International Journal of Ayurveda and Pharma Research
Not a member yet
2276 research outputs found
Sort by
Conceptual Study of Shatkriyakala in Shuskashipaka (Dry Eye Syndrome)
Get PDFShushkakshipaka is considered as a Sarvakshi roga by Ayurveda acharyas. Among different Acharyas there is difference in opinion about the Dosha predominance of the disease. According to Susruth Acharya it is a Vataja disease; but Vagbhata describes it as a Vatapitta entity. Vata, Pitta and Rakta play major roles in the pathogenesis of Sushkakshipaka. The term Kriyakala refers to the progress of the disease, which helps to determine the treatment modalities to be given to make the Doshas in equilibrium. The Kriya Kala explained by Susrutha is having six stages, consider as Shadkriyakala. Here is an attempt to explain Shushkakshipaka in terms of Shadkriyakala so that one can understand the stage of the disease and decide the treatment to be given
Role of Katankateriyadi Kwatha in the Management of Madhumeha (Diabetes Mellitus Type II)
Get PDFHigh blood sugar levels are a hallmark of a verity of metabolic disease together referred to as Diabetes mellitus (DM). It is divided into two categories: (type 1 DM) and (type 2 DM). Type 1 diabetes results from a complete or nearly complete lack of insulin, while type 2 diabetes includes various disorders marked by differing levels of insulin resistance, impaired insulin secretion, and increased glucose production. This report presents a case of a newly diagnosed type 2 diabetes patient who received three follow-ups with Katankateriyadi Kwatha over three months (90 days). Following treatment, there were reductions in the patient\u27s fasting blood glucose, post-prandial blood glucose levels and HbA1c levels. Further-more, no adverse effects were observed. The finding in this clinical study are encouraging and provide evidence supporting the effectiveness of Katankateriyad Kwatha in reducing type 2 diabetes mellitus in a patient
Physicochemical Analysis and Phytochemical Evaluation of Gokshuradi Churna and its Hydro-Alcoholic Extract
Get PDFDrug is an essential tool of a physician included in Chatushpada. Many single as well as compound drugs are mentioned in classics in different contexts for internal as well as external use. It is always the cumulative impact of all the ingredients in the solution that plays a critical role in therapeutics, rather than the action of the individual medication. Synergistic action, combined action and toxicity neutralizing action and basic purpose are envisaged to serve drug combinations. One such important formulation prescribed in the Ashtanga Haridya Uttartantra is Gokshuradi Churna provides specifics of the drugs Gokshuradi Churna which was chosen for study. Acharya Vaghbhatta in Uttartantra listed numerous drugs that are useful in the treatment of Alpa, Dushta Retas that specifically influence the properties of Shukrajanana (spermatogenesis) and Shukra Shodhana. This formulation consists of five ingredients i.e., Gokshura (Tribulus terrestris Linn), Ikshura (Asteracantha longifolia Nees), Mash (Phaseolus mungo Linn), Atmagupta seeds (Mucuna prurita Hook) & Shatavari (Asparagus racemosus Wild). Many formulations are available in various texts under the same name Gokshuradi Churna with different ingredients and different Rogadhikara. Keeping this aim into consideration, the present study was designed to scientific evaluation of Gokshuradi Churna and its hydroalcoholic extract on different analytical and phytochemical parameters. The study includes macro and microscopic characters, powder microscopic characteristics, heavy metals analysis and High Performance Thin Layer Chromatography fingerprints (HPTLC). The information generated by this particulars study provides relevant pharmacognostical and physicochemical data needed for proper identification and authentication of Gokshuradi Churna and its hydroalacoholic extract
Effect of Jala Neti and Soopya Yoosha in Allergic Rhinitis
Get PDFAllergic rhinitis is a common health problem affecting immune system. It is an allergic response to specific allergens causing the inflammation of nasal mucosa. Allergic rhinitis is a major risk factor for poor asthma control and affects quality of life. Cardinal symptoms include nasal congestion, rhinorrhea, and pruritis of the nose and eyes. Patients who suffer from allergic rhinitis sustain significant morbidity and loss of productivity. The symptoms of allergic rhinitis can be co-related with Lakshanas of Pratishyaya mentioned in Ayurveda. This study aimed at yoga therapy and diet as an efficient treatment protocol for the disease. Jalaneti procedure which was mentioned in yoga, helped in preventing and managing upper respiratory tract infections. Since ancient time Yoosha had been suggested as Pathya for both healthy and diseased people. Soopya yoosha containing Mudga and Moolaka is a dietary preparation having Pratishyayahara property. In present study Jalaneti and Soopya yoosha were used in patients of allergic rhinitis
