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Depression as a mediator between fear of COVID-19 and death anxiety
Get PDFThe COVID-19 pandemic has affected the world deeply and an increase in psychological distress have been observed in globally. Therefore, investigation of the psychological problems associated with the COVID-19 has become an important research area. Accordingly, this study aimed to examine the relationships among Fear of COVID-19 (FoC), depression, and death anxiety. Further, the study investigated the mediating role of depression in the relationship between FoC and death anxiety. The Fear of COVID-19 scale, Depression Scale and Death Anxiety Scale were used to collect data from 372 emerging adults aged between 18 and 25 years. The results indicated that FoC was a positive and significant predictor of both depression and death anxiety. The results further indicated that depression was a positive and significant predictor of death anxiety. Depression partially mediated the relationship between FoC and death anxiety. The findings suggested that the FoC may trigger depression and death anxiety, and therefore, preventive measures should be more emphasized. The findings have implications for mental health professionals and practitioners in counseling
Analysis of crude protein utilisation in ruminant rations: supplementation of limiting amino acids and their effect on the environment - an updated review
Get PDFProtein quality plays a pivotal and dynamic role in the growth, productivity, and reproduction of ruminants. Increasing the proportion of dietary protein (CP) alone cannot balance the concentration of limiting amino acids (AA) in the duodenum of high -yielding dairy cows. However, supplying rumen -protected AA is believed to improve productivity and reproduction rates. Malabsorption of CP -rich meals in the rumen leads to high nitrogen (N) excretion through urine and faeces in the form of nitric oxide, nitrous oxide, ammonia and nitrate in the environment. Research data indicate that lysine and methionine are the two most limiting AA in the ruminant ration. Supplementing these limiting AA in ruminant diets is one of the most effective strategies to improve CP usage and reduce the negative impact of CP in the diet. Several in vivo and in vitro experimental studies have demonstrated that even low -quality dietary CP, when supplemented with rumen -protected AA (Met + Lys), exhibited a greater ability to reduce N2 or NH3 losses, while also supporting a decrease in enteric fermentation gas production and minimising soil or water pollution associated with animal production. However, further research is necessary to explore the molecular and genetic mechanisms underlying the effects of AA dietary supplementation on the rumen microbiota in ruminants
Investigation and Characterization of Novel Biologically Active Secondary Metabolites from Melissa officinalis L.
Get PDFPlants have very important chemical components, known as secondary metabolites, for the pharmaceutical industry, as well as for the chemical, cosmetics, and agricultural control industries. These secondary metabolites isolated from essential oils are used to obtain the raw material or fragrance component of the drug by semi-synthesis. For this reason, plants have been used to treat many diseases in the past, and their active ingredients are still used in medicine today. Each plant, each drug, contains differences owing to their natural structure. However, making the drug obtained from a plant a standard product is important in terms of using it as a medicine in treatment. Therefore, in our study, both the characterization of secondary metabolites and the antioxidant, antimicrobial and antiproliferative potential of Melissa officinalis were investigated. beta-Citral (30.900%) was the main component of the essential oil. Total phenolic and flavonoid contents of M. officinalis were found to be 923.33 mu g/mL gallic acid equivalent and 1.650 mu g/mL quercetin equivalent. The free radical scavenging percentage of M. officinalis was 42.17%. M. officinalis had antimicrobial activity against Enterococcus faecalis, Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus, and Candida parapsilosis. In mouse fibroblast cells, the cell viability was found to be 87.50%, 88.235%, and 94.118% respectively, at low doses. In a human breast cancer cell line, it was observed that the cell viability at low concentrations was 77.861%, 85.40%, and 89.474% respectively. The inhibitory concentrations IC50 of M. officinalis calculated for mouse fibroblast and human breast cancer cells in the GraphPad Prism 9.1.1 program were found to be 6229 and 4417 mu g/mL respectively. In conclusion, M. officinalis has high bioactive secondary metabolites such as beta-citral, beta-caryophyllene, 6-methyl-5-hepten-2-one, and cis-1,2-dihydroperillaldehyde, has strong antimicrobial activity, and inhibits viability on breast cancer cells.Duzce University DUBAP project [2020.11.01.1145]This work was supported by grants from the Duzce University DUBAP project 2020.11.01.1145
