Ufuk Universitesi Akademik Acikerisim Sistemi
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Ganglion cell complex thickness and optical coherence tomography findings in stargardt macular dystrophy and retinitis pigmentosa
No full textAim: In this study, we aimed to assess ganglion cell complex (GCC) thickness with spectral domain optical coherence tomography (SD-OCT) and to detect changes in retinal layers in eyes with Stargardt macular dystrophy (SMD) and retinitis pigmentosa (RP) patients. Material and Methods: Fifty-four eyes of 27 patients with RP and 46 eyes of 23 patients with SMD were enrolled. Each subject underwent a complete ophthalmic examination before SD-OCT was obtained. Macular scans were taken with software version 6.0 of the ganglion cell analysis (GCA) algorithm. Patients were divided into 3 grades according to photoreceptor layer integrity. GCC thickness was evaluated automatically as the average, minimum and six sectors by SD-OCT, and parameters were compared between groups. Result: The mean age was 41.66 +/- 19. 77 years in group 1 (RP patients), and 28.00 +/- 10.37 years in group 2 (SMD patients). There were no significant differences in mean age, gender distribution, intraocular pressure and spherical equivalent at imaging between the groups (p>0.05). The mean (+/- SD) GCC thicknesses were evaluated and there were no significant differences between the two groups in each segment (Mann-Whitney U, p>0.05), but there were significant differences between patients in each grade (Kruskal-Wallis, p<0.05). Discussion: This study showed that progressive degeneration and loss of function in the outer retinal layers are accompanied by damage to the inner retinal layers in patients with RP and SMD. However, some of the ganglion cells are protected after photoreceptor cell death, which may point us to the target tissue for future treatment modalities
KASTEN YARALAMA SONUCU YÜZDE SABİT İZE NEDEN OLMA (TCK m.87/1-C)
No full textİnsanların karşı karşıya geldiklerinde ilk göze çarpan vücut bölgesi “yüz” bölgesidir. “Yüz”, kişiler üzerinde olumlu veya olumsuz etkilere neden olur. Yüzdeki değişimler ve yaralanma sonucu oluşan izler, kişilerin psikolojisini, sosyal ve ekonomik hayatını olumsuz etkiler. O nedenle, kanun koyucu kasten yaralama sonucu yüzde sabit ize neden olunmasını neticesi sebebiyle ağırlaşan yaralama olarak kabul etmiştir (TCK m.87/1-c). Ancak yüzdeki bir izin TCK’nın 87/1-c maddesi anlamında sabit iz niteliğinde olup olmadığına ilişkin tespit büyük ölçüde sübjektif değerlendirmelere dayanmaktadır. Bu da, kanunun uygulanmasında belirsizliğe, kanunun benzer olaylar bakımından farklı şekilde uygulanmasına neden olmaktadır. Bu yönüyle TCK’nın 87/1-c maddesindeki düzenleme, kanunilik ilkesinin sonuçlarından olan belirlilik ilkesine aykırı olup, kanımızca TCK’nın 87/1-c maddesi kanundan çıkarılmalıdır. Bu maddenin korunmasının tercih edilmesi halinde ise, nesnel kriterlere dayalı olarak yüzde sabit izin tespiti yoluna gidilmelidir
Evaluation of MCV/RDW Ratio and Correlations With Ferritin in Telogen Effluvium Patients
No full textIntroduction: Telogen effluvium is one of the chronic diseases that affect the quality of life (QoL) in women. Genetic factors, vitamin deficiencies, hormonal and environmental conditions take roles in the etiology of hair loss. Objectives: The study aimed to evaluate the RDW(Red cell distribution witdh)/MCV(Mean corpuscular volume) ratio and its correlation with ferritin in Telogen Effluvium patients and to reveal their potential role in the etiopathogenesis of Telogen effluvium. Methods: We retrospectively evaluated the medical data of 250 patients who were admitted to the dermatology outpatient clinic between September 2020 and December 2020 with a diagnosis of telogen effluvium. The control group was created retrospectively from the medical records of 250 healthy individuals. HB(Hemoglobin), HCT(Hematocrit), MPV(mean platelet volume), MCV, RDW, ferritin, and MCV/RDW ratio of both groups were compared and evaluated statistically. Results: All telogen effluvium patients were women in terms of gender. The mean age of the patient group was 33.11 +/- 9.66 years and the mean age of the control group was 34.98 +/- 12.37 years. The ratio of MCV/RDW, MPV, MCV, and ferritin is lower in the group with telogen effluvium compared to the control group and a statistically significant difference was found (P < 0.05). Conclusions: Iron deficiency anemia is thought of as a factor in female patients with telogen effluvium. Although the data shows the correction of iron deficiency is insufficient telogen effluvium, we proposed that laboratory tests should be routinely used in the diagnosis and treatment phase of patients who apply with the complaint of hair loss
Comparative analysis of classical primary continuous and novel technique uterine suturing methods on uterine scar formation after caesarian section: A prospective clinical study