Determination of Polyphenolic Compounds Present in Guduchyadi Kashaya Using Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Get PDFThe utilization of various contemporary analytical methods has become indispensable when it comes to assessing polyherbal Ayurvedic formulations, aiming to ensure their quality, safety, and effectiveness. Quality control of herbal medicines involve analytical evaluation using instrumental techniques such as TLC, HPTLC, HPLC, GC-MS, LC-MS and spectrophotometer etc. Among them Liquid Chromatography with tandem Mass Spectrometry (LC-MS/MS) is a powerful hyphenated analytical technique that combines the separating power of liquid chromatography with the mass analysis capabilities of mass spectrometry. Generally, its application is oriented towards the specific detection and potential identification of chemicals in a complex mixture. Polyphenolic compounds are usually referred to as a diverse group of naturally occurring compounds containing multiple phenolic functionalities. The anti-inflammatory, anti-aging, antiproliferative, and antioxidant like biological properties of phenolic compounds have been described in several studies. This research study was taken to analyse polyphenolic compounds in Guduchyadi kashaya by LC-MS/MS. Phenolic compounds are abundant in the ingredients of Guduchyadi kashaya, as evidenced by previous studies. So, to determine the polyphenolic contents of Guduchyadi kashaya, this study was conducted. The quantification of the polyphenols was carried out on Shimadzu Shim Pack GISS C18 column with .1%formic acid as mobile phase. A total of 28 polyphenolic compounds were analysed, and 24 of these compounds were found to be present in Guduchyadi kashaya. The results showed that the phenolic compounds present in the ingredients were also present in the formulation in high abundance
A Conceptual Review of the Effectiveness of Limonia Acidissima Decoction in Vitiligo Management
Get PDFLimonia acidissima also known as wood apple is a wild-growing medicinal plant distributed throughout India and Sri Lanka. Traditional practitioners in Sri Lanka, along with those using folk medicine and Ayurvedic toxicology principles, have reported that different extracts of Limonia acidissima are effective in managing vitiligo. Further research using advanced techniques is required to scientifically validate Ayurvedic and traditional medicines, yet there is limited emphasis on clinical studies and a deeper understanding of the specific properties of Limonia acidissima. This study aims to review and integrate current information on the pharmacological features of Limonia acidissima decoction component and assess its efficiency in treating vitiligo. Authentic Ayurvedic scriptures, modern writings, and previous research projects were used to gather information regarding Limonia acidissima. This study identified for various pharmacological properties, according to the Ayurveda, Vishagna (antitoxic), Shotha (anti-inflammatory), Yakrut Uttejaka (hepato-protective) along with its immune-modulatory, anti-oxidant, anti-inflammatory, regulation of cytokines and its potential utility in vitiligo treatment. Bioactive compounds present in wood apple contribute to its antioxidant functions. These are indirectly support vitiligo treatment and its application specifically to vitiligo is not well-established in direct clinical research. Limonia acidissima is used in traditional and folk medicine to treat vitiligo, a condition with white spots. However, there is a lack of scientific proof in clinical settings, mechanisms of action, including, autoimmune response regulation, melanogenesis enhancement, and interaction with other vitiligo-related signaling pathways. Therefore, clinical, immunological, and analytical research could provide valuable information for vitiligo treatment
Need-Based Apatarpana (Depleting) and Santarpana (Nourishing) Interventions in Managing Prameha with special reference to Type 2 Diabetes Mellitus
