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Effect of thymoquinone on NRF2/NF-kB/MAPK pathway in methotrexate-induced rat testis injury
Get PDFObjective(s): In this study, we aimed to investigate the protective effect of Thymoquinone (THQ) against testicular damage caused by Methotrexate (MTX). Materials and Methods: This study consists of 5 groups: Control, Olive oil, THQ, MTX, and MTX+THQ. At the end of the experiment, spermiogram analysis was performed on the rats. In addition, testicular tissues were taken and histopathology, immunohistochemistry, and biochemistry analysis were performed. Biochemical analyses were performed on the serums. Results: According to the results obtained, spermiogram values, Johnson's testicular biopsy score, SOD, CAT, GPx, FSH, LH, and testosterone values were statistically significantly decreased in the MTX group compared to the control group. In the MTX+THQ group, spermiogram values, Johnson's testicular biopsy score, SOD, CAT, GPx, FSH, LH, and testosterone values increased statistically significantly compared to the MTX group. NRF2 and HO-1 immunoreactivity were statistically significantly decreased in the MTX group compared to the control group. In the MTX+THQ group, NRF2 and HO-1 immunoreactivity were statistically significantly increased compared to the MTX group. The level of MDA, which is important in lipid damage, and the level of biochemistry results of TNF-alpha, IL1-beta, and IL-6, which are important markers, and the results of p-NF-kB and P38 immunoreactivity were statistically significantly increased in the MTX group compared to the control group. In the MTX+THQ group, these parameters showed a significant decrease compared to the MTX group. Conclusion: According to these results, it is thought that THQ will play a protective role against infertility caused by chemotherapy-induced testicular damage.Yozgat Bozok Universimath;ty Scientific Research Projects Coordination Unit [6602c-TF/21-458]This Project [Project No: 6602c-TF/21-458] Was Supported By the Yozgat Bozok Univers & imath;ty Scientific Research Projects Coordination Unit
Nomophobia, loneliness and depressive symptom levels of adults living in a district of Türkiye
Get PDFThis study was conducted to evaluate whether smart cell phones detach people from social life, make them lonely, cause depressive symptoms and whether there is a relationship between them. This is a cross-sectional study using face-to-face survey method. The sample was determined as 376 participants, with 95% confidence interval, 50% probability depending on the probability of having a smartphone or not. Participants in the sample were determined by systematic random sampling from adults aged 20 and over in & Ccedil;iftlik district of Ni & gbreve;de province. The NMP-Q, DASS-42 and UCLA-LS were used. The median age of the 376 participants (192 male, 184 female) was 30 and the mean age was 32.0 (+/- 10.94) years. Participants that had social media accounts were 68.9% of the population. Over 70% of the participants had mild, moderate or severe nomophobia. Nomophobia status of the participants was affected by the mean duration of the first-time smartphone use (P = .017), the mean daily smartphone usage time of the participants (P .05). The duration of daily smartphone use, the duration of first-time smartphone use, and having multiple smartphone users in family increased nomophobia. Also, having active social media accounts and self-reported smartphone addiction found correlated to nomophobia. Smartphone addiction increases depression, anxiety, and stress scores of the participants
The effect of digital story supported applications in primary school science teaching on students' academic achievement and attitudes
