International Journal of Ayurveda and Pharma Research
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Role of Rakthadushti in the Pathogenesis of Vicharchika: A Review of Classical and Keraleeya Ayurveda Perspectives
Full text linkVicharchika, classified as a Kshudra kushta, is a common dermatological disorder with predominant Kapha dosha involvement. However, Raktadushti plays a crucial role in its pathogenesis, as evidenced by various descriptions in Ayurvedic classics. Ayurvedic texts, including Bruhat Trayis and Keraleeya Ayurveda Granthas, highlight the interconnection between Kushta, Vatarakta, and Rakthavatha, emphasizing the role of vitiated Rakta in disease manifestation. Symptoms such as Pidaka, Srava, Kandu, Daha, and Syavata indicate varying degrees of Rakthadushti, correlating with the Uthana avastha of Vatharakta. The presence of Paka of Raktha further supports the similarity between Vicharchika and Rakthavatha. The treatment axis in Ayurveda revolves around Hethu (causative factors), Linga (clinical features), and Oushadha (medications), making the analysis of Rakthadushti essential for precise intervention. Therapeutic approaches such as Rakthamokshana, Sodhana (purification), and Samana (palliative measures) play a key role in disease management. Keraleeya Ayurveda texts, including Chikitsa Manjari and Arogyaraksha kalpadruma, provide additional insights into the pathology and treatment of Vicharchika through the concept of Rakthavatha and Rakthasthambha. A comprehensive understanding of Rakthadushti enables effective treatment planning, ensuring holistic management and better clinical outcomes in Vicharchika
Pharmacognostical Evaluation of Bhringaraja (Eclipta alba Hassk): An Ayurvedic Drug
Full text linkThis study explores the pharmacognostical properties of Bhringaraja (Eclipta alba Hassk) churna, an herb highly valued in Ayurvedic medicine for its therapeutic benefits. The primary aim is to authenticate the identity of Bhringaraja churna and assess its quality parameters through comprehensive macroscopic, microscopic, and physicochemical, phytochemical evaluations. Macroscopic Analysis: The macroscopic examination confirmed the characteristic features of Bhringaraja, such as its yellowish-brown color, fine texture, and characteristic earthy aroma and bitter taste. Microscopic Analysis: Leaf microscopy showed upper and lower epidermis, cuticle, hypodermis, collenchyma, simple trichome, vascular bundle phloem, proto and meta xylem. Affirming the herb\u27s identity and physicochemical parameters: Various physicochemical parameters were measured, including moisture content, ash values, extract values, and pH. These parameters ensure the stability, and quality of the Churna. This study underscores the importance of pharmacognostical and phytochemical research in enhancing the understanding and application of traditional herbal medicines in contemporary healthcare
Krishna\u27s Diabic Care: An Evidence-Based Review of Ingredients for Diabetes Control
Full text linkKrishna’s Diabic Care is an Ayurvedic formulation aimed at managing diabetes by combining traditional herbal remedies with holistic approaches. This review explores the potential benefits, safety profile, challenges, and future directions of this product in the context of diabetes management. Krishna’s Diabic Care utilizes a blend of herbs traditionally used in Ayurvedic medicine, such as Trigonella foenum-graecum, Syzygium cumini, Momordica charantia, Gymnema sylvestre, Azadirachta indica, Aegle marmelos, Ocimum sanctum, Pterocarpus marsupium, Phyllanthus emblica, Tinospora cordifolia, and Picrorhiza kurroa, known for their roles in supporting blood sugar regulation, improving insulin sensitivity, and reducing complications related to diabetes. However, scientific validation through clinical trials is needed to confirm the long-term efficacy and safety of Krishna’s Diabic Care. While the product demonstrates promise, its integration into mainstream diabetes management is hindered by the lack of robust clinical evidence, potential variations in formulation quality, and regulatory challenges. Collaborations between Ayurvedic practitioners and modern researchers could further bridge traditional knowledge with contemporary medical practices, facilitating broader acceptance of Ayurveda in managing chronic conditions like diabetes. The review concludes that Krishna’s Diabic Care holds potential as part of a holistic diabetes management strategy, with the need for rigorous clinical validation to enhance its credibility and integration into global healthcare systems
Phytochemistry and Pharmacology of Helicteres Isora Linn. (Marodphali): Ayurvedic Insights and Medicinal Overview
