HAL-UNILIM
Not a member yet
39506 research outputs found
Sort by
Chronologie sommaire de l'histoire judiciaire de Poitiers du Moyen Age à nos jours
No full textInternational audienc
Co-Simulation Methodology for the Study of Active Electronically Scanned Arrays (AESA)
No full textInternational audienc
CONSTRUIR A PAZ COM O VIVO: UMA PERSPECTIVA JURÍDICO-ANTROPOLÓGICA DA JUSTIÇA TRANSICIONAL
No full textAlice BRITES OSORIO. Faire la paix avec le vivant: une perspective juridico-anthropologique de la justice transitionnelle. Università degli Studi di Trento. Grandi transizioni, vulnerabilità e ruolo del diritto = Les grandes transitions, vulnérabilités et rôle du droit, IRIS, 2025, 978-88-5541-123-3. ⟨10.15168/11572_463217⟩. ⟨hal-05304557
Étude de l'endommagement par fissuration en surface des chaussées routières: Approche probabiliste intégrant les incertitudes liées à la localisation des charges
No full textLe déplacement latéral des roues des poids lourds dans une voie de circulation, appelé également balayage transversal, est un paramètre stochastique entraînant des effets significatifs sur la durabilité des chaussées. Cependant, son rôle dans l’évolution des dommages dans les couches de surface reste largement inexploité. Cet article propose d’évaluer cet endommagement sous chargement cyclique, en s’appuyant sur la simulation numérique de l’interaction pneu-chaussée à l’aide d’une méthode de résolution semi-analytique. Ce travail se concentre sur l’initiation des fissures, une des dégradations les plus courantes dans les couches de surface des chaussées routières. Les analyses portent sur deux conditions de chargement distinctes : le roulement pur et le virage tractif. Le balayage transversal des roues est simulé à l’aide d’un algorithme Monte Carlo par chaînes de Markov, en supposant que ce paramètre suit une distribution normale tronquée. Les simulations numériques montrent que le virage ainsi que la non prise en compte du balayage sont particulièrement critiques pour l’initiation des fissures. Ces résultats sont importants dans la planification des opérations de maintenance
Une forme scolaire de relations sociales « personnalisée » : le cas des conseillers principaux d’éducation
No full textInternational audienc
Key domains involved in the interaction and assembly of the HCMV terminase complex
No full textInternational audienceHuman cytomegalovirus (HCMV) causes life-threatening infections, particularly in immunocompromised patients. Letermovir targets the viral terminase complex (pUL56, pUL89, pUL51), essential for DNA packaging, but resistance mutations in pUL56 underline the need for new antiviral strategies. Targeting critical interaction domains within the complex, such as the pUL56 peptide 671WMVVKYMGFF680, has emerged as a promising approach. This study identifies two additional pUL56 motifs, 514EVNVRKRAY522 and 757YLLLYRHL764, as key mediators of terminase assembly. These motifs were deleted or mutated in an HCMV-BAC clone, and protein-protein interactions were assessed using NanoBit® PPI/PCI-neo assays in HEK293T cells. Interaction domains were mapped on a 3D model of HCMV terminase and compared with the cryo-EM structure of HSV-1 homologs (PDB 6M5R, 6M5S). Mutations in these motifs strongly impaired viral replication. Functional assays showed that 514EVNVRKRAY522 directly mediates interaction with pUL89, while modeling indicated that 671WMVVKYMGFF680 and 757YLLLYRHL764 stabilize the multimeric ring-shaped complex through contacts with pUL89 and pUL51. Our results suggest that two novel pUL56 regions are essential for terminase assembly and conformation and may represent promising targets for future antiviral development
Une « culture psychologique » produisant des « je » isolés ? Usages réformateurs du registre « psy » par des travailleuses des services dans la sphère professionnelle et privée
No full textInternational audienc
Advancements in c-axis-oriented apatite-type lanthanum silicate polycrystal formed by reactive diffusion between La2SiO5 and SiO2
No full textInternational audienceC-axis oriented apatite based on lanthanum silicates (LSO) exhibit an anisotropic character in their ionic conduction properties; hence, a preferential orientation of the crystals along the c-axis is desirable to achieve optimal ionic conductivity. The fabrication route employed in this study to obtain oriented LSO materials involves a reactive diffusion technique between layers of La2SiO5 and SiO2 compounds. In this study, the impact of both the multilayers configuration and an additional annealing step on the chemical composition, microstructure, and electrochemical properties of LSO materials was investigated. The homogeneity of the chemical composition and the degree of crystals orientation throughout the cross-section was evaluated through XRD, EBSD and EPMA. The ionic conductivity along the c-axis of non-annealed and annealed LSO material was measured between 250°C and 500°C.Through a high control of the initial reactive phases and the reactive diffusion processing steps, the resulting materials exhibit significantly higher ionic conductivity compared to the literature, and the conventional zirconia electrolytes (one order of magnitude), thereby offering a real breakthrough for improving SOFC performances and efficiency.</div
Le fonds « Histoire de l’éducation » de l’INSPÉ de l’académie de Limoges : Une ressource pour explorer les mathématiques et leur enseignement
No full textInternational audience1. Quelle composition ? 2. Quelle(s) origine(s) ? 3. Quels usages
From in vivo models to in vitro bioengineered neuromuscular junctions for the study of Charcot-Marie-Tooth disease
No full textInternational audiencePeripheral neuropathies are disorders affecting the peripheral nervous system. Among them, Charcot-Marie-Tooth disease is an inherited sensorimotor neuropathy for which no effective treatment exists yet. Research on Charcot-Marie-Tooth disease has been hampered by difficulties in accessing relevant cells, such as sensory and motor neurons, Schwann cells, and myocytes, which interact at the neuromuscular junction, the specialized synapses formed between nerves and skeletal muscles. This review first outlines the various in vivo models and methods used to study neuromuscular junction deficiencies in Charcot-Marie-Tooth disease. We then explore novel in vitro techniques and models, including complex hiPSC-derived cultures, which offer promising isogenic and reproducible neuromuscular junction models. The adaptability of in vitro culture methods, including cell origin, cell-type combinations, and choice of culture format, adds complexity and excitement to this rapidly evolving field. This review aims to recapitulate available tools for studying Charcot-Marie-Tooth disease to understand its pathophysiological mechanisms and test potential therapies