Get PDFEğitim Bilimleri Enstitüsü, Temel Eğitim Ana Bilim Dalı, Sınıf Öğretmenliği Eğitimi Bilim DalıAraştırmanın temel amacı; kazanım odaklı dijital hikâyelerle desteklenen fen öğretiminin, ilkokul 3. sınıf öğrencilerinin fen bilimleri dersi 'Kuvveti Tanıyalım' ünitesindeki akademik başarılarına, fen bilimleri dersine yönelik tutumlarına ve akademik başarılarının kalıcılığına etkisinin incelenmesidir. Araştırmanın çalışma grubu 2022-2023 eğitim öğretim yılı güz döneminde, Niğde ili Çamardı ilçesindeki bir ilkokulda eğitim gören 3. sınıf öğrencileridir. Araştırmada, nicel araştırma yaklaşımlarından deneme modeli kullanılmıştır. Araştırmanın deney grubunda 16 öğrenci, kontrol grubunda ise 18 öğrenci yer almaktadır. Deney ve kontrol grubu, iki şubenin denklik çalışmaları sonucunda ve yansız-tesadüfi olarak belirlenmiştir. Araştırmada veri toplama araçları olarak 'Fen Bilimleri Dersi Tutum Ölçeği' ve 'Kuvveti Tanıyalım Ünitesi Başarı Testi' kullanılmıştır. Araştırma sonucunda elde edilen verilerin analizi neticesinde; ? Deney grubu, akademik başarı ve tutum ölçeği ön test, son test puan ortalamaları incelendiğinde, puan ortalamalarının son test lehine anlamlı farklılık gösterdiği tespit edilmiştir. ? Kontrol grubu, akademik başarı ve tutum ölçeği ön test, son test puan ortalamaları incelendiğinde, akademik başarı puan ortalamaları arasında son test lehine anlamlı farklılık tespit edilirken, tutum ölçeği puan ortalamaları arasında istatistiksel açıdan anlamlı farklılık tespit edilmemiştir. ? Deney ve kontrol grubu, akademik başarı ve tutum ölçeği son test puan ortalamaları incelendiğinde, deney grubu lehine anlamlı farklılık tespit edilmiştir. ? Deney ve kontrol grubu, akademik başarı kalıcılık testi puan ortalamaları incelendiğinde, deney grubu lehine anlamlı farklılık tespit edilmiştir. Bu çalışmada elde edilen bulgular doğrultusunda dijital hikâye destekli uygulamaların farklı kademelerde, farklı yaş gruplarında ve farklı konularda çeşitli değişkenlere etkisinin incelenmesi önerisi getirilmiştir.The main purpose of this research is to examine the effect of science teaching supported by achievement-oriented digital stories on the academic achievement, attitudes towards science course and retention of academic achievement of 3rd grade primary school students in the unit 'Let's Know the Force' of science course. The study group of the research is 3rd grade students studying in a primary school in Çamardı district of Niğde province in the fall semester of the 2022-2023 academic year. In the study, the experimental model, one of the quantitative research approaches, was used. There were 16 students in the experimental group and 18 students in the control group. The experimental and control groups were determined randomly as a result of the equivalence studies of the two classes. In the study, 'Science Course Attitude Scale' and 'Let's Know the Force Unit Achievement Test' were used as data collection tools. As a result of the analysis of the data obtained as a result of the research ; ? When the mean scores of the experimental group, academic achievement and attitude scale pre-test and post-test were examined, it was found that the mean scores showed a significant difference in favor of the post-test. ? When the pre-test and post-test mean scores of the control group, academic achievement and attitude scale were examined, a significant difference was found between the mean scores of academic achievement in favor of the post-test, while no statistically significant difference was found between the mean scores of the attitude scale. ? When the post-test mean scores of the experimental and control groups, academic achievement and attitude scale were examined, a significant difference was found in favor of the experimental group. ? When the mean academic achievement retention test scores of the experimental and control groups were examined, a significant difference was found in favor of the experimental group. In line with the findings obtained in this study, it was suggested to examine the effects of digital story-supported applications on various variables at different levels, in different age groups and in different subjects
Impact of Stereotype Threat on Evaluating Female Drivers' Skills
