable. Topical treatments containing 0.01–1.0% sodium metabisulfite act as antioxidants. Therefore, a face mist preparation was made with variations in the concentration of sodium metabisulfite, namely 0.25%, 0.5%, and 1%. This study aims to see an increase in the stability of vitamin C face mist preparations with an increase in the concentration of sodium metabisulfite through physicochemical stability testing under real-time storage conditions for 28 days. The parameters to be observed in the stability test include organoleptic test, pH, specific weight, viscosity, and vitamin C levels. The F1 formula with the smallest concentration of sodium metabisulfite (0.25%) has been able to maintain the stability of vitamin C face mist preparations for 28 days of storag
Artikel review : validasi metode penentuan kadar asam retinoat pada sediaan kosmetik dalam bentuk krim dengan menggunakan berbagai instrumen
Full text linkWhitening cream cosmetics are widely used to treat skin and are often employed to lighten the complexion of skin and reduce marking. Unfortunately, these products mostly contain hazardous ingredients like retinoic acid, effective yet capable of causing harm with its side effects in terms of skin inflammation, desiccation, and teratogenicity. This review will discuss the evaluation and comparison of the validity of the analytic method in the determination of retinoic acid in cosmetic cream formulations with different instruments; High-Performance Liquid Chromatography, Chromatography-Photodiode Array Detector, and UV-Vis Spectrophotometry methods were discussed. The conducted review used a literature review method wherein various national and international relevant studies of these analytic techniques had been analyzed. Results indicate that HPLC, especially with UV detection, presents the highest accuracy, precision, and sensitivity for quantifying retinoic acid, although it requires a longer analysis time. UV-Vis Spectrophotometry, on the other hand, though less sensitive, offers advantages in terms of simplicity, cost, and shorter duration of the analysis. Among the methods reviewed here, HPLC provides comprehensive validation parameters, demonstrating a linearity of 0.9999, an RSD of 0.99%, an accuracy of 114.3%, an LOD of 0.0165 ppm, and an LOQ of 0.0495 ppm.. Therefore, in order to ensure the safety and regulatory compliance of cosmetic products, the validation of the analytical methodologies for the detection of retinoic acid becomes indispensable, and hence the selection of the most optimal technique is highly relevant
Edukasi dampak negatif minuman berenergi bagi anak-anak dan remaja di SMP Muhammadiyah 2 Kota Ternate
Full text linkEnergy drinks have become increasingly popular recently, especially among children and adolescents. According to the survey, adolescents are the largest consumers of energy drinks. Due to the lack of knowledge among parents and the public regarding the adverse effects of energy drinks, supervision of energy drink consumption among children and adolescents is uncontrolled. Therefore, education for children and adolescents needs to be done regularly. This activity was carried out at SMP Muhammadiyah 2 Ternate City. The targets of this activity are students in grades VII, VIII, and IX. The stages in implementing this activity consist of determining the activity's location, observing the activity's location, planning the program, preparing the material, implementing the activity, and evaluating it. Activities were carried out through counseling (lectures and discussions) about the adverse effects of energy drinks on children and adolescents. The activities were evaluated using pre-test and post-test questionnaires. The results showed that students' understanding of the counseling material increased significantly (P < 0.000) with average pre-test and post-test scores, 30.95 ± 15.05 and 61.43 ± 18.05, respectively
Formulasi serum antiaging nanopartikel emas dengan fraksi daun sirih hutan gambut Kalimantan (Piper aduncum)
Full text linkFree radicals are molecules with unpaired electrons that are reactive and unstable. Gold nanoparticles (AuNPs) have an antioxidant reducing Au3+ to Au+ which can stabilize free radicals. This research aims to characterize AuNPs, formulate and evaluate AuNPs antiaging serum with sirih hutan leaves fraction and antioxidant activity test. The research method used was maceration, sirih hutan leaves were extracted using 96% ethanol, fractionation using n-hexane, biosynthesis of AuNPs, formulation, and antioxidant activity using the DPPH method. The data analysis used One Way Anova test and post hoc Tukey (CI 95%). The research results showed that ethanol extract and n-hexane fraction were obtained at 132.5059 g and 18.3804 g respectively. Biosynthesis characterization of AuNPs have a particle size of 424.9 nm. Formulation and evaluation of AuNPs formulation were generally obtained according to SNI. The antioxidant activity of the formulation and vitamin C showed that the percentage of DPPH increased with increasing concentration, IC50 values of the formulaion and vitamin C showed 35.21 ± 0.95; 17.95 ± 0.34 ppm respectively. Based on One Way Anova test, there was significant difference in each concentration in the percentage of DPPH (p<0.05). and the formulation and vitamin C were classified as very strong antioxidants (IC50<50)