Institute of Psychology, Chinese Academy of Sciences
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Transcranial temporal interference stimulation for treating bipolar disorder with depressive episodes: a feasibility Study
No full textBipolar depression (BD-D) is a significant clinical challenge associated with high disease burden. Transcranial temporal interference stimulation (tTIS), a novel and noninvasive approach for targeting deep brain structures, was investigated for its efficacy and safety in BD-D patients in this trial. Thirty-six patients were recruited for a single-arm, open-label trial, and 25 completed the 5-day intervention consisting of 10 tTIS sessions targeting the left nucleus accumbens. Each session lasted 20 min, with a maximum current intensity of 2 mA and an envelope stimulation frequency of 40 Hz. Significant symptom reductions were observed following treatment, with mean HAMD-17 scores decreasing from 23.36 to 16.16 (p < 0.0001), MADRS scores from 39.12 to 31.28 (p < 0.01), HAMA scores from 19.68 to 15.44 (p < 0.05), and QIDS scores from 13.52to 9.68 (p < 0.001). Eleven participants (44.0%) met improvement criteria and seven (28.0%) achieved response. Cognitive assessments indicated improvements in memory and executive function, and changes in reward-related brain activity correlated positively with symptom reduction. Adverse events were mild, mainly transient scalp discomfort. These findings provide preliminary evidence supporting the efficacy and safety of tTIS for alleviating depressive symptoms and cognitive impairments in BD-D
Long-Term Efficacy and Resting-State Functional Magnetic Resonance Imaging Changes of Deep Brain Stimulation in the Lateral Habenula Nucleus for Treatment-Resistant Bipolar Disorder
No full textBackground To explore the long-term efficacy and resting-state functional magnetic resonance imaging (fMRI) changes of lateral habenula nucleus (LHb) deep brain stimulation (DBS; LHb-DBS) for treatment-resistant bipolar disorder (TRBD). Methods An 18-year-old woman with TRBD received bilateral LHb-DBS. We assessed changes in Hamilton Depression Scale-17 (HDRS-17), Bech-Rafaelsen Melancholia Scale (BRMS), Hamilton Anxiety Scale (HAMA), and Pittsburgh Sleep Quality Scale (PSQI) scores from preoperative baseline to postoperative continuous 24-month follow-up. Brain activity and resting-state functional connectivity (rsFC) were examined off-stimulation at 0.6 and 15 months post-LHb-DBS. Overall improvement and adverse events were analyzed. Results Continuous 24-month follow-up showed average improvements from baseline of 65.33%, 54.90%, 63.33%, and 48.72% for HDRS-17, BRMS, HAMA, and PSQI scores, respectively. At the final follow-up, improvement was 96.00%, 88.24%, 84.85%, and 69.23%, respectively. Resting-state fMRI results revealed an increase in fractional amplitude of low-frequency fluctuations (fALFF) within the putamen, ventral tegmental area (VTA), and substantia nigra pars compacta (SNc) over 15 months of continuous bilateral LHb stimulation when DBS was off. From baseline to 15 months, fALFF in the putamen, VTA, and SNc increased by 1.68%, 6.36%, and 1.10%, respectively. Consistently reduction in rsFC was observed between the left nucleus accumbens (NAcc) and left hippocampus. Over the 15 months of continuous stimulation, rsFC decreased by 72% from baseline. Conclusions Long-term LHb-DBS can control symptoms and improve the quality of life in patients with TRBD. This may be attributed to an increase in fALFF in the putamen, VTA, and SNc, and a reduction in rsFC between the left NAcc and left hippocampus
Neural representation of mixed feelings during real-time processing of negative words in pun-humor
No full textPeople commonly experience mixed feelings in everyday life. However, whether and to what extent mixed feelings represent a truly simultaneous experience of ambivalent emotional states remains elusive. This electroencephalogram (EEG) study aimed to investigate how mixed feelings blending amusement and negativity are dynamically experienced over time. Specifically, the neural representations of negativity and amusement were quantified during the real-time processing of negative words in pun-humor sentences. The results showed that, compared to non-humor and nonsensical sentences, pun-humor sentences with negative words received higher ratings of both amusement and negativity, indicating that such material can effectively elicit mixed feelings at the level of explicit behavior. Moreover, within the dynamic representation of mixed feelings, negativity was experienced first, whereas amusement was subsequently felt within a brief period, during which negativity was not offset but rather continued to be represented over a longer time span, resulting in the simultaneous presence of both amused and negative feelings. These findings revealed that mixed feelings can be dynamically experienced in the highly simultaneous pattern, offering insights into the genuine blend of conflicting emotional states at the level of neural representation