Get PDFThe study aimed to explore stereotype threat's impact on evaluating driving performance, specifically focusing on stereotypes about female drivers. Participants, totaling 90 female and 70 male drivers, were randomly assigned to groups emphasizing, countering, or neutralizing these stereotypes. They were then tasked with assessing the driving skills of other male and female drivers using the Driver Skill Inventory. The results revealed significant differences in how female drivers were evaluated by both male and female participants in groups where stereotypes were emphasized or countered. However, in the group where stereotypes were neutralized, no significant differences were found between male and female evaluations of driving skills. The study highlighted that emphasizing or countering stereotypes had a distinct effect on gender-based evaluations of driving skills. Explicitly or implicitly making female driver stereotypes salient enhanced existing gender-based stereotypical evaluations, while providing counter ideas to these stereotypes diminished the gender-based evaluation effects. The implications of these findings are substantial, particularly in raising awareness about the potential impact of gender stereotypes on traffic studies. Addressing and challenging these biases could significantly improve road safety, especially in regions characterized by wide gender gaps. © Associação Brasileira de Psicologia 2024
Relationship Between Diabetes and Acalculose Cholestitis in the Elderly
Get PDFAim: The clinical picture of acute stoneless cholecystitis can be seen in a wide range from mild lesions to the size that threatens the patient's life. In this study, we aimed to contribute to the literature by investigating the relationship between patients with acute stone-free cholecystitis and diabetes mellitus (DM). Materials and Methods: Patients were analyzed for age, sex, and blood tests. Descriptive statistics for numerical variables are presented as mean, standard deviation, min-max values. Non-parametric test procedures were performed on non-normally distributed data. In this context, dependent and independent sample t-test and Mann-Whitney U test were used to determine the relationships between the parameters. Spearman's correlation analysis was used, and chi-square analysis was performed to evaluate the relationship between categorical data. Results: The parameters measured by complete blood count and biochemistry were as follows: neutrophil: 56.72 +/- 23.17, C-reactive transferase (GGT): 142.99 +/- 236.08, urea: 37.14 +/- 24.41, creatinine: 0.90 +/- 0.50, glucose: 115.42 +/- 53.70, white blood cell: 8.49 +/- 6.66, percentage of neutrophils: 63.80 +/- 14.10, platelet: 245.63 +/- 84.62. There was a positive correlation between CRP and AST, CRP and ALT, CRP and GGT, and Conclusion: It can be said that advanced age and the presence of DM increase the risk of stoneless cholecystitis, and blood parameters are used to show the presence of infection. In addition, deterioration in liver function tests increases more in patients with DM
The mediating role of emotional labor in the effect of psychological contract violation on counterproductive work behaviors
Get PDFSosyal Bilimler Enstitüsü, İşletme Ana Bilim Dalı, Yönetim ve Organizasyon Bilim DalıPsikolojik sözleşmeler işletmelerde, yönetici ve çalışan arasındaki karşılıklı güvene ve beklentilere dayandığı için, ihlal edilmesi durumunda, yönetici ve çalışanlar açısından birçok olumsuz durumlara neden olmaktadır. Bu olumsuz durumlar arasında işletmeyi ve çalışanları etkileyen üretkenlik karşıtı iş davranışları ve duygusal emek gelmektedir. Psikolojik sözleşme ihlali algılayan çalışanların işletmeyi zarara uğratan üretkenlik karşıtı iş davranışlarını daha fazla gösterdikleri ve görevlerini yerine getirirken gerçek duygularını sakladıkları tespit edilmiştir. Duygusal emek kavramı, çalışanların performanslarını yükseltmek ve duygularını istedikleri gibi sergilemek için büyük öneme sahiptir. Bu çalışmada psikolojik sözleşme ihlali, üretkenlik karşıtı iş davranışları alt boyutları ve duygusal emek alt boyutları genel olarak incelenmiş, araştırma kapsamında psikolojik sözleşme ihlaline uymama algısı ve psikolojik sözleşme ihlali hissinin araştırma değişkenleriyle ilişkileri araştırılmıştır. Psikolojik sözleşmeye uymama algısı ve psikolojik sözleşme ihlali hissinin çalışanların üretkenlik karşıtı iş davranışları ve duygusal emekleri üzerindeki etkisi bir aracılık modeli üzerinde incelenmiştir. Bu amaçla, bir kamu üniversitesinde görev yapan 457 