Eureka Herba Indonesia (EHI - E-Journal)
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Potential of Legetan Leaves (Acmella oleracea) as a Therapeutic Modality for Osteoarthritis: An In Vivo Study
Full text linkOsteoarthritis (OA) is a degenerative joint disease characterized by inflammation and cartilage damage. Legetan leaves (Acmella oleracea) have anti-inflammatory and antioxidant potential that may help relieve OA symptoms. This study aims to evaluate the potential of legetan leaves as a therapeutic modality for OA in a rat model. Legetan leaf extract was formulated into an oral preparation and given to rats induced by OA with monosodium iodate. The positive control group received standard OA medications. Parameters measured include pain scores, joint inflammation, and cartilage damage. Legetan leaf extract significantly reduced pain scores and joint inflammation in rats with OA. Legetan leaf extract also shows a protective effect against cartilage damage. In conclusion, Legetan leaves have potential as a therapeutic modality for OA
Analysis of Behavioral Factors in the Use of Traditional Medicine: Observational Study in Yogyakarta, Indonesia
Full text linkTraditional medicine has long been used by the people of Yogyakarta, Indonesia as an alternative treatment to modern medicine. Various factors influence traditional medicine use, including psychological factors such as attitudes, subjective norms, and perceived behavioral control. This research aims to determine the factors that influence the use of traditional medicine among the people of Yogyakarta Indonesia using the theory of planned behavior (TPB). This research was conducted using an analytical observational research design with a cross-sectional design. Data was collected from 110 respondents living in Yogyakarta who met the inclusion and exclusion criteria. The research instrument is a questionnaire that refers to the TPB construct which has been tested for validity and reliability. Data analysis was carried out using logistic regression statistical tests and Pearson correlation tests. The results of the analysis show that attitudinal factors and perceived behavioral control partially contribute to the intention to use traditional medicine, while the subjective norm construct does not contribute. Attitudes and perceived behavioral control are important factors that influence the intention to use traditional medicine among Indonesian people. This suggests that interventions that focus on increasing positive attitudes and perceived behavioral control can increase the use of traditional medicine
Effectiveness Test of Avocado Seed Extract (Persea Americana Mill.) in Inhibiting the Growth of Staphylococcus aureus Bacteria In Vitro
Full text linkStaphylococcus aureus can cause several health problems in the oral cavity, including stomatitis, tooth abscess, soft tissue infections, gingivitis, and periodontitis. The exploration of new therapeutic modalities for Staphylococcus aureus infection is urgent. Staphylococcus aureus has developed resistance to many of the antibiotics commonly used to treat bacterial infections. This study aimed to determine the antibacterial effectiveness of avocado seed extract (Persea americana Mill.) in inhibiting bacterial growth of Staphylococcus aureus in vitro. This study is an in vitro study in which 28 petri dishes have been added with 1-2 oses of bacterial culture Staphylococcus aureus and MHA (Mueller Hinton Agar) were used in this study. There were 7 test groups, namely 0.2% chlorhexidine as a positive control (K1), negative control, DMSO (K2), avocado seed extract treatment group 2%, 4%, 6%, 8%, and 10% respectively as K3-K7. Treatment of avocado seed extract with a concentration of 6% has the ability to grow bacteria Staphylococcus aureus better than the bacterial growth ability of the positive control, chlorhexidine. The increase in extract concentration was in line with the increase in the diameter of the bacterial inhibition zone Staphylococcus aureus. Avocado seed extract (Persea americana mill.) showed effectiveness in inhibiting bacterial growth of Staphylococcus aureus in vitro.