Full text linkIt is a small, sub-deciduous tree or shrub that is commonly cultivated. People have used it for medicinal purposes since antiquity, in organized (Ayurveda, Unani & Siddha) and unorganized (folk, native and tribal) forms. Marodphali is a well-known Ayurvedic remedy for curing various diseases and has several pharmacological effects. Marodphali, scientifically classified as Helicteres isora Linn., is a member of the Sterculiaceae family. It is also referred to as Avartani. On the preliminary phytochemical screening, it is reported that the plant of Marodphali consist of several bioactive compounds like alkaloids, steroids, phenolic compounds, carbohydrates, proteins, saponins and flavonoids, which proclaim various important Pharmacological effects encompass antioxidant properties, lipid-lowering (hypolipidemic) effects, antibacterial and antiplasmin actions, cardiotonic benefits, anti-oxidative and anti-peroxidative potential, neuroprotective antioxidative capacity, anticancer effects, analgesic (anti-nociceptive) properties, liver-protective (hepatoprotective) effects, anti-diarrheal benefits, and wormicidal activity. Marodphali\u27s multifaceted therapeutic profile positions it as a promising natural remedy for a range of pathological conditions, highlighting its potential for broader clinical applications pending further research into its molecular mechanisms of action
Traditional Medicine in the Management of Adenomyosis
Full text linkAdenomyosis is a benign gynecological condition characterized by the presence of endometrial glands and stroma within the myometrium, leading to uterine enlargement and a spectrum of symptoms. Endometrial cells from the lining of endometrial cavity, migrate; most commonly into the posterior side or back wall of uterus, as these cells respond to monthly hormonal change. Severity and symptoms associated with adenomyosis, directly proportional to degree of involvement and penetration of uterine muscle. Untreated adenomyosis can progress to endometriosis, potentially leading to severe complications where hysterectomy may become necessary. Ayurvedic formulations with properties such as Anulomaka, Vatashamaka and Rakta Prasadaka have shown significant benefits. These treatments provide relief from pain and irregular menstrual cycles while enhancing the patient’s overall quality of life, offering a non-invasive alternative to conventional approaches. This is a case report of 32 year old female complaining of severe lower abdomen pain during menstruation associated with low back ache and pain during sexual intercourse. In this case treatment focused on Vata anulomana, Soolahara, Ama sophahara and Rasarakthaprasadana. Sthanika karmas like Yoni kshalana and Yoni Pichu were adopted for treating the Sthanika dosha dushti. After the course of treatment patient got complete relief from symptoms and on investigation adenomyotic changes were found resolved
Formulation and Evaluation of Usiradi Yoga Ointment for Dermatological Conditions
Full text linkThe prevalence of skin and subcutaneous illnesses and the worldwide burden of skin disorders has increased significantly in recent times. In addition to physical health, these medical and cosmetic issues also affect mental health and self-esteem. In Ayurveda, skin conditions are mostly categorized under the spectrum of Kushta. Classical literature describes eighteen different forms of Kushtas, and their treatment. In the treatment of dermatological conditions, medicinal powders are utilized as external therapies in forms such as Lepa, Udwartana, and Udsadana. Nevertheless, using powder can cause discomfort and pain in certain skin conditions. Given today\u27s fast-paced lifestyle, there is a need for a convenient dosage form made from easily available raw materials. The goal of this study is to formulate an ointment using Usiradi Yoga churna, mentioned in Vaidyamanorama (Chikilsa krama), and to improve patient compliance without compromising its efficacy. This report includes the development and quality analysis of Usiradi Yoga ointment (USYO). Fine powders of Vetiveria zizanoides, Soot, Plumbago zeylanica, Psoralea corylifolia, Pongamia pinnata, Piper longum triturated with cow’s urine distillate (3.16% each) were added to the liquid paraffin and bees wax mixture (6:1) as ointment base. In addition to physicochemical parameters, microbiological test and finger printing of phytochemical constituents of USYO was conducted. The Results showed that USYO was of good consistency and fair extrudability and successfully passed the microbiological test. HPTLC fingerprinting of USYO demonstrated the presence of several constituents
An Open Label Single Arm Clinical Study on the Combined Effectiveness of Tila Bakuchi Churna and Nimbadi Lepa in Dadru (Dermatophytosis)
