Ufuk Universitesi Akademik Acikerisim Sistemi
Not a member yet
2287 research outputs found
Sort by
Pay Senedi Piyasalarında Balon Varlığının Test Edilmesi: MIST Ülkeleri Örneği
No full textBu çalışmanın temel amacı, MIST (Meksika, Endonezya, Güney Kore ve Türkiye) ülkeleri pay senedi piyasalarının endeks getirilerinde fiyat balonlarının varlığını test etmektir. Finansal varlıkların piyasa değerinin temel değerinden sapmasını ifade eden fiyat balonları, tarihten günümüze kadar birçok pay senedi piyasasında görülmüştür. Tüm dünyada, özellikle 2008 küresel finans krizi nedeniyle, 2008 ve sonrasında finansal piyasalar üzerine çalışan araştırmacıların üzerinde yoğunlaştığı konuların başında fiyat balonları gelmektedir. Bu çalışmada, MIST ülkeleri pay senedi piyasa endekslerinde fiyat balonlarının varlığı, Nisan 2001 – Kasım 2020 dönemleri için haftalık endeks kapanış fiyat verileri ile araştırılmıştır. MIST ülkeleri pay senedi piyasa endeks getirilerinde birçok alt-örneklem dönemi için fiyat balonlarının varlığı, standart genişletilmiş Dickey Fuller (SADF) test sonuçları ve genelleştirilmiş genişletilmiş Dickey Fuller (GSADF) test sonuçları, bootstrap simülasyon yöntemi ile gösterilmiştir. Bu ülkelerin pay senedi piyasalarının endeks getirilerinde farklı zamanlar içinde fiyat balonu varlığı uygulama ile kanıtlanmıştır
Demir Eksikliği Tespit Edilip Anemi Tespit Edilmeyen Hastalar ile Yaş Uyumlu Sağlıklı Kontroller Arasındaki Enflamasyon ve Oksidatif Durumu Gösteren Hematolojik ve Biyokimyasal Parametrelerin Karşılaştırılması
No full textAmaç: Anemi olmadan demir eksikliği olan hastalar ile oksidatif durumu etkileyen tiyol disülfid dengesi arasındaki ilişkinin ortaya konulması amaçlanmıştır. Gereç ve Yöntem: Pediatri polikliniğinde başvuran 5-15 yaş aralığı demir eksikliği (n=35) olan grup ile yaş ve cinsiyet uyumlu sağlıklı kontrol grubunun (n=36) oluşturduğu toplam 71 olgu çalışmaya dahil edildi. Demir eksikliği tanısı, yaş ve cinsiyete göre normal hemoglobin seviyesine sahip olup, ferritin değeri <12 ng/mL altında olan hastalara konuldu. Bulgular: Demir eksikliği grubunda ferritin düzeyi 11,01±0,89 ng/mL iken, kontrol grubunda ise 25,27±2,57 ng/mL idi (p<0,001). Demir eksikliği grubunda nativ tiyol ve total tiyol değerleri anlamlı olarak düşükken (p<0,001 ve p<0,001, sırasıyla), disülfid, disülfid/nativ tiyol ve disülfid/total tiyol değerleri anlamlı olarak yüksekti (p<0,001, p<0,001 ve p<0,001, sırasıyla). Ferritin düzeyi ile sadece total tiyol düzeyi arasında pozitif korelasyon mevcuttu (r=0,330, p=0,049). Sonuç: Bu çalışmada anemi olmadan da demir eksikliğinin oksidatif strese neden olduğu izlendi
In Vitro Bedaquiline and Clofazimine Susceptibility Testing in Mycobacterium abscessus
No full textBedaquiline and clofazimine are increasingly used to treat infections with Mycobacterium abscessus. We determined distributions of MICs by broth microdilution for bedaquiline and clofazimine for 61 M. abscessus clinical isolates using different media and incubation times. We show that incubation time and growth media critically influence the MIC. Our data will aid in defining future clinical breakpoints for in vitro susceptibility testing for bedaquiline and clofazimine in M. abscessus.University of Zurich; Schweizerische Gesellschaft fur Cystische Fibrose (CFCH); Swiss National Science Foundation [310030_197699]; Federal Office of Public Health (FOPH); TUBITAK Turkey; Swiss National Science Foundation (SNF) [310030_197699] Funding Source: Swiss National Science Foundation (SNF)We thank the technicians of the National Reference Center for Mycobacteria, Institute of Medical Microbiology, University of Zurich for their dedicated help, and E. C. Bottger for critical reading of the manuscript and continuous support. This study was supported by the University of Zurich. We acknowledge financial support from Schweizerische Gesellschaft fur Cystische Fibrose (CFCH), Swiss National Science Foundation (310030_197699), and the Federal Office of Public Health (FOPH). F. N. Akdoan Kittana was supported by TUBITAK Turkey. B. Schulthess, conceptualization, project administration, formal analysis, visualization, writing - original draft, writing - review & editing; F. N. Akdoan Kittana, investigation, data curation, writing - review & editing; R. Homke, resources, methodology, writing - review & editing; P. Sander, supervision, funding acquisition, writing - review & editing