 
Comparison of Standardization of Ash Content of Butterfly Pea Simplicia (Clitoria ternatea L.): A Systematic Literature Review
Full text linkButterfly pea flower (Clitoria ternatea L.) has been used extensively in traditional medicine due to its various health benefits. The ash content in the butterfly pea simplicia can provide important information about the mineral content and residues present in the material. This study aimed to carry out a systematic review in order to explore a comparison of the standardization of ash content of the butterfly pea flower simplicia. The literature search process was carried out on various databases (PubMed, Web of Sciences, EMBASE, Cochrane Libraries, and Google Scholar) regarding the comparison of standardization of ash content of Clitoria ternatea. This study follows the preferred reporting items for systematic reviews and meta-analysis (PRISMA) recommendations. Several studies have shown variations in the ash content of butterfly pea flowers (Clitoria ternatea L.). The ash content of the butterfly pea flower (Clitoria ternatea L.) is in the range of 3.8 ± 0.42 mg/100 gram dry weight to 10.93 ± 0.29 mg/100 gram dry weight. Each plant has unique chemical characteristics, including different mineral content. Therefore, the ash content may vary between different plant species
The Potential of Jamblang Bark Plants (Syzygium cumini (L) Skeels) as Anticancer: A Literature Review
Full text linkJamblang plant (Syzygium cumini) is one of the local fruits of Indonesia. All parts of this plant can be used for treatment, one of which is jamblang bark as an anticancer agent. Genus Syzygium family myrtaceae is one of the largest genera in Indonesia. The purpose of this literature review is to provide an overview of the active compounds contained in jamblang plants that work as anti-cancer. Based on the results of the research that has been done, the jamun plant contains the compounds β-sitosterol, friedelin, betulinic acid, flavonoids, terpenes, alkaloids, phenolics, ellagic acid, glucoside, anthocyanins, kaempferol, quercetin, isoquercetin, myricetin, tannins, carbohydrates, albumin, and so on which can be used as antiviral, cardioprotective, anti-inflammatory, anticancer, antidiabetic, carminative, antihypertensive, anti-atherosclerotic, antifungal, antioxidant and hepatoprotector. It can be concluded that the active compound that works as an anticancer is a chemical compound of flavonoids located in jamblang bark (Syzygium cumini (L) Skeels)
The Relationship of Mother’s Knowledge to the Incidence of Stunting in Children at the Bromo Public Health Center, Medan Denai, Indonesia
Full text linkStunting is a condition where there is a growth disorder in a child caused by a lack of intake of both macronutrients and micronutrients. A mother is an individual who is very close to a child regarding the growth and development of the child. This study aimed to determine the relationship between mother’s knowledge and the incidence of stunting in children at the Bromo Public Health Center, Medan Denai, Indonesia. Cross-sectional analytic observational study. A total of 62 respondents who were mothers of children aged 36-60 months were included in this study. Data analysis was carried out with the help of SPSS software in a univariate and bivariate to determine the relationship between mother’s knowledge and the incidence of stunting. The majority of children with stunting nutritional status have mothers with poor knowledge regarding nutritional intake. In conclusion, there is a statistical relationship between the mother's knowledge and the incidence of stunting in children, with p <0.05
Risk Factors and Clinical Course of Patients with Acute Kidney Injury: A Systematic Literature Review
Full text linkAcute kidney injury (AKI) is a serious health problem and can be life-threatening if not treated quickly and appropriately. There are several risk factors that can increase a person's chances of experiencing AKI. This study aimed to carry out a systematic review to explore the risk factors for acute kidney injury and the clinical course of acute kidney injury. The literature search process was carried out on various databases (PubMed, Web of Sciences, EMBASE, Cochrane Libraries, and Google Scholar) regarding risk factors and clinical overview of acute kidney injury. The search was performed using the terms: (1) " risk factors " OR " Clinical" OR" symptoms " OR" sign " AND (2) " acute kidney injury". There are several risk factors that can increase a person's chances of experiencing acute kidney injury (AKI). These factors can be intrinsic (inside the patient's body) or extrinsic (outside the patient's body). Patients with heart disease or other blood vessel diseases have a higher risk of developing AKI. Cardiovascular risk factors such as high blood pressure, coronary artery disease, heart failure, or chronic kidney disease can contribute to the development of AKI. In conclusion, acute kidney injury is caused by intrinsic and extrinsic risk factors. While the clinical course of patients with acute kidney injury begins with the prerenal, intrinsic, oliguric, diuretic, and recovery phases