katılımcıdan, Psikolojik Sözleşme İhlali Ölçeği, Üretkenlik Karşıtı İş Davranışları Ölçeği, Duygusal Emek Ölçeği kullanılarak kesitsel veriler toplanmıştır. Araştırma hipotezlerini test etmeye yönelik nicel analiz uygulanmıştır. Yapılan analizler sonucunda, psikolojik sözleşme ihlalinin üretkenlik karşıtı iş davranışlarına etkisinde duygusal emeğin aracılık rolünün olduğu görülmüştür. Anahtar Kelimeler: Psikolojik Sözleşme İhlali, Üretkenlik Karşıtı İş Davranışları, Duygusal Emek.Since psychological contracts are based on mutual trust and expectations between the manager and employee, when they are violated, they cause many negative situations for managers and employees in businesses. Among these negative situations, there are counter-productive work behaviors and emotional labor that affect the business and employees. It has been determined that employees who perceive a psychological contract violation are more likely to display counter-productive work behaviors that harm the business and hide their true emotions while performing their duties. The concept of emotional labor is of great importance to increase the performance of employees and to display their emotions as they wish. In this study, psychological contract violation, counter-productive work behavior's sub-dimensions, and emotional labor's sub-dimensions are examined in general, and within the scope of the research, the relationship between the perception of non-compliance with psychological contract violation and the feeling of psychological contract violation with the research variables are investigated. The effect of the perception of non-compliance with psychological contract violation and the feeling of psychological contract violation on employees' counterproductive work behaviors and emotional labor is examined on a mediation model. For this purpose, cross-sectional data is collected from 457 participants who work at public university by using the Psychological Contract Violation Scale, Counterproductive Work Behavior Scale and Emotional Labor Scale. Quantitative analyses are applied to test the research hypotheses. As a result of the analyses, it was seen that emotional labor had a mediating role in the effect of psychological contract violation on counterproductive work behaviors. Key Words: Psychological Contract Violation, Counterproductive Work Behaviors, Emotional Labo
Green in sustainable local development the role of cities: Türkiye practices
Get PDFSosyal Bilimler Enstitüsü, İktisat Ana Bilim DalıTürkiye'de sürdürülebilir yerel kalkınma çabaları, yeşil şehir kavramının benimsenmesi ve uygulanmasıyla güçlenmektedir. Bu bağlamda, çeşitli alanlarda atılan adımlar, yeşil şehirlerin yerel kalkınma süreçlerine olan önemini vurgulamaktadır. Ülkede kentsel dönüşüm projeleri ile çevre dostu uygulamaların hayata geçirilmesi, yeşil binaların ve enerji verimliliği projelerinin teşvik edilmesi, yeşil ulaşımın desteklenmesi, yenilenebilir enerji kaynaklarının kullanımının artırılması, yeşil alanların korunması ve artırılması, atık yönetimi ve geri dönüşüm projelerinin uygulanması gibi stratejiler, Türkiye'nin sürdürülebilir yerel kalkınma hedeflerine ulaşmasında etkili olmuştur. Sosyal katılımı teşvik eden projeler ve çevre bilincini artırmaya yönelik kampanyalar da yerel halkın aktif rol almasını sağlamıştır. Bu sayede, sürdürülebilirlik ilkelerinin benimsenmesi ve yeşil şehir anlayışının yerleşmesi desteklenmiş, çevresel, ekonomik ve sosyal açıdan dengeli bir kalkınma modeli oluşturulmuştur. Türkiye'de yeşil şehirlerin rolü, yerel düzeyde sürdürülebilir kalkınma hedeflerine ulaşma yolunda önemli bir rehberlik ve örnek teşkil etmektedir. Bu çalışmanın amacı, sürdürülebilir yerel kalkınma perspektifinde yeşil şehirlerin rolünü Türkiye uygulamaları üzerinden akademik bir dilde incelemek, yeşil şehir kavramının yerel kalkınma süreçlerinde oynadığı rolü anlamak ve Türkiye'nin bu alandaki uygulamalarını detaylı bir şekilde değerlendirmektir. Yeşil şehirlerin sürdürülebilir kalkınma üzerindeki etkilerini analiz etmek, bu kapsamda kullanılan strateji ve politikaları incelemek, Türkiye'nin yeşil şehir uygulamalarının başarıları ve zorluklarına odaklanmak, çalışmanın temel amaçları