Preparing Prospective English Language Teachers for ICT Integration
Get PDFThis paper reports on a case study of six prospective English language teachers' ICT training experiences and the connections between these experiences and their beliefs about how well their language teacher education program prepared them for effective technology integration in language classrooms. This study aimed at arguing the importance of the situational factors in the university coursework and fieldwork components of teacher education on future teachers' technology-related beliefs and technology use. Data were gathered through surveys and semi- structured face-to-face interviews. The results provided some implications for curriculum updates in teacher education programs and necessary improvements in relevant policies to prepare their graduates to teach with technology-integrated classrooms. The development of a practical and integrated knowledge base of ICT use should be a visible component in teacher education programs.on the examination of the findings, this study clearly supported the general view in the literature on the impact of teacher education experiences on future teachers' ICT -related beliefs and technology use (Insook et al., 2017; Forkosh-Baruch, 2018; Pozas & Letzel, 2013)
The establishment, avtivities and financial status of Nigde Municipality (1869-1960)
Get PDFSosyal Bilimler Enstitüsü, Tarih Ana Bilim DalıNiğde'de ilk kez belediye teşkilatının kuruluşuna Konya Vilayeti Salnamelerinden elde edilen bilgiler doğrultusunda 1869 yılında tesadüf edilmiştir. Niğde tarihi üzerine pek çok akademik araştırma ve inceleme eser bulunmaktadır. Fakat halka en yakın hizmet ve yerel yönetim kuruluşu olarak kabul edilen ve uzun yıllar boyunca Niğde halkına hizmet veren Niğde Belediyesi tarihi ile ilgili 1869-1960 yılları arası dönemi kapsayan araştırmaların sayısının az olması sebebiyle araştırma bu yönde şekillendirilmiştir. Bu araştırmanın amacı; Osmanlı Devleti'nde Tanzimat Dönemi ile başlayan belediye faaliyetleri içerisinde, Niğde Belediyesi'nin kuruluşu, Niğde belediye başkanlarının kimler olduğu, belediye meclis üyeleri, belediyenin mali durumu, 1930 yılında çıkarılan Belediyeler Kanunu sonrasında Niğde Belediyesi'nde yaşanan değişimler, belediyenin gerçekleştirmiş olduğu imar, elektrik, su, sosyal yardım, sağlık, itfaiye, denetleme gibi faaliyet ve hizmetlerinin neler olduğu sorusuna cevap aramaktır. Araştırma konusu hakkında Konya Vilayet Salnameleri, Cumhurbaşkanlığı Devlet Arşivleri Başkanlığı Osmanlı Arşivi, Cumhuriyet Arşivi, Resmi Niğde Gazetesi, Niğde Gazetesi, Niğde'nin Sesi Gazetesi Arşivleri, Niğde İl Yıllıkları, Türkiye Büyük Millet Meclisi Yayınları, belediyecilik ve belediye tarihi üzerine yazılan araştırma ve inceleme eserler taranarak Niğde Belediyesi tarihi elde edilen bilgi ve belgeler ışığında detaylandırılmaya çalışılmıştır. Araştırma sonucunda Niğde Belediyesi'nin kuruluş yılı, Niğde Belediyesi'nin 1869-1960 yılları arasında görev alan belediye başkanları, Niğde Belediyesi'nin mali durumu, Niğde Belediyesi'nin Niğde halkına sunduğu hizmetlerin neler olduğu tespit edilmiştir. Anahtar Kelimeler: Niğde, Belediye, Belediye Başkanı, Niğde Belediyesi.The establishment of the municipal organization for the first time in Niğde was encountered in 1869 in line with the information obtained from the Konya Vilayet Salnames. There are many academic researches and studies on the history of Niğde. However, the research has been shaped in this direction due to the small number of studies covering the period between 1869-1960 on the history of Niğde Municipality, which is accepted as the closest service and local government organization to the people and has served the people of Niğde for many years. The aim of this research is to answer the question of the establishment of Niğde Municipality, the mayors of Niğde, the members of the municipal council, the financial status of the municipality, the changes in Niğde Municipality after the Law on Municipalities enacted in 1930, and the activities and services such as zoning, electricity, water, social aid, health, fire brigade, and supervision carried out by the municipality within the municipal activities that started with the Tanzimat Period in the Ottoman Empire. Konya Vilayet Salnames, Presidential State Archives Presidency Ottoman Archives, Republican Archives, Official Niğde Newspaper, Niğde Newspaper, Niğde'nin Sesi Newspaper Archives, Niğde Provincial Yearbooks, Turkish Grand National Assembly Publications, research and review works on municipalism and municipal history were scanned and the history of Niğde Municipality was tried to be detailed via the information and documents obtained. As a result of the research, the establishment year of Niğde Municipality, the mayors of Niğde Municipality between 1869-1960, the financial status of Niğde Municipality, and the services provided by Niğde Municipality to the people of Niğde were determined. Keywords: Niğde, Municipality, Mayor, Niğde Municipality