No full textObjectives: The study investigated isthmocele rate, residual myometrium thickness, blood loss, and closure lengths through comparing the classical primary continuous suturing (CPCS) and novel technique uterine suturing (NTUS) after caesarian section. Material and methods: A total of 402 C/S patients were included in this single-center prospective clinical study. All patients were divided into two groups according to suture technique. Classical primary continuous suturing (CPCS) was applied to the patients in Group 1, while the novel technique uterine suturing (NTUS) was applied in Group 2 as Z suture on both corners and 8 sutures in the remaining middle part incision closure. Results: Patients in the NTUS group bled less than in the CPCS groups (p<0.0001). Incision length after closure was longer in the CPCS than in the NTUS (p<0.0001). Similarly, the number of sutures we applied was higher in the CPCS (p<0.0001). In comparison of residual myometrium thickness, the mean values measured 197 ± 50 mm in the NTUS and 146 ± 39 mm in the CPCS (p<0.0001). Residual myometrium thickness showed a negative strong correlation with incision length after closure (r = –0.436; p<0.0001), how many times the needles have been passed (r = –0.423; p<0.0001) and time for suturing (r = –0.237; p<0.0001). NTUS and CPCS groups were similar in comparison to isthmocele. Conclusions: The NTUS, termed as Erkayiran’s suture, showed a successful reflection in our surgical cesarean section application compared to the classical suture. Although the occurrence of isthmocele in patients was similar, results were quite successful operationally in terms of both minimal blood loss and increased residual myometrium thickness. Copyright © 2022 PTGi
Regional distribution of glucose-6-phosphate dehydrogenase deficiency in Turkey and evaluation of clinical findings: a multicenter study
No full textObjectives: The single most inherited enzyme deficiency is that of glucose-6-phosphate dehydrogenase (G6PD) with a presence in almost 400 million of theworld’spopulation. Thenumber of reported G6PD mutations is 186. Furthermore, geographical location is a determining factor for the prevalence of G6PD. Therefore, much of the existing epidemiological literature concerning this issue in Turkey has reported data specific to cities and regions. The purpose of this study was to examine G6PD deficiency in a sample of subjects. Outcome measures reported in this study include the clinical factors as sociated with the deficiency, as well as in geographical dispersion across regional locations in Turkey. Methods: This is a retrospective, cross-sectional study. The sample comprised 308 subjects with a G6PD diagnosis. Data collection commenced in January 2011, and was completed by May 2020. Results: In Turkey, the Mediterranean region has the greatest prevalence of G6PD enzyme deficiency. Subjects presenting with this deficiency were also diagnosed with haemolytic anaemia that was attributed to favism. Subsequently, drug and neonatal hyperbilirubinemia-induced haemolysis ensued. Over 90% of subjects diagnosed with a critical G6PD deficiency and recurrent haemolysis were allocated to the Class II variant. Conclusions: The Mediterranean, along with Agean and Marmara regions are where the highest prevalence of G6PD enzyme deficiency are observed. Favism-induced haemolytic anaemia is the most often identified clinical precursor to diagnosis of G6PD deficiency in Turkey. The most common clinical feature after this condition is drug related haemolysis and the onset neonatal hyperbilirubinemia
Evaluation of the effects of the COVID-19 pandemic on pain, stress, sleep and quality of life in patients with chronic musculoskeletal pain
No full textAims: The study aimed to evaluate the association between the novel Coronavirus disease-2019 (COVID-19) pandemic and the level of pain, stress, sleep quality, and quality of life in patients with chronic musculoskeletal pain. Methods: This cross-sectional study included patients aged 18-65 years with chronic musculoskeletal pain. Age, gender, body mass index, systemic diseases, dominant pain area, duration of pain, analgesic use, and exercise habit before and after the pandemic were recorded. Participants were asked to evaluate their pain severity and global assessments in the last month and the pre-pandemic period with a visual analog scale (VAS). The Perceived Stress Scale (PSS), The Pittsburgh Sleep Quality Index (PSQI), and The Nottingham Health Profile (NHP) were administered Results: The study included 100 participants (age, mean ± SD: 42.8±12.5 years, female: 69%). Compared with the pre-pandemic period, an increase in pain and global assessment scores, and poorer sleep hygiene in the last month were reported by 82%, 67%, and 66%, respectively. Pain severity VAS score (pre-pandemic: 3.9±2 vs. post-pandemic: 5.9±2.1, p<0.001), global assessment VAS score (pre-pandemic: 3.8±2 