Evaluation of Pediatric Patients with First Seizure
No full textObjective: Pediatric seizure is a condition that occurs due to many different underlying causes and causes fear and anxiety in families. In our study, it was aimed to evaluate pediatric seizure cases who applied to our hospital. Methods: Patients aged 0-18 years, who applied to the pediatric emergency department of our hospital between May 2018 and May 2020, were retrospectively analyzed. The patients were evaluated in terms of age, gender, seizure types, familial genetic predisposition, examination, treatment and follow-up. Seizures were divided into 2 groups as focal and generalized according to the International League Against Epilepsy (ILAE) 2017 classification. The treatment methods applied with cranial magnetic resonance imaging and electroencephalography recordings of the patients were evaluated. Results: Of the 118 patients included in the study, 70 (59 %) were girls and 48 (41 %) were boys. The mean age was 60 (3-192) months. Family history was present in 18 (15 %) cases. 8 (7 %) of the seizures are partial and 110 (93 %) of them are generalized. Since seizure recurrence was observed within 24 hours in 5 of 36 patients who were evaluated as febrile seizures, they were evaluated as complicated febrile seizures and drug treatment was started. The other 31 patients were evaluated as simple febrile seizures. There was no biochemical abnormality in the seizure etiology in any of the cases. Cranial magnetic resonance imaging revealed polymicrogyria in 2 patients, hydrocephalus in 2 patients, brain tumor in 1 patient, and arteriovenous malformation in 1 patient. Conclusions: In cases presenting with seizures, the underlying causes should be identified and their treatment should be arranged. Cases with recurrent seizures should also be followed closely
Serum calprotectin levels as markers of inflammation, insulin resistance and hyperandrogenism in women with polycystic ovary syndrome
No full textPolycystic ovary syndrome (PCOS) is a common, complex endocrine, and metabolic disorder. Inflammation has been thought to play an important role in PCOS pathogenesis in recent years, and various inflammatory markers have been investigated; however, no definite conclusion has been reached. As a multifunctional regulatory protein in different inflammatory processes, calprotectin may play a role in the etiology of PCOS. Therefore, based on this hypothesis, we aimed to determine serum calprotectin concentrations in women with PCOS and to compare them with healthy controls. This cross-sectional study was conducted at a tertiary referral center during the study period. Forty-three women (n = 43) with PCOS and 47 women (n = 47) in the control group were enrolled in this cross-sectional study. Serum calprotectin concentrations were measured using enzyme-linked immunosorbent assay and compared with markers of glucose and lipid metabolism. Clinical characteristics and hormonal parameters were evaluated in both groups. Levels of serum calprotectin were measured as 347 +/- 28.8 and 188 +/- 15.3 ng/mL in the PCOS and healthy control groups, respectively (P = .009). The mean homeostatic model assessment for insulin resistance([1]) index and total testosterone levels were significantly higher in the PCOS group than in the control group (both P < .001). Spearman's correlation test demonstrated linear correlations between calprotectin and C-reactive protein, waist circumference, insulin resistance index, and total testosterone levels in the PCOS group (all P < .05). Serum calprotectin levels were higher in women with PCOS. This biomarker may be an indirect sign of insulin resistance, hyperandrogenism, or chronic inflammation in women with PCOS