Effect of Na2S+NaOH pre-identification leaching on oxidized refractory Au-Ag ores
Get PDFThis study was conducted to investigate the effect of the alkaline sulfide (Na2S+NaOH) pre-identification process on cyanide leaching performance in oxidized refractory gold-silver ores. The ore has intensive oxide, carbonate, and silicate content, and contains Au/Ag minerals containing electrum, acanthite, and silver-bearing FePbZn Sulphate-Arsenate/Hydroxide minerals together with Fe, Pb, and Zn minerals. Niğde Ulukışla refractory Au/Ag ore has 8-9 g/T gold and 170-180 g/T silver grades. In mineralogical examinations, it was found that these metals were closed in minerals such as iron oxy/oxyhydroxide, calcite, and quartz or neighboring these minerals. In the cyanide soluble process after alkali sulfide preliminary procedure at room temperature, metal extraction yields were obtained as 62% for gold and 7% for silver. It is seen that silver is adversely affected by this process compared to the direct cyanidation process. However, after the hot alkali treatment process, metal extractions improved by approximately 25% of gold and 74% of silver. This increase in yield can be considered as converting Ag-oxyhydroxide into soluble Ag forms as a result of the effect of hot alkaline sulfur leaching on the cyanide process. The most important advantage of this decomposition process is to achieve high metal extraction efficiency in lower alkali concentrations
Forecasting Seasonal Milk Production Using MARS Algorithm for Multiple Continuous Responses in Holstein Dairy Cattles
Get PDFIn this study, seasonal milk yield estimation will be made using multivariate adaptive regression spline (MARS) algorithm for multiple continuous responses in dairy cattle (Holstein hybrid). For the research, milking records for the years 2020-2021 were collected from 157 dairy animals using Holstein hybrid dairy cattle from a research farm in Konya, Türkiye. The amount of feed given in this experiment was not changed and the effect of the season on the estimation of milk yield was investigated in the study. The analyzed independent variables used in the study were pregnancy status (PS), number of days milked (MDN), Lactation Number (LN), age of cows (months), average seven-day milk yield (7-Day Average Milk-SDMY), last lactation milk yield (last_MY), number of inseminations (IN), peak yield (Pik_Yield) and target variables were calculated as (YieldAutumn/winter/spring/summer (kg) = Mean milk mean of season. In this context, the ehaGoF package was used to measure the prediction performance of the simultaneous MARS model established with the earth package for MARS analysis. MARS estimation equations obtained simultaneously for four dependent variables (multiple responses) are given. By looking at the MARS equation, the MARS model estimation equation was determined for the optimum milk yield, the threshold values, the three threshold values determined in the model were determined as MDN, Age, Peak_Yield, and the corresponding values were respectively; 159 days, 39.6 (months) and 37.1 kg/day. Considering the estimation equation, it is seen that the independent variables MDN, SDMY and LN are the most important variables in determining the estimation equation. It is seen that the best fitting value for the estimation equation of the dependent variables is the YieldWinter variable
Milk proteins: chemistry, functionality and diverse industrial applications
Get PDFMilk proteins play a pivotal role in human nutrition and serve as abundant reservoirs of essential amino acids and bioactive compounds. Beyond their nutritional significance, they are also crucial ingredients in the food industry due to their unique physicochemical properties, which include emulsification, foaming, viscosity, and gelation capabilities. Despite the increasing popularity of plant-based proteins, the indispensability of milk protein remains undeniable. This review highlights the significance of milk proteins, focusing on casein and whey, their chemistry, functional properties, and applications in various industries. It delves into the chemical composition and functional properties of these proteins, shedding light on their multifaceted applications and the technological advancements employed for their extraction and refinement. Animal-derived protein fractions can be modified into micro- or nanoscale delivery systems, which deliver and shield bioactive compounds, promoting specific responses at specific sites in the body. A comprehensive understanding of the unique attributes of milk proteins continues to drive their widespread integration into the food industry and beyond, reaffirming their role in fostering balanced metabolism and supporting overall human health. This review provides insights into the potential of milk proteins to drive innovations for future demands across various sectors
