International Journal of Ayurveda and Pharma Research
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Ayurvedic Management of Infertility
Full text linkInfertility is a condition which could affect the entire world. This case study discusses a patient diagnosed with secondary infertility who had a history of one abortion after one year of unprotected sexual life and could not conceive subsequently after that. Considering the chances of abortion and the need for healthy uterus capable of childbirth, ayurvedic treatment plans were adopted. This case was diagnosed as Garbhasravi Vandhyata. Treatment plan included both Shodhana followed by Uthara vasthi and Shamana therapies. As a result of the Ayurvedic interventions made in three courses of treatment, the patient conceived and delivered a healthy baby boy
Significance and Utility of Raktashali (Red Rice) in Ayurveda - A Narrative Review
Full text linkRaktashali, or red rice, recognized for its distinctive red bran and unrefined nature, holds a place of prominence in Ayurveda for its nutritional richness and therapeutic potential. Ancient Ayurvedic scriptures- including the Charaka Samhita, Sushruta Samhita, Ashtanga Hridaya, and Bhavaprakasha Nighantu repeatedly affirm Raktashali’s ability to harmonize the Tridoshas Vata, Pitta, and Kapha. It is described as having a sweet taste (Madhura rasa), cooling energy (Shita virya), light digestive quality (Laghu), and nourishing effect (Pushtiprada), making it especially beneficial in conditions such as fever, inflammation, ulcers, and overall physical debility. Ayurveda regards food as fundamental to health, and Raktashali is classified as Nitya Sevaniya Ahara, a food suitable for daily consumption owing to its role in tissue nourishment, digestive support, and immune modulation. Its applications are extensive: it plays a vital role in Samsarjana Krama, the graduated dietary regimen following Panchakarma therapies; it is recommended during monsoon (Varsha Ritu) to rekindle digestive strength (Agni); and it serves as a traditional staple in regions like Coastal Karnataka and Kerala. Modern nutritional science corroborates these benefits, identifying high levels of antioxidants, flavonoids, iron, and zinc, along with a low glycemic index that supports heart health, reduces inflammation, and aids in glycemic control. Additionally, its bran is rich in bioactive compounds, such as tocopherols, tocotrienols, and catechins- known for liver-protective and anticancer properties. By synthesizing ancient Ayurvedic wisdom with current scientific evidence, this review underscores Raktashali’s role as a versatile functional grain suitable for both therapeutic use and everyday nutrition in preventive and integrative healthcare models
Pharmacognostic and Phytochemical Evaluation of Panchakola Choornam for Digestive Health: A Classical Ayurvedic Perspective
Full text linkPanchakola Choornam is a classical Ayurvedic formulation known for its Deepana and Pachana properties, traditionally used to correct digestive dysfunction and eliminate metabolic waste. This study aimed to validate and standardize the formulation through organoleptic, physicochemical, phytochemical, and TLC analyses. The Choornam exhibited characteristic sensory features and a mildly acidic pH (5.95), supporting its digestive role. Phytochemical screening confirmed the presence of glycosides, phenols, alkaloids, flavonoids, and coumarins, with water extracts highlighting hydrophilic constituents. TLC fingerprinting showed strong correlation with individual ingredients, ensuring formulation integrity, and revealed unique markers suggesting synergistic interactions. These findings affirm the safety, efficacy, and traditional use of Panchakola Choornam, providing a scientific basis for its standardization and future integration into evidence-based Ayurvedic practice
Formulation and In Vitro Evaluation of Gabapentin Controlled Release Tablets Using Natural Polymers
Full text linkThis research set out to find the best way to use various grades of controlled-release polymer. To create a new one that would be just as effective as the original, but cheaper, and of better quality. The dosage form was designed using Hydroxypropyl Methyl Cellulose (HPMC K15MCR) as matrix builders. Research on the compatibility of medication and polymer was carried out. The flowability of the powder blend was optimized after studying the blend. Uniformity Compressing free-flowing powder directly into tablet form was the method of choice. They were successfully combined with the HPMC, MCC, and DCP networks. In order to compare different dissolution characteristics, we also presented the mean dissolving time. Clinical trials have shown that controlled-release gabapentin tablets are formulated by direct compression outperforms its immediate-release counterparts in terms of therapeutic efficacy
An Experimental Study to Evaluate the Anti-Microbial Effect of Fumigation with Sarshapanimbadi Dhoopa
