Ufuk Universitesi Akademik Acikerisim Sistemi
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Determinación del Sexo de la Cavidad Glenoidea Mediante Tomografía Computarizada en la Población Turca
No full textThe aim of this study is to contribute to sex determination studies from the scapula in the Turkish population and compare with previous studies. This study was performed with 200 scapulae (100 males and 100 females). The age range of the patients was between 18-93 years old. Computed tomography scans were used and length of glenoid cavity (LGC), breadth of glenoid cavity (BGC), depth of glenoid cavity (DGC), perimeter (PM) and volume (VL) were measured. Randomly selected 20 scapulae were measured three times for examine the intra-rater reliability from those measurements. Gender logistic regression analysis was conducted to find the significant variables at sex determination from the scapula. The most effective parameter in determining sex from scapula was found to be VL (88.5%). The effects of LGC, PM, BGC and DGC at sex determination from scapula were found to be 83%, 82.5%, 79.5%, 66%, respectively. The combination of VL and PM (89.5%) was found to be the most effective combination at sex determination from the scapula. The intraclass correlation values of all measurements were found to be at high reliability. According to the literature, PM and DGC along with the VL in Turkish population, were not used previously for sex determination from the scapula. A combination of the VL and PM was found to be the most effective parameters at sex determination from scapula in the Turkish population. There are few studies on the sex determination from scapula in the Turkish population. This study will guide anthropologists, forensic scientists and anatomists at sex determination studies from scapula and surgeons by morphometrically in clinical situations related to the scapula. © 2022, Universidad de la Frontera. All rights reserved
Does memantine show chemopreventive effect against mice 4T1 breast tumor model?
No full textBackground/aim: Cancer cells express higher levels of N-methyl-d-aspartate (NMDA) receptor. In this study, we aimed to use memantine as a potential blocker to inhibit the action of the NMDA receptor in cancer cells in vivo in order to investigate the potential chemopreventive effect of memantine in 4T1 tumor-bearing mice. Materials and methods: To determine the potential chemopreventive effect of the compound, mice weights, tumor volumes, spleen IL-6, and tumor DNA methylation levels were investigated. A total of 26 Balb/c female mice were allocated into three groups. G1 (n = 6): tumor control group, G2 (n = 10): low dose (5mg/kg) memantine group, G3: high dose (10 mg/kg) memantine group (n = 10). G1 was inoculated with 4T1 cells without any memantine treatment. G2 and G3 were pretreated with 5 and 10 mg/kg memantine daily intraperitoneal (ip) injection (weekend off) for 10 days, respectively. Both G2 and G3 were subdivided into two groups as G2a (n = 4) and G3a (n = 4): tumor free groups and G2b (n = 6) and G3b (n = 6) tumor bearing groups. Results: Our results revealed that G3: high dose (10 mg/kg) memantine group, significantly (p = 0.0248) reduced the tumor volumes. We found that spleen IL-6 levels were significantly higher in memantine pretreated tumor free group p = 0.0204 ) We also found that high dose memantine treated tumor free group (G3a) has significantly lower genome-wide DNA methylation levels when compared to tumor control group (G1) p = 0.0012. Conclusion: To the best of our knowledge, it is the first study that highlights a potential chemopreventive effect of memantine in vivo in the mouse 4T1 breast tumor model. But further investigations should be carried out to explore the chemopreventive mechanism of action for memantine in cancer.Gazi University Projects of Scientific Investigation: BAP [64/2018-01]This research was supported by Gazi University Projects of Scientific Investigation: BAP (No: 64/2018-01), and partially presented as an oral presentation at 29th National Biochemistry Congress in Bodrum, Turkey on October 26-30, 2018