arasında yer almaktadır. Araştırmada, doküman analizi yöntemi kullanılmıştır. Bu çalışmada toplanan veriler, detaylı bir literatür taraması süreci sonucunda çeşitli kaynaklardan derlenmiştir. Literatür taraması sürecinde elde edilen bilgiler, araştırmanın temel argümanlarını desteklemek ve genişletmek amacıyla dikkatlice değerlendirilmiştir. Bu zengin ve çeşitli kaynaklar, araştırmanın bilimsel temellerini güçlendirmiş ve konuyla ilgili kapsamlı bir anlayışın oluşturulmasına katkıda bulunmuştur. Bu çalışmanın sürdürülebilir yerel kalkınma çerçevesinde Türkiye'deki yeşil şehir uygulamalarını incelemesi, önemli gözlemler ortaya koymaktadır. Yeşil şehir konsepti, Türkiye'nin yerel kalkınma stratejilerinde belirgin bir rol oynamaktadır. Elde edilen bulgular, yeşil şehir uygulamalarının sürdürülebilir kalkınma hedeflerine anlamlı bir katkı sağladığını göstermektedir. Türkiye'deki yeşil şehir uygulamalarının, çevresel sürdürülebilirlik, enerji verimliliği ve sosyal adalet gibi temel unsurları kapsadığı gözlemlenmiştir. Anahtar Kelimeler: Kalkınma, Sürdürülebilir Yerel Kalkınma, Yeşil ŞehirSustainable local development efforts in Turkey are strengthened by the adoption and implementation of the green city concept. In this context, steps taken in various fields emphasize the importance of green cities to local development processes. Strategies such as implementing environmentally friendly practices with urban transformation projects in the country, encouraging green buildings and energy efficiency projects, supporting green transportation, increasing the use of renewable energy resources, protecting and increasing green areas, implementing waste management and recycling projects are among the sustainable developments of Turkey. It has been effective in achieving local development goals. Projects that encourage social participation and campaigns to raise environmental awareness have also enabled local people to take an active role. In this way, the adoption of sustainability principles and the establishment of the green city concept were supported, and an environmentally, economically and socially balanced development model was created. The role of green cities in Turkey provides an important guide and example towards achieving sustainable development goals at the local level. The aim of this study is to examine the role of green cities in the sustainable local development perspective in an academic language through Turkey's practices, to understand the role played by the green city concept in local development processes and to evaluate Turkey's practices in this field in detail. Analyzing the effects of green cities on sustainable development, examining the strategies and policies used in this context, and focusing on the successes and difficulties of Turkey's green city applications are among the main objectives of the study. In the research, document analysis method was used. The data collected in this study was compiled from various sources as a result of a detailed literature review process. The information obtained during the literature review process was carefully evaluated in order to support and expand the main arguments of the research. These rich and diverse sources have strengthened the scientific foundations of the research and contributed to a comprehensive understanding of the subject. This study's examination of green city practices in Turkey within the framework of sustainable local development reveals important observations. The green city concept plays a prominent role in Turkey's local development strategies. The findings show that green city practices make a significant contribution to sustainable development goals. It has been observed that green city practices in Turkey include basic elements such as environmental sustainability, energy efficiency and social justice. Key Words: Development, Sustainable Local Development, Green Cit
Investigation of the effect of oxygen flow modulation on ITO film properties to improve the performance of SHJ solar cells
