International Journal of Health and Clinical Research
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A brief overview on transdermal patches and marketed preparations
Full text linkTransdermal drug delivery systems, sometimes referred to as "patches," have significantly improved patient outcomes by offering the benefit of a relatively painless method of administering medication through the skin to provide a systemic effect. Benefits of these patches include regulated medication release, convenience of usage, and avoiding first-pass metabolism. Transdermal drug delivery system was presented to overcome the difficulties of drug delivery especially oral route. A transdermal patch is a medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through the skin and into the bloodstream. It promotes healing to an injured area of the body.The review gives valuable information about the transdermal patch like its advantage, disadvantage, types of transdermal patch, factors basic components, methods, evaluation, technologies and marketed products
Efficacy of physiotherapy rehabilitation following total hip arthroplasty: A literature review
Full text linkIntroduction: Total hip arthroplasty (THA), which is regarded as one of the most successful orthopaedic procedure. In THA, both the femoral head and acetabulum are replaced. It is reconstructive procedure that has bettered the operation of those conditions of the hip joint that have responded inadequately to conventional medical remedy. The hip is a true ball-and-socket joint consists of well-balanced muscles, enabling a wide range of motion in several physical planes while also exhibiting remarkable stability. It plays a major role in the static and dynamic physiology of the locomotor system and, although it is the most stable ball-and-socket joint in the body and maintains an extraordinary range of motion. Non-operative and nonconservative approaches such as physiotherapy techniques and alternative therapies are used as post operative treatment. The main goal is to explore the effectiveness of physiotherapy interventions in total hip replacement surgery including their impact on pain, range of motion, strength, and functional outcomes. Also assess the timing and duration of physiotherapy interventions and their effect on patient outcomes. Method: A systematic review was conducted using the Pubmed and Google Scholar databases, analyse the relevant studies on total hip arthroplasty following physiotherapy rehabilitation, many research papers have studied from 2000 to 2022 out of which 32 were examined on the basis of exclusion and inclusion criteria. Result: Our result provided the evidence that physiotherapy rehabilitation for post total hip arthroplasty is necessary also provides the effective results in patients to improve the functional mobility of the patient. Discussion: The findings suggest that Physiotherapy rehabilitation proved to beneficial in all the parameters like stability, posture, core muscle strength, ROM, functional mobility, balance. However, further research is needed to determine optimal protocols, long-term effects, and individual characteristics influencing treatment outcomes
Formulation of lipstick from the Rhodamine B in cosmetic formulations
Full text linkCosmetics are preparations used to enhance the arrival and cowl up flaws in the skin, which include blemishes on the pores and skin in order that the consumer looks more energizing. Examples of cosmetics include lipstick, blusher, eye shadow, and so forth, which might be usually given the addition of synthetic dyes including rhodamine B. Natural beauty is in growing demand within the world market as these are the priceless gift of nature with greater pastime and lesser or no aspect results. So, in gift research paintings this challenge changed into carried out for the education of natural lipstick. first of all, the extract of flower of Rhodamine B a as a colorant, have been implemented for the formula of natural lipstick in combination with bees wax, Coconut oil, Acacia, Castor oil, Turmeric powder, Lemon juice. The formulated lipstick successfully evolved on the premise of melting factor, solubility, or consistency, pores and skin irritation. From the prevailing investigation it became found that that the Rhodamine B giving promising effects consisting of, melting point 210°C, Rhodamine b is soluble in water and the display absorbance at 555 nm. The results of the precision checking out indicated that the percentage RSD changed into less than two thirds. The take a look as it's qualitative evaluation found out that all of the samples examined negative for rhodamine B. in step with this take a look at, UV-visible spectrophotometry is a reliable technique for determining the amount of rhodamine B present in lipstick. The method developed changed into cost-effective solvent are précised, correct and may be applied to quantify rhodamine b in marketed lipstick formula
“A Prospective Observational Study Assessing the Morbidity Outcomes of Late Preterm Neonates”
Full text linkBackground & Objectives: To study on early neonatal morbidities in late preterm neonates admitted to neonatal intensive care (NICU).Methods: All late preterm babies (34 0/7weeks-36 6/7 weeks) admitted to neonates who meet the inclusion criteria were studied for a period of 1st October 2019 to 31st March 2021. The infants in the sample were followed throughout their stay in the neonatal intensive care unit (NICU), up until hospital discharge. All the data was collected from infants' and mothers' medical records and at the time of the discharge. Short-term outcomes such as neonatal morbidities, mortality, hospitalization and also maternity risk factors were assessed. Result: A total of 103 late preterm and term neonates were included in the study. Male preponderance was noticed with a ratio of 1.2:1. Majority of the neonates were born with birth weight of more than 2 kg. PROM and previous history of LSCS forms the major maternal risk factor for preterm. This study confirmed that late-preterm infants are a population at risk of increased neonatal morbidity. Neonatal Hyperbilirubinemia requiring phototherapy forms the major one followed by respiratory distress, sepsis and feed Intolerance. Duration of hospital stay also prolonged in late preterm. Majority of late preterm neonates required more than 7 days of hospital duration. Mortality rate and the rate of rehospitalization were also high. Conclusion: Late-preterm infants are therefore a high-risk group of children and need special attention. Immaturity is the major factor contributing to adverse morbidities. Further research is required to develop specific guidelines and protocols to reduce neonatal late preterm mortalities and morbidities