The real-world outcomes of Lutetium-177 PSMA-617 radioligand therapy in metastatic castration-resistant prostate cancer: Turkish Oncology Group multicenter study
Get PDFMetastatic castration-resistant prostate cancer (mCRPC) remains a challenging condition to treat despite recent advancements. This retrospective study aimed to assess the activity and tolerability of Lutetium-177 (Lu-177) PSMA-617 radioligand therapy (RLT) in mCRPC patients across multiple cancer centers in Turkey. The study included 165 patients who received at least one cycle of Lu-177 PSMA-617 RLT, with the majority having bone metastases and undergone prior treatments. Prostate-specific antigen (PSA) levels were assessed before each treatment cycle, and the biochemical response was evaluated in accordance with the Prostate Cancer Work Group 3 Criteria. The PSA decline of ?50% was classified as a response, while an increase of ?25% in PSA levels was indicative of progressive disease. Neither response nor progression was considered as stable disease. The Lu-177 PSMA-617 RLT led to a significant PSA response, with 50.6% of patients achieving a >50% decrease in PSA levels. Median overall survival (OS) and progression-free survival were 13.5 and 8.2 months, respectively. Patients receiving Lu-177 PSMA-617 RLT in combination with androgen receptor pathway inhibitors (ARPIs) had a higher OS compared to those receiving Lu-177 PSMA-617 RLT alone (18.2 vs 12.3 months, P =.265). The treatment was generally well-tolerated, with manageable side effects such as anemia and thrombocytopenia. This study provides real-world evidence supporting the effectiveness and safety of Lu-177 PSMA-617 RLT in mCRPC patients, particularly when used in combination with ARPIs. These findings contribute to the growing body of evidence on the potential benefits of PSMA-targeted therapies in advanced prostate cancer. © 2023 UICC
Alleviation of the adverse effects of drought stress on solanum lycopersicum by UV-B priming
Get PDFFen Bilimleri Enstitüsü, Biyoteknoloji Ana Bilim DalıKuraklık stresi domates fidelerinde büyüme ve gelişmeyi etkileyen önemli stres faktörlerindendir. Bu çalışmanın amacı, domates tohumlarında kuraklık ve/veya UV-B hazırlamanın neden olduğu fizyolojik ve biyokimyasal değişikliklerin ve iyileşmenin etkilerini araştırmaktır. Kök gelişiminde kontrole oranla yalnız kuraklığa maruz bırakılan fidelerde azalma, UV-B hazırlama yapılan tüm uygulamalarda artma meydana gelmiştir. Sürgün gelişiminde ise tüm uygulama gruplarında artışlar tespit edilmiştir. Klorofil miktarlarında 20' UV-B hazırlama dışındaki tüm gruplarda, karotenoid ve toplam protein miktarlarında ise tüm uygulamalarda kontrole oranla artışlar saptanmıştır. DPPH değerleri tüm uygulama gruplarında, SOD ve CAT aktiviteleri 20' UV-B hazırlama dışındaki uygulamalarda azalmıştır. Toplam fenolik madde miktarı ise 10' UV-B uygulması dışındaki tüm uygulamalarda azalmıştır. Domates tohumlarının UV-B ile hazılanmasının stressiz ve stresli koşullarda biyokimyasal ve fizyolojik parameterelerde iyileşmeye neden olduğu tespit edilmiştir. UV-B prime uygulamalarının domateste kuraklık stresi etkilerini azaltmak ve iyileşme oranını arttırmak için etkili bir araç olduğu düşünülmektedir.Drought stress is one of the important stress factors affecting growth and development in tomato seedlings. The aim of this study was to investigate the effects of physiological and biochemical changes and recovery caused by drought and/or UV-B preparation in tomato seeds. In root development, a decrease occurred in seedlings exposed to drought only and an increase occurred in all UV-B preparation treatments compared to control. Increases were detected in shoot development in all treatment groups. Increases were detected in chlorophyll amounts in all groups except 20' UV-B preparation, and in carotenoid and total protein amounts in all treatments compared to control. DPPH values ??decreased in all treatment groups, SOD and CAT activities reduced in treatments except 20' UV-B preparation. Total phenolic substance amount decreased in all treatments except 10' UV-B treatment. It was determined that UV-B preparation of tomato seeds caused improvements in biochemical and physiological parameters in both stress-free and stressed conditions. UV-B prime applications are thought to be an effective tool to reduce the effects of drought stress in tomato and increase the recovery rate