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Physiological and gene expression responses of the mussel Mytilus galloprovincialis to low pH and low dissolved oxygen
No full textThe prevalence and frequency of hypoxia events have increased worldwide over the past decade as a consequence of global climate change and coastal biological oxygen depletions. On the other hand, anthropogenic emissions of CO2 and consequent accumulation in the sea surface result in a perturbation of the seawater carbonate system, including a decrease in pH, known as ocean acidification. While the effect of decreases in pH and dissolved oxygen (DO) concentration is better understood, their combined effects are still poorly resolved. Here, we exposed adult mussels (Mytilus galloprovincialis) to two pHs (8.27 and 7.63) and DO concentrations (7.65 and 2.75 mg L−1) over 17 days in a full-factorial design. These levels correspond to extremes of the present natural variability and are relevant in the context of ocean acidification and hypoxia. No mortality was observed during the experiment. However, sublethal effects were observed for clearance and oxygen consumption rates, as well as total haemocytes count and haemocytes viability and gene expression in mussels exposed to the combination of low pH and low DO. Respiration and excretion rates were not significantly impacted by low pH and DO, alone or in combination. Overall, low pH alone led to a decrease in all tested physiological parameters while low DO alone led to a decline in clearance rate, haemocyte parameters and an increase in carbohydrate content. Both parameters led to up- or down-regulation of most of the selected genes. Not surprisingly, the combined effect of low pH and low DO could not be predicted by a simple arithmetic additive response at the effect level, highlighting more complex and non-linear effects. © 2023 Elsevier Lt
The mechanical testing and performance analysis of three-dimensionally produced lingual retainers
No full textBackground: Introducing three-dimensional (3D) printing has opened new visions in the orthodontic field. This research evaluates three-dimensionally produced orthodontic retainers and their future possible uses. For this purpose, in vitro tests were performed for these groups, including bond strength, failure analysis, discoloration, and biodegradation. Methods: A total of 30 specimens (n = 30), lower incisor human teeth, were randomly divided into three groups for a bond strength failure analysis (for each group n = 10). In the experimental groups, lingual retainers were fabricated using 3D systems (group 1 with 3D dental pen and group 2 with 3D-printed). In the control group (group 3), the retainer system was a combination of a wire and composite, which is being used worldwide. A total of 30 specimens (n = 30) from the 3D dental pen and 3D-printed for discoloration and biodegradation tests were divided into three groups (water, tea, and coffee). Data were analyzed using the Mann-Whitney U test, ANOVA, and chi-square test. Results: For all parameters tested, significant differences were determined among groups. The 3D pen group had the highest score for bond strength, whereas discoloration differed significantly. Conclusions: According to the limitations of this research, 3D-printed retainers have the potential for clinical use in the near future. © 2023 World Federation of Orthodontist
Comparison of two different delivery methods of home-based exercise on neck pain
No full textAimThis study aimed to compare the effects of two different home-based exercise delivery methods on compliance, pain, and disability in participants with non-specific neck pain.Materials & methodsThe study, which was carried out at Istanbul Arel University between February and May 2018, was carried out with 60 participants from university staff, aged 25-60, suffering from non-specific neck pain. The cases were randomly assigned to two groups. A home exercise method with printed material exercise was given to the patients in Group 1, and a video phone reminder exercise was given to Group 2 for six weeks in both groups. Pain severity and neck disability were evaluated before and after the exercise with the 'Visual Analogue Scale' and the 'Neck Pain and Disability Score.'ResultsDescriptive statistics showed that the video phone reminder exercise group had greater compliance. Neck pain and neck disability assessments improved before and after the exercise in both groups (p 0.8).ConclusionsThe home exercise method with video and telephone reminders, which can be applied instead of the traditional method provided with printed materials, is more effective for compliance, pain severity, and neck disability