Knowledge, attitude and perception regarding spectacle use among patients attending eye OPD in a tertiary care hospital
Full text linkBackground: Uncorrected refractive error is a major cause of avoidablevisionimpairment which significantly affects every aspectof a human’s lifeand is a treatable cause of visualimpairment that can be easily corrected by the use ofspectacles whichremains atime-tested to correct refractive errors.Method: Thishospital-basedobservational study was conducted in the OPD of the Department of Ophthalmology, Government Medical College, Jammu over a period of three months from January 2022 to March 2022.A total of 212 patientswere asked questions regarding knowledge, attitude, and perception regarding spectacle use. Data was interpreted in both descriptive and inferential statistics i.e., frequency and percentage distributionusing SPSS, version 20.0. Results: It was observed that the majority of patients were in the age group of 28-37 years (32.54%) and the male: female ratio was 1.14:1.Most (56.41%) of the patients had inadequate knowledge regarding the use of spectacles. There was a mixed perception and a favorable attitude noted among study participants. Themost common problem faced was the fogging of glasses (70.2%). Conclusions: It was concluded that some of these issues are minor and can be corrected using better quality lenses available nowadays. Lenses can be chosen according to the needs. However, there is an issue of financial expense due to frames and glasses. Education and propagation of information about refractive errors and spectacle use in schools and colleges by various stakeholders would help in clearing the fallacies and any misconceptions regarding the use of spectacle use. A concerted effort from eye care professionals, mass media, and ministries of health and education in India, should thus be the way forward
An analytical cross-sectional study on the impact of Clinical profile on the Outcome of patients on Mechanical Ventilation at a Tertiary care centre
Full text linkIntroduction: Mechanical ventilation (MV) is an invasive life supporting device to mimic the respiratory physiological function at the time of impending respiratory failure. There is dramatic improvement in the survival of critically ill patients, but also associated with complications affecting the overall outcome. A part from the severity of underlying disease, MV and care related parameters also influence the outcome. Aim: To determine the outcome of mechanically ventilated patients in an ICU depending on their clinical profile. Materials and Method: Retrospective cross sectional study for duration of 6 months. Inclusion criteria: Patients >18years of age, male and female patients, All patients requiring MV support for >12hours, Patients with failing respiratory drive or who failed O2 therapy and NIV are eligible for the study. Exclusion criteria: Patients <18years of age, Patients who died within12 hours of intubation, Patients who were extubated <12 hours of intubation, Pregnant and lactating women, patients with Incomplete data. Conclusion: Increased mortality observed in patients with sepsis and more number of ventilator days and increased length of hospital stay
Effectiveness of Physiotherapy and Physical Rehabilitation in the Treatment of Chronic Hemophilic Arthropathy: A Prospective Study From a Comprehensive Hemophilia Care Center in Eastern India
Full text linkHemophilia is a blood-clotting disorder caused by a deficiency in factor VIII (FVIII) or factor IX (FIX), which manifests itself through bleeding in the muscles and joints. Haemophilic arthropathy causes pain and deterioration in movement, thereby causing disability and permanent joint damage. Aim of the study was to determine the effect of physiotherapy on range of motion on target joints in people with hemophilia. This was a prospective study done on 50 patients of all age groups with hemophilia in the study period from March 2022 to February 202
Development of Quality Control Parameter of Datura alba
Full text linkPlants have been an exemplary source of medicine. Daturaalba is a wild weed belonging to family Solanaceae. The preliminary phytochemical investigation was performed on methanolic, acetone extract of Datura alba revealed the presence of alkaloids, tannins, cardiac glycosides, flavonoids, carbohydrates, amino acids and phenolic compounds, while phytochemical analysis of Datura albashowed that it contained alkaloids, saponins, tannins, Terpenoids, steroids, flavonoids, phenols and cardiac glycosides
A study of esophageal candidiasis in patients with ca esophagus
Full text linkEsophageal candidiasis is a condition mostly seen in immunocompromised patients. It is usually caused by Candida albicans, but other species are occasionally found Esophageal candidiasis has strong assosiation with esophageal cancer. Esophageal candidiasis is also the risk factor for development of esophageal cancer in addition to other risk facors like smoking, alcohol, GERD
Efficacy of Oral Eplerenone for the Treatment of Chronic Central Serous
Full text linkBackground: Central serous chorioretinopathy is a sight threatening disease characterized by accumulation of serous sub retinal fluid occurs due to serous detachment of neurosensory retina and retinal pigment epithelium.Purpose: To evaluate the efficacy of oral Eplerenone in patients with chronic CSCR. Methods: In a tertiary care hospital, a prospective analysis of all the patients with chronic CSCR treated with oral Eplerenone who had been seen for at least three months were prospectively analyzed in a tertiary care hospital. Changes in CMT as measured by spectral-domain OCT served as the primary outcome. Changes in BCVA as measured by log MAR and the number of patients obtaining full resolution of SRF served as the secondary outcomes.Results: In 25 patients (15M /10F) treated with 25mg and 50mg of oral Eplerenone were included. The mean age of follow up was 21±17.6 wks. Mean CMT decreased from 401±133 to 317±75μm at 6 wks& to 285±68μm at 3 months. Mean height of SRF decreased from 157±113 to 78±89μm at 6 wks& to 51±79μm at 3 months. Complete resolution of SRF was found in 15 pts after 3 months. BCVA (log MAR) improved from 0.2±0.18 to 0.14±0.16 at 6 wks & to 0.07±0.13 in 3 months.Conclusion: Eplerenone therapy may improve BCVA & decrease CMT and SRF height in pts with chronic CSCR