Get PDFPrameha is a disease with different pathological conditions as per Ayurveda, comparable to Type 2 Diabetes mellitus. The main line of therapeutic intervention for Prameha, a disease due to over-nourishment, is Apatarpana (depleting regimens of Ayurveda to reduce the bulk of body tissues, particularly Meda and Mamsa dhatu in the present context). As a general principle of Ayurveda diagnosis, a disease is dynamic and changes its status and presentation with time, diet, and interventions. Complementing this, each therapeutic intervention is defined with deficit, optimum, and excess use features. Administering the intervention less than or beyond the requirement may harm the individual, resulting in hampered structure and/or function of other body components. In the present review, we have attempted to put forth this principle of need-based Apatarpana and Santarpana (bulk/strength promoting therapies of Ayurveda) interventions, in managing Prameha with special reference to Type 2 Diabetes Mellitus
Ayurvedic Insights into Re-Emerging Human Brucellosis
Get PDFBrucellosis is a bacterial infection caused by Brucella melintensis. It is one of the most widespread endemic zoonotic diseases present globally, more prevalent in developing countries. It is transmitted to humans either through direct contact with infected animal tissues or fluids or indirectly by ingesting contaminated meat and unpasteurized dairy products. The route of transmission includes mainly mucocutaneous. Farmers, butchers, hunters, and veterinarians are mainly at higher risk of contracting this condition. Mostly the affected individuals exhibit flu-like symptoms, remittent fever, malaise, arthralgia, and weight loss which lasts from a few days to several years. The condition is often misdiagnosed due to nonspecific clinical symptoms, leading to inadequate treatment and prolonged illness leading to severe complications like endocarditis. Currently, there is no vaccine for human brucellosis. The modern management includes administration of antibiotics. The gold standard diagnostic tool is direct bacteriological testing. Ayurvedic understanding of endemic diseases highlights the unique concept of Janapathhodhwamsa proposed by Acharyas. They considered Vayu, Jala, Kala, and Desa as common factors in manifestation of disease. Any alteration in these factors can be understood as imbalance and disease outbreak emerged due to urbanization, lack of hygienic measures in animal husbandry, etc. remaining a public health hazard. Brucellosis is known by its undulant nature which closely resembles the Vishama Jwara in classics which is a Sannipatika type of Jwara. Amapachana, Shodhana, and Samana line of management followed by Rasayana, Satvritta Palana as a preventive line can be adopted to manage Brucellosis
Role of Basti and Snehana Putapaka in the Management of Shushkaakshipaka with respect to Sjogren’s Syndrome
Get PDFSjogren’s syndrome is an autoimmune disorder in which the immune system attacks the glands that make moisture in the eyes, mouth, and other parts of the body. The triad of Sjogren’s syndrome consists of keratoconjunctivitis sicca (dry eye), xerostomia (dry mouth) and rheumatoid arthritis. From Ayurvedic perspective, the pathophysiology of Sjogren’s shows Vata dosha dushti leading to Sandhigata vikara, Roukshya and Shushkaakshipaka. Shushkaakshipaka is a Vata-pittaja, Sarvagata netra vikara that matches the clinical picture of dry eyes disease. To control this Prakupit vata dosha; Sanshodhan and Shaman both are required. As a result, Vata shodhana was achieved by Basti upakram and Basti pashchat Snehana Putapaka, Nasya and Snehapana brought about Vata shamana. Patient’s dryness of eyes was assessed using Schirmers test and Tear film Break up test. After treatment Schirmer’s reading showed significant improvement from 2mm to 10mm and from 4mm to 8mm in right and left eye respectively. Other symptoms of patient like dryness of mouth and joint pain also reduced to a certain amount. This case report shows a classical Ayurvedic treatment protocol used to treat Sjogren’s Syndrome
Ayurveda Upachara on Amavata
Get PDFThis study delves into the positive impact of a 15-day Snehapana treatment on a patient, revealing significant relief from pain, reduced joint stiffness, and overall improvement. The subsequent follow-up assessment demonstrates the complete elimination of pain, swelling, sensitivity, and hardness. The success underscores the pivotal role of addressing Agni impairment, Ama formation, and Vata dosha vitiation in effectively managing Amavata. The sequential approach, encompassing the transformation of Ama into Niramaavasta, coupled with Virechan and Snehana treatments, proved to be successful. Notably, Snehana emerged as a crucial element, playing a key role in eliminating Ama-related issues, calming Vata, and clearing impurities. These findings provide valuable insights into a comprehensive and successful strategy for Amavata management, emphasizing the importance of a tailored treatment plan targeting the root causes of the condition