International Journal of Ayurveda and Pharma Research
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Pharmacognostical and Phytochemical Evaluation of a New Anti-Hypertensive Ayurvedic Formulation [NIA/DG/2020/01]
Get PDFHypertension, also known as high or raised blood pressure, is a multifactorial disease with multiple causes and multiple treatments. The prevalence of hypertension in the urban Indian population was estimated to be 40.8% and in the rural population was 17.9%. Though there are multiple treatment of disease still it is challenge to manage this disease effectively with lower side effects as all available treatments are full of side effects and toxic effects. NIA/DG/2020/01 is a new anti-hypertensive Ayurvedic ghan formulation, containing Arjuna (Terminalia arjuna Roxb.), Ashwagandha (Withania somnifera Linn.), Jatamansi (Nordostachys jatamansi DC.), Shankhpushpi (Convolvulus pluricaulis Chois.), Punarnava (Boerhavia diffusa Linn.), Gojihwa (Onosma Bracteatum Wall.), Guduchi (Tinospora cordifolia Willd.), Mukta Shukti (Margarita) and Praval Pisti (Corrallium Rubrum). All these components are very well known for Hridya, Mootral, Rasayana, Pitta shamak effect and pharmacological actions like cardioprotective, anti-Hypertensive, antioxidant, antimicrobial, antifungal, Antidepressant or anxiolytic, anti-inflammatory, psycho-immunomodulatory effect and acetyl-cholinesterase inhibitory activity etc. Aim and Objective: To perform pharmacognostical, physio-chemical, phytochemical and chromatography evaluation of a new anti-hypertensive Ayurvedic formulation [NIA/DG/2020/01]. Material and Methods: This study involves pharmacognostical, physio-chemical, phytochemical and chromatography evaluation of a new anti-hypertensive Ayurvedic formulation [NIA/DG/2020/01] to ensure its purity, safety and quality. Observations and Results: All the findings of the pharmacognostical, physio-chemical, phytochemical and chromatography evaluation were within the standards of quality. Conclusion: The present sample of a new anti-hypertensive Ayurvedic formulation [NIA/DG/2020/01] was found to be rich in quality and was safe, pure and authentic
Ayurvedic Protocol in the Management of Bipolar Disorder with Psychotic Features in Young-Adult- Case Report
Get PDFBipolar Disorder (BD) is one of the world’s ten most disabling conditions taking away years of healthy functioning from individuals who have the illness. BD is a long-term, progressive psychiatric condition characterized by mood swings, including manic and depressive episodes. The prevalence rate is approximately 1% across all populations. Most of the complete aetiology or pathogenesis of BD is unknown. As per Ayurveda, Bipolar Disorder shows symptoms as mentioned in Unmada. In Unmada, there is considerable impairment in Ashtavibrama such as Manas, Buddhi, Samjnajnana, Smrti, Bhakti, Shila, Ceshta, as well as Acara. The present article deals with a diagnosed case of BD with psychotic features as per DSM 5 criteria, approached for an Ayurvedic management. A 20-year-old male presented in the hospital OPD with increased worries especially during evening hours, helplessness regarding his future, increased irritability, and sadness. On assessing Patient was an Avara Satwa. Management was planned with integrative approach comprising of Yukti vypasharaya and Satwawajaya. Internally he was given medicines to manage his depression and anxiety. He was advised with procedures namely Takrapana followed by Sodhananga snehapana, Sarvanga abhyanga and Bashpa sweda. Thereafter Virecana, and Yoga Vasti was given. During this time, he was also subjected to internal meditation and counselling techniques as well. The patient responded satisfactorily to the treatment and his symptoms improved significantly. There was marked reduction in his fear and pessimistic attitude. As an outcome, the care of BD using an integrative Ayurvedic approach proved effective
A Review of the Therapeutic Effect of Musli in (Chlorophytum Borivilianum) Sukra Alpata which Correlates to Oligospermia