Full text linkNowadays rising airborne diseases are one of the major health concerns of the entire world. Prevalence of various respiratory diseases are increasing in persons exposing to contaminated environment. Therefore, disinfection of our environment is most important. In Ayurveda, Dhoopana is a method of disinfection. Sarshapanimbadidhoopa mentioned in Sushruta Samhita with ingredients Sarshapa, Nimba, Saindhava and Ghrita was selected for the study to evaluate its antimicrobial activity. Primarily Staphylococcus aureus and Candida albicans were identified from different treatment procedure rooms of hospital by placing petri dishes open for one hour with suitable medium. Fumigation of identified microbes were done within a glass chamber with and without adding Dhoopanadravya to red hot charcoal. In addition to that one set of microbial plate of bacteria and fungus were kept as such without fumigation for the assessment of efficacy of fumigation. Fumigation was done with varying doses (15g, 20g, 25g and 30g) and time span (5minutes, 10minutes, 15minutes and 20minutes). Results obtained were statistically analyzed using independent t-test, ANOVA test and paired t-test. Reduction in Colony Forming Unit (CFU) of bacteria and fungi were found to be significant and fumigation with adding Dhoopachoorna was found to be more significant than without adding Dhoopachoorna to charcoal. Complete cessation of bacterial CFU was found on fumigation with 30g Choorna for 20minutes and fungal CFU was found on fumigation of 25g Choorna for 15minutes. The study concluded that Sarshapanimbadi Dhoopa has antimicrobial effect
A Clinical Trial to Evaluate the Combined Effect of Ekavimshatika Guggulu and Bala Taila Matra Vasti in Sciatica
Full text linkEkavimshatika Guggulu is mentioned in Bhavaprakasha Madhyamakhanda Kushta Adhyaya and Bala Taila mentioned in Bhela Samhita Vata Vyadhi Adhyaya. Most of the drugs in Ekavimshatika Guggulu are of Vata-kapha Shamana and also mitigate Gridhrasi as per the Phalasruthy. Bala Taila is having Vatahara property and is Balya in nature. Matra Vasti possess the qualities of Vata Anulomana and Snehana properties. The study was an interventional study with pre and post-test, without control group. Subjects of either gender with age group 20-60 years registered in Pankajakasthuri Ayurveda Medical College & Post Graduate Centre, satisfying the inclusion and exclusion criteria were subjected to positive sampling and total of 27 subjects were selected and 27 subjects completed the clinical trial. The selected subjects were administered Ekavimshatika Guggulu in a dosage of 2 tablets orally thrice daily before food along with 75ml Bala Taila as Matra Vasti for 14 days. Assessment of the subjects was done on 0th day, 15th day and follow up done on 30th day with subjective and objective parameters. RESULTS: On analysing the results, it has been found that subjective parameters like tenderness, radiating pain, ODI scale, Sciatica Bothersomeness Index Scale, Sciatica Frequency Index Scale and objective parameters like SLR, Lessigues sign, also other parameters like Gridhrasi lakshanas got statistically significant improvement. Friedman test was used to assess the overall significance between three points. P-value <0.05 was found to be significant. Wilcoxon Sign Rank test was used to find out overall difference between before treatment and after follow up in subjective parameters. Significance in range of movements was assessed by repeated measures of Anova. CONCLUSION: Based on the observations and results of the clinical study, the alternate hypothesis, Ekavimshatika Guggulu and Bala Taila Matra Vasti is effective in the management of sciatica is accepted and null hypothesis is rejected
The Application of Nasya in Pakshaghata
Full text linkPakshaghata is among the eighty Nanatmaja vikara explained by Acharya Charaka in Sutrasthana, Maharoga adhyaya. The major Lakshanas include Chesta nivruthi of Ardhanga, rujam and Vaksthambha. Even though it is generally mentioned under Kevala vata vyadhi, Acharya Susrutha has mentioned its subtypes as Kaphanubandhi and Pittanubandhi. According to Ayurveda, the disease affects the Madhyama roga marga and causes the Soshana of Sira and Snayu. From this, it can be inferred that Raktha dhathu is also involved in the pathogenesis of the disease. Specific Nidanas of Pakshaghata have not been mentioned, therefore general factors causing Vata prakopa can be considered. Some consider Ardhita as synonym of Pakshaghata, then Ardhita nidana becomes applicable. Ultimately it occurs due to Dhathu kshaya or Margavarana. In Pakshaghata margavarodha of Vyana vayu occurs due to Nidanas causing impairment in Dhathu poshana, finally leading to Dhathu kshaya. In modern medicine this condition may be correlated to hemiplegia that occurs after a cerebro vascular accident. It is considered as a disease of difficult prognosis if not managed immediately. But in Ayurveda, the treatment concept is different and has received wide acceptance. The line of treatment according to Acharya Charaka is Snehana, Swedana and Virechana. This highlights the importance of Panchakarma chikitsa in Ayurveda. Even though Virechana is the Shodana procedure mentioned in Chikitsa sidhanta, all the Shamana and Shodana therapies mentioned in Ayurveda are found to be effective in managing Pakshaghata. This article aims to review the mode of action of Nasya in Pakshaghata. Nasya is one among the Panchakarma and is indicated for Urdwa jatrugata vikaras. Nasa being the Siraso dwaram, medicine instilled through nostrils can cure the diseases of the head by spreading through Sringataka marma. This is considered as the concept behind the action of Nasya
