Jurnal Farmasi Fakultas Kedokteran Universitas Mataram
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Kajian pustaka toksisitas tanaman nanas (Ananas comosus [L.] Merr)
Get PDFPineapple plants are used ethnomedicinally in various countries, especially in Indonesia. Several studies have shown that pineapple plants have pharmacological effects both in vitro and in vivo on various diseases. Ananas Plant has the potential to be cultivated as medicine products. The toxicity of Ananas comosus (L) Merr important to acknowledge. This literature review aims to provide comprehensive information through a literature review regarding the toxicity of pineapple (Ananas comosus [L.] Merr). The literature review was collected in the period 2010 to 2021 which was obtained from the Google Scholar and Pubmed databases with a total of 9544 and a study was carried out on 10 works of literature. Based on the results of 10 literatures that have met the inclusion criteria, it shows that the in vitro toxicity test on pineapple (Ananas comosus [L.] Merr) has an LC50 of 403.83 to 9000 ppm which belongs to the category of practically non-toxic to moderately toxic. In vivo toxicity test showed that LD50 > 5000 mg/kgBW showed no deaths which were classified as practically non-toxic. From the results of literature research, it can be said that toxic plants (Ananas comosus [L.] Merr) have a toxicity category of practically non-toxic to moderately toxic in vitro studies. The results of the in vivo test showed that there were no deaths in the test animals which were in the category of practically non-toxic to mildly toxic
Pelatihan pembuatan minuman kekinian boba herbal untuk immune booster pada remaja di masa pandemi Covid-19
Get PDFAn efficient immune response to SARS-Co V-2 may be considered a major solution in Covid-19 cases. Covid-19 can infect all ages including adolescence. The role of parents is important in providing protection to the transmission of Covid-19 infection. Phytochemical herbal ingredients have biological properties as immune system stimulants. Product innovation with herbal ingredients that can attract the attention of adolescence needs to be developed, because it can provide immune booster to them. Therefore, it takes training to improve the skill of parents in making interesting product innovations for adolescence, namely “Bobalthy (Boba Herbal and Healthy)â€. The goal was improve the health of adolescents, by making innovations in immune booster products and as business innovations that can be applied during the Covid-19 pandemic. The target of this community service activity were PKK and adolescent parents. The methods were presentation, demonstrations on how to make products “Bobalthy (Boba Herbal and Healthy)â€. Evaluation with redemonstration and questionnaires. Outcome this community service activities were increased understanding about herbal ingredients as immune system enhancers and soft skills in the manufacture of innovation products herbal boba that are favored by all adolescents and can simultaneously benefit improving the immune system of adolescents
Optimalisasi pencegahan dan penanggulangan stunting di Desa Sungai Tuan Ilir
Get PDFStunting is one of the chronic nutritional problems which is still an important problem in Indonesia. Lack of nutritional intake in the first 1000 days of life or lack of nutritional intake for a long time is the main cause of stunting. Indonesia is one of the developing countries with more than half the number of children experiencing stunting. The prevalence of stunting is in position 115 out of 151 countries in the world. Banjar Regency is ranks third out of 13 regencies/cities in South Kalimantan which is children experiencing stunting at 48.2%. Through community service activities by conducting stunting prevention and control programs is hoped that there will be an increase in community knowledge and attitudes in the family environment. The focus targets of this community service activity are families who have children under five and or couples of childbearing age in Sungai Tuan Ilir Village. The program is carried out in three stages, namely providing health education, interpersonal communication (KAP), and stunting prevention campaigns. The activities were carried out well according to the program planning that was made as evidenced by the increase in community knowledge and attitudes both during the mass counseling process and during KAP activities and stunting prevention campaigns in the family sphere
Perspektif mahasiswa farmasi universitas mataram terhadap vaksinasi COVID-19
Get PDFCOVID-19 is an infectious disease caused by SARS-CoV-2 with a high transmission rate. The Indonesian Ministry of Health made efforts to contain the spread of the virus by conducting a vaccination program. This study’s objective to examine the extent to which UNRAM Pharmacy students provide the opportunity to vaccinate, the known types of COVID-19 vaccines, and student responses to the outbreak of the emergence of a new variant, namely the COVID-19 Delta variant. The method used in this study was cross-sectional, with a sample of 163 active students of Pharmacy UNRAM. Sampling was done boldly by using google forms. The results of the study were 98% of respondents started to vaccinating against COVID-19. There are three types of vaccines known to students, namely Sinovac, Astra Zeneca, and Moderna
Molecular docking of the bioactive compound Ocimum sanctum as an inhibitor of Sap 1 Candida albicans
Get PDFCandida albicans (C. albicans) is the norm microbiota that lives in humans' oral cavity, digestive tract, and urinary tract. However, C. albicans, under certain circumstances can cause superficial infections of the mucosa such as oropharyngeal candidiasis (OPC) or vulvovaginal candidiasis (VVC) and even systemic infections. Secreted aspartic proteinase (Sap) 1 plays a role in the phenotype change of C. albicans. The study aimed to perform molecular docking using the bioactive compound Ocimum sanctum to inhibit Sap 1 C. albicans. Methods used include preparation of protein structures, ligands preparation, simulation of docking, and analysis and visualization. The results showed Apigenin had the highest binding energy of 7,792 kcal/mol and was followed by methyl eugenol ligand 5,361 kcal/mol, Citral 5,307 kcal/mol, Ursolic acid 4,967 kcal/mol, and Taxol 2,118 kcal/mol. Known interactions from the docking results showed that the four ligands hit the catalytic residue Asp32/Asp218, but only ursolic acid did not hit the catalytic residue. This study concludes that all ligands have binding energies that inhibit Sap 1, resulting in various interactions, amino acid residue contacts, and dissociation constants
