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Exploring the Molecular Interaction of PCOS and Endometrial Carcinoma through Novel Hyperparameter-Optimized Ensemble Clustering Approaches
No full textPolycystic ovary syndrome (PCOS) and endometrial carcinoma (EC) are gynecological conditions that have attracted significant attention due to the higher prevalence of EC in patients with PCOS. Even with this proven association, little is known about the complex molecular pathways that connect PCOS to an increased risk of EC. In order to address this, our study presents two main innovations. To provide a solid basis for our analysis, we have first created a dataset of genes linked to EC and PCOS. Second, we start by building fixed-size ensembles, and then we refine the configuration of a single clustering algorithm within the ensemble at each step of the hyperparameter optimization process. This optimization evaluates the potential performance of the ensemble as a whole, taking into consideration the interactions between each algorithm. All the models in the ensemble are individually optimized with the suitable hyperparameter optimization method, which allows us to tailor the strategy to the model's needs. Our approach aims to improve the ensemble's performance, significantly enhancing the accuracy and robustness of clustering outcomes. Through this approach, we aim to enhance our understanding of PCOS and EC, potentially leading to diagnostic and treatment breakthroughs
Experiences of Healthcare Professionals Providing Women's Health Services to Asylum Seeking Women at the Hospitals
No full textObjective: This study aimed to describe the experiences of healthcare professionals providing women's health services to asylum seeking women at hospitals. Methods: A qualitative design was used in this study. The data were collected from thirty-four healthcare professionals providing women's healthcare services to asylum seeking women through semi -structured, face-to-face, individual in-depth interviews. The data were evaluated using Colaizzi's seven -step analysis method in the NVivo12 package program. Results: Three themes were identified (1) challenges, (2) reflections, and (3) needs. Healthcare professionals evaluated the process of providing women's healthcare services to asylum seeking women from a positive and negative point of view. They stated that they should be supported personally, professionally, and as a health team in improving this experience. Conclusion: This study narrows the gap in the literature and expands the scope of existing knowledge concerning the healthcare professionals experience about asylum seeking women health care
A treasure trove of new antimicrobial agents, macrolidycin, and pyrachlomycin
No full textMacrolidycin (1) and pyrachlomycin (2) were isolated from the culture broth of the marine bacterium Streptomyces sp. GSCWU 39. The isolates were characterized due to 1D and 2D-NMR spectral analyses and high resolution mass spectrometry, and were evaluated for their anti-bacterial and anti-fungal activities. At a concentration of 30 μg/mL, the compounds 1 and 2 inhibited the growth of a gram positive bacterium Streptomyces viridochromogenes and the fungus Mucor miehei. Further in order to deep the understanding for antibacterial and antifungal activities the isolates were docked against methyltransferase AviRb and ergosterol. Compounds 1 and 2 had strong binding energies of −7.32 and −6.32 kcal/mol, respectively, for the methyltransferase AviRb. Additionally, our findings for antifungal activities are further corroborated by the docking results of ergosterol with compounds 1 and 2. © 2024 Elsevier Lt
Development of sinter linings for high-speed trains
No full textIn this study, brake linings with Cu (copper)-based and Cu-10Sn (bronze)-based matrix structures have been developed and produced by the powder metallurgy method using sinter metal technology for use in high-speed trains. The developed linings were compared with commercial high-speed train linings. Firstly, the mixing process was carried out in a Turbulo 3V three-dimensional mixer for 4.5 h at 50 rpm. The pressing process was performed at room temperature, under the pressure of 350-450 MPa, and the sintering temperature for Cu-based linings was 1,000 °C, while for Cu-10Sn-based linings, it was 800 °C. After the pressing and sintering processes, lining sample density calculations were conducted, and hardness tests were carried out in the Rockwell L scale. Shear strength tests, friction coefficient, and wear tests were conducted according to SAE J 661 standards. It was observed that sinter metal brake linings with Cu and Cu-10Sn main matrix structures showed similar properties and met the technical requirements. It was determined that the developed production prescriptions are promising for industrial production and patent studies. © 2024 Walter de Gruyter GmbH, Berlin/Boston 2024
Sources of Turkish, Iranian, and Saudi soft power in the Middle East
No full textThis article examines the sources of Turkish, Iranian, and Saudi soft power in the Middle East through the utilization of Joseph Nye's soft power concept. The study is based on three claims. The first claim argues that there exists an increasing discrepancy between espoused values and actual practices in Turkey, Iran, and Saudi Arabia at home, which may undermine their soft power. The second claim contends that cognizant of the fact that the Palestinian cause is a major concern for most of the Middle Eastern people, all of the three states pursue an active foreign policy to alleviate the plight of the Palestinians. Finally, the last claim upholds that Turkey, Iran, and Saudi Arabia have been benefitting, albeit to varying extents, from high culture products such as education and popular culture products such as mass entertainment and tourism to appeal to the public in the Middle East
Genetic Alterations in Lung Cancer