Türk İstiklal Harbinde Batı Cephesi Tayyare Bölükleri
No full textMillî Mücadele sırasında Batı Cephesi’nde cereyan eden Kütahya-Eskişehir Muharebeleri’nden sonra Türk ordusu tüm birliklerini Mustafa Kemal Paşa’nın emriyle 25 Temmuz 1921’den itibaren Sakarya Nehri’nin doğusunda 100 kilometre genişliğinde bir cephe hattında topladı. Bu emir, kesin sonuç alınabilecek bir meydan muharebesi için verilen stratejik bir karar olsa da ordunun geri çekilmesi kamuoyunda ve Mecliste büyük bir hayal kırıklığı yarattı. Türkiye Büyük Millet Meclisi (TBMM) bu duruma bir çare olarak 5 Ağustos 1921 tarihinde Başkomutanlık Yasasını kabul ederek “Başkomutanlık” unvanıyla birlikte sorumluluk ve yetkiyi Mustafa Kemal Paşa’ya devretti. Sakarya Meydan Muharebesi’nde yaklaşık 100 kilometre boyunca mevzilenen kara birliklerinden başka harbin başından sonuna kadar Pilot Yüzbaşı Fazıl Bey’in (Şehit Binbaşı) idaresinde Malıköy’de konuşlanan Cephe Tayyare Bölüğü, mevcut iki tayyaresiyle yapmış olduğu uçuşlarda düşmanın yaklaşma/çekilme istikametleri, yığınakları, toplanma bölgeleri konularında elde ettikleri bilgileri cepheye ulaştırarak kara harekâtını yürüten komutan ve birliklere önemli destek sağladığı gibi Yunan kuvvetlerini ateş altına alarak verdirdikleri zayiat ile önemli hizmetlerde bulundular. Büyük zaferin kazanılmasına kadar olan süreçte kara birliklerinin durumuna göre yer değiştiren Cephe Tayyare Bölüğünün faaliyetleri, Batı Cephesi içinde önemli bir yere sahiptir. Bu makalede; Millî Mücadele sırasında Batı Cephesi’nde kara birliklerine havadan destek veren ve kazanılan büyük zafere önemli etkide bulunan Türk havacılık faaliyetlerinin bilinmeyen yönlerinin ortaya konulması ve kahraman havacılarımızın fedakârlıklarının gün yüzüne çıkarılması amaçlanmıştır. Yaşanan tüm zorluklar, büyük yokluklara rağmen havacıların yurdun kurtuluşu için almış oldukları tedbirler ve gayretleri, başta ATASE Arşivi belgeleri olmak üzere mevcut kaynaklar ışığında değerlendirilerek açıklanmaya çalışılmıştır
Simülasyon Laboratuvarında Verilen Eğitimin Hemşirelik Öğrencilerinin İntravenöz Kateterizasyon Becerisine
No full textAmaç: Bu çalışmanın amacı, senaryo temelli yüksek gerçeklikli simülasyon eğitiminin öğrencilerin intravenöz kateterizasyon becerileri ile endişe düzeyleri üzerine etkisini değerlendirmektir. Gereç ve Yöntem: Araştırma yarı deneysel olarak planlanmış ve yürütülmüştür. Araştırmanın evrenini ve örneklemini 48 birinci sınıf hemşirelik bölümü öğrencisi oluşturmuştur. Verilerin toplanmasında öğrencilerin tanımlayıcı özelliklerini içeren soru formu, ‘Durumluk-Sürekli Kaygı Ölçeği’ ve ‘İntravenöz Kateterizasyon Beceri Kontrol Listesi’ kullanılmıştır. Simülasyon laboratuvarında eğitim için hasta odası olarak donanımlı hale getirilmiş bir salonda insan vücudunu simüle edebilir yapıda bir simülatör kullanılmıştır. Bulgular: Çalışmaya katılan öğrencilerin %81.2’si kadınlardan oluşmaktadır ve %95.8’si lise mezunudur. Öğrencilerin demonstrasyon eğitimi sonrası ve senaryo temelli yüksek gerçeklikli simülasyon eğitimi sonrası intravenöz kateterizasyon beceri kontrol listesinden aldıkları puanlar arasındaki fark istatistiksel olarak anlamlıdır (p0.05). Sonuç: Öğrencilerin eğitiminde senaryo temelli yüksek gerçeklikli simülasyon yönteminin kullanımı intravenöz kateterizasyon becerilerini olumlu yönde etkilemiştir ancak kaygı düzeylerini etkilememiştir
The epidemiology of adult fractures according to the AO/OTA fracture classification