Pelatihan metodologi penelitian sains dan teknologi bagi santri Madrasah Aliyah Negeri Insan Cendekia Lombok Timur
Get PDFBasic knowledge on scientific method is important for the preparation of scientific papers for student of Madrasah Aliyah Negeri. Since, research methodology was not teached in Madrasah Aliyah curriculum. Writing scientific papers is an activity related to education from elementary school to university level, which teaches rational and empirical thinking by using scientific method. This training was intended to provide knowledge about research methodologies, especially in the fields of science and technology for the preparation of students' final assignments of Madrasah Aliyah Negeri Insan Cendekia East Lombok. The method of activity was by lectures, discussions and guidance for writing research proposal. This activity took place on July 1, 2022 in the Hall of MAN Insan Cendekia, attended by 111 students. This activity consist three session, first is the explanation about material from the lectures, followed by discussion and the last session is mentoring. The students followed the activity enthusiastically marked by so many question in the discussion session about the topic of research and its design
The influence concentration gel agent propolis combination of mulberry leaf on the growth of the bacteria Propionibacterium acnes
Get PDFThis research was carried out with the aim of determining the inhibitory power of the combination gel of propolis extract and mulberry leaf extract against Propionibacterium acnes bacteria and determining the concentration of propolis extract that provided the greatest inhibitory power against the test bacteria. The research method includes the extraction of mulberry leaves by maceration using 70% ethanol as a solvent and the propolis extract used is a ready-to-use extract. The formulations were designed with various concentrations of propolis (0.5%, 1%, 1.5%) and 0.5% mulberry leaf concentration. Testing the antimicrobial activity of propolis extract in combination with mulberry extract in gel preparations against the growth of Propionibacterium acnes bacteria was carried out using the agar diffusion method. The results showed that the average diameter of the inhibition area at 0.5% concentration was 36.87 mm, at 1% concentration was 44.557 mm and at 1.5% concentration was 45.97 mm, positive control was 49.21 mm. Based on the data obtained, it is concluded that the gel formula with a propolis concentration of 1.5% is the preparation with the largest zone of inhibition
Evaluasi penerapan standar pelayanan kefarmasian di Puskesmas
Get PDFPharmacy services is a direct service and obligation to the patients regarding the pharmacy substances with the aim to increase the public health services in the field of pharmacy. The purpose of this study is to evaluate the implementation of pharmaceutical standard at the primary health services Puskesmas. This study is conducted in descriptive research, data collection using a cross sectional survey approach. The instruments in this study was a questionnaire sourced from the Regulation of the Minister of Health No. 74 of 2016 concerning pharmaceutical service standards in Puskesmas. Respondents in this study were pharmacists at the Pagesangan Puskesmas. The management activities reach 100% of drug and medical consumables, 93.75% of equipment and supporting facilities, 100% of human resources. These results indicate that the evaluation of the implementation of pharmaceutical service standards at the Puskesmas based on pharmaceutical service indicators has been carried out well at the Pagesangan Puskesmas with an average value of 96.77%. The implementation of pharmaceutical service standards at the Pagesangan Puskesmas has met all the indicators of pharmaceutical service standards at the Puskesmas
Kecambah: Agen penghidrolisis pati yang potensial
Get PDFStarch is a group of complex carbohydrates containing amylose and amylopectin. Starch can be broken down into simpler molecules such as maltose, isomaltose, and glucose which is called the hydrolysis process. Starch hydrolysis is very useful in several food industries. Enzymatic hydrolysis of starch usually uses the amylase enzyme derived from saliva. However, if you are going to carry out the hydrolysis process on a large scale, it requires large amounts of enzymes. Therefore, this study aimed to examine the ability of enzymes in sprouts to hydrolyze starch and compare it with the ability of starch hydrolysis by saliva and HCl. The isolated sprout samples were added to the starch solution and then incubated at 37oC. Every 5 minutes the mixture was tested qualitatively with Benedict's test and iodine. The same treatment for saliva and HCL. However, HCl was incubated at 100oC. The results of the qualitative test using Benedict's test and the iodine test showed enzymatic process had a higher ability to hydrolyze starch than chemically with HCl. The α-amylase enzyme produced from sprouts showed a higher starch hydrolysis ability than saliva. Sprouts are a natural source that can be developed as a starch hydrolyzing agent
Penetapan rendemen dan kandungan kimia ekstrak daun katuk (Sauropus androgynus (L.) Merr.) berdasarkan perbedaan metode pengeringan
Get PDFKatuk leaves contain chemicals in the form of alkaloids, triterpenoids, saponins, tannins, polyphenols, glycosides and flavonoids, so they are widely used as antioxidants. One factor can affect in chemical content and yield extract is the drying method. The purpose of this study was to determine the effect of different drying methods on yield and chemical content of katuk leaf extract. This research method was experimental Posttest Only Design. Katuk leaves were dried using wind, oven, sun and continued by maceration with ethanol 96% as solvent. The macerate was filtered and air-dried to thick extract which was calculated yield and tested chemical content form of polyphenols, alkaloids, flavonoids, saponins, tannins and terpenoids. Yield data analysis was carried out using One Way ANOVA test. The average yield value of katuk leaf extract in the wind-dry drying method was 11.86±0.23%, the sun was 12.26±0.70%, the oven was 13.64±0.74%. One Way ANOVA test showed significant differences in wind and oven drying, sun and oven drying. Phytochemical screening of each drying showed the presence of polyphenols, alkaloids, flavonoids, saponins, tannins and triterpenoids. The conclusion of this study was that the drying method affects the yield of katuk leaf extract but has no effect on chemical content