Phytochemical Analysis and Potential Pharmacological Activity of Frangipani Flower Simplicia (Plumeria spp.) as a Source of Medicinal Ingredients
Full text linkFrangipani flower simplicia contains various phytochemical compounds, such as alkaloids, flavonoids, saponins, and tannins. These phytochemical compounds have the potential to have various pharmacological activities, such as antibacterial, antifungal, anti-inflammatory, antioxidant, and anticancer. This study aims to explore the phytochemical analysis and potential pharmacological activity of frangipani flower simplicia (Plumeria spp.) as a source of medicinal ingredients. The literature search process was carried out on various databases (PubMed, Web of Sciences, EMBASE, Cochrane Libraries, and Google Scholar) regarding phytochemical analysis and potential pharmacological activity of frangipani flower simplicia (Plumeria spp.). The frangipani flower is a traditional medicinal plant that has various benefits. The phytochemical content contained in frangipani flowers, such as alkaloids, flavonoids, saponins, and tannins, has the potential to have various pharmacological activities, such as antibacterial, antifungal, anti-inflammatory, antioxidant, and anticancer
Effects of Red Galangal Rhizome Extract (Alpinia purpurata) as an Inhibitor of Staphylococcus aureus Bacterial Biofilm
Full text linkStaphylococcus aureus is a type of bacteria that causes infection through the virulence mechanism of biofilm formation, namely forming a layer by removing the matrix as a form of defense from the immune system and from antibacterial agents. This bacterium makes it very easy to form biofilms, thereby reducing the effectiveness of therapy with antibiotics. Red galangal is a spice plant that grows a lot in Indonesia. It is known to contain flavonoids, tannins, and terpenoids, which are thought to have activity in inhibiting biofilm formation. This study aimed to determine the effect of red galangal rhizome extract in inhibiting the formation of biofilms of Staphylococcus aureus bacteria. The method used is the test tube method using crystal violet dye. The results of the tube test method were photographed and quantified into the mean gray value (MGV) found in the Adobe Photoshop CS6 application. The thicker the biofilm is indicated by the lower the MGV value. Red galangal extract was obtained by maceration using 96% ethanol solvent, while the extract concentrations for treatment were 50%, 25%, 12.5%, 6.25%, 3.125%, 1.56%, and 0%. The results of statistical analysis showed that the higher the concentration of the extract, the thinner the biofilm ring formed (Pearson correlation, r = -0.980, p = 0.000). In conclusion, the ethanol extract of red galangal rhizome has the potential to inhibit Staphylococcus aureus biofilm formation with minimal biofilm inhibition at a concentration of 12.5%
CYP2A6 Gene Polymorphism Allele *4 Study in Hypertensive Patients with a History of Smoking
Full text linkNicotine is a specific CYP2A6 substrate found in cigarettes. Nicotine levels in the blood are affected by the metabolic rate of the CYP2A6 enzyme, which is known to have a high level of polymorphism. High levels of nicotine in the blood can result in an increased risk of cardiovascular disease through the mechanism of increasing lipolysis and causing an increase in triglyceride levels in the blood. This study is an observational study conducted on 31 hypertensive men with a history of smoking. The purpose of this study was to determine the frequency of the CYP2A6 allele *4 genes in hypertensive patients with a history of smoking. Result analysis was performed on PCR products using electrophoresis, then the frequency of each allele was determined. The results showed that there was a CYP2A6 allele *4 gene in hypertensive patients with a history of smoking in Yogyakarta with an allele frequency of 62.90%, and only 2 respondents (6.45%) had the CYP2A6*1/*1 genotype or wildtype