Eureka Herba Indonesia (EHI - E-Journal)
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Andrographis Paniculata in the Treatment of Upper Respiratory Tract Infections
Get PDFAndrographis paniculata is a species of Andrographis paniculata (Burm. F) The herbaceous plant Nees, sometimes known as "king of bitters," is a member of the Acanthaceae family. It's commonly used to treat sore throats, flu, and upper respiratory tract infections in China, India, Thailand, and Malaysia. In numerous studies, andrographolide, a significant bioactive chemical ingredient of the plant, has shown anticancer potentialIn experimental models of asthma, stroke, and arthritis, andrographolide and its derivatives show anti-inflammatory properties. Pharmaceutical chemists have recently synthesized a number of andrographolide derivatives with important pharmacological properties such as anti-inflammatory, antibacterial, anticancer, antidiabetic, anti-HIV, antifeedant, and antiviral properties. The summary of the effects of andrographolide on cardiovascular illness, platelet activation, infertility, and NF-B activation in this research is remarkable. In traditional Indian and Chinese medicine, a variety of plant items were frequently recommended as medications. We investigate the potency of four selected phytochemicals from the A. paniculata plant, namely andrographolide (AGP1), 14-deoxy 11,12-didehydro andrographolide (AGP2), neoandrographolide (AGP3), and 14-deoxy andrographolide (AGP4), against four key targets, including three non-structural protein (3 L main protease (3CLpro), Papain like proteinase (PLpro) and RNA-directed RNA polymerase (RdRp)) and a structural protein (spike protein (S)) of the virus which are responsible for replication, transcription and host cell recognition. This paper intended to know the mechanism of A.Panniculata bioactive compounds and its effect to relief the upper respiratory tract infection symptomps
The Anticancer Activity of Curcumin: A Literature Review
Get PDFCancer is the world's second largest cause of mortality and one of the most serious public health issues. Despite significant advancements in cancer treatment, cancer incidence and mortality rates remain high. Current research is still focused on developing more effective and less hazardous cancer treatment options. Curcumin has gotten a lot of press in the last two decades as an anti-oxidant, anti-inflammatory and cancer-fighting agent Curcumin modulated intracellular signaling pathways that affect tumor growth, angiogenesis, metastasis, inflammation, invasion, and apoptosis, among other things. Curcumin suppresses tumor cell growth and enhances apoptosis via upregulating the expression and activity of p53. Curcumin also has a strong inhibitory impact on the NFB and COX2 activity, which are involved in the upregulation of antiapoptotic genes like Bcl2. It can also reduce the control of antiapoptosis PI3K signaling and enhance MAPK expression, resulting in endogenous reactive oxygen species generation. The goal of this research is to review curcumin's anticancer properties
Methods of Extraction: Maceration, Percolation and Decoction
Get PDFToday, natural medicines not only provide the primary healthcare needs for the majority of the population in developing countries but have attracted more and more attention in developed countries due to soaring healthcare costs and universal financial austerity. In the USA, approximately 49% of the population has tried natural medicines for the prevention and treatment of diseases. Chemicals known to have medicinal benefits are considered to be “active ingredients” or “active principles” of natural medicines. Natural products have provided the primary sources for new drug development
The Efficacy of the Consumption of Manalagi Apples and Fuji Apples on Decreasing Plaque Index in Students of Madrasah Aliyah Al-Hidayah Labuhan Batu Selatan, North Sumatra
Get PDFCaries is a common oral and dental disease. The main etiology of caries is plaque. Chewing fibrous fruits can prevent plaque accumulation, including Manalagi apples and Fuji apples. The purpose of this study was to determine the differences in the effectiveness of consuming manalagi apples with fuji apples on the reduction of the plaque index in Madrasah Aliyah Al-Hidayah students. This type of research is a quasi-experimental design with pre-test and post-test control groups. The total sample was 32 students aged 16-18. Data were analyzed by statistical test T-Test. Based on the results of the paired t-test statistical test, it was found that the average plaque index before chewing an apple was 0.63 ± 0.42 after 0.26 ± 0.26 with a mean of 0.37 ± 0.16. Meanwhile, the plaque index before chewing on Fuji apples was 1.01 ± 0.59 after 0.87 ± 0.54 with a mean of 0.14 ± 0.05. The results of the independent statistical t-test showed that the value of p = 0.001, which means that there is a difference in chewing Manalagi apples with Fuji apples to decrease the plaque index. The conclusion of this study is that consuming manalagi apples is more effective than fuji apples in reducing the plaque inde
Topical Application of Coconut Oil as Neonatal Management: A Review