Work stress and depressive symptoms of employees in the logistics industry: Willingness to communicate and rumination as parallel mediators
No full textTo explore the relationship between work stress and depressive symptoms, as well as the dual mechanisms of willingness to communicate and rumination, we surveyed 520 logistics employees who completed the Work Stress Questionnaire, the Willingness to Communicate Scale, the Rumination Responses Scale, and the Center for Epidemiological Studies Depression Questionnaire-Short Version. The results revealed that work stress was significantly and positively associated with depressive symptoms and rumination, whereas it was significantly and negatively associated with willingness to communicate. Further, willingness to communicate was significantly and negatively associated with depressive symptoms, and rumination was significantly and positively associated with depressive symptoms. Finally, willingness to communicate and rumination acted as parallel mediators between work stress and depressive symptoms. These results have theoretical implications and offer practical references for managers and employees in logistics organizations
Targeting the glymphatic system: Aβ accumulation and phototherapy strategies across different stages of Alzheimer's disease
No full textThe glymphatic system serves as the brain's clearance system. It deteriorates with age and is a significant contributor to the onset and progression of Alzheimer's disease (AD). Modulating cerebrospinal fluid (CSF)-based clearance and targeting key components of the glymphatic system, such as aquaporin-4, can enhance amyloid-beta (A beta) clearance. Light therapy is emerging as a potential AD treatment approach, which involves the use of visible and near-infrared light at specific wavelengths (630/680/808/850/1070 nm), photosensitive proteins, and sensory stimulation at particular frequencies (e.g., 40 Hz). This phototherapy strategy can broadly influence the intracerebral fluid dynamics, including cerebral blood flow, CSF, and interstitial fluid (ISF), as well as structures related to the glymphatic system, such as vascular endothelial cells, glial cells, and neurons. Additionally, it may directly or indirectly inhibit A beta accumulation by modulating endogenous small molecules, thereby improving cognitive function. Our previous research demonstrated that 630-nm red light can inhibit A beta cross-linking by clearing endogenous formaldehyde and promoting ISF drainage. Notably, A beta accumulation exhibits distinct characteristics at different phases of AD, accompanied by varying features of glymphatic system impairment. In the early stages, deep brain regions are significantly affected, whereas in the late stages, accumulation primarily occurs in the paracentral, precentral, and postcentral cortices. Owing to the limited penetration depth of light, this may pose a challenge to the clinical efficacy of phototherapy. Therefore, different stages of AD may require tailored phototherapeutic strategies. Meanwhile, it is important to acknowledge the ongoing controversies associated with lymphovenous anastomosis, a procedure that targets the glymphatic system. Therefore, this article reviews the characteristics of glymphatic system impairment across various AD stages and the mechanisms by which effective phototherapies modulate the glymphatic system. Potential phototherapeutic strategies corresponding to different stages of A beta accumulation are also proposed.</p
The shared neural substrates of emotional mimicry and emotional contagion: an activation likelihood estimation meta-analysis and meta-analytic connectivity modeling analysis
No full textEmotional contagion is an important aspect of social interaction. Traditional theories suggest that it relies on mimicry of facial or emotional movements. To address the question of whether there is a distinction between emotional contagion and emotional mimicry, we conducted a meta-analysis using the Activation Likelihood Estimation algorithm to identify brain regions activated by the two tasks. We then evaluated the co-activation patterns of these common regions using meta-analytic connectivity modelling (MACM). The results show partial overlap in brain regions, such as the cingulate gyrus, middle frontal gyrus, and inferior parietal lobule, between emotional contagion and emotional mimicry. Contrast analyses further identified distinct brain regions activated by each task. MACM analysis indicated that regions including the thalamus, putamen, precentral gyrus, and insula play critical roles in the co-activation network
