Ufuk Universitesi Akademik Acikerisim Sistemi
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The utility of ischemia modified albumin as an oxidative stress biomarker in seborrheic dermatitis
No full textAim: Seborrheic dermatitis (SD) is a commonly seen chronic inflammatory skin disease that occurs as scaly reddish-brown itchy patches on sebaceous, gland-rich areas of the scalp, face, and trunk. The relation between SD disease and serum IMA (Ischemia modified albumin) levels remains unknown. To investigate the potential role of serum IMA and corrected IMA levels in SD disease. Materials and Methods: Thirty-seven participants who were diagnosed with SD disease and sixty-two healthy subjects (control group) were enrolled in the study. Venous blood samples were collected from each participant, and serum IMA was measured spectrophotometrically using the albumin cobalt binding test. Results: The serum IMA and corrected IMA levels were statistically significant between the groups, and the levels of IMA and corrected IMA were measured as SD patients group 0.70, 0.70 and control group 0.52, 0.51 ABSU (absorbance units), respectively (p < 0.05). Moreover, serum IMA and corrected IMA levels were statistically significant between male and female groups in terms of gender as 0.75 and 0.69 ABSU, respectively (p < 0.05). Serum albumin levels, age, and BMI (body mass index) were statistically insignificant between these groups. Conclusion: Our results show increased serum IMA and corrected IMA levels in patients with SD. Evaluation of IMA and corrected IMA levels in SD disease may contribute to diagnosis and prognosis. Further and comprehensive studies are neede
A 9-year retrospective cohort of patients with lumbar disc herniation: Comparison of patient characteristics and recurrence frequency by smoking status
No full textTo evaluate the association between smoking status and patient characteristics and to identify risk factors associated with recurrence in patients who underwent surgery for lumbar disc herniation (LDH). This retrospective study was carried out at Lokman Hekim University, Ankara, Turkey between January 1, 2021 and January 1, 2022. The medical data of patients who underwent microsurgical discectomy for LDH were retrospectively recorded. Patients with any reemergence of LDH within a 6-month period after surgery were defined as having recurrent LDH. A total of 1109 patients were included in the study and mean age was 50.7 +/- 14.3 years. The frequency of hernia at L2-L3 and L3-L4 levels was higher in the nonsmoker group (P < .001). The frequency of cases with Pfirrmann Grade 4 degeneration was higher in the nonsmoker group than in smokers and ex-smokers (P < .001). Protrusion-type hernias were more common in nonsmokers (P = .014), whereas paracentral hernias were more common in smokers (P < .001). The overall frequency of recurrence was 20.4%, and was higher in smokers than in non-smokers and ex-smokers (P < .001). Multivariable logistic regression revealed that current smoking (OR: 2.778, 95% CI [confidence interval]: 1.939-3.980, P < .001), presence of Pfirrmann Grade 4&5 disc degeneration (OR: 4.217, 95% CI: 2.966-5.996, P < .001), and paracentral herniation (OR: 5.040, 95% CI: 2.266-11,207, P < .001) were associated with higher risk of recurrence, whereas presence of sequestrated disc was associated with lower risk of recurrence (OR: 2.262, 95% CI:0.272-0.717, P = .001). Taken together, our data show that smoking, increased degree of degeneration and paracentral hernia increase the risk of LDH recurrence, while sequestrated disc appears to decrease risk. Taking steps to combat smoking in individuals followed for LDH may reduce the risk of recurrence in LDH patients
Hekim Adaylarının Sophie’nin Seçimi Filminde Yer Alan Ahlaki İkilem Üzerine Görüşleri: Kalitatif Bir Araştırma