Get PDFMale infertility is one of today\u27s most pressing issues, and the prevalence of this condition is rising owing to a change in lifestyle. Low sperm count denotes a lower-than-normal sperm count in the semen you produce during orgasm. Oligospermia is another name for low sperm counts. A zero sperm count is referred to as azoospermia. Oligozoospermia is a disorder associated with male infertility that is characterized by a low sperm count. Ayurveda, the Indian medical system\u27s science, defined several terminologies linked to male infertility, including Kshina shukra, Alpa Retasa, and Shukra dosha, which are similar to disorders connected with oligozoospermia. Ayurveda also described several medications for treating oligozoospermia. Musli is the most widely used remedy for oligospermia. Musli is one of the well-known medications described in Ayurvedic texts. Musli has exceptional aphrodisiac and revitalizing qualities. It is beneficial to overall health development. In Ayurveda, musli is also known as Talamuli, Suvaha, Talamulika, Deerghakandika, and Talapatri. It is a Rasayana medication that is useful in Ayurvedic Materia Medica for vigor and vitality. Sweta Musli\u27s therapeutic value has long been praised and supported due to its aphrodisiac properties. Samhita Sweta Musli and Krishna Musli are the two main varieties of Musli. It works to treat impotence, and infertility, increase male potency, and has immune-modulating and adaptogenic qualities
The Pharmacological Usage of Panchadeepakini Chooranam for Respiratory Ailments
Get PDFAn old Indian traditional medical practice called Siddha developed in South India. The Lord typically serves as the source of the system. It is believed that Goddess Parvathi, represented by Lord Shiva, received the Siddha system\u27s knowledge from the Almighty, who then passed it on to Nandikeswara. Nandikeswara was appointed to set up for the framework to be spread in the midst of humankind thus, he obediently granted the information to Sage Agastya. Agastya gave all of the relevant information to his various disciples, who helped spread the system around the world. Diet and lifestyle play a significant role in both health and disease treatment, according to the Siddha medicine system. Pathiyam and Apathiyam refer to this Siddha medicine concept, which is essentially a rule-based system with a list of "dos and don\u27ts.” The aim of this review article is to explore the scientific literary evidence for the therapeutic usage of Panchadeepakini chooranam for (Silethuma Noi/Kaba Noi) as mentioned in Citta Vaittiya Tirattu and to assign effort to entity the pharmacological activity for the curative nature of the drug. Most of the raw drugs used for the preparation of Panchadeepakini chooranam have bronchodilatory activity, anti-tussive activity, anti-allergic activity, immunomodulatory activity, anti-histamine activity hence justifying its usage in respiratory illness
Pharmacological Basis of Similia Similibus Curantur and the Nature of Homeopathic Materia Medica
Get PDFSimilia Similibus Curantur is also called the law of similars. That is, when a drug produces pathological/pathogenic symptoms in healthy individual means, the same drug can relieve similar kinds of symptoms in individuals with the disease. The biological, pharmacological and toxicological action of capsaicin alkaloids is a perfect example to explain the Similia Similibus Curantur principle. Most of the drugs in homoeopathic materia medica contain toxicological, pharmacological, drug-proving, and traditional use-related symptoms and indications. Abnormal sensations and symptoms of the disease are caused by the involvement of a specific receptor or molecular pathway and gene functions. These receptors or molecules may be stimulated or suppressed by environmental, natural or artificial agents. In such conditions, the administration of specific homoeopathic medicine having a similar kind of affinity towards the particular receptors or molecules involved in the disease process leads to modulation of such receptor or molecular pathways (e.g., desensitization, sensitization, inhibition). These kinds of actions cause the betterment of symptoms or curative effects. So “Similia similibus curanter” can be understood as a similar receptor or molecular pathway involved in both drug molecules biological/ pharmacological and toxicological action and disease pathogenesis". The selection of medicine is by comparing the similarity between the receptor or molecular pathway in disease pathogenesis and drug pathogenesis. To avoid unwanted aggravations or side effects while using mother tinctures or solutions, administer them less than their physiological dose. The theory of the pharmacological basis of Similia Similia Curantur creates a rational method to apply this Similia Principle. Based on this theory, there is a possibility of discovering Novel drugs in the future that acts and gives a cure in similia similibus curantur way