A Cross-Sectional Survey on the Challenges Faced by the Ayurvedic Drug Manufacturing Industry in Kerala
Full text linkAyurveda is the traditional system of medicine in India. As an alternative system of medicine, it is getting global acceptance in the present decade especially in the post Covid scenario. Rising health consciousness among the people, increasing prevalence of epidemics and lifestyle diseases, evidence-based Ayurveda practices and the tremendous changes in the global trade happened in the past few years can be considered as the reason for the same. The annual turnover of Indian market of Ayurveda medicine industry in the year 1998 was 25 billion which was reached a size of INR 626 billion in the year 2022. As per the current researches it is expected to grow at a Compound Annual Growth rate of 12% from 2022 to 2028. Out of the small, medium, and large manufacturing units situated in India, 12% are situated in the state Kerala. Being a small state with such a considerable share in the market a survey has been conducted among 15 Ayurveda drug manufacturing units in the state. The paper expects to assess the possible challenges faced by the industry currently, analyze the methods to resolve them by which improve the productivity without compromising the quality of medicines. The study may also help to check the difficulties faced by the industry at the levels of collection of raw drugs, processing, manufacturing, pacing and marketing and also to suggest the necessary policy shifting if needed
Natural Food Toxins and its Ayurvedic Purview
Full text linkToxins are poison of plant or animal origin, produced by or derived from microorganisms and acting as an antigen in the body. These are formed in dietary articles as a part of the defence mechanism of the plant against predators or insects or in response to extreme climatic conditions. These secondary metabolites are chemical compounds having diverse structure and differ in biological function and toxicity, will have adverse impact on human or animal health when consumed in excess. Natural food toxins can be categorized under phytotoxins and marine toxins. Cyanogenic glycosides, glycoalkaloids, lectins, glucosinolates and pyrrolizidine alkaloids are the major phytotoxins. Marine or aquatic toxicity occurs by the ingestion of shellfish that have consumed toxin producing algae, or by bacterial growth in fish due to improper handling. Some of these toxins are extremely potent and harmful when consumed in large quantities. These toxins possess a serious health threat to both humans and livestock. It may result in acute and chronic toxicity ranging from gastrointestinal upset to fatality. So, detoxification of dietary articles containing natural food toxins is crucial as it helps to eliminate these chemicals and thereby ensuring food safety. So, this article intends to highlight the Ayurvedic viewpoint of natural food toxins and the importance of precautionary measures for preventing toxicity of natural food toxin from daily consuming dietary article
Exploration of the Pharmacological Properties, Actions and Therapeutic Potential of Amritotharam Kwatha
Full text linkNature and its elements are closely attached to human existence as the five elements that makes up the human body reflects the five elements that makes up all the matter that we see around us which has been one prime reason that herbal medicine has existed from time immemorial. Its prime principle is that deficiencies and defects in a five elemental body could always be repaired by drugs filled with abundance of same elements. Humans are also prone to a vast variety of diseases and health disorders as they tend to deviate from the things that keep the functional elements of the body in equilibirum and this leads to the onset of diseases. Such cases required medicines that can remove Dosha imbalance, promote and maintain the digestive fire, and at the same time act as a preventive measure for possible secondary diseases as well providing an immunomodulatory effect as well. Amritotharam kwatha is a renowned, widely accepted and therapeutically used Ayurvedic formulation by all Ayurvedic physicians throughout the country. The formulation is mentioned specifically in the text Sahasrayogam as well as other texts like Chikitsamanjari, Yogamritam in the contexts of Jwara chikitsa to combat Jwara of all types and its associated health issues. This article is intended to explore the pharmacological properties, actions and the therapeutic potential of Amritotharam Kwatha