COVID-19 Pandemi sürecinde Tüberküloz Tanısı Alan Hastaların Deneyimleri: Nitel Araştırma
No full textAmaç: Bu araştırma, COVID-19 pandemi sürecinde tüberküloz tanısı alan hastaların yaşadıkları deneyimlerin belirlenmesi amacıyla yürütülmüştür. Yöntem: Nitel bir araştırma olarak yapılan araştırmada, Samsun İlkadım Verem Savaş Dispanseri’ne kayıtlı 14 tüberküloz hastası ile 19 Kasım-15 Aralık 2021 tarihleri arasında yüz yüze görüşmeler yapılmıştır. Görüşmeler esnasında, yarı yapılandırılmış görüşme formu kullanılmıştır. Elde edilen veriler tümevarımsal tematik analiz prosedürüne göre analiz edilmiştir. Bulgular: Bu araştırmada iki ana tema belirlenmiştir. Bunlar; bireysel tepkiler ve baş etme temalarıdır. Bu temalar, alt temalara ayrılmıştır. Bireysel tepkiler temasının alt temaları emosyonel, fizyolojik ve davranışsal tepkiler; baş etme temasının alt temaları dini baş etme ve kabullenmedir. Sonuç: COVID-19 pandemi sürecinde tüberküloz hastalarının tanı aldıklarında emosyonel, fizyolojik ve davranışsal olarak bireysel tepkiler gösterdikleri, dini baş etme ve kabullenme yöntemleri ile bu tepkilerle baş ettikleri belirlenmiştir. Tüberküloz hastalarında fizyolojik, emosyonel ve davranışsal tepkilerin azaltılması ve bu tepkilerle etkili baş etme tekniklerinin öğretilmesi için hastalara tüberkülozun semptomları, semptom yönetimi, tedavi süreci, ilaçlar ve stresle baş etme teknikleri konularında eğitim verilmesi önerilmektedir
Can Investors Benefit from the Phase Difference Between Countries and Overreaction of the Major World Markets During the Pandemics? Study on the Covid-19 Case
No full textWhile the Covid-19 pandemic affected the world economies and investors' behavior, it caused serious volatility in asset prices. Studies on Covid-19 in the literature generally analyzed the relationship between the number of cases, the number of deaths, and the performance of the stock markets. In this study, different from the literature, it has been tested whether investors can benefit from the phase difference between countries and overreaction in stock prices during the pandemic. In the study, which included 48 of the world's leading stock exchanges, countries were classified according to the time the epidemic progressed and the loss of stock market indices. Regardless of the country-based progression of the pandemic, it was observed that the global news flow was more effective in the pricing of different stock markets. On the other hand, it has been observed that the indices of the countries where the epidemic first spread, performed 6% worse than other indices on average, but this difference has closed over time. Another finding of the study is that the indices that lost the most during the period when the pandemic spread were the ones that showed the highest performance in the following period. This finding supports the overreaction hypothesis
Investigation of the relationship between early pregnancy losses and urinary iodine concentration
No full textAim: The aim of this study was to evaluate the relationship between the development of spontaneous abortion (SpA) and hypothyroidism developing during pregnancy in patients who were euthyroid before pregnancy. Material and Methods: This prospective study included 44 women with singleton pregnancies with a history of pregnancy loss and 43 women with singleton pregnancies with no history of loss. All patients were in the first 12 weeks of pregnancy. Age, gestational age, number of miscarriages, gravida, body mass index, free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulant hormone (TSH), and urinary iodine concentration levels (UIC) were measured. Parameters were compared between the groups using the independent samples t-test. Correlation analysis was performed to determine relationships between the parameters in the groups. The Pearson correlation coefficient was calculated. A value of p<0.05 was considered statistically significant. Results: The mean UIC (145.3 +/- 56.01 mu g/L) in the SpA group was lower than in