Full text linkDadru is categorized under both Kshudrakusta and Mahakusta, which is a Tridoshshajavyadhi primarily vitiated by the Pitta-kapha dosha and characterized by Kandu, Raga, Pidaka, Mandala and Rukshata. It can be correlated to dermatophytosis on the basis of symptomatology and pathogenesis. As India being a tropical country, there has been a rise in chronic and relapsing dermatophytosis, with a prevalence of 65.3% and 34.6%, respectively. The study was undertaken with an intention to evaluate the combined effectiveness of Tila bakuchichurna internally and Nimbadilepa externally in the management of Dadru. The ingredients of the intervention possess Tikta rasa, Ushnnaveerya, Tridoshaghna, Krimighna, Kandughna and Kushtaghna properties in contrast to the properties of Dadru. Objectives: To clinically evaluate the combined effectiveness of Tila bakuchichurna and Nimbadilepa in the management of Dadru (dermatophytosis). Methodology: Among 34 registered participants, 30 of them completed the course of treatment. They were administered with 6gm of Tila bakuchichurna internally, once daily in the morning, before food, with Anupana of warm water and Nimbadilepa application externally, once daily in the daytime with water for a period of 30 days. Ordinal data was analysed with Friedman’s test followed by Wilcoxon signed rank test after applying Bonferroni correction with a 95% confidence interval; p<0.05 was considered significant. Results: Statistically significant improvement was observed on the parameters Kandu, Raga, Pidaka, Mandala, Rookshata, 5-D Pruritus scale and DLQI scale. Conclusion: Tilabakuchichurna and Nimbadilepa were found to be effective in the management of Dadrukusht
Acute Toxicity Study of Vishatindukadi Vati Prepared by two References: Evaluation of Toxic Effects in Wistar Rats
Full text linkAcute toxicity studies were conducted to assess the short-term adverse effects of two formulations of Vishatindukadi Vati (VTV1 and VTV2) in rats, as per OECD 423 guidelines. VTV1 contains Kupilu, Maricha, Puga Phala and Chincha Beeja while VTV2 contains Kupilu, Maricha and Bhavana of Nagavalli Patra Svarasa. This study aims to conduct an acute toxicity study of Vishatindukadi Vati, prepared with two references. The experimental procedure involves using female Wistar rats (Rattus norvegicus), aged 8 weeks. Each rat weighs between 200 and 300 grams, with a variation of ±20% of the mean weight. A total of 3 animals are used per set for the study. Mortality occurred in all animals administered VTV1 at 2000mg/kg body weight, whereas no mortality was observed in VTV2 at the same dose. VTV1 exhibited toxicity, potentially due to the high concentration of Kupilu, which contains the neurotoxic alkaloids strychnine and brucine. The Bhavana of Nagavalli Patra in VTV2, known for its antidote properties, may reduce oxidative stress and inflammation, potentially mitigating toxicity. The LD50 of VTV1 was classified under GHS Category 4 (greater than 300mg/kg), while VTV2 fell under GHS Category 5 or Unclassified (greater than 2000mg/kg). This study emphasizes the significance of Shodhana (purification) processes and antidote substances in mitigating the toxicity of formulations
Achieving Equilibrium in Ayurveda: The Role of Dosha, Dhatu, and Mala in Promoting Wellness
Full text linkAyurveda, the oldest Indian medicine system, focuses on the balance of Dosha (bio-energies), Dhatu (tissues), and Mala (waste products)- the essences of which is critical to the health. The article explores prerequisites for health in Bharatiya (Indian) lifestyle - Samyata (equilibrium) of Dosha (Vata, Pitta, Kapha), Dhatu (seven bodily tissues) and Mala (urine, feces, sweat). This study narratively reviews classical Ayurvedic texts and modern interpretations to illustrate their roles and interrelationships as well as practical strategies for maintaining equilibrium. The results emphasize that lifestyle factors, which include diet (Ahara), daily routine (Dinacharya) and mental well-being (Manas) are essential to achieving Samyata. These principles, still relevant in our contemporary health discourse, provide a guide to holistic preventive and therapeutic care. This research validates Ayurveda’s eternal principles for sustainable well-being
Ayurvedic Management of Asrgdhara
Full text linkAsrgdhara is a condition of ‘Raja pradeerana’, that is excessive flow of Raja or Arthava. One who follows the Nidana sevana like Lavana, Amla, Guru aharas, Snigdha aharas, Adhyashana, h/o Garbha pata etc. can result in Asrgdhara. This can be corelated to abnormal uterine bleeding. Present case study is about a patient with heavy menstrual bleeding with dysmenorrhea and passage of clots after attaining menstruation following her delivery and irregular cycles since menarche. In modern she was suggested for hysterectomy since her family is completed but patient denied. Here, after taking a detailed menstrual and personal history, the Doshas involved were analysed as Vata and Kapha. Since Asrgdhara is a Basti Sadhya vyadhi and following the Samanya chikitsa, the treatment plan was done. Treatment plan included Picha basti and required internal medications. Patient had significant symptomatic relief with gradual reduction in clots to no clots, reduced dysmenorrhea and also the cycles became regular within 3 months of intervention. This case is a perfect example for conditions where even after suggesting surgical management, how Ayurveda helps in leading a healthy life by bringing the condition under complete control