vs. post-pandemic: 5.6±2.3, p<0.001), the proportion of patients using routine analgesics (pre-pandemic: 44% vs. post-pandemic: 52%, p=0.008), and the number of routine analgesics (pre-pandemic: 10.4±18.6 vs. post-pandemic: 15.3±24, p<0.001) in the last month was significantly more compared to the pre-pandemic period. There were no significant differences in pain score, patient’s global assessment score, the number of routine analgesics, PSS-14, PSQI, NHP-1, and NHP-2 scores between subjects with and without a history of COVID-19. Conclusions: In patients with chronic musculoskeletal pain, an increase in pain severity, analgesic use, and deterioration in general well-being were observed during the COVID-19 pandemic. The pronounced changes were not found to be dependent on the history of COVID-19. © 2022. by the University of Health Sciences Turkey, Gülhane Faculty of Medicine / Gülhane Medical Journal published by Galenos Publishing Hous
Evaluation of the Relationship Between Rosacea Cutaneous Subtype and Meibography Findings
No full textObjective: Acne rosacea (AR) is a chronic inflammatory skin disease that can cause serious ocular complications. This study was designed to evaluate dry eye disease (DED) and meibomian gland dysfunction (MGD) in AR patients and to investigate the relationship between the cutaneous subtype of AR and ocular involvement. Materials and Methods: This study included 67 participants with AR and 50 healthy individuals. Patients diagnosed with 3 cutaneous subtypes were examined: erythematotelangiectatic rosacea (ETR), papulopustular rosacea (PPR), and phymatous rosacea (PR). An ophthalmatological examination was performed that included an evaluation of lid margin alterations due to meibomian gland (MG) obstruction, Ocular Surface Disease Index assessment, tear film break-up time testing, Schirmer testing, and a corneal conjunctival fluorescein staining assessment. Meibography was used to evaluate the upper and lower lids for MG loss. Results: Findings in the AR group revealed MGD in 45.5% and DED in 28.1%. The meibomian gland loss rate (MGLR) was 38.7 +/- 16.9% and the meibomian gland loss grade (MGLG) was 1.57 +/- 0.82%. The rate of MGLR and MGLG was significantly greater in the AR group than in the control group (p<0.001). PPR was seen in 59.7% of the 67 patients, ETR in 29.9%, and PR in 13.4%. A comparison of the MGD, MGLR, MGLG, and presence of DED in the 3 cutaneous subtype groups yielded statistically insignificant results. Conclusion: AR can affect MG morphology, which may result in MGD or DED. Though we did not find a significant difference in the ocular findings by subgroup, ocular involvement is a recognized risk in AR. Ophthalmologists and dermatologists should cooperate in the evaluation of AR patients. Additional studies to further examine the effects in subtype groups are recommended
Val109Asp polymorphism in Intelectin 1 gene is associated with coronary artery disease severity in women
No full textObjective: Intelectin-1 is an anti-inflammatory adipokine encoded by the Intelectin 1 (ITLN1) gene. Genetic variations in the ITLN1 gene affect the risk of coronary artery disease (CAD) and related CAD risk factors. In this study, we aimed to investigate whether the ITLN1 gene Val109Asp polymorphism has an effect on the severity of CAD and serum lipid levels in both men and women. Methods: A total of 493 subjects who underwent coronary angiography (43.5% women, mean age 63.1 +/- 9.5 years) were grouped as individuals with critical CAD (>= 70% stenosis, n=202), non-critical CAD (31%-69% stenosis, n=90), and non-CAD (control group) (1%-30% stenosis, n=201). Genotyping was performed using LightSNiP assay in Real-Time PCR. Results: The frequency of the Val allele was significantly different among all the patients with critical CAD (n=41) and non-CAD control (n=51) groups in women (p=0.033) but not in men (n=77 and n=38). Women with the Val allele had a 1.69-fold increased risk for critical CAD (p=0.033). In addition, the presence of Val allele was associated with higher coronary stenosis after adjustment for several confounders only in women with critical CAD (p=0.025). Furthermore, carriers of the Val allele exhibited an increased low-density lipoprotein cholesterol (LDL-C) in men with critical CAD than in those with non-CAD (p<0.05). Conclusion: These results suggest that the Val allele of the ITLN1 Val109Asp polymorphism is associated with critical CAD and high LDL-C levels in our study population. Further studies are required to elucidate the effect of Val109Asp polymorphism on CAD pathogenesis.Research Support Unit of Istanbul UniversityIstanbul University [22659]This study was supported by the Research Support Unit of Istanbul University (Project number: 22659)
An examination of the relationship among the psychological flexibility, self compassion, perceived stress and marital quality and with some demographic variables