No full textLung cancer is the leading cause of cancer -related deaths worldwide. Due to the prevalence of late -stage diagnoses, treatment options are frequently constrained. Molecular profiling of lung cancer is crucial for the clinical management and successful therapy of the disease because lung cancer originates from a multilayered carcinogenesis consisting of multiple genetic and epigenetic abnormalities. The potential of anomalies involved in carcinogenesis as biomarkers that can be used in the diagnosis and treatment of lung cancer has begun to be evaluated due to the development of new generation sequencing methods and their more frequent application in the clinic. This review presents information regarding the genetic alterations responsible for the malignant transformation of lung cells. The article highlights the predominant gene mutations that are specific to a particular subtype of lung cancer, their impact on the clinical progression of the disease, and the response to treatment. However, in summarizing all genetic features, the latest information from the NCCN v2.2024 guide was taken into account
Physicochemical investigation, surface chemistry and in vitro cytotoxicity evaluation
No full textHydroxychloroquine (HCQ) is a very substantial drug active substance that was approved for emergency use by the FDA during the peak of the COVID-19 pandemic due to its potent antiviral properties. In this study, adsorption and desorption of hydroxychloroquine on sulfur (S)-doped graphene powders were investigated. While the adsorption experiments were carried out in the environment of distilled water (pH 5.0-6.0), HEPES buffer (pH 7.6), and Tris.HCl buffer (pH 8.0) the desorption studies were performed in distilled water. The HCQ adsorbed S-doped graphene powders were characterized by UV-Vis, FT-IR, XRD, BET and TEM techniques. According to UV-Vis measurements, the adsorption efficiency in the HEPES buffer medium at pH 7.6 was the highest (68.72% for H3 (HCQ adsorption with SGr3 graphene in HEPES medium)). FT-IR and XRD analyses confirmed the presence of HCQ on the graphene powders' surface. While morphological changes on the surfaces of graphene powders were imaged by TEM, BET surface area changes proved the HCQ adsorption. The in vitro toxicity of the developed H3 was found to be lower than that of HCQ alone on the L929 cell line. These fundamental findings of the surface interaction between HCQ and graphene are precious for the design and optimization of a targeted drug based on this molecule and material. The adsorption/desorption features of HCQ onto graphene-based carrier systems which in particular doped with sulfur from functional metals have been investigated for the first time
Skin Lesions and Leishmania donovani Amastigotes in the Bone Marrow
No full textKaradeniz Bölgesinden Bir Visseral Leishmaniasis Olgusu: Deri Lezyonları ve Kemik İliğinde
Leishmania donovani Amastigotları
Mathematical model for energy management of plug-in PV-based electric metrobuses
No full textIn which internal combustion engines are used, public transportation systems undoubtedly have an important role in increasing carbon emissions. On the other hand, to reduce the carbon footprint and satisfy sustainability targets, the demand for electric vehicles with high energy conversion efficiency is increasing. At that point, various studies have been carried out to find out greener solutions in recent years, and it is demonstrated that it is also important to electrify public vehicles. This study contributes to the related literature and focuses on metrobuses, which are frequently used in the public transportation sector, and have garages in Istanbul, Turkey's most populated city. An environmentally friendly Metrobus Charging Station Optimization Model, which is integrated with the grid and renewable energy systems and can exchange energy with the grid, when necessary, is designed for the IETT Avcılar Metrobus garage where the metrobuses are located which has static conditions and optimal scheduling. The single objective MILP maximizes the usage of renewable energy by minimizing the cost of non-renewable energy usage and points out the best assignment of metrobuses to the scheduled departures. Finally, the model is solved in GAMS solver and it is observed that an environmentally friendly approach is not costly. © 2023 Elsevier Lt
A Pooled Analysis
No full textBackground and Objectives: Visible perivascular spaces are an MRI marker of cerebral small vessel disease and might predict future stroke. However, results from existing studies vary. We aimed to clarify this through a large collaborative multicenter analysis. Methods: We pooled individual patient data from a consortium of prospective cohort studies. Participants had recent ischemic stroke or transient ischemic attack (TIA), underwent baseline MRI, and were followed up for ischemic stroke and symptomatic intracranial hemorrhage (ICH). Perivascular spaces in the basal ganglia (BGPVS) and perivascular spaces in the centrum semiovale (CSOPVS) were rated locally using a validated visual scale. We investigated clinical and radiologic associations cross-sectionally using multinomial logistic regression and prospective associations with ischemic stroke and ICH using Cox regression. Results: We included 7,778 participants (mean age 70.6 years; 42.7% female) from 16 studies, followed up for a median of 1.44 years. Eighty ICH and 424 ischemic strokes occurred. BGPVS were associated with increasing age, hypertension, previous ischemic stroke, previous ICH, lacunes, cerebral microbleeds, and white matter hyperintensities. CSOPVS showed consistently weaker associations. Prospectively, after adjusting for potential confounders including cerebral microbleeds, increasing BGPVS burden was independently associated with future ischemic stroke (versus 0-10 BGPVS, 11-20 BGPVS: HR 1.19, 95% CI 0.93-1.53; 21+ BGPVS: HR 1.50, 95% CI 1.10-2.06; p = 0.040). Higher BGPVS burden was associated with increased ICH risk in univariable analysis, but not in adjusted analyses. CSOPVS were not significantly associated with either outcome. Discussion: In patients with ischemic stroke or TIA, increasing BGPVS burden is associated with more severe cerebral small vessel disease and higher ischemic stroke risk. Neither BGPVS nor CSOPVS were independently associated with future ICH. © 2023 American Academy of Neurology