Commentators View on Medicinal Plants of Sushrutokta Salsaradi Gana Regarding their Controversial Botanical Identity: A Review
Get PDFSushruta Samhita is one of the foundational literature included in the Brihat traiye literatures of Ayurveda. Out of 37 different Ganas mentioned in Sutra Sthana of Sushruta Samhita, Dravya-sangrahaniya-adhyaya; Salsaradi-gana is one of them in which 23 medicinal plants have been described. Classically Salsaradi-gana is clinically indicated for Kushta (skin diseases), Prameha (diabetes mellitus), Pandu (anemia), and Kapha-medo-vishoshana (anti-hyperlipidaemic) disease. For this study, a review of the original commentary of Acharya Dalhana and Acharya haranchandra on Sushruta Samhita and the scientific research papers published on the medicinal plants listed in the Salsaradi-gana of Sushruta Samhita in indexed journals is done. Out of 23 medicinal plants mentioned 8 plants have controversial identification. The controversy in the identification of these medicinal plants is seen directly affecting the pharmacological action and clinical efficacy. Those 8 plants’ controversial identity is cleared with the establishment of a genuine plant for each of the plants through scientific and classical justification.  
Added Effect of Pratimarsha Nasya with Ksheerabala Taila (14 Aavartita) over Selected Yoga Techniques in Insomnia
Get PDFInsomnia is a prevalent psycho physiological sleeping disorder, included in the International Classification of Sleep Disorders-2 (ICSD-2). By definition insomnia is a difficulty in initiating or maintaining sleep, or both or the perception of a poor quality sleep. Insomnia leads to various social, interpersonal and occupational impairments. Clinical studies have proven that Yoga is effective in insomnia. Present study was to find out the added effect of Pratimarsha nasya with Ksheerabala taila (14 Aavartita) over selected Yoga techniques in relieving insomnia. As per Acharya Susrutha in Chikitsa Sthana, doing Pratimarsha nasya daily during evening hours (Sayamkala) renders Sukhanidraprabhodanam. A pre-post interventional study was performed in 40 participants both male and female, satisfying the inclusion and exclusion criteria. Out of 40 participants, 20 each were randomly allocated to Group I and Group II. In Group I, Pratimarsha nasya using Ksheerabala taila (14 Aavartita) was administered 1ml in each nostril at evening time along with the practice of selected yoga techniques during morning hours. In Group II, only selected Yoga techniques were advised. The study period was for 30 days. The pre & post changes in mean score value was assessed using Pittsburgh Sleep Quality Index (PSQI) score. The data was analyzed using unpaired t test, and was statistically significant with a p value ≤0.01. Thus the added effect of Pratimarsha nasya with Ksheerabala taila (14 Aavrtita) over selected Yoga techniques in insomnia is more effective than selected Yoga techniques alone
Ayurvedic Management of Acute Dissociative Reactions to Stressful Life Events - A Case Study
No full textMental diseases known as dissociative disorders are characterised by a sense of discontinuity and separation from one\u27s thoughts, memories, environment, activities, and identity. People with dissociative disorders unintentionally and unhealthily flee reality, which makes it difficult for them to carry on with daily activities. Dissociative identity disorder (DID, sometimes known as multiple personality disorder), fugue, "psychogenic" or "functional" amnesia, and depersonalization disorder are examples of dissociative disorders. Other specified dissociative disorder is subcategory of dissociative disorders that describes presentations in which symptoms are typical of a dissociative disorder but do not fully match the diagnostic criteria for any of the illnesses in the diagnostic class of dissociative disorders. In Ayurveda this condition can be considered as Unmada. 