Eureka Herba Indonesia (EHI - E-Journal)
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Potential of Sambung Nyawa Leaves (Gynura procumbens) as Antidiabetic Mellitus
Full text linkDiabetes mellitus is a metabolic disease characterized by an increase in blood sugar due to defects in insulin secretion, insulin sensitivity, or both. The number of people with diabetes mellitus in Indonesia has increased every year. The number of people with diabetes is 6.9% in 2013 to 10.9% in 2018. Various therapies have been carried out for the treatment of Diabetes Mellitus, one of which is herbal therapy. Gynura procumbens is a plant that is widely used as a treatment for diabetes mellitus, kidney, rash and fever, and hypertension. The flavonoid content in Gynura procumbens replaces the decrease in blood sugar. This review article attempts to explain the role of Gynura procumbens as an antidiabetic therapy in previous studies. The method used in this article is through searching articles through the NCBI database and Google Scholar. The results of an article search found that Gynura Procumben has antidiabetic potential which can reduce blood sugar in patients with Diabetes Mellitus
The Effects of Sambiloto Leaf Extract (Andrographis paniculata) on Blood Sugar Regulation: An In Vivo Study
Full text linkoai:ojs2.eurekabiomedical.com:article/1Sambiloto (Andrographis paniculata) is one of the most common plants in Indonesia. Sambiloto contains quite varied secondary metabolites, where this plant is rich in flavonoids, alkaloids, terpenes and glycosides. This study aims to assess the effect of Sambiloto (Andrographis paniculata) leaf extract on blood sugar levels and the expression of GLUT4 protein in muscle tissue which indicates the potential of the test extract's ability to improve blood glucose intake to cells so that it can maintain blood sugar regulation. The process of extracting sambiloto is carried out by maceration in which 500 grams of simplicia are macerated with 96% ethanol for 72 hours. After 1 week of adaptation, the mice were randomly divided into the following six groups, each containing 5 animals: Normal control group, diabetes group (negative control), diabetes + metformin group (Met; 45 mg/kg), Diabetes + ES group (50 mg/kg), diabetes + ES group (100 mg/kg) and diabetes + ES group (200 mg/kg). The treatment with sambiloto extract was able to reduce blood sugar levels significantly, were at the ES 100 and 200 mg/kg BW doses it was able to reduce blood sugar levels to reach the target below 200 mg/kg BW. The dominant flavonoids in Sambiloto leaf extract are believed to be responsible for the effect of blood glucose regulation. In conclusion, Sambiloto extract affects lowering blood sugar levels in diabetes mellitus white rats by increasing glucose intake in cells and tissues
The Effect of Soursop Leaves Fraction (Annona squamosa L.) as Anticancer
Full text linkAnticancer drugs are primarily aimed at inhibiting the growth and proliferation of cancer cells. The soursop plant (Annona squamosa L.) has the potential to be developed as an anticancer drug. This plant contains several active compounds including flavonoids, borneol, camphor, alkaloids, terpenes, saponins, tannins, polyphenols, and polyketide compounds. This study was conducted to assess the efficacy of the polar fraction of soursop leaves on cytotoxic activity based on the IC₅₀ value in T47D cells. This research is experimental in vitro study using cell line T47D. The methanol fraction of soursop leaves was diluted with DMSO and DMEM to obtain a concentration of 500; 250; 125; 62.5; 31.25 µg/ mL cisplatin with a concentration of 50:25:12,5: 6,25:3,125 µg/mL. The methanol fraction of soursop from the highest concentration of 500 µg/ml has average viability of 46.77% and the average percentage of viability will increase in proportion to the decrease in the concentration of the test compound. The IC50 value shows the concentration value that results in the inhibition of cell proliferation by 50% of the population. In conclusion, the methanol fraction of soursop leaves have an anticytotoxic effect on the T47D cell line through the role of flavonoid metabolites