Get PDFNeonates or children under 28 days of age, are at the highest risk of dying. There were 4 million neonates who reported deaths each year in 2000 and 2.4 million in 2019 at the first 4-week of their life. It arises especially in low-income and middle-income countries. The cause of neonatal deaths was related to a preventable and treatable condition indeed postnatal management. Coconut oil proved as one of the herbals which safe and efficient for neonatal management. It’s had a low-cost, reachable, and widely produced in developing countries. This review collects and analyzes randomized controlled trial published studies. The database used from PubMed. The result demonstrates that coconut oil as a topical treatment is safe for neonatal management. It’s also feasible for use and has various benefits in reducing the risk of infant weight problems, apnea, hypothermia, trans-epidermal water loss (TEWL), and increasing the quality of skin conditions, vitamin D3 serum level, and increasing motor-mental development. Coconut oil could be considered a proven therapeutic option
The Potential Treatment of Guava Leaf (Psidium guajava Linn.) For Diarrhea in Children
Get PDFDiarrhea is one of the common health problems which is causes death in children especially in a developed country. Not everybody can access the diarrhea treatment suggested by WHO. Some people decided to utilize alternative treatment, such as the medicinal plant in their environment. It is cheaper and easier to get. One of herb plant that uses is guava leaf (Psiidium guajava Linn.). It contains some active ingredients such as quercetin, tannins, flavonoids, and phenols which have the potential to antidiarrheal activity. To date no death or unusual behavior reported. Guava leaf (Psiidium guajava Linn.) extract can be provided as potential antidiarrheal in children
Garlic and Cardiovascular Disorders: A Current Review of Literature
Get PDFGarlic, a member of the Allium family, widely used as culinary and medicinal herbs since ancient histories, displays aptly described anti-inflammatory and antioxidant properties. Garlic’s therapeutic benefit is showed to be result of its constituent organosulfur compounds. Previous study reported garlic to possess several benefits on cardiovascular health including antihypertensive, anti-atherosclerotic, and antilipidemic activities. This review elaborates the phytochemical composition, pharmacological activities, mechanism of actions, and current clinical evidence of garlic in mitigating cardiovascular disease
Use of Herbal Medicinal Products among Children
Get PDFThe use of herbal medicinal products for the treatment and prevention of diseases has a long tradition over the world. The herbal medicinal products are defined as exclusively herbal active substances-contained medicinal products which used for prevention or treatment of disease. Because of its process, it chemically different defined substances in several aspects; mostly because they consist of complex multi-component mixtures which from the extraction of plant parts such as roots and leaves. Many substances could be used for relieving clinical symptoms among children. The perception that “natural” products are harmless is still dominant in many consumers. Therefore, adverse effects of herb medicines are rarely reported by patients who have taken them.4 This review will discuss about use of herbal medicinal products and what is the impact for using this in children
Antifungal Effect of Aloe Vera Extract on Otomycosis: A Review
Get PDFOtomycosis is a common disease that can cause a variety of complications, including involvement of the inner ear and, in rare cases, death. Otomycosis management can be difficult and requires close monitoring. There is currently no standardized treatment regimen for otomycosis, which opens up new treatment options such as the use of herbal medicine. Aloe barbadensis miller, also known as Aloe vera, is one of over 400 Aloe vera species and a member of the Liliaceae family. Several studies have shown that Aloe vera extract has antifungal properties. The purpose of this literature review is to identify the components of Aloe vera as well as the mechanism of action in the treatment of otomycosis. The articles chosen were all published in PubMed within the last six years. The review included 7 articles that were obtained
Benefits of Honey Extract Againt Wound Healing
Get PDFThe use of honey in wound care was widely used since ancient times. Honey bee shown to have antibacterial properties, and low pH levels create environmental conditions and are not supportive for bacterial growth. Clinical observations from human trials report that honey helps granulated tissue formation, increases epithelization, and reduces inflammation, which affects the acceleration of wound healing. The purpose of this study is to find out the effect of honey on wound healing. Research takes the form of literature review. Literature is taken from one database, PubMed. The key word used is honey and wound healing. and selected with the criteria of inclusion and exclusion obtained ten literature to be reviewed. Honey gives good results and affects the healing of skin wounds, among which there are several types of honey studied in experimental animals and in trying people. In conclusion, honey has an influence on the healing of skin wounds.