No full textBACKGROUND: The epidemiology of adult fractures has been changing timely, in a multifactorial fashion. The aim of this study was to put forward a recent 5-year epidemiological analysis of adult fractures, according to the current AO/OTA fracture classification, in the current decade of action for road safety. METHODS: 5324 adult patients who were diagnosed with at least one fracture related with orthopedics and traumatology in a level-one trauma center were included in this retrospective, epidemiological descriptive study. The patients were grouped according to their ages as; 18-35, 36-55, 56-69, and >= 70. The fractures were examined according to the AO/OTA classification. RESULTS: 5865 fractures were present in 5324 patients. The mean age of the patients was 48.6 +/- 21.5. The number of patients according to the age groups was as follows; 1947 (36.6%), 1636 (30.7%), 881 (16.5%), and 860 (16.2%), respectively. The most frequent three fractures according to the AO/OTA fracture classification were; 7 (hand 19.6%), 23 (distal forearm, 12.1%), and 8 (foot, 11.8%). About 54.4% and 45.4% of the patients were treated non-surgically and surgically, respectively. About 0.2% of the patients preferred an alternative treatment. Overall mortality rate was 0.4%. CONCLUSION: To the best of our knowledge, this study represents the first analysis of adult fractures according to the AO/OTA classification, over a 5-year period. As a future prospect, further multi-centric epidemiological studies are warranted to constitute a sustainable action plan for the prevention of major traumas
Early Maladaptive Schemas in Medical Students and Law Students
No full textCareer choice is an important stage in the life of young people. It has been previously reported that career choice may be related to psychological factors. In this study, we aimed to investigate the relationship of early maladaptive schemas with university selection. A total of 135 medical students and 98 law students participated in the study. Sociodemographic data form and Young Schema Questionnarie short form-3 were given to the participants. According to our findings, dependence/incompetence (p = 0.027) and subjugation (p = 0.013) scores were significantly higher in medical school students. The self-punitiveness score was found to be higher (p= 0.032) in law faculty students. In addition, medical faculty students had significantly higher scores (p=0.043) in the impaired autonomy and performance schema domain scores. According to our findings, early maladaptive schemas scores of university students differ according to their departments. These findings may be useful in career selection and higher education programs guidance process
Association Between Insulin Resistance Estimated by Triglyceride Glucose Index and In-Stent Restenosis in Non-Diabetic Patients
No full textObjectives: The triglyceride glucose index (TGI) is associated with poor prognosis in cardiovascular disease. The usefulness of TGI to predict coronary in-stent restenosis (ISR) has not been determined. This study aimed to investigate the relationship between TGI and ISR in patients with stable coronary artery disease (CAD) undergoing angiography. Materials and Methods: This retrospective study analyzed the data of 224 non-diabetic patients with coronary drugeluting stents and undergoing angiography. The patients were divided into two groups based on the angiogram results: the non-ISR group (n=114) and the ISR group (n=100). TGI was compared between the two groups. The clinical characteristics and laboratory data were considered for univariate and multivariate analyses. Results: No significant differences in age, sex, hypertension, and smoking history were found between the ISR and nonISR groups. TGI was higher in the ISR group than in the non-ISR group (p=0.011). According to the multiple logistic regression analysis, Gensini score and SYNTAX score, TGI and white blood cell count were independent predictors of ISR. Conclusion: Patients with ISR were found to have higher TGI than those without ISR, suggesting that TGI might be a valuable predictor of ISR in patients with stable CAD
Effect of vitamin D deficiency on ocular blood flow