No full textÇalışmanın amacı, Sophie’nin Seçimi filminde yer alan örnekteki ahlaki ikilemin tıp fakültesi öğrencilerinin etik farkındalıkları üzerine etkisini belirlemektir. İkincil olarak ise kullanılan film üzerinden etik eğitimi müfredatının geliştirmesine katkı sağlamaktır. Araştırmada 2020- 2021 eğitim ve öğretim yılında Mersin Üniversitesi Tıp Fakültesinden 10 ve Ufuk Üniversitesi Tıp Fakültesinden ise 9 toplam 19 öğrencinin final sınavları retrospektif olarak değerlendirilmiştir. Araştırmada hekim adaylarına Sophie’nin Seçimi filminde yer alan gerçek bir ahlaki ikilem örneğine yönelik araştırmacılar tarafından hazırlanan açık uçlu 4 soru soruldu. Sorular sırasıyla “Sophie neden kızını ölüme göndermiştir?”, “Nasıl hızlı karar verdi”, “Ahlaken suçlu muydu?”,“Sophie seçim yapmayı reddedebilir miydi, etseydi kararını savunabilir miydi, bu seçim yüzünden suçlanır mıydı?” Yanıtlar içerik analizi yapılarak tematik olarak kodlanmıştır. Elde edilen verilerin analizinde betimsel istatistiklerden yararlanılmıştır. Sophie'nin kızını neden ölüme gönderdiği sorulduğunda, öğrencilerin yaklaşık yarısı cinsiyete dayalı bir seçim yaptığını söyledi. 3 öğrenci 1'i kurtarmak için, 2 öğrenci de yaşa bağlı olduğunu belirtti.“ Sophie seçim yapmayı reddedebilir miydi?” sorusuna, 10 öğrenci reddedebileceğini, 9 öğrenci reddedemeyeceğini, öğrencilerin çoğunluğu ret kararını savunamayacağını, yarıya yakın öğrenci ise ahlaken suçlanamayacağını belirtti. Öğrencilerin ahlaki sıkıntı, etik ikilem ve sorun konusunda farkındalıklarının olduğu, toplumsal cinsiyet konusunda geleneksel yapıya benzer görüş belirttikleri saptandı. Tıp fakültesi öğrencilerinin Sophie’nin Seçimi filminin tıp etiği eğitiminde kullanımıyla ahlaki sıkıntı, etik ikilem ve zor seçim konusunda etik farkındalıklarının artmasına ve toplumsal cinsiyet, cinsiyet ayrımcılığı gibi konularda geleneksel bakış açısının değişmesi yönünde olumlu katkısı olduğu düşünülmektedir. Bunun yanı sıra tıp etiği eğitimi müfredatının öğrencilerin etik farkındalıklarına yönelik geliştirilmesi önemlidir
MANAGING EBOLA AND COVID-19 CRISES FOR AVIATION INDUSTRY: DID INDUSTRY LEARN HOW TO LEARN?
No full textLearning is necessary for an organization to evolve, improve and innovate. We are all conditioned to benefit from the evident effects of our behaviors. After the first try, we do not touch the hot stove again. We are also conditioned to recognize complex scenarios and apply fast solutions. Companies are like humans and they also learn as people do. From this point of view, the aviation industry is discussed in this study beyond the learning loops approach of Agrysis which is an effective tool that encourages the kind of thought and action that is needed to transform an organization into a learning one. Turkish Airlines, EasyJet, Delta Airlines, Air China, United Airlines, China Eastern Airlines, China Southern Airlines, American Airlines, Southwest Airlines and Ryanair had chosen as the sample of this study and data collected from the annual reports of these companies was analyzed with document analysis methodology. By comparing the crisis management styles of the industry during Ebola and Covid-19 Diseases the question did the industry learn how to learn? tried to be answered and as a result, the study found that the way the industry responded to both crises had not gone too far from single loop learning, or in other words, the industry had only given a reaction to the actions on time and forgot every experience till the next crisis. In the end, the study discussed that single loop learning style of airline companies may be the reason for the rapid spread of those kinds of diseases all over the world
Succesfull Management of Pregnancy Complicated with Congenital AT-3 Deficiency
No full textAntithrombin-3 (AT-3) is a natural anticoagulant that inhibits thrombin, activated factor X and other serine proteases in the coagulation cascade, and its activity accelerated more than 1000-fold by heparin binding. Congenital AT-3 deficiency is inherited as an autosomal dominant trait and affects less than 0.2% of the general population.1 This deficiency is considered to be a high-risk thromboembolic condition, with an odds ratio venous thromboembolism (VTE) of 16.3 compared with individuals with a nonthrombophilic status.1 In this case report, succesfull management and delivery of a congenital AT-3 deficient pregnant woman was extensively discussed along with the lşterature findinds
Relationship between the beliefs on social appearance, anxiety, and intolerance of uncertainty in rhinoplasty patients Psychological factors associated with rhinoplasty satisfaction