Cryogenic X-ray crystallographic studies of biomacromolecules at Turkish Light Source "Turkish DeLight"
No full textAbstract: X-ray crystallography is a robust and powerful structural biology technique that provides high-resolution atomic structures
of biomacromolecules. Scientists use this technique to unravel mechanistic and structural details of biological macromolecules (e.g.,
proteins, nucleic acids, protein complexes, protein-nucleic acid complexes, or large biological compartments). Since its inception,
single-crystal cryocrystallography has never been performed in Türkiye due to the lack of a single-crystal X-ray diffractometer. The
X-ray diffraction facility recently established at the University of Health Sciences, İstanbul, Türkiye will enable Turkish and international
researchers to easily perform high-resolution structural analysis of biomacromolecules from single crystals. Here, we describe the
technical and practical outlook of a state-of-the-art home-source X-ray, using lysozyme as a model protein. The methods and practice
described in this article can be applied to any bi
Multiband Microstrip Elliptical Monopole Antenna Design with Mushroom-Like Loadings for DCS, 5G and Ku-Band Applications
No full textIn this study, a compact multiband, low-profile and low-cost microstrip antenna design covering DCS (Digital Cellular System, 1.7–1.8 GHz), mid-band 5G and Ku-band has been realized. The proposed monopole antenna consists of an elliptical patch element and mushroom-shaped metallic loadings placed on both sides of this patch. The elliptical patch element operates in the 3.3–3.8 GHz range for the mid-band 5G frequency band alone. In addition, the mushroom-shaped structures used on the front surface of the design enables the antenna to operate in the frequency ranges of 1.72–1.8 GHz DCS and 10–15 GHz Ku-band, as well as the 5G operating frequency. The proposed microstrip line fed antenna is 50 × 40 mm2 in size. The antenna has a bandwidth of 1.71 GHz and a maximum gain of 5.73 dBi at the 5G operating frequency. In addition, the designed antenna has a bandwidth of 80 MHz for the DCS band and 5 GHz for the Ku-band. The simulations of the proposed antenna were carried out in the CST Microwave Studio and the obtained performance parameters are presented in detail. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG
An investigation on the mechanical behavior of mixed adhesively bonded composite joints subjected to transverse pre-impact following by axial post-tensile
No full textIn this study, mixed adhesive joints were formed to create a more homogeneous stress distribution in order to increase the failure load that the joints could bear. Single-lap joints (SLJs) made of glass fiber-reinforced plastic (GFRP) composites were formed using a rigid adhesive (Araldite AV138) in the middle and a more flexible adhesive (3 M DP8005) at the ends of the joint. Rigid and flexible adhesives were applied to the surface with lf/lr = 1 and lf/lr = 0.5 bond-length ratio (lf is bond length for the flexible adhesive and lr is bond length for the rigid adhesive). Mono adhesive joints were also created using the same adhesives. Tensile tests at 1 mm/min were carried out without applying pre-impact to some joints and applying 2.5, 3.5, 7.5, and 10 J transverse impacts to other joints to reveal how joint strength changes with the potential impacts to which adhesive joints might be exposed. Mixed adhesive joints bore more load under impact and non-impact conditions compared to mono adhesive joints. The impacts applied in these tests increased the load-bearing capacity of mono DP8005 adhesive joints. The largest decrease of strength after impact was observed for the mixed adhesive joints with lf/lr = 0.5 bond-length ratio. © 2023 Elsevier Lt
Is social appearance anxiety a reason for rejecting a hearing aid in geriatric patients?