Intervention research on music dance therapy for patients with mixed anxiety and depression disorder
No full text目的 探讨音乐舞动疗法在混合性焦虑抑郁患者中的应用效果。方法 选择云南省精神病医院混合性焦虑抑郁的患者76例作为研究对象，按随机数字抽取法分为试验组（n=35）和对照组（n=41），两组均进行常规药物治疗及健康宣教，而试验组在此基础上，接受了10天的音乐舞动治疗，两组在生活起居饮食活动区域等完全相同。经过干预10天后，分别采用心理弹性量表、抑郁自评量表及焦虑自评量表对干预效果进行评定。结果 干预进行10天后，试验组的心理弹性量表、抑郁自评量表及焦虑自评量表得分与对照组相比，差异均有统计学意义（P<0.05）。结论 音乐舞动疗法在一定程度上可以有效提高混合性焦虑抑郁患者的心理弹性水平，对焦虑抑郁情绪有改善效果。</p
心理学要以科学与人文“双腿走路”——张建新教授访谈录
No full text<正>近年来，张建新教授从宏观理论的角度对心理学科发展提出了诸多有益的见解，本文前两部分呈现了张教授对心理学学科的宏观思考，第三部分为《心理新青年》编辑部对张教授的采访，经《心理新青年》编辑部允许为本刊转发。一对心理学两种研究路径的探讨在心理学的历史发展脉络中，以心理咨询—治疗为落脚点的人文心理学和以实验心理学为核心的科学心理学同时起步、平行发展。</p
The Covariation of Emotion and Passage of Time Judgments: Insights from Weibo
No full textPrevious studies have suggested that emotions influence individuals' passage of time judgments (PoTJs). However, it remains unclear how this relationship manifests in daily life. Weibo provides a wealth of daily verbal expressions from individuals, offering valuable data for analyzing how emotions and PoTJs vary. Utilizing this resource and choosing a specific period of time-COVID-19-the authors innovatively examined the relationships between emotional valence, discrete emotions, and PoTJs across different timescales: weekly, bi-weekly, monthly, and over the entire year. First, they constructed a PoTJ lexicon and template based on Weibo data. This was followed by an analysis of emotional expressions in PoTJ-related posts extracted by the lexicon and template using natural language processing techniques. The findings reveal a distinct pattern: most individuals perceived time as passing quickly during the COVID-19 pandemic, while fewer experienced slow PoTJ. Regarding the relationship between emotional valence and PoTJ, the daily average percentage of posts expressing positive and negative emotions was positively correlated with fast and slow PoTJs from a dynamic perspective, respectively, and a similar pattern was found from an overall perspective. More importantly, a unique relationship was identified between discrete emotions and PoTJs. Specifically, both the dynamic and overall analyses showed a robust finding: only joy and anxiety were positively associated with fast and slow PoTJs, respectively. In contrast, for other emotions (e.g., hope, sadness), the dynamic analyses yielded inconsistent results across the different time windows, diverging from the overall analysis. These findings highlight the importance of adopting a dynamic perspective and considering discrete emotions when understanding the relationship between emotions and PoTJs
Functional connectivity of semantic and default mode networks during narrative comprehension
No full textUnderstanding narratives requires at least transient access to the semantic system, to decode incoming content, and prolonged access to the default mode network to maintain and manipulate the narrative model. Subregions within the integrative semantic hubs in bilateral anterior temporal lobe appear differentially sensitive to the need to rapidly decode external input (exogenous processing) versus reflecting on context stored in the narrative model (endogenous processing). The latter is most consistently reported in the middle temporal gyrus portion of the hub, suggesting that this region serves as a critical hinge point, dynamically interacting with the default mode network to facilitate endogenous processing. The present study investigated this by characterizing the functional connectivity profiles of anterior temporal lobe subregions during movie-viewing and examining content-evoked changes in these profiles. Compared to other anterior temporal lobe subregions, middle temporal gyrus was more functionally connected to the default mode network, and these connections were strengthened during moments with limited incoming information, providing viewers with a chance to reflect on the content. Rather than being functionally distinct networks, the semantic and default mode systems dynamically interact to facilitate reflection or endogenous semantic processing. Future work should further characterize how neural systems dynamically shift from integrated to segregated states in response to everyday processing demands.</p
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