34 year female patient hailing from Malappuram, Kerala, brought to Manasanthi OPD of VPSV Ayurveda College, Kottakka,l by husband and relatives complains of lack of desire to live, wants to end her life, loss of sleep, difficulty to walk and doing daily activities since 3 days. She was very much concerned about the behavioural issues and wellbeing of her elder son since 12 years. According to the informant, the patient was having increased tension, repeated talking about her elder son, making loud noises and suicidal thoughts. Also, she had an attempt to suicide. She was treated on an IP level with a combination of Ayurvedic internal medications and Panchakarma procedures. The treatment protocol includes Snehapana, Virecana, Nasya, Shirodhara, and Dhoopana. Satvavajaya methods including Yoga also administered. There were considerable relief from symptoms and HAM D score was reduced from 21 to 6
The Role of Kunjal Kriya in Upper Respiratory Tract Disorders w.s.r. to Bronchial Asthma
Get PDFBronchial Asthma is one of the distressing ailments of the present time and is notable for its episodic and chronic course which influences the entire human race & it is a sickness of the human respiratory framework where the aviation routes get restricted. This limiting causes side effects, for example, wheezing, windedness, chest snugness, and hacking, which answer bronchodilators. Kunjal Kriya is the most straightforward technique among all types of Dhouti. The cleaning up of the whole track beginning from the mouth to the stomach related way toward the start of the small digestion tracts, that is mouth, and throat. Asthmatics might notice huge globs of mucus in the ousted water; the solid reflex from the pyloric valve will release bodily fluid discharges from the bronchial cylinders. Kunjal Kriya is suggested as a protected technique during an assault, as the strong activity of the vagus nerve delivers fit in the respiratory framework. Every day Kunjal Kriya is suggested for asthmatics under the arrangement of prepared instructors. In this review study, the author focused to rule out the mode of action of Kunjal Kriya in Upper Respiratory Tract Infections w.s.r. to Bronchial Asthma
Phytochemical Investigation and in Vitro Antioxidant Activity of Panchavalkala Bark Extracts
Get PDFNatural antioxidants have an important role in the prevention of many age-related diseases and promotion of health. Among natural antioxidants from plants, flavonoids and other phenolic compounds are potent antioxidants and chelating agents. Panchavalkala the barks of five trees i.e. Nyagrodha (Ficus benghalensis L.), Udumbara (Ficus racemosa L.), Ashwatha (Ficus religiosa L.), Plaksha (Ficus virens Aiton) and Parisha (Thespesia populnea (L.)Sol.ex Correa) are also known as Pancha Ksheeri Vrikshas in use since Vedic period. Barks of these trees are dried in shade and are used for different formulations (Pancha Kashaya Kalpanas), in different pathological conditions, especially as wound healing, gynecological disorders and etc. The plant samples were extracted using ethanol and water, and subjected for the phytochemical analysis. It was confirmed that samples contain many biologically active compounds like flavonoids, polyphenols, tannins, alkaloids, glycosides and terpinoids etc. The marker compound of each trial drug and the quantitative analysis has been carried out by high performance liquid chromatography. The antioxidant study was done by using in vitro method 1, 1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging assay. The marker compounds caffeic acid and gallic acid were quantified in each extract for their quality and efficacy. PVK barks showed high free radical scavenging activity as evidenced by the low IC50 values in DPPH (EE PVK- 20.46µg/ml, AE PVK-37.79µg/ml, EE T.poulenea-22µg/ml, AE T. poulenia- 23.31µg/ml AE F. benghalensis- 25.53µg/ml, EE F. benghalensis- 26.23µg/ml, EE F. religiosa - 34µg/ml). Quercetin- IC50 value 4.026µg/ml is used as standard.
The results of the study demonstrated that PVK barks possess phyto-constituent’s viz. tannins, flavonoids, polyphenols etc. and has potential antioxidant activity. Thus these barks have good therapeutic potential as natural antioxidant and might be used in life style related conditions like hyperlipidemia, diabetes, obesity, cardiovascular disorders and etc