No full text- OBJECTIVE: Hearing impair-ment is a global health problem due to its im-pact on quality of life and communication prob-lems between individuals. Hearing aids are the recommended intervention, but use of hearing aids is low. In this study, the effect of social ap-pearance anxiety on the decision to use a hear-ing aid was investigated.PATIENTS AND METHODS: The study com-prised 107 individuals aged 65-81 years who were offered hearing aids due to bilateral severe or moderate sensorineural hearing loss. The pa-tients were divided into three groups, according to their hearing aid preferences and usage deci-sions. Social appearance anxiety scale was ap-plied to all patients.RESULTS: The mean age of the 107 patients included in the study was 70.19 +/- 5.35 years. The social appearance anxiety scores of those who did not want to use a hearing aid were much higher than those of whom desired to use a be-hind-the-ear or in-canal hearing aid. The social appearance anxiety scores of the patients who wanted to use in-canal hearing aids were also higher than the group who wanted to use be-hind-the-ear hearing aids.CONCLUSIONS: In this study, which focused on the hearing aid candidate group who had never obtained a device, rather than why they stopped using a hearing aid, it was assumed that social appearance concern was relevant in the phase of receiving a hearing aid
Screening for Chemical Characterization and Pharmacological Properties of Different Extracts from Nepeta italica
No full textPlants from the Nepeta genus have been proved to possess different pharmacological properties, among which are antimicrobial, antioxidant, anti-inflammatory, analgesic, and cytotoxic effects. Nepeta italica is a medicinal plant traditionally used for its analgesic effects, and in the present study, the phytochemical composition and biological effects of hexane, dichloromethane (DCM), ethyl acetate (EA), ethanol, ethanol-water, and water extracts of the aerial parts were investigated for determining phenolic composition, antioxidant effects, and anti-inflammatory effects in isolated mouse colon specimens exposed to lipopolysaccharide (LPS). Polar extracts were the richest in terms of phenolic compounds, especially rosmarinic acid. In parallel, ethanol, ethanol-water, and water extracts were also the most effective as scavenging/reducing and enzyme inhibition agents, especially towards cholinesterases and & alpha;-glucosidase, and in inhibiting the LPS-induced cyclooxygenase-2 (COX-2) and tumor necrosis factor & alpha; (TNF & alpha;) gene expression in mouse colon. This poses the basis for future in vivo investigations for confirming the protective effects of polar extracts of N. italica against inflammatory bowel diseases
Measurement of the B0 lifetime and flavor-oscillation frequency using hadronic decays reconstructed in 2019-2021 Belle II data
No full textWe measure the B0 lifetime and flavor-oscillation frequency using B0→D(∗)-π+ decays collected by the Belle II experiment in asymmetric-energy e+e- collisions produced by the SuperKEKB collider operating at the ϒ(4S) resonance. We fit the decay-time distribution of signal decays, where the initial flavor is determined by identifying the flavor of the other B meson in the event. The results, based on 33000 signal decays reconstructed in a data sample corresponding to 190 fb-1, are τB0=(1.499±0.013±0.008) ps, Δmd=(0.516±0.008±0.005) ps-1, where the first uncertainties are statistical and the second are systematic. These results are consistent with the world-average values. © 2023 authors. Published by the American Physical Society. Published by the American Physical Society under the terms of the "https://creativecommons.org/licenses/by/4.0/"Creative Commons Attribution 4.0 International license. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI. Funded by SCOAP3
The effect of postnatal breastfeeding education given to women on breastfeeding self-efficacy and breastfeeding success
No full textOBJECTIVE: This study was conducted to determine the effect of postnatal breastfeeding education given to women who had normal vaginal and cesarean delivery on breastfeeding self-efficacy and breastfeeding success.METHODS: This is a pretest-posttest randomized controlled quasi-experimental study. This study included 76 women (38 intervention group and 38 control group) who gave birth in a women's and children's diseases training and research hospital.ClinicalTrials.gov Identifier: NCT 05666817. The data were collected by means of the introductory information form, breastfeeding knowledge level diagnosis form, LATCH scale, and postnatal self-efficacy scale. In the evaluation of the data, independent group t-tests and dependent group t-tests were used.RESULTS: Research findings indicate that the women's breastfeeding knowledge level, LATCH scale, and postnatal breastfeeding self-efficacy scale scores were statistically higher than the control group in the post-test (p<0.05).CONCLUSION: It was found by the researchers that postnatal breastfeeding education is effective in increasing the level of breastfeeding knowledge, breastfeeding success, and breastfeeding self-efficacy