No full textAim: Rhinoplasty is a surgical procedure performed for functional and/or cosmetic purposes. The purpose of the study is to evaluate the psychological factors that determine patient satisfaction in rhinoplasty surgery. Material and Methods: A total of 121 patients (85 women, 36 men) participated in the study. Sociodemographic data form, social appearance anxiety scale (SAAS), beliefs about appearance scale (BAAS), short form of intolerance of uncertainty (IUS) scale and rhinoplasty outcomes evaluation questionnaire (ROEQ) were applied to the participants before and at the 3rd- month control after rhinoplasty. Results: Before and after the operation, patients were divided into two groups, according to their SAAS scores. Preoperative BAAS, preoperative SAAS and postoperative REOQ scores were significantly higher in the group of patients whose SAAS scores decreased after the operation. It was determined that the change in ROEQ scores could be predicted by the change in SAAS scores (beta=-0.454, p<0.005). Discussion: Psychological factors such as appearance anxiety can act as a bridge between patient satisfaction and rhinoplasty outcomes. This study indicates a complex cognitive process and suggests that multidisciplinary approaches may be important to improve patient satisfaction after rhinoplasty
Treatment preferences of orthopedic surgeons for closed, isolated middle-third diaphyseal long bone fractures without neurovascular injury in children: A cross-sectional survey
No full textObjective: This study aimed to assess the treatment trends and the factors influencing the treatment methods of Orthopaedic Surgeons in closed, isolated, middle-third diaphyseal long bone fractures without any neurovascular injury in children. Methods: This was a cross-sectional electronic survey of Turkish Orthopaedic Surgeons who were active members of the Turkish Society of Children's Orthopaedics (TSCO) and still managing the children's fractures in their daily clinical practice. An initial e-mail including the electronic survey followed by three reminder e-mails was sent to 110 members, and then reminder telephone calls were made. Results: The survey response rate was 66/110 (60%). In recent years, a definitive trend to surgical treatment was not seen 98%, 77%, 39%, and 88% of the responders in the closed humerus, forearm, femur, and tibia mid-shaft fractures, respectively. Neither the years of expertise nor the intensity of daily pediatric patients of the participants did not affect the treatment trend in any fracture scenarios. The patient's age was the most cited factor influencing the responders' decisions on whether conservative or surgical treatment would be performed in each fracture scenario. The most cited lowest age limits for surgical treatment inclosed mid-shaft fractures of the humerus, forearm, femur, and tibia, were the adolescent age group, 10-12 years, six years, and ten years, respectively. Conclusion: This is the first study assessing the daily clinical practice of members of TSCO in the management of closed, isolated, non-complicated middle-third diaphyseal long bone fractures in children just before the covid-19 pandemic started. A marked tendency toward surgical treatment is seen in femur mid-shaft fractures, followed by forearm mid-shaft fractures up to a certain level. The patient's age is the main determinant of the responders' decisions on the type of treatment in closed, isolated, non-complicated middle-third diaphyseal long bone fractures in children
Serum HDL, LDL ve ürik asit düzeyinin toplum kökenli pnömönide prognoz tahminindeki rolü
No full textPurpose: Community-acquired pneumonia (CAP) leads to inflammation and oxidative stress as a result in infection. In the present study, we aimed to investigate the relationship between initial serum high-density lipoprotein (HDL), low-density lipoprotein (HDL), and uric acid levels on short-term (30-day) changes in the course of CAP. Materials and methods: The retrospective study included 113 patients with CAP that received inpatient care between 2012 and 2018.The HDL, LDL and uric acid values in the blood received in hospital admission were examined for their relationship with short-term mortality and correlation with hospitalization. Results: The 113 patients comprised 71 (62.8%) men and 42 (37.2%) women with a mean age of 74±11 years. Of the 113 patients, 30-day mortality occurred in 12 (10.6%) patients. Of the 113 patients, 17 (16.5%) patients were hospitalized in ICU. All cases detected as mortality were followed