No full textAim: In this study, we aimed to evaluate the effects of vitamin D deficiency (VDD) on retrobulbar blood flow in healthy eyes.Material and Methods: In this prospective study, thirty eyes of 30 patients with VDD (Group 1) and 25 eyes of 25 individuals without VDD (Group 2) were included. The peak systolic flow velocity (PSV), end-diastolic flow velocity (EDV) and vascular resistance index (RI) were obtained from the ophthalmic artery (OA) with color doppler imaging. Multiple linear regression was performed for the covariate-adjusted comparison.Results: Mean ages were 37.83 +/- 9.89 years in Group 1 and 35.32 +/- 9.61 years in Group 2, (p = 0.347). Mean values of serum 25(OH)D3 level were 11.38 +/- 3.85 ng/dl in Group 1 and 26.80 +/- 10.03 ng/dl in Group 2 (p < 0.001). PSV and EDV were significantly higher in Group 2 than in Group 1 (p<0.001, p=0.001, respectively). RI was slightly higher in Group 1 than in Group 2, but this difference was not statistically significant. In multivariate linear regression, PSV and EDV were positively correlated with OPP, and negatively affected by the presence of VDD.Discussion: VDD can be an important factor in reducing ocular blood flow
Serum albumin and C-reactive protein/albumin ratio in communityacquired pneumonia
No full textIntroduction: Community-acquired pneumonia (CAP) is a common type of respiratory tract infections with high morbidity and mortality. Prognostic role of CRP/Albumin ratio in CAP patients still is unknown. The aim of this study was to investigate the role the CRP/albumin ratio in predicting 30-day mortality and ICU requirement in hospitalized patients with CAP. Material and Method: The study included patients with CAP.Clinical records and plain radiographic images of the patients were retrieved from hospital database and were reviewed for each patient. Results: The 179 CAP patients who were hospitalized were included. CRP level and the CRP/albumin ratio were found to have no significant effect on mortality and ICU requirement (p=0.728, p=0.232, and p=0.110, respectively), whereas low albumin level was associated with high mortality and ICU requirement (p<0.001 for both). Conclusion: Increased albumin concentration was associated with a lower risk of 30-day mortality. The CRP/albumin ratio was found to have no significant role in predicting short-term mortality and morbidity in CAP patients. Further large-scale, multicenter studies are needed to investigate the prognostic value of the CRP/albumin ratio in predicting long-term prognosis in CAP patients
Effects of open adductor tenotomy and adductor muscle botulinum toxin A injection on the hip instability in spastic type cerebral palsy
No full textPurpose: We aimed to evaluate the clinical and radiographic outcomes of hip instability in children with spastic-type Cerebral Palsy (CP) who had undergone open Adductor Tenotomy (AT) or received Botulinum Toxin-A (BTX-A) injections to the hip adductor muscles . Materials and Methods: Maximum Hip Abduction Angles (MHAA) with the knees and hips in extension were measured preoperatively and the latest clinical findings of all patients in the AT and BTX-A groups were recorded. Reimers' Migration Percentage (RMP) was measured as the radiographic assessment in the AT group. Results: There were 30 patients (mean age: 8.3 years) in the AT Group and 25 (mean age: 5.9 years) in the BTX-A Group whose clinical and radiographic data were available. The mean follow-up period in the AT Group was 29.6 months. In the AT Group, the mean MHAA before surgery and at the last assessment were 21.20 and 37.10 respectively. In the BTX-A Group, the mean MHAA before the injection and at the latest assessment were 25.30 and 34.20 respectively. The change in the mean MHAA in the AT Group was 16.20 and 8.80 in the BTX-A Group. In the AT Group, the preoperative RMP was 28.2% and the latest RMP was 22.2%. Conclusion: AT and BTX-A injections significantly improved hip abduction angles. However, AT provided better clinical improvement and considerable radiographic correction in pediatric patients with spastic-type CP and hip instability