No full textBu araştırmanın amacı; psikolojik esneklik, öz şefkat, algılanan stres ve evlilik kalitesi kavramlarının birbirleri ile olan ilişkisini incelemektir. Bu amaç doğrultusunda ilişkisel tarama modeli kullanılmıştır. İncelenen bir diğer unsur ise katılımcıların sosyodemografik özelliklerine (cinsiyet, yaş, eğitim düzeyi, çalışma durumu, ekonomik durum, evlilik sayısı, evlilik süresi ve çocuk sayısı) göre psikolojik esneklik, öz şefkat, algılanan stres ve evlilik kalitesi düzeylerindeki farklılıkların değerlendirilmesidir. Bu amaçla Demografik Bilgi Formu, Kabul ve Eylem Formu II, Öz-duyarlık Ölçeği, Algılanan Stres Ölçeği ve Evlilik Kalitesi Ölçeği katılımcılara çevrim içi şekilde uygulanmıştır. Çalışmaya 2021 yılında Ankara'da yaşayan evli bireylerden 553 kişi katılım göstermiştir. Elde edilen veriler normal dağılım göstermediğinden sosyodemografik özellikler ile ölçekler arasındaki ilişkileri analiz etmede Mann Whitney U testi ve Kruskal Wallis testi kullanılmıştır. Ölçekler arasındaki ilişkileri analiz etmede ise Spearman sıralama korelasyon katsayısından yararlanılmıştır. Analizler sonucunda psikolojik esneklik, öz şefkat, algılanan stres ve evlilik kalitesinin her biri arasında anlamlı ilişkiler olduğu tespit edilmiştir. Öz şefkatin olumsuz alt boyutları, algılanan stresin yetersiz öz yeterlik algısı ve stres/rahatsızlık algısı alt boyutları ve psikolojik katılık ile evlilik kalitesinin tartışma alt boyutu arasında pozitif yönlü ve anlamlı bir ilişki, tartışma alt boyutu arasındaysa negatif yönlü ve anlamlı bir ilişki olduğu saptanmıştır. Değişkenler arası diğer ilişkiler ve demografik özelliklere göre anlamlı farklılıklar, literatürle ilişkilendirilerek tartışılmıştır.This research aims to analyse the relations between psychological flexibility, self compassion, perceived stress, and marital quality. In accordance with this purpose, correlational survey model was used. In addition to this, the differences according to the participant's socio-demographic characteristics (sex, age, educational level, employment status, economic condition, number of marriages, duration of marriage, and number of children) with psychological flexibility, self compassion, perceived stress, and marital quality were analysed. For this purpose, Demographic Information Form, Acceptance and Action Questionnaire-II, Self-Compassion Scale, Perceived Stress Scale, and Marital Quality Scale were carried out with the participants online. 553 married individuals living in Ankara in 2021 participated to this study. Since the gathered data do not show normal distribution, Mann Whitney U test and Kruskal Wallis test were applied to analyse the relations between socio-demographic characteristics and scales. Spearman's rank correlation coefficient was conducted to analyse the relations between scales. Based on the results of the analyses, it was determined that there are significant relations between each variable which are psychological flexibility, self-compassion, perceived stress, and marital quality. It was determined that there are significant and positive relations between the negative sub-dimensions of self compassion, the sub-dimensions of perceived stress, psychological inflexibility, and the discussion sub-dimension of marital quality. Also, there is negative and significant relation between the above-mentioned scales and the compassion sub-dimension of marital quality. Other relations between scales and significant differences in demographic characteristics were discussed in relation to the literature
Assessment of serum glucose potassium ratio as a predictor for morbidity and mortality of blunt abdominal trauma
No full textBACKGROUND: Our hypothesis is that glucose-potassium (GLU/K) ratio can be used to predict morbidity and mortality in the evaluation of patients with blunt abdominal trauma in emergency departments. The aim of the study is to demonstrate the effect of changes in serum GLU/K ratio on morbidity and mortality and to ensure that patient management is performed more quickly and effectively. METHODS: The hemogram and biochemical parameters of 99 patients with isolated blunt abdominal trauma, applied to our hospital between January 2016 and January 2020, have been retrospectively reviewed. Patients were divided into two groups as non-survivors and survivors. The GLU/K ratio was calculated, and their ability to predict mortality and morbidity was statistically evaluated between the groups. RESULTS: In the non-survivor (mortal) group; blood urea nitrogen, serum creatinine, serum GLU and GLU/K ratio were statistically higher than the living group (p<0.005). Moreover, the sensitivity and specificity of the serum GLU/K ratio were found 72.7% and 84.1% respectively. CONCLUSION: We think that serum GLU/K ratio can have an important role in the follow-up and management of patients using it as a simple, quickly accessible, and easy predictor in evaluating patients with blunt abdominal trauma