Get PDFPhotovoltaic technology offers a sustainable solution for the growing energy needs of the world, while reducing environmental impact. Transparent Conductive Oxides (TCOs), which are essential in photovoltaic technology, offer high light transmittance and effective charge carrier extraction. This research focuses on the impact of oxygen (O2) flow rates in the deposition of indium tin oxide (ITO) films on n-type crystalline silicon (c-Si) substrates by DC magnetron sputtering. The structural, optical, and electrical properties were analyzed. Based on the results, the optimal O2 ratio was determined and used in the fabrication of SHJ solar cells, achieving an efficiency of 18.6%
Investigation of fracture characteristics of titanium/CFRP hybrid composites through experimental and numerical methods
Get PDFIn this study, the delamination resistance of carbon fiber reinforced polymers (CFRP) consolidated with titanium alloy at the interface between the metal and composite was investigated experimentally and numerically. End-notched flexure (ENF) tests were performed to assess the fracture toughness (GIIC) for Mode II crack expansion of Ti6Al4V titanium alloy/CFRP composite parts. The EFN test is applied to Ti6Al4V-carbon fiber/low melt poly (aryl ether ketone) (CF/LM-PAEK) and Ti6Al4V-carbon fiber/poly (ether ketone ketone) (CF/PEKK) composites with the [0°]24 stacking sequence of unidirectional (UD) fibers. Experimental results indicate that the LM-PAEK composites exhibited Mode II strain energy release rate values 27.64 % higher than those of the PEKK composites. The finite element simulation by LS?DYNA shows good correlations with the experimental results, with an average error of 5.44 % for the PEKK and 10.58 % for the LM-PAEK, respectively. © 2024 Growing Science Ltd. All rights reserved
The Impact of Silver Diamine Fluoride Only or Simultaneously With Potassium Iodide Treatment on the Bond Durability of Resin Composite Material on Primary Teeth
Get PDFWe aim to evaluate the bond strength between resin composite and primary demineralized dentin, pretreated with silver diamine fluoride (SDF) and simultaneous SDF with potassium iodide (KI) after thermal aging. In this in vitro study, human carious-free primary molars were randomly assigned into three groups and prepared by exposing the superficial dentin. The primary dentin of each molar was demineralized. The first group (the control) received saline treatment before bond application. SDF was pretreated for the second group, whereas SDF and KI were used for the third. After that, the pretreated dentin was immediately built with resin composite bonded with a universal adhesive and kept wet for 24 hours. Then, the pretreated molars were prepared into beam specimens for microtensile bond strength (mu TBS), 16 for each group, and subjected to thermal aging. Lastly, they were tested using a universal testing machine, and the resulting data were analyzed using one-way analysis of variance (ANOVA) followed by Tukey's post hoc test. It was found that the SDF-KI group had a significant difference with both the control and SDF groups (p < 0.05), while the control and SDF groups showed no significant differences (p = 0.310). The SDF-KI group had the highest mean value of 11.73 +/- 4.39 megapascal (MPa). In contrast, the control group had the lowest mean value of 9.31 +/- 3.41 MPa. Post hoc pairwise comparison results showed that SDF-KI pretreatment had a significantly higher strength value than the control and SDF groups. Pretreatment of demineralized primary dentin with SDF-KI does not negatively affect the immediate loading of resin composite. However, under the limitation of this study, KI application after SDF pretreatment is recommended to enhance the bond's durability of resin composite to demineralized dentin.Deputyship for Research and Innovation, Ministry of Education in Saudi Arabia [IFP-IMSIU-2023030]; Deanship of Scientific Research at Imam Mohammad Ibn Saud Islamic University (IMSIU)The authors extend their appreciation to the Deputyship for Research and Innovation, Ministry of Education in Saudi Arabia for funding this research through project number IFP-IMSIU-2023030. The authors also appreciate the Deanship of Scientific Research at Imam Mohammad Ibn Saud Islamic University (IMSIU) for supporting and supervising this project