the non-abortus group (186.9 +/- 68.80 mu g/L) (p= 0.001). In the SpA group, there more hypothyroidic patients, and FT4 values were statistically significantly low (p=0.004). Correlation analysis determined a significant correlation between UIC and SpA (r: -0.438((SIC)), p<0.001). As a result of the binary logistic regression analysis, recurrent SpA and moderate and severe iodine deficiency were seen to have contributed to the development of SpA in the current pregnancy. Discussion: The results of this study showed that even in patients who were euthyroid before pregnancy, with the increasing iodine requirement in pregnancy, iodine deficiency can emerge and this can cause hypothyroidism and increase the risk of the development of SpA
Serum Prealbumin: A potential predictor of Right Ventricular Dysfunction in patients receiving programmed hemodialysis
No full textOBJECTIVE: Prealbumin has been a reliable marker to predict protein energy malnutrition and hypercatabolic state. In this analysis, we particularly aimed to investigate the potential association between serum prealbumin levels and right ventricular dysfunction in patients receiving programmed hemodialysis. METHODS: A total of 57 subjects were included in the analysis. The subjects were then categorized into two groups: right ventricular dysfunction (n=18) and non-right ventricular dysfunction (n=39) groups. In all patients, detailed transthoracic echocardiography (following hemodialysis) were performed along with the evaluation of complete blood count, routine biochemistry parameters, and, in particular, serum prealbumin levels. RESULTS: Mortality rate at 3 years was found to be significantly higher in the right ventricular dysfunction group (p=0.042). Serum prealbumin levels were also significantly lower in the right ventricular dysfunction group compared with the non-right ventricular dysfunction group (23.83±8.50 mg/dL versus 31.38±6.81 mg/dL, p=0.001). In the receiver operating characteristics curve analysis, a prealbumin cutoff value of <28.5 mg/dL was found to predict right ventricular dysfunction, with a sensitivity of 67% and a specificity of 62% (area under the curve: 0.744). In the correlation analysis, a moderate yet significant positive correlation was demonstrated between serum prealbumin and tricuspid annular plane systolic excursion (r=0.365, p=0.005). CONCLUSION: This study suggests that low serum prealbumin might serve as a potential predictor of right ventricular dysfunction (and its clinical consequences) in patients receiving programmed hemodialysis. © 2022 Associacao Medica Brasileira. All rights reserved
Evaluation of Oxidative Stress Marker and Ischemia Modified Albumin Levels in Patients with Psoriasis Vulgaris
No full textObjective: As a systemic inflammatory skin disease, psoriasis vulgaris (PS) is associated with cellular immune mechanisms. We aimed to evaluate oxidative stress markers and ischemia modified albumin levels in patients with PS and controls.Materials and Methods: The participants (over age of 18) who applied to the dermatology outpatient clinic between September 2020 - May 2021 and diagnosed with PS (n=50) were enrolled into the study. Oxidative stress markers such as nitric oxide (NO), malondialdehyde (MDA), 8-hydroxy 2-deoxy guanosine (8-OHdG), superoxide dismutase (SOD), glutathione peroxidase (GPx) parameters and ischemia modified albumin (IMA) levels in patients with PS and controls were evaluated.Results: A total of 100 volunteers, 50 with PS and 50 healthy controls were enrolled in the study. In the measurements of oxidative stress markers, GPX, 8-OHdG, MDA, IMA, IMA/Albumin and NO parameters were found to be statistically as significant between the patient and control groups. Also, SOD, 8-OHdG, IMA and NO were found to be statistically as significant between two psoriasis severity index (PASI) groups.Conclusion: Elevated levels of 8-OHdG, MDA, IMA, IMA/Albumin, NO and decreased levels of GPx were observed in patients with PS. To clarify this topic, further and comprehensive studies are needed