Ufuk Universitesi Akademik Acikerisim Sistemi
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A New Risk-Scoring System for Colorectal Cancer and Polyp Screening by Turkish Colorectal Cancer and Polyp Study Group
No full textBackground: Colorectal cancer is one of the most commonly diagnosed types of cancer worldwide. An early diagnosis and detection of colon cancer and polyp can reduce mortality and morbidity from colorectal cancer. Even though there are a variety of options in screening tests, the question remains on which test is the most effective for the early detection of colorectal cancer. In this prospective study, we aimed to develop a simple, useful, effective, and reliable scoring system to detect colon polyp and colorectal cancer. Methods: We enrolled 6508 subjects over the age of 18 from 16 centers, with colonoscopy screening. The age, smoking status, alcohol consumption, body mass index polyp incidence, polyp size, number and localization, and pathologic findings were recorded. Results: The age, male gender, obesity, smoking, and family history were found as independent risk factors for adenomatous polyp. We have developed a new scoring system which can be used for these factors. With a score of 4 or above, we found the following: sensitivity 81%, specificity 40%, positive predictive value 25.68%, and negative predictive value 89.84%, for adenomatous polyp detection; and sensitivity 96%, specificity 39%, positive predictive value 3.35%, negative predictive value 99.29%, for colorectal cancer detection. Conclusion: Even though the first colorectal cancer screening worldwide is generally performed for individuals over 50 years of age, we recommend that screening for colorectal cancer might begin for those under 50 years of age as well. Individuals with a score >= 4 must be included in the screening tests for colorectal cancer
Comparison of Mood, Physical Symptoms, Cognitive Failure and Life Satisfaction in Women with Premenstrual Dysphoric Disorder, Premenstrual Syndrome and No/Mild Premenstrual Syndrome: A Controlled Study
No full textObjective: This study aimed to compare the mood, physical symptoms, cognitive failure, and life satisfaction in women with premenstrual dysphoric disorder (PMDD), premenstrual syndrome (PMS), and No/Mild PMS (No/Mild PMS).Methods: Totally 195 women participated in this study. The participants were divided into three groups according to the scores they received from premenstrual symptom screening tool. premenstrual symptom screening tool, beck depression inventory, beck anxiety inventory, cognitive failures questionnaire, and satisfaction with life scale were applied to all participants.Results: The study findings demonstrated that there was a significant difference between the groups in terms of the mean scores of anxiety, depression, cognitive failure, and life satisfaction (p<0.05). Women with PMDD group had significantly higher anxiety, depression, and life satisfaction scores than women with PMS and No/Mild PMS (p<0.05). There was a significant difference between the groups in terms of CFQ (p<0.05); however, the difference between groups was not significant in post-hoc comparisons.Conclusion: Women with PMDD had higher anxiety, depression, and physical symptoms and lower life satisfaction than women with PMS and No/Mild PMS. The results suggest that health professionals should be sensitive to the emotional and cognitive sides of PMDD/PMS. Holistic intervention programs may be developed considering current study findings
Evaluation of visceral adiposity index with cardiovascular risk factors, biomarkers in postmenopausal women to predict cardiovascular disease: A 10 year study