in ICU. Normal ranges of HDL, LDL, and uric acid concentrations were accepted as 40-70 mg/dL, 60-130 mg/dL, and 1.8-8 mg/dL, respectively. The mean serum LDL, HDL, and uric acid levels were 97.95±42.11 (range, 26-271) mg/dL, 40.94±13.70 (range, 5.10-83.20) mg/dL, and 5.99±2.18 (range, 1.40-13.20) mg/dL, respectively. HDL and LDL levels were found to be insignificant predictors of 30-day mortality (p=0.482 and p=0.725, respectively). Similarly, serum HDL, LDL, and uric acid levels were found to be insignificant predictors of the duration of hospitalization and ICU requirement. On the other hand, multivariate logistic regression analysis indicated that uric acid concentration was a protective factor for 30-day mortality (OR, 0.694; 95% Cl, 0.478-0.989, p=0.048), whereby increased uric acid concentration was found to decrease the risk of mortality and reduced uric acid concentration was found to increase the risk of mortality by 1.44 times (1/0.694). Conclusion: We suggest that monitoring uric acid levels with serial measurements in patients with CAP may be useful for predicting the short term prognosis. Further prospective multicentric studies with larger patient series are needed to investigate the correlation between serum uric acid levels and clinical risk scores. © 2022, Pamukkale University. All rights reserved
A different look on the importance of lateralization and localization of figure 4 symptoms in epilepsy
No full textBackground Clinical seizure semiology provides valuable information in the evaluation of focal-onset bilateral tonic-clonic seizures. In the evaluation of these patients, long-term video-EEG monitoring (VEM) and neuroimaging studies are of great significance in determining lateralization together with clinical semiology. In this study, we examined the features of the figure 4 sign that we detected in patients with refractory epilepsy whom we followed up in the VEM unit. Methods In the study, 175 patients followed in the VEM unit were examined. Twenty-two patients for whom the figure 4 sign was detected were included in the study. Patients with the side indicated by the figure 4 sign comply with ictal EEG compatible were named as 1st group (G1), and those not were named as 2nd group (G2). Demographic characteristics, seizure type, number of seizures per month, duration of epilepsy, number of seizures during VEM, duration of figure 4 sign, medical history, and cranial MRI characteristics were compared between the two groups. Results When G1 and G2 were compared, it was observed that temporal lobe seizures were statistically significantly higher in G1. When the figure 4 sign durations were examined, this period was 16.3 +/- 8.2 s in frontal lobe seizures and 20.8 +/- 7.4 s in temporal lobe seizures. When the duration of the figure 4 sign was examined by gender, it was found that the duration was longer in males, which was statistically significant. Conclusion In conclusion, it is essential to evaluate ictal EEG findings together with brain imaging while performing semiological localization and lateralization in epileptic patients
Investigation into the effect of systemic single high-dose erythropoietin on the healing of Achilles tendons in rats
No full textObjective: This study aimed to examine systemic erythropoietin's effect on the Achilles tendon's healing in a rat model. Methods: Twenty-five adult Wistar rats were randomly assigned to one of two groups. The Achilles tendon of each rat was transected 5 mm proximal to its insertion to the calcaneus. All Achilles tendons were then repaired using modified Kessler methods. A single dose (5000 U/kg) of intraperitoneal erythropoietin (EPO) was administered to group I. Group II was a control group and did not receive an EPO injection. Four rats from each group were sacrificed at 1, 3 and 6 weeks after injection. Histopathological assessments were performed by observers blinded to the treatment. Results: Groups I and II showed a similar increase in fibroblast cytoplasmic content and fibrillar collagen in the extracellular matrix. Collagen deposition, cellular proliferation, number of lipid vacuoles and capillary increases were similar between the groups. Conclusion: Evidence from this study has shown no direct effect of a single systemic high dose of EPO on the histological properties of the Achilles tendon in rats