No full textBackground and aim: Visceral adiposity index (VAI) is reportedly beneficial in predicting cardiovascular disease (CVD) and metabolic syndrome (MetS). However, long-term studies analyzing the efficacy of VAI in the pre-diction of CVD risk are limited. The relationship between VAI and electrolytes is unclear. This study aimed to determine if VAI can be used as a predictor of CVD and provide early diagnosis possibility for future CVD pa-tients. Moreover, the impact of biomarkers and electrolytes on VAI therefore indirect relation to CVD was analyzed.Methods: Postmenopausal women (aged >40 years) admitted to our hospital in 2011 were included and cate-gorized into two groups according to their VAI scores: mild/moderate and severe. Groups were compared with insulin resistance, biochemical parameters, and anthropometric measurements. Patients have been reached out after 10 years and questioned for additional disease and cardiovascular risk. Statistical Package for Social Sci-ences (SPSSv22.0) was used for data analysis. The p < 0.05 value was considered significant.Results: Mean VAI score of patients with MetS (7.30 +/- 4.75) was significantly higher than without MetS (2.95 +/- 1.05) (p < 0.01). Serum magnesium level was found significantly lower in the severe group. Serum zinc (Zn) and hsCRP levels were higher in the severe group. Correlation analysis showed significant positive correlations be-tween VAI scores and total cholesterol (r = 0.289, p < 0.05), Zn (r = 0.397, p < 0.01), fasting insulin (r = 0.455, p < 0.01) and no significant association with the 10-year CVD incidence (OR: 1.034 (0.888-1.203); p = 0.668).Conclusion: Previous VAI results cannot assist in predicting the 10-year CVD risk. Additionally, including mea-surements of serum Zn, total cholesterol, fasting insulin, and FBG levels are reasonable approach for managing postmenopausal women with unfavorable CVD risk profiles
Brucellosis in pregnancy and its response to the changing immunoglobulin A: A prospective controlled study
No full textObjective: This study aimed to define the rare Brucella infection in pregnancy and its effects on immunoglobulins (Ig). Materials and Methods: This prospective study has conducted Brucella screening using the Rose Bengal test on pregnant and non-pregnant outpatients who did not show any specific Brucella symptoms. The immunoglobulin levels were measured using the enzyme-linked immunosorbent assay. The study group consisted of pregnant women who were at 20 weeks or below gestation and applied to our hospital outpatient clinic for routine check-ups. The control group consisted of healthy patients who applied for routine controls. Results: This study included a total of 584 participants, 293 of whom were controls and 291 were the study (pregnant) participants. The study revealed a 1.5% incidence of Brucella during pregnancy. In acute and chronic Brucella infection, lower levels of IgA response were observed in pregnant cases compared to the control group. Conclusion: Brucella infection is a disease that can cause fetal problems, especially in endemic areas. The role of the altered IgA response in pathologies that are associated with Brucella infection stands out as a new target for disease pathophysiology
Effects of psychiatric symptoms, age, and gender on fear of missing out (FoMO) and problematic smartphone use:Apath analysis with clinical-based adolescent sample
No full textBackground: Fear of missing out (FoMO) is a kind of anxiety that arises from FoMO on rewarding online social experiences that others might be having. Recent studies demonstrated that there is a strong relationship between FoMO and problematic smartphone use (PSU). In this study, we aimed to address the relationship between age, gender, psychiatric symptoms, PSU, and FoMO among a clinical-based adolescent sample. Methods: In total, 197 adolescents (136 boys, 1218 years) who applied to psychiatry clinics were recruited in the study. Path analysis with observed variables was used to investigate the relationships of PSU and FoMO with each other and with psychiatric symptoms (somatization, obsession-compulsion, interpersonal sensitivity, depression, anxiety, phobic anxiety, paranoid ideation, and psychoticism), age, and gender. Results: Path analysis showed that age (B-1 = 2.35, P < 0.001), somatization (B1 = 1.19, P < 0.001), hostility (B-1 = 0.92, P = 0.001), and paranoid ideation (B-1 = 0.93, P = 0.005) have significant positive effect on PSU, when interpersonal sensitivity has a significant negative effect (B-1 = -1.47, P < 0.001). For FoMO, male gender (B-0 = 0.35, P < 0.001), anxiety (B-1 = 1.37, P < 0.001), and PSU have positive effects, whereas age (B-1 = -1.60, P < 0.001), depression (B-1 = -0.58, P = 0.004), and hostility (B-1 = -0.49, P = 0.001) have a negative effect. Conclusions: Our study demonstrated that although PSU and FoMO are closely related to each other in previous studies, they have different associations with age, gender, and psychiatric symptoms among a clinical-based adolescent sample. The positive effects of PSU, anxiety on FoMO are predictable; however, the negative effect of age, hostility, and depression on FoMO was interesting. These relationships could be related to social exclusion-hostility and impulsivity-male gender/younger age associations in adolescence. In addition, we did not find a significant effect of FoMO on PSU, this could be related to the social and non-social use of smartphones, and should be reevaluated in clinical samples in the future
The predictors of COVID-19 mortality in a nationwide cohort of Turkish patients
Get PDFhe COVID-19-related death rate varies between countries and is affected by various risk factors. This multi center registry study was designed to evaluate the mortality rate and the related risk factors in Turkey. We retrospectively evaluated 1500 adults with COVID-19 from 26 centers who were hospitalized between March 11 and July 31, 2020. In the study group, 1041 and 459 cases were diagnosed as definite and highly probable cases, respectively. There were 993 PCR-positive cases (66.2%). Among all cases, 1144 (76.3%) were diagnosed with non-severe pneumonia, whereas 212 (14.1%) had severe pneumonia. Death occurred in 67 patients, corre sponding to a mortality rate of 4.5% (95% CI:3.5–5.6). The univariate analysis demonstrated that various factors, including male sex, age ?65 years and the presence of dyspnea or confusion, malignity, chronic obstructive lung disease, interstitial lung disease, immunosuppressive conditions, severe pneumonia, multiorgan dysfunction, and sepsis, were positively associated with mortality. Favipiravir, hydroxychloroquine and azithromycin were not associated with survival. Following multivariate analysis, male sex, severe pneumonia, multiorgan dysfunction, malignancy, sepsis and interstitial lung diseases were found to be independent risk factors for mortality. Among the biomarkers, procalcitonin levels on the 3rd-5th days of admission showed the strongest associations with mortality (OR: 6.18; 1.6–23.93). This study demonstrated that the mortality rate in hospitalized patients in the early phase of the COVID-19 pandemic was a serious threat and that those patients with male sex, severe pneumonia, multiorgan dysfunction, malignancy, sepsis and interstitial lung diseases were at increased risk of mortality; therefore, such patients should be closely monitored
Isıtılmış tütün ürünü ilişkili subakut akciğer hasarı
Get PDFHeated tobacco products release nicotine without burning tobacco with an electronically controlled heating system. 56-year-old male patient admitted with sudden onset of chest pain and shortness of breath. He had been using a heated tobacco product (I quit ordinary smoking, IQOS) for 2.5 years. Thoracic computed tomography scan revealed pleural-based atelectasis and fibroatelectatic changes in the lower lobe of the right lung, pleural fluid in the right upper lobe, fibroatelectatic changes and pleural thickening in the left lung. Biopsy taken with video-assisted thoracic surgery (VATS) showed lymphoid aggregation in nodular form and widespread anthracosis around the lung, fibrillar material that double-refracting the light in the alveoli, hyaline membrane-like material in the alveoli, type 2 pneumocyte hyperplasia, an interstitial organization, and a subacute lung injury picture with exogenous lipoid material. These findings were evaluated in accordance with toxic substance-induced chemical pneumonia. It was thought that it might be related to 2.5 years of using heated tobacco product
Tip 2 Diabetes Mellitus’ lu hastalarda serum ve ı?drar galektin-3 düzeyi ile mikroalbuminüri arasındaki ı?lişkinin deg?erlendirilmesi
No full textAmaç: Bu çalıs?manın amacı Tip 2 diyabetes mellitusu olan hastalarda mikroalbuminürigelis?imi ile serum ve idrar galektin-3 düzeyleri arasındaki ilis?kiyi deg?erlendirmektir.Yöntem: Tip 2 diyabet tanısı olan mikroalbüminüri gelis?mis? 30 hasta ve tip 2 diyabettanısı olan normoalbüminürik 30 hasta çalıs?maya dahil edildi. Tüm hastalarda açlık kans?ekeri, hemoglobin A1c, kan üre nitrojeni, kreatinin, düs?ük dansiteli lipoproteinkolesterol, total kolesterol, tam idrar tetkiki, spot idrarda albümin, spot idrarda kreatinin,serum galektin-3 ve idrar galektin-3 çalıs?ıldı. Serum galektin-3, idrar galektin-3,hemoglobin A1c, düs?ük dansiteli lipoprotein kolesterol, total kolesterolmikroalbüminürik ve normoalbüminürik gruplar arasında kars?ılas?tırıldı. Bulgular:Çalıs?mamızda mikroalbüminürik grupta, normoalbüminürik gruba göre hem serumgalektin-3 düzeyi (20.1±14.9 ng/ml ve 4.8±5.6 ng/ml, p <0.001) hem de idrar galektin-3düzeyi (19.6±18.7 ng/ml ve 10.5±10.2 ng/ml, p = 0.027) yüksek tespit edildi.Mikroalbüminüri düzeyi ile serum ve idrar galektin-3 düzeyi arasında pozitif korelasyontespit edildi (r=0.614, p<0.01 ve r=0.268, p<0.05, sırasıyla). Serum galektin-3 düzeyinin,mikroalbüminüriyi öngörmede bag?ımsız bir etken oldug?u görüldü (Odds oranı:1.26,güven aralığı:1.07-1.46, p=0.004). Sonuç: Tip 2 diyabetes mellitusu olan hastalardamikroalbüminürisi olan hastalarda normoalbüminürisi olanlara göre hem serum hem deidrar galektin-3 düzeylerinde artıs? saptandı. Çalıs?mamızın bulguları diyabetiknefropatide galektin-3’ün bir biyobelirteç olarak kullanılabileceg?i görüs?ünüdesteklemis?tir
Information security awareness scale (ısas) for university students: a validity and reliability study
Get PDFThe purpose of this study is to develop a scale for university students
to determine information security awareness levels. The categories and
the indicators related to information security awareness were
determined by the literature review. A question pool of 90-items
related to the categories and the indicators was generated. Next, 23
field experts evaluated the draft scale form for the content validity.
After that, the 67-point scale, which was redesigned in line with expert
assessments, was practiced to the students studying at Ankara
University. As a result of exploratory factor analysis, it was
determined that the scale consists of 34 items and 4 subscales ('privacy
and safe browsing', 'attacks and threats', ‘general security’ and
‘cyberbulling’).A confirmatory factor analysis with the data of the
second group of 156 participants was performed at the following stage
of the study, and the structure with four factors was confirmed. At the
end of the construct validity analysis, the scale consists of four factors
and 34 items, and the total variance that it can explain is 50,42%. The
Cronbach Alpha internal consistency coefficient and the Spearman Brown split-half reliability coefficient were calculated to confirm the
reliability of the scale. Besides, the significance of the differences
between the upper and lower 27 % group item averages was examined
using the corrected item-total correlation and t-test. The Cronbach
alpha internal consistency coefficient was 0.949 and the Spearman Brown split half reliability coefficient was 0.861 for the whole scale,
while it was calculated as PSB: 0.927/0.833, AT: 0.923/0.871, GS:
0.821/0.801, and CS: 0.898/0.887 for the sub-scales, respectively. All
findings show that a high reliability and validity scale that can be used
to determine the levels of information security awareness of university
students was obtained
A new mathematical model for determining optimal workforce planning of pilots in an airline company
No full textThis study aims to model a workforce-planning problem of pilot roles which include captain and first officer in an airline company and to make an efficient plan having maximal utilization of minimum workforce requirements. To tackle this problem, a mixed integer programming based a new mathematical model is proposed. The model considers different conditions such as employing pilots with different skill types, resignations, retirements, holidays of pilots, transitions between different skills regarding needs of the demands during the planning horizon. The application of the proposed approach is investigated using a case study with real-world data from an airline company in Turkey. The results show that a company can use transitions instead of new employment and this